NPL4 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

NPL4 family - putative

Species:

Leishmania infantum

UniProt:

A4I1H3_LEIIN

TriTrypDb:

LINF_250019000

Length:

247

Annotations

Annotations by Jardim et al.

Nuclear proteins, NPL4 family, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1H3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.326
CLV_PCSK_KEX2_1	188	190	PF00082	0.326
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.326
CLV_PCSK_SKI1_1	12	16	PF00082	0.263
CLV_PCSK_SKI1_1	131	135	PF00082	0.394
CLV_PCSK_SKI1_1	144	148	PF00082	0.284
CLV_PCSK_SKI1_1	161	165	PF00082	0.316
CLV_PCSK_SKI1_1	228	232	PF00082	0.299
DEG_Nend_UBRbox_1	1	4	PF02207	0.374
DOC_MAPK_gen_1	185	194	PF00069	0.310
DOC_MAPK_MEF2A_6	2	11	PF00069	0.317
DOC_PP2B_PxIxI_1	67	73	PF00149	0.375
DOC_PP4_FxxP_1	155	158	PF00568	0.311
DOC_PP4_MxPP_1	172	175	PF00568	0.314
DOC_USP7_MATH_1	220	224	PF00917	0.275
DOC_USP7_MATH_1	37	41	PF00917	0.448
DOC_USP7_MATH_1	54	58	PF00917	0.507
DOC_USP7_MATH_1	59	63	PF00917	0.491
DOC_WW_Pin1_4	154	159	PF00397	0.310
DOC_WW_Pin1_4	77	82	PF00397	0.265
LIG_14-3-3_CanoR_1	144	150	PF00244	0.288
LIG_14-3-3_CanoR_1	189	195	PF00244	0.287
LIG_14-3-3_CanoR_1	219	225	PF00244	0.278
LIG_BRCT_BRCA1_1	190	194	PF00533	0.300
LIG_FHA_1	112	118	PF00498	0.317
LIG_FHA_1	145	151	PF00498	0.292
LIG_FHA_1	67	73	PF00498	0.375
LIG_FHA_2	120	126	PF00498	0.356
LIG_FHA_2	137	143	PF00498	0.287
LIG_FHA_2	195	201	PF00498	0.241
LIG_FHA_2	211	217	PF00498	0.273
LIG_LIR_Gen_1	147	155	PF02991	0.311
LIG_LIR_Gen_1	200	208	PF02991	0.236
LIG_LIR_Nem_3	143	149	PF02991	0.282
LIG_LIR_Nem_3	200	204	PF02991	0.235
LIG_MYND_1	64	68	PF01753	0.438
LIG_NRBOX	203	209	PF00104	0.238
LIG_Pex14_1	145	149	PF04695	0.285
LIG_SH2_CRK	237	241	PF00017	0.262
LIG_SH2_PTP2	149	152	PF00017	0.310
LIG_SH2_STAT5	149	152	PF00017	0.310
LIG_SH2_STAT5	183	186	PF00017	0.297
LIG_SH2_STAT5	206	209	PF00017	0.244
LIG_SH3_3	167	173	PF00018	0.345
LIG_SUMO_SIM_par_1	67	73	PF11976	0.375
LIG_TYR_ITSM	145	152	PF00017	0.294
MOD_CDK_SPxxK_3	154	161	PF00069	0.316
MOD_CK1_1	40	46	PF00069	0.509
MOD_CK1_1	62	68	PF00069	0.452
MOD_CK2_1	190	196	PF00069	0.288
MOD_CK2_1	211	217	PF00069	0.273
MOD_CK2_1	93	99	PF00069	0.324
MOD_GlcNHglycan	42	45	PF01048	0.516
MOD_GlcNHglycan	47	50	PF01048	0.522
MOD_GlcNHglycan	56	59	PF01048	0.507
MOD_GlcNHglycan	61	64	PF01048	0.477
MOD_GlcNHglycan	94	98	PF01048	0.320
MOD_GSK3_1	131	138	PF00069	0.374
MOD_GSK3_1	140	147	PF00069	0.272
MOD_GSK3_1	190	197	PF00069	0.281
MOD_GSK3_1	206	213	PF00069	0.254
MOD_GSK3_1	220	227	PF00069	0.286
MOD_GSK3_1	40	47	PF00069	0.511
MOD_GSK3_1	54	61	PF00069	0.502
MOD_GSK3_1	62	69	PF00069	0.443
MOD_LATS_1	129	135	PF00433	0.396
MOD_NEK2_1	165	170	PF00069	0.341
MOD_NEK2_1	194	199	PF00069	0.238
MOD_NEK2_1	92	97	PF00069	0.308
MOD_PIKK_1	206	212	PF00454	0.247
MOD_PKA_1	188	194	PF00069	0.303
MOD_PKA_2	165	171	PF00069	0.344
MOD_PKA_2	188	194	PF00069	0.303
MOD_Plk_1	19	25	PF00069	0.270
MOD_Plk_4	145	151	PF00069	0.292
MOD_Plk_4	66	72	PF00069	0.392
MOD_ProDKin_1	154	160	PF00069	0.313
MOD_ProDKin_1	77	83	PF00069	0.259
TRG_ENDOCYTIC_2	149	152	PF00928	0.310
TRG_ENDOCYTIC_2	237	240	PF00928	0.272
TRG_NES_CRM1_1	196	210	PF08389	0.244
TRG_NES_CRM1_1	5	20	PF08389	0.274
TRG_NLS_MonoExtN_4	185	192	PF00514	0.322