Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1F6_LEIIN

TriTrypDb:

LINF_250017500

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.632
CLV_NRD_NRD_1	12	14	PF00675	0.422
CLV_NRD_NRD_1	176	178	PF00675	0.580
CLV_PCSK_FUR_1	174	178	PF00082	0.584
CLV_PCSK_KEX2_1	12	14	PF00082	0.422
CLV_PCSK_KEX2_1	176	178	PF00082	0.580
CLV_PCSK_SKI1_1	527	531	PF00082	0.621
DEG_SCF_FBW7_1	242	249	PF00400	0.630
DEG_SPOP_SBC_1	109	113	PF00917	0.595
DOC_CDC14_PxL_1	182	190	PF14671	0.451
DOC_CKS1_1	243	248	PF01111	0.611
DOC_CKS1_1	53	58	PF01111	0.400
DOC_PP2B_LxvP_1	313	316	PF13499	0.514
DOC_PP2B_LxvP_1	74	77	PF13499	0.537
DOC_PP2B_PxIxI_1	361	367	PF00149	0.428
DOC_PP4_FxxP_1	212	215	PF00568	0.592
DOC_USP7_MATH_1	103	107	PF00917	0.575
DOC_USP7_MATH_1	138	142	PF00917	0.607
DOC_USP7_MATH_1	150	154	PF00917	0.587
DOC_USP7_MATH_1	220	224	PF00917	0.576
DOC_USP7_MATH_1	234	238	PF00917	0.631
DOC_USP7_MATH_1	246	250	PF00917	0.550
DOC_USP7_MATH_1	269	273	PF00917	0.555
DOC_USP7_MATH_1	327	331	PF00917	0.594
DOC_USP7_MATH_1	338	342	PF00917	0.553
DOC_USP7_MATH_1	408	412	PF00917	0.633
DOC_USP7_MATH_1	532	536	PF00917	0.649
DOC_USP7_MATH_1	8	12	PF00917	0.487
DOC_USP7_MATH_1	93	97	PF00917	0.608
DOC_USP7_UBL2_3	136	140	PF12436	0.640
DOC_WW_Pin1_4	126	131	PF00397	0.583
DOC_WW_Pin1_4	236	241	PF00397	0.617
DOC_WW_Pin1_4	242	247	PF00397	0.631
DOC_WW_Pin1_4	278	283	PF00397	0.650
DOC_WW_Pin1_4	287	292	PF00397	0.525
DOC_WW_Pin1_4	306	311	PF00397	0.352
DOC_WW_Pin1_4	342	347	PF00397	0.650
DOC_WW_Pin1_4	385	390	PF00397	0.593
DOC_WW_Pin1_4	412	417	PF00397	0.643
DOC_WW_Pin1_4	422	427	PF00397	0.571
DOC_WW_Pin1_4	507	512	PF00397	0.581
DOC_WW_Pin1_4	52	57	PF00397	0.403
DOC_WW_Pin1_4	528	533	PF00397	0.544
LIG_14-3-3_CanoR_1	47	53	PF00244	0.464
LIG_14-3-3_CanoR_1	527	532	PF00244	0.574
LIG_Actin_WH2_2	462	480	PF00022	0.453
LIG_BIR_III_2	393	397	PF00653	0.611
LIG_BRCT_BRCA1_1	410	414	PF00533	0.607
LIG_EVH1_1	212	216	PF00568	0.621
LIG_EVH1_2	429	433	PF00568	0.634
LIG_FHA_1	26	32	PF00498	0.414
LIG_FHA_1	386	392	PF00498	0.522
LIG_FHA_1	486	492	PF00498	0.464
LIG_FHA_1	5	11	PF00498	0.445
LIG_FHA_1	507	513	PF00498	0.632
LIG_FHA_1	531	537	PF00498	0.584
LIG_FHA_2	216	222	PF00498	0.710
LIG_FHA_2	520	526	PF00498	0.634
LIG_FHA_2	53	59	PF00498	0.394
LIG_FHA_2	67	73	PF00498	0.450
LIG_LIR_Apic_2	209	215	PF02991	0.562
LIG_LIR_Apic_2	330	334	PF02991	0.589
LIG_LIR_Gen_1	436	447	PF02991	0.457
LIG_LIR_Gen_1	464	473	PF02991	0.490
LIG_LIR_Gen_1	69	78	PF02991	0.522
LIG_LIR_Nem_3	298	303	PF02991	0.456
LIG_LIR_Nem_3	436	442	PF02991	0.446
LIG_LIR_Nem_3	464	469	PF02991	0.420
LIG_LIR_Nem_3	471	476	PF02991	0.360
LIG_LIR_Nem_3	69	74	PF02991	0.492
LIG_MYND_1	311	315	PF01753	0.500
LIG_NRBOX	58	64	PF00104	0.432
LIG_NRP_CendR_1	541	543	PF00754	0.639
LIG_PTAP_UEV_1	129	134	PF05743	0.634
LIG_SH2_CRK	303	307	PF00017	0.436
LIG_SH2_CRK	331	335	PF00017	0.593
LIG_SH2_CRK	452	456	PF00017	0.383
LIG_SH2_PTP2	359	362	PF00017	0.436
LIG_SH2_SRC	359	362	PF00017	0.436
LIG_SH2_STAT3	61	64	PF00017	0.375
LIG_SH2_STAT5	18	21	PF00017	0.385
LIG_SH2_STAT5	192	195	PF00017	0.513
LIG_SH2_STAT5	198	201	PF00017	0.500
LIG_SH2_STAT5	29	32	PF00017	0.424
LIG_SH2_STAT5	359	362	PF00017	0.436
LIG_SH2_STAT5	439	442	PF00017	0.366
LIG_SH2_STAT5	476	479	PF00017	0.371
LIG_SH2_STAT5	61	64	PF00017	0.375
LIG_SH3_2	426	431	PF14604	0.642
LIG_SH3_3	127	133	PF00018	0.635
LIG_SH3_3	180	186	PF00018	0.484
LIG_SH3_3	210	216	PF00018	0.666
LIG_SH3_3	237	243	PF00018	0.679
LIG_SH3_3	245	251	PF00018	0.600
LIG_SH3_3	308	314	PF00018	0.535
LIG_SH3_3	386	392	PF00018	0.633
LIG_SH3_3	423	429	PF00018	0.665
LIG_SH3_3	50	56	PF00018	0.416
LIG_SH3_3	513	519	PF00018	0.593
LIG_SH3_3	87	93	PF00018	0.677
LIG_SUMO_SIM_par_1	96	102	PF11976	0.523
LIG_WW_3	419	423	PF00397	0.543
LIG_WW_3	428	432	PF00397	0.490
MOD_CDC14_SPxK_1	415	418	PF00782	0.609
MOD_CDC14_SPxK_1	428	431	PF00782	0.516
MOD_CDK_SPK_2	242	247	PF00069	0.631
MOD_CDK_SPxK_1	412	418	PF00069	0.604
MOD_CDK_SPxK_1	425	431	PF00069	0.528
MOD_CK1_1	108	114	PF00069	0.603
MOD_CK1_1	190	196	PF00069	0.449
MOD_CK1_1	250	256	PF00069	0.794
MOD_CK1_1	281	287	PF00069	0.673
MOD_CK1_1	295	301	PF00069	0.352
MOD_CK1_1	309	315	PF00069	0.424
MOD_CK1_1	317	323	PF00069	0.578
MOD_CK1_1	341	347	PF00069	0.621
MOD_CK1_1	412	418	PF00069	0.630
MOD_CK1_1	510	516	PF00069	0.555
MOD_CK1_1	531	537	PF00069	0.596
MOD_CK2_1	52	58	PF00069	0.385
MOD_CK2_1	66	72	PF00069	0.423
MOD_DYRK1A_RPxSP_1	422	426	PF00069	0.544
MOD_GlcNHglycan	105	108	PF01048	0.642
MOD_GlcNHglycan	122	125	PF01048	0.603
MOD_GlcNHglycan	140	143	PF01048	0.573
MOD_GlcNHglycan	271	274	PF01048	0.646
MOD_GlcNHglycan	283	286	PF01048	0.546
MOD_GlcNHglycan	300	303	PF01048	0.341
MOD_GlcNHglycan	319	322	PF01048	0.484
MOD_GlcNHglycan	351	354	PF01048	0.482
MOD_GlcNHglycan	522	525	PF01048	0.593
MOD_GlcNHglycan	83	86	PF01048	0.639
MOD_GlcNHglycan	93	96	PF01048	0.532
MOD_GSK3_1	103	110	PF00069	0.642
MOD_GSK3_1	111	118	PF00069	0.578
MOD_GSK3_1	134	141	PF00069	0.662
MOD_GSK3_1	187	194	PF00069	0.447
MOD_GSK3_1	232	239	PF00069	0.611
MOD_GSK3_1	242	249	PF00069	0.651
MOD_GSK3_1	265	272	PF00069	0.625
MOD_GSK3_1	337	344	PF00069	0.783
MOD_GSK3_1	4	11	PF00069	0.516
MOD_GSK3_1	408	415	PF00069	0.637
MOD_GSK3_1	464	471	PF00069	0.473
MOD_GSK3_1	48	55	PF00069	0.588
MOD_GSK3_1	506	513	PF00069	0.576
MOD_GSK3_1	527	534	PF00069	0.762
MOD_GSK3_1	66	73	PF00069	0.362
MOD_GSK3_1	77	84	PF00069	0.586
MOD_GSK3_1	93	100	PF00069	0.557
MOD_N-GLC_1	409	414	PF02516	0.527
MOD_N-GLC_1	66	71	PF02516	0.405
MOD_NEK2_1	158	163	PF00069	0.491
MOD_NEK2_1	188	193	PF00069	0.447
MOD_NEK2_1	376	381	PF00069	0.472
MOD_NEK2_1	433	438	PF00069	0.539
MOD_NEK2_1	48	53	PF00069	0.461
MOD_NEK2_2	18	23	PF00069	0.422
MOD_PIKK_1	158	164	PF00454	0.523
MOD_PIKK_1	232	238	PF00454	0.646
MOD_PKA_2	384	390	PF00069	0.629
MOD_PKA_2	48	54	PF00069	0.457
MOD_Plk_1	409	415	PF00069	0.619
MOD_Plk_4	295	301	PF00069	0.413
MOD_ProDKin_1	126	132	PF00069	0.583
MOD_ProDKin_1	236	242	PF00069	0.615
MOD_ProDKin_1	247	253	PF00069	0.655
MOD_ProDKin_1	278	284	PF00069	0.654
MOD_ProDKin_1	287	293	PF00069	0.514
MOD_ProDKin_1	306	312	PF00069	0.359
MOD_ProDKin_1	342	348	PF00069	0.645
MOD_ProDKin_1	385	391	PF00069	0.594
MOD_ProDKin_1	412	418	PF00069	0.648
MOD_ProDKin_1	422	428	PF00069	0.568
MOD_ProDKin_1	507	513	PF00069	0.580
MOD_ProDKin_1	52	58	PF00069	0.397
MOD_ProDKin_1	528	534	PF00069	0.546
MOD_SUMO_rev_2	436	445	PF00179	0.396
TRG_DiLeu_BaEn_1	58	63	PF01217	0.426
TRG_DiLeu_BaEn_2	153	159	PF01217	0.495
TRG_ENDOCYTIC_2	303	306	PF00928	0.443
TRG_ENDOCYTIC_2	439	442	PF00928	0.366
TRG_ENDOCYTIC_2	452	455	PF00928	0.387
TRG_ER_diArg_1	12	14	PF00400	0.422
TRG_ER_diArg_1	173	176	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z7	Leptomonas seymouri	52%	100%
A0A3Q8ID95	Leishmania donovani	99%	100%
A4HE58	Leishmania braziliensis	70%	99%
E9AXJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q9X9	Leishmania major	91%	100%