Putative cytochrome c oxidase VII

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase VII - putativeGeneDB:LmjF.25.1130

Species:

Leishmania infantum

UniProt:

A4I1F5_LEIIN

TriTrypDb:

LINF_250017400

Length:

165

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase VII

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1F5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	63	69	PF00089	0.375
CLV_NRD_NRD_1	116	118	PF00675	0.543
CLV_NRD_NRD_1	158	160	PF00675	0.537
CLV_PCSK_SKI1_1	37	41	PF00082	0.366
DOC_MAPK_gen_1	77	87	PF00069	0.557
DOC_MAPK_MEF2A_6	77	86	PF00069	0.553
DOC_PP4_FxxP_1	161	164	PF00568	0.317
DOC_PP4_FxxP_1	40	43	PF00568	0.569
DOC_PP4_FxxP_1	49	52	PF00568	0.524
DOC_USP7_UBL2_3	118	122	PF12436	0.350
DOC_WW_Pin1_4	128	133	PF00397	0.354
LIG_14-3-3_CanoR_1	117	121	PF00244	0.458
LIG_14-3-3_CanoR_1	66	72	PF00244	0.581
LIG_EH_1	22	26	PF12763	0.561
LIG_EH1_1	80	88	PF00400	0.450
LIG_FHA_2	11	17	PF00498	0.513
LIG_LIR_Apic_2	38	43	PF02991	0.520
LIG_LIR_Gen_1	131	139	PF02991	0.365
LIG_LIR_Gen_1	92	103	PF02991	0.317
LIG_LIR_Nem_3	28	32	PF02991	0.557
LIG_LIR_Nem_3	92	98	PF02991	0.267
LIG_PDZ_Class_2	160	165	PF00595	0.327
LIG_Pex14_2	25	29	PF04695	0.601
LIG_SH2_SRC	162	165	PF00017	0.333
LIG_SH2_STAP1	142	146	PF00017	0.353
LIG_SH2_STAP1	27	31	PF00017	0.635
LIG_SH2_STAT5	162	165	PF00017	0.367
LIG_SH3_3	36	42	PF00018	0.621
LIG_SH3_3	4	10	PF00018	0.605
LIG_SH3_3	76	82	PF00018	0.572
LIG_TRAF2_2	52	57	PF00917	0.532
LIG_UBA3_1	97	102	PF00899	0.304
MOD_CK2_1	10	16	PF00069	0.517
MOD_GlcNHglycan	98	101	PF01048	0.375
MOD_GSK3_1	112	119	PF00069	0.446
MOD_N-GLC_1	128	133	PF02516	0.554
MOD_NEK2_1	150	155	PF00069	0.466
MOD_NEK2_1	25	30	PF00069	0.638
MOD_PKA_2	116	122	PF00069	0.452
MOD_PKA_2	65	71	PF00069	0.572
MOD_Plk_4	104	110	PF00069	0.424
MOD_Plk_4	58	64	PF00069	0.556
MOD_ProDKin_1	128	134	PF00069	0.354
MOD_SUMO_for_1	35	38	PF00179	0.640
TRG_ER_diArg_1	17	20	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGN0	Leptomonas seymouri	92%	100%
A0A0S4IVN1	Bodo saltans	69%	100%
A0A1X0NLX0	Trypanosomatidae	68%	100%
A0A1X0NML5	Trypanosomatidae	70%	100%
A0A3Q8IDG0	Leishmania donovani	100%	100%
A0A3R7LCN3	Trypanosoma rangeli	70%	100%
A4HE57	Leishmania braziliensis	94%	100%
C9ZK13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AXJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9Y0	Leishmania major	99%	100%