Aldehyde dehydrogenase, mitochondrial

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldehyde dehydrogenase - mitochondrial precursor

Species:

Leishmania infantum

UniProt:

A4I1F4_LEIIN

TriTrypDb:

LINF_250017300

Length:

499

Annotations

Annotations by Jardim et al.

Aldehyde metabolism, Aldehyde dehydrogenase, mitochondrial ALDH2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1F4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004029	aldehyde dehydrogenase (NAD+) activity	6	6
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	5	6
GO:0016491	oxidoreductase activity	2	9
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	9
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	9
GO:0043878	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	5	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.409
CLV_NRD_NRD_1	319	321	PF00675	0.271
CLV_NRD_NRD_1	326	328	PF00675	0.185
CLV_NRD_NRD_1	81	83	PF00675	0.227
CLV_PCSK_KEX2_1	152	154	PF00082	0.216
CLV_PCSK_KEX2_1	326	328	PF00082	0.185
CLV_PCSK_KEX2_1	369	371	PF00082	0.224
CLV_PCSK_KEX2_1	415	417	PF00082	0.289
CLV_PCSK_KEX2_1	81	83	PF00082	0.227
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.205

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0E3T3B5	Malus domestica	39%	99%
A0A0E3T552	Malus domestica	40%	99%
A0A0N0P2K9	Leptomonas seymouri	83%	100%
A0A0N1HV25	Leptomonas seymouri	29%	89%
A0A0N1I2U5	Leptomonas seymouri	30%	94%
A0A0N1IL67	Leptomonas seymouri	37%	98%
A0A0N1PB61	Leptomonas seymouri	32%	85%
A0A0S4IS93	Bodo saltans	28%	98%
A0A0S4ITF6	Bodo saltans	34%	90%
A0A0S4IZS0	Bodo saltans	30%	97%

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