LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I1F0_LEIIN
TriTrypDb:
LINF_250016900
Length:
448

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 70
Promastigote: 220, 222, 226, 302

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1F0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1F0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 155 157 PF00675 0.342
CLV_NRD_NRD_1 294 296 PF00675 0.544
CLV_NRD_NRD_1 300 302 PF00675 0.580
CLV_NRD_NRD_1 446 448 PF00675 0.599
CLV_PCSK_FUR_1 153 157 PF00082 0.464
CLV_PCSK_KEX2_1 155 157 PF00082 0.401
CLV_PCSK_KEX2_1 294 296 PF00082 0.544
CLV_PCSK_KEX2_1 300 302 PF00082 0.580
CLV_PCSK_KEX2_1 446 448 PF00082 0.553
CLV_PCSK_SKI1_1 201 205 PF00082 0.499
CLV_PCSK_SKI1_1 238 242 PF00082 0.620
CLV_PCSK_SKI1_1 49 53 PF00082 0.395
CLV_PCSK_SKI1_1 81 85 PF00082 0.555
DEG_APCC_DBOX_1 226 234 PF00400 0.484
DOC_CYCLIN_yCln2_LP_2 88 94 PF00134 0.351
DOC_MAPK_gen_1 153 161 PF00069 0.330
DOC_MAPK_gen_1 6 15 PF00069 0.441
DOC_MAPK_MEF2A_6 153 161 PF00069 0.396
DOC_PP2B_LxvP_1 88 91 PF13499 0.393
DOC_USP7_MATH_1 179 183 PF00917 0.594
DOC_USP7_MATH_1 368 372 PF00917 0.657
DOC_USP7_MATH_1 431 435 PF00917 0.538
DOC_USP7_MATH_1 74 78 PF00917 0.580
DOC_USP7_UBL2_3 45 49 PF12436 0.530
DOC_USP7_UBL2_3 7 11 PF12436 0.530
DOC_WW_Pin1_4 246 251 PF00397 0.535
DOC_WW_Pin1_4 258 263 PF00397 0.464
DOC_WW_Pin1_4 304 309 PF00397 0.564
DOC_WW_Pin1_4 351 356 PF00397 0.586
DOC_WW_Pin1_4 373 378 PF00397 0.653
LIG_14-3-3_CanoR_1 100 109 PF00244 0.364
LIG_14-3-3_CanoR_1 300 308 PF00244 0.590
LIG_14-3-3_CanoR_1 406 410 PF00244 0.604
LIG_14-3-3_CanoR_1 9 14 PF00244 0.510
LIG_14-3-3_CterR_2 446 448 PF00244 0.553
LIG_BRCT_BRCA1_1 128 132 PF00533 0.303
LIG_deltaCOP1_diTrp_1 29 35 PF00928 0.583
LIG_EH_1 319 323 PF12763 0.589
LIG_FHA_1 10 16 PF00498 0.445
LIG_FHA_1 117 123 PF00498 0.356
LIG_FHA_1 140 146 PF00498 0.368
LIG_FHA_1 71 77 PF00498 0.616
LIG_FHA_2 101 107 PF00498 0.214
LIG_FHA_2 352 358 PF00498 0.604
LIG_FHA_2 82 88 PF00498 0.525
LIG_Integrin_isoDGR_2 380 382 PF01839 0.668
LIG_LIR_Gen_1 105 116 PF02991 0.463
LIG_LIR_Gen_1 129 140 PF02991 0.283
LIG_LIR_Gen_1 56 65 PF02991 0.528
LIG_LIR_Nem_3 105 111 PF02991 0.460
LIG_LIR_Nem_3 129 135 PF02991 0.269
LIG_LIR_Nem_3 439 445 PF02991 0.561
LIG_MYND_1 311 315 PF01753 0.528
LIG_PCNA_yPIPBox_3 164 178 PF02747 0.494
LIG_Pex14_2 108 112 PF04695 0.255
LIG_Pex14_2 92 96 PF04695 0.353
LIG_SH2_PTP2 158 161 PF00017 0.344
LIG_SH2_STAP1 57 61 PF00017 0.464
LIG_SH2_STAT5 158 161 PF00017 0.344
LIG_SH2_STAT5 22 25 PF00017 0.440
LIG_SH3_1 427 433 PF00018 0.563
LIG_SH3_3 210 216 PF00018 0.588
LIG_SH3_3 274 280 PF00018 0.549
LIG_SH3_3 302 308 PF00018 0.589
LIG_SH3_3 309 315 PF00018 0.507
LIG_SH3_3 427 433 PF00018 0.581
LIG_SUMO_SIM_par_1 141 146 PF11976 0.493
LIG_TRAF2_1 103 106 PF00917 0.366
MOD_CK1_1 182 188 PF00069 0.543
MOD_CK1_1 217 223 PF00069 0.709
MOD_CK1_1 249 255 PF00069 0.593
MOD_CK1_1 261 267 PF00069 0.486
MOD_CK1_1 288 294 PF00069 0.692
MOD_CK1_1 323 329 PF00069 0.550
MOD_CK1_1 344 350 PF00069 0.626
MOD_CK1_1 375 381 PF00069 0.566
MOD_CK1_1 70 76 PF00069 0.527
MOD_CK2_1 100 106 PF00069 0.351
MOD_CK2_1 351 357 PF00069 0.677
MOD_Cter_Amidation 153 156 PF01082 0.364
MOD_GlcNHglycan 136 139 PF01048 0.381
MOD_GlcNHglycan 184 187 PF01048 0.562
MOD_GlcNHglycan 242 245 PF01048 0.663
MOD_GlcNHglycan 302 305 PF01048 0.707
MOD_GlcNHglycan 322 325 PF01048 0.453
MOD_GlcNHglycan 341 346 PF01048 0.553
MOD_GlcNHglycan 370 373 PF01048 0.661
MOD_GlcNHglycan 412 416 PF01048 0.547
MOD_GlcNHglycan 419 423 PF01048 0.659
MOD_GlcNHglycan 426 430 PF01048 0.575
MOD_GlcNHglycan 433 436 PF01048 0.469
MOD_GSK3_1 139 146 PF00069 0.394
MOD_GSK3_1 219 226 PF00069 0.544
MOD_GSK3_1 300 307 PF00069 0.616
MOD_GSK3_1 349 356 PF00069 0.621
MOD_GSK3_1 368 375 PF00069 0.679
MOD_GSK3_1 400 407 PF00069 0.545
MOD_GSK3_1 70 77 PF00069 0.514
MOD_LATS_1 298 304 PF00433 0.461
MOD_N-GLC_1 100 105 PF02516 0.346
MOD_N-GLC_1 61 66 PF02516 0.599
MOD_NEK2_1 147 152 PF00069 0.331
MOD_NEK2_1 240 245 PF00069 0.648
MOD_NEK2_1 299 304 PF00069 0.721
MOD_PIKK_1 160 166 PF00454 0.477
MOD_PKA_1 300 306 PF00069 0.655
MOD_PKA_2 172 178 PF00069 0.570
MOD_PKA_2 182 188 PF00069 0.651
MOD_PKA_2 299 305 PF00069 0.641
MOD_PKA_2 405 411 PF00069 0.534
MOD_Plk_1 147 153 PF00069 0.335
MOD_Plk_1 288 294 PF00069 0.533
MOD_Plk_1 341 347 PF00069 0.602
MOD_Plk_1 404 410 PF00069 0.524
MOD_Plk_1 55 61 PF00069 0.525
MOD_Plk_2-3 357 363 PF00069 0.553
MOD_Plk_4 107 113 PF00069 0.480
MOD_ProDKin_1 246 252 PF00069 0.534
MOD_ProDKin_1 258 264 PF00069 0.463
MOD_ProDKin_1 304 310 PF00069 0.562
MOD_ProDKin_1 351 357 PF00069 0.589
MOD_ProDKin_1 373 379 PF00069 0.651
MOD_SUMO_for_1 338 341 PF00179 0.575
MOD_SUMO_rev_2 351 360 PF00179 0.594
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.324
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.491
TRG_ENDOCYTIC_2 158 161 PF00928 0.344
TRG_ENDOCYTIC_2 57 60 PF00928 0.522
TRG_ER_diArg_1 153 156 PF00400 0.477
TRG_ER_diArg_1 299 301 PF00400 0.586
TRG_ER_diArg_1 445 447 PF00400 0.492
TRG_NLS_MonoExtN_4 4 10 PF00514 0.486
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.329

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3F7 Leptomonas seymouri 65% 100%
A0A0S4IKR5 Bodo saltans 37% 100%
A0A1X0NLV4 Trypanosomatidae 45% 100%
A0A3S7WZ21 Leishmania donovani 100% 100%
A4HE44 Leishmania braziliensis 84% 98%
C9ZJX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AXI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 98%
Q4Q9Y5 Leishmania major 95% 100%
V5BKV0 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS