BRCT domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1E8_LEIIN

TriTrypDb:

LINF_250016700

Length:

851

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 755
Promastigote: 122, 166, 188, 210, 289, 348, 56, 78
Promastigote/Amastigote: 117, 120, 161, 164, 183, 186, 205, 208, 279, 287, 296, 51, 54, 587, 590, 724, 73, 741, 76, 834

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.620
CLV_C14_Caspase3-7	460	464	PF00656	0.435
CLV_C14_Caspase3-7	778	782	PF00656	0.669
CLV_C14_Caspase3-7	815	819	PF00656	0.600
CLV_NRD_NRD_1	573	575	PF00675	0.566
CLV_NRD_NRD_1	711	713	PF00675	0.684
CLV_NRD_NRD_1	760	762	PF00675	0.707
CLV_PCSK_KEX2_1	434	436	PF00082	0.534
CLV_PCSK_KEX2_1	454	456	PF00082	0.356
CLV_PCSK_KEX2_1	573	575	PF00082	0.633
CLV_PCSK_KEX2_1	577	579	PF00082	0.620
CLV_PCSK_KEX2_1	713	715	PF00082	0.604
CLV_PCSK_KEX2_1	760	762	PF00082	0.709
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.484
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.322
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.633
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.620
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.542
CLV_PCSK_SKI1_1	335	339	PF00082	0.711
CLV_PCSK_SKI1_1	356	360	PF00082	0.687
CLV_PCSK_SKI1_1	570	574	PF00082	0.677
DEG_APCC_DBOX_1	287	295	PF00400	0.561
DEG_SCF_FBW7_1	414	421	PF00400	0.609
DOC_CDC14_PxL_1	610	618	PF14671	0.624
DOC_CKS1_1	350	355	PF01111	0.691
DOC_CKS1_1	415	420	PF01111	0.608
DOC_CKS1_1	617	622	PF01111	0.662
DOC_MAPK_gen_1	701	711	PF00069	0.620
DOC_MAPK_gen_1	763	772	PF00069	0.693
DOC_MAPK_MEF2A_6	611	618	PF00069	0.657
DOC_MAPK_MEF2A_6	704	711	PF00069	0.619
DOC_PIKK_1	814	822	PF02985	0.513
DOC_PP2B_LxvP_1	325	328	PF13499	0.633
DOC_USP7_MATH_1	255	259	PF00917	0.621
DOC_USP7_MATH_1	273	277	PF00917	0.492
DOC_USP7_MATH_1	306	310	PF00917	0.561
DOC_USP7_MATH_1	382	386	PF00917	0.538
DOC_USP7_MATH_1	5	9	PF00917	0.528
DOC_USP7_MATH_1	543	547	PF00917	0.665
DOC_USP7_MATH_1	597	601	PF00917	0.562
DOC_USP7_MATH_1	632	636	PF00917	0.692
DOC_USP7_MATH_1	775	779	PF00917	0.549
DOC_USP7_MATH_1	796	800	PF00917	0.646
DOC_USP7_UBL2_3	571	575	PF12436	0.613
DOC_USP7_UBL2_3	577	581	PF12436	0.559
DOC_USP7_UBL2_3	607	611	PF12436	0.582
DOC_WW_Pin1_4	339	344	PF00397	0.730
DOC_WW_Pin1_4	349	354	PF00397	0.656
DOC_WW_Pin1_4	389	394	PF00397	0.642
DOC_WW_Pin1_4	405	410	PF00397	0.593
DOC_WW_Pin1_4	414	419	PF00397	0.590
DOC_WW_Pin1_4	616	621	PF00397	0.685
DOC_WW_Pin1_4	624	629	PF00397	0.647
DOC_WW_Pin1_4	661	666	PF00397	0.698
DOC_WW_Pin1_4	677	682	PF00397	0.512
DOC_WW_Pin1_4	721	726	PF00397	0.555
DOC_WW_Pin1_4	763	768	PF00397	0.639
LIG_14-3-3_CanoR_1	25	33	PF00244	0.469
LIG_14-3-3_CanoR_1	344	350	PF00244	0.726
LIG_14-3-3_CanoR_1	354	362	PF00244	0.641
LIG_14-3-3_CanoR_1	657	665	PF00244	0.649
LIG_14-3-3_CanoR_1	692	696	PF00244	0.697
LIG_14-3-3_CanoR_1	704	710	PF00244	0.533
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BIR_III_4	463	467	PF00653	0.460
LIG_BRCT_BRCA1_1	7	11	PF00533	0.642
LIG_EH_1	847	851	PF12763	0.620
LIG_FHA_1	118	124	PF00498	0.475
LIG_FHA_1	162	168	PF00498	0.468
LIG_FHA_1	184	190	PF00498	0.480
LIG_FHA_1	206	212	PF00498	0.487
LIG_FHA_1	25	31	PF00498	0.505
LIG_FHA_1	317	323	PF00498	0.598
LIG_FHA_1	511	517	PF00498	0.478
LIG_FHA_1	52	58	PF00498	0.476
LIG_FHA_1	617	623	PF00498	0.613
LIG_FHA_1	649	655	PF00498	0.642
LIG_FHA_1	667	673	PF00498	0.487
LIG_FHA_1	74	80	PF00498	0.487
LIG_FHA_1	753	759	PF00498	0.682
LIG_FHA_1	808	814	PF00498	0.648
LIG_FHA_2	257	263	PF00498	0.647
LIG_FHA_2	287	293	PF00498	0.630
LIG_FHA_2	295	301	PF00498	0.592
LIG_FHA_2	495	501	PF00498	0.569
LIG_FHA_2	513	519	PF00498	0.317
LIG_FHA_2	832	838	PF00498	0.658
LIG_LIR_Apic_2	359	365	PF02991	0.661
LIG_LIR_Gen_1	263	273	PF02991	0.552
LIG_LIR_Gen_1	440	450	PF02991	0.442
LIG_LIR_Gen_1	468	479	PF02991	0.467
LIG_LIR_Gen_1	804	813	PF02991	0.599
LIG_LIR_Nem_3	263	269	PF02991	0.553
LIG_LIR_Nem_3	440	445	PF02991	0.449
LIG_LIR_Nem_3	468	474	PF02991	0.475
LIG_PTAP_UEV_1	680	685	PF05743	0.642
LIG_PTB_Apo_2	504	511	PF02174	0.366
LIG_PTB_Phospho_1	504	510	PF10480	0.362
LIG_SH2_CRK	362	366	PF00017	0.659
LIG_SH2_CRK	625	629	PF00017	0.647
LIG_SH2_GRB2like	745	748	PF00017	0.634
LIG_SH2_NCK_1	832	836	PF00017	0.691
LIG_SH2_PTP2	471	474	PF00017	0.510
LIG_SH2_PTP2	487	490	PF00017	0.294
LIG_SH2_SRC	643	646	PF00017	0.640
LIG_SH2_STAP1	247	251	PF00017	0.660
LIG_SH2_STAP1	510	514	PF00017	0.464
LIG_SH2_STAT5	471	474	PF00017	0.510
LIG_SH2_STAT5	487	490	PF00017	0.294
LIG_SH2_STAT5	643	646	PF00017	0.640
LIG_SH2_STAT5	806	809	PF00017	0.636
LIG_SH3_2	565	570	PF14604	0.606
LIG_SH3_3	305	311	PF00018	0.568
LIG_SH3_3	347	353	PF00018	0.722
LIG_SH3_3	562	568	PF00018	0.625
LIG_SH3_3	678	684	PF00018	0.659
LIG_SH3_3	692	698	PF00018	0.603
LIG_SH3_3	719	725	PF00018	0.551
LIG_SH3_3	839	845	PF00018	0.628
LIG_SUMO_SIM_anti_2	448	454	PF11976	0.454
LIG_SUMO_SIM_par_1	119	126	PF11976	0.465
LIG_SUMO_SIM_par_1	163	170	PF11976	0.456
LIG_SUMO_SIM_par_1	185	192	PF11976	0.477
LIG_SUMO_SIM_par_1	207	214	PF11976	0.510
LIG_SUMO_SIM_par_1	31	38	PF11976	0.510
LIG_SUMO_SIM_par_1	511	518	PF11976	0.471
LIG_SUMO_SIM_par_1	53	60	PF11976	0.487
LIG_SUMO_SIM_par_1	75	82	PF11976	0.465
LIG_TRAF2_1	238	241	PF00917	0.586
LIG_TRAF2_1	297	300	PF00917	0.694
LIG_TRAF2_1	371	374	PF00917	0.616
LIG_TRAF2_1	564	567	PF00917	0.545
LIG_TRAF2_1	783	786	PF00917	0.621
LIG_TRAF2_2	281	286	PF00917	0.557
LIG_TRFH_1	323	327	PF08558	0.633
MOD_CDK_SPK_2	339	344	PF00069	0.704
MOD_CDK_SPK_2	349	354	PF00069	0.596
MOD_CDK_SPK_2	616	621	PF00069	0.659
MOD_CDK_SPK_2	624	629	PF00069	0.591
MOD_CDK_SPxK_1	661	667	PF00069	0.650
MOD_CDK_SPxxK_3	349	356	PF00069	0.715
MOD_CK1_1	117	123	PF00069	0.576
MOD_CK1_1	139	145	PF00069	0.604
MOD_CK1_1	161	167	PF00069	0.652
MOD_CK1_1	183	189	PF00069	0.594
MOD_CK1_1	205	211	PF00069	0.587
MOD_CK1_1	228	234	PF00069	0.615
MOD_CK1_1	250	256	PF00069	0.695
MOD_CK1_1	276	282	PF00069	0.767
MOD_CK1_1	29	35	PF00069	0.502
MOD_CK1_1	309	315	PF00069	0.626
MOD_CK1_1	330	336	PF00069	0.647
MOD_CK1_1	345	351	PF00069	0.548
MOD_CK1_1	357	363	PF00069	0.604
MOD_CK1_1	389	395	PF00069	0.600
MOD_CK1_1	4	10	PF00069	0.658
MOD_CK1_1	51	57	PF00069	0.497
MOD_CK1_1	538	544	PF00069	0.631
MOD_CK1_1	587	593	PF00069	0.657
MOD_CK1_1	656	662	PF00069	0.666
MOD_CK1_1	682	688	PF00069	0.719
MOD_CK1_1	73	79	PF00069	0.492
MOD_CK1_1	759	765	PF00069	0.716
MOD_CK1_1	95	101	PF00069	0.492
MOD_CK2_1	119	125	PF00069	0.631
MOD_CK2_1	141	147	PF00069	0.603
MOD_CK2_1	163	169	PF00069	0.680
MOD_CK2_1	185	191	PF00069	0.616
MOD_CK2_1	207	213	PF00069	0.664
MOD_CK2_1	230	236	PF00069	0.629
MOD_CK2_1	256	262	PF00069	0.571
MOD_CK2_1	271	277	PF00069	0.630
MOD_CK2_1	294	300	PF00069	0.694
MOD_CK2_1	31	37	PF00069	0.507
MOD_CK2_1	382	388	PF00069	0.605
MOD_CK2_1	494	500	PF00069	0.577
MOD_CK2_1	53	59	PF00069	0.488
MOD_CK2_1	543	549	PF00069	0.614
MOD_CK2_1	75	81	PF00069	0.533
MOD_CK2_1	97	103	PF00069	0.527
MOD_DYRK1A_RPxSP_1	763	767	PF00069	0.639
MOD_GlcNHglycan	236	240	PF01048	0.513
MOD_GlcNHglycan	3	6	PF01048	0.631
MOD_GlcNHglycan	300	304	PF01048	0.542
MOD_GlcNHglycan	347	350	PF01048	0.736
MOD_GlcNHglycan	356	359	PF01048	0.638
MOD_GlcNHglycan	384	387	PF01048	0.668
MOD_GlcNHglycan	388	391	PF01048	0.632
MOD_GlcNHglycan	421	424	PF01048	0.642
MOD_GlcNHglycan	437	440	PF01048	0.396
MOD_GlcNHglycan	532	535	PF01048	0.598
MOD_GlcNHglycan	545	548	PF01048	0.578
MOD_GlcNHglycan	586	589	PF01048	0.654
MOD_GlcNHglycan	681	684	PF01048	0.657
MOD_GlcNHglycan	687	690	PF01048	0.589
MOD_GlcNHglycan	738	743	PF01048	0.751
MOD_GlcNHglycan	777	780	PF01048	0.660
MOD_GlcNHglycan	796	799	PF01048	0.503
MOD_GSK3_1	1	8	PF00069	0.670
MOD_GSK3_1	345	352	PF00069	0.726
MOD_GSK3_1	354	361	PF00069	0.663
MOD_GSK3_1	382	389	PF00069	0.651
MOD_GSK3_1	414	421	PF00069	0.717
MOD_GSK3_1	441	448	PF00069	0.448
MOD_GSK3_1	492	499	PF00069	0.431
MOD_GSK3_1	593	600	PF00069	0.648
MOD_GSK3_1	648	655	PF00069	0.620
MOD_GSK3_1	657	664	PF00069	0.609
MOD_GSK3_1	675	682	PF00069	0.595
MOD_GSK3_1	687	694	PF00069	0.676
MOD_GSK3_1	752	759	PF00069	0.731
MOD_GSK3_1	773	780	PF00069	0.659
MOD_LATS_1	433	439	PF00433	0.356
MOD_N-GLC_1	255	260	PF02516	0.650
MOD_N-GLC_1	458	463	PF02516	0.491
MOD_N-GLC_1	584	589	PF02516	0.650
MOD_N-GLC_1	675	680	PF02516	0.654
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	249	254	PF00069	0.682
MOD_NEK2_1	294	299	PF00069	0.673
MOD_NEK2_1	794	799	PF00069	0.715
MOD_NEK2_2	119	124	PF00069	0.504
MOD_NEK2_2	163	168	PF00069	0.497
MOD_NEK2_2	185	190	PF00069	0.517
MOD_NEK2_2	207	212	PF00069	0.513
MOD_NEK2_2	31	36	PF00069	0.513
MOD_NEK2_2	53	58	PF00069	0.493
MOD_NEK2_2	75	80	PF00069	0.504
MOD_PIKK_1	294	300	PF00454	0.648
MOD_PIKK_1	330	336	PF00454	0.695
MOD_PIKK_1	342	348	PF00454	0.572
MOD_PIKK_1	466	472	PF00454	0.479
MOD_PIKK_1	538	544	PF00454	0.637
MOD_PIKK_1	807	813	PF00454	0.606
MOD_PK_1	441	447	PF00069	0.469
MOD_PK_1	687	693	PF00069	0.618
MOD_PKA_1	573	579	PF00069	0.562
MOD_PKA_2	24	30	PF00069	0.492
MOD_PKA_2	292	298	PF00069	0.613
MOD_PKA_2	306	312	PF00069	0.515
MOD_PKA_2	330	336	PF00069	0.729
MOD_PKA_2	573	579	PF00069	0.562
MOD_PKA_2	597	603	PF00069	0.561
MOD_PKA_2	656	662	PF00069	0.634
MOD_PKA_2	666	672	PF00069	0.566
MOD_PKA_2	691	697	PF00069	0.705
MOD_PKA_2	730	736	PF00069	0.616
MOD_PKA_2	759	765	PF00069	0.758
MOD_PKB_1	354	362	PF00069	0.717
MOD_Plk_1	21	27	PF00069	0.477
MOD_Plk_1	247	253	PF00069	0.624
MOD_Plk_1	276	282	PF00069	0.692
MOD_Plk_1	398	404	PF00069	0.534
MOD_Plk_1	510	516	PF00069	0.475
MOD_Plk_1	632	638	PF00069	0.659
MOD_Plk_2-3	781	787	PF00069	0.588
MOD_Plk_4	441	447	PF00069	0.441
MOD_Plk_4	637	643	PF00069	0.697
MOD_ProDKin_1	339	345	PF00069	0.732
MOD_ProDKin_1	349	355	PF00069	0.657
MOD_ProDKin_1	389	395	PF00069	0.643
MOD_ProDKin_1	405	411	PF00069	0.595
MOD_ProDKin_1	414	420	PF00069	0.591
MOD_ProDKin_1	616	622	PF00069	0.687
MOD_ProDKin_1	624	630	PF00069	0.649
MOD_ProDKin_1	661	667	PF00069	0.701
MOD_ProDKin_1	677	683	PF00069	0.510
MOD_ProDKin_1	721	727	PF00069	0.558
MOD_ProDKin_1	763	769	PF00069	0.640
MOD_SUMO_for_1	371	374	PF00179	0.533
MOD_SUMO_rev_2	106	115	PF00179	0.527
MOD_SUMO_rev_2	128	137	PF00179	0.530
MOD_SUMO_rev_2	150	159	PF00179	0.532
MOD_SUMO_rev_2	172	181	PF00179	0.532
MOD_SUMO_rev_2	194	203	PF00179	0.544
MOD_SUMO_rev_2	40	49	PF00179	0.458
MOD_SUMO_rev_2	499	506	PF00179	0.535
MOD_SUMO_rev_2	62	71	PF00179	0.447
MOD_SUMO_rev_2	84	93	PF00179	0.445
TRG_DiLeu_BaEn_4	240	246	PF01217	0.625
TRG_ENDOCYTIC_2	471	474	PF00928	0.510
TRG_ENDOCYTIC_2	487	490	PF00928	0.294
TRG_ENDOCYTIC_2	806	809	PF00928	0.636
TRG_ER_diArg_1	353	356	PF00400	0.721
TRG_ER_diArg_1	711	714	PF00400	0.654
TRG_ER_diArg_1	760	763	PF00400	0.654
TRG_NLS_MonoExtC_3	569	574	PF00514	0.688
TRG_NLS_MonoExtN_4	568	574	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	611	615	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF98	Leishmania donovani	100%	100%
A4HE42	Leishmania braziliensis	37%	86%
E9AXI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q9Y7	Leishmania major	80%	97%