Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1E6_LEIIN

TriTrypDb:

LINF_250016500

Length:

967

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.570
CLV_C14_Caspase3-7	74	78	PF00656	0.620
CLV_C14_Caspase3-7	777	781	PF00656	0.711
CLV_C14_Caspase3-7	808	812	PF00656	0.730
CLV_C14_Caspase3-7	888	892	PF00656	0.746
CLV_C14_Caspase3-7	942	946	PF00656	0.569
CLV_MEL_PAP_1	429	435	PF00089	0.653
CLV_NRD_NRD_1	212	214	PF00675	0.698
CLV_NRD_NRD_1	556	558	PF00675	0.535
CLV_NRD_NRD_1	571	573	PF00675	0.495
CLV_NRD_NRD_1	614	616	PF00675	0.711
CLV_NRD_NRD_1	695	697	PF00675	0.750
CLV_NRD_NRD_1	729	731	PF00675	0.761
CLV_NRD_NRD_1	758	760	PF00675	0.660
CLV_NRD_NRD_1	761	763	PF00675	0.658
CLV_NRD_NRD_1	796	798	PF00675	0.587
CLV_NRD_NRD_1	830	832	PF00675	0.658
CLV_NRD_NRD_1	849	851	PF00675	0.730
CLV_NRD_NRD_1	902	904	PF00675	0.727
CLV_PCSK_FUR_1	758	762	PF00082	0.671
CLV_PCSK_KEX2_1	212	214	PF00082	0.698
CLV_PCSK_KEX2_1	347	349	PF00082	0.574
CLV_PCSK_KEX2_1	556	558	PF00082	0.535
CLV_PCSK_KEX2_1	571	573	PF00082	0.495
CLV_PCSK_KEX2_1	613	615	PF00082	0.606
CLV_PCSK_KEX2_1	728	730	PF00082	0.760
CLV_PCSK_KEX2_1	758	760	PF00082	0.670
CLV_PCSK_KEX2_1	761	763	PF00082	0.667
CLV_PCSK_KEX2_1	796	798	PF00082	0.587
CLV_PCSK_KEX2_1	830	832	PF00082	0.658
CLV_PCSK_KEX2_1	849	851	PF00082	0.730
CLV_PCSK_KEX2_1	902	904	PF00082	0.831
CLV_PCSK_KEX2_1	935	937	PF00082	0.827
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.664
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.663
CLV_PCSK_PC1ET2_1	935	937	PF00082	0.827
CLV_PCSK_PC7_1	725	731	PF00082	0.714
CLV_PCSK_PC7_1	898	904	PF00082	0.754
CLV_PCSK_SKI1_1	369	373	PF00082	0.479
CLV_PCSK_SKI1_1	376	380	PF00082	0.458
CLV_PCSK_SKI1_1	458	462	PF00082	0.731
CLV_PCSK_SKI1_1	601	605	PF00082	0.580
CLV_PCSK_SKI1_1	761	765	PF00082	0.614
CLV_PCSK_SKI1_1	802	806	PF00082	0.621
DEG_APCC_DBOX_1	760	768	PF00400	0.666
DEG_SPOP_SBC_1	153	157	PF00917	0.593
DEG_SPOP_SBC_1	17	21	PF00917	0.709
DEG_SPOP_SBC_1	229	233	PF00917	0.703
DEG_SPOP_SBC_1	248	252	PF00917	0.755
DEG_SPOP_SBC_1	821	825	PF00917	0.772
DOC_ANK_TNKS_1	775	782	PF00023	0.756
DOC_CKS1_1	124	129	PF01111	0.685
DOC_CYCLIN_yCln2_LP_2	197	200	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	640	646	PF00134	0.764
DOC_MAPK_gen_1	290	297	PF00069	0.576
DOC_MAPK_gen_1	369	377	PF00069	0.476
DOC_MAPK_RevD_3	600	615	PF00069	0.458
DOC_PP2B_LxvP_1	197	200	PF13499	0.667
DOC_PP2B_LxvP_1	239	242	PF13499	0.719
DOC_PP2B_LxvP_1	32	35	PF13499	0.605
DOC_PP2B_LxvP_1	526	529	PF13499	0.746
DOC_PP2B_LxvP_1	783	786	PF13499	0.733
DOC_USP7_MATH_1	114	118	PF00917	0.696
DOC_USP7_MATH_1	131	135	PF00917	0.518
DOC_USP7_MATH_1	153	157	PF00917	0.616
DOC_USP7_MATH_1	167	171	PF00917	0.609
DOC_USP7_MATH_1	17	21	PF00917	0.701
DOC_USP7_MATH_1	246	250	PF00917	0.747
DOC_USP7_MATH_1	270	274	PF00917	0.744
DOC_USP7_MATH_1	413	417	PF00917	0.624
DOC_USP7_MATH_1	52	56	PF00917	0.623
DOC_USP7_MATH_1	552	556	PF00917	0.741
DOC_USP7_MATH_1	736	740	PF00917	0.783
DOC_USP7_MATH_1	766	770	PF00917	0.728
DOC_USP7_MATH_1	821	825	PF00917	0.772
DOC_USP7_MATH_1	896	900	PF00917	0.655
DOC_USP7_MATH_1	939	943	PF00917	0.655
DOC_USP7_MATH_2	24	30	PF00917	0.605
DOC_USP7_UBL2_3	372	376	PF12436	0.521
DOC_WW_Pin1_4	110	115	PF00397	0.596
DOC_WW_Pin1_4	123	128	PF00397	0.519
DOC_WW_Pin1_4	136	141	PF00397	0.542
DOC_WW_Pin1_4	198	203	PF00397	0.694
DOC_WW_Pin1_4	211	216	PF00397	0.590
DOC_WW_Pin1_4	282	287	PF00397	0.707
DOC_WW_Pin1_4	450	455	PF00397	0.769
DOC_WW_Pin1_4	481	486	PF00397	0.631
DOC_WW_Pin1_4	487	492	PF00397	0.688
DOC_WW_Pin1_4	524	529	PF00397	0.745
DOC_WW_Pin1_4	639	644	PF00397	0.725
DOC_WW_Pin1_4	672	677	PF00397	0.760
DOC_WW_Pin1_4	690	695	PF00397	0.512
DOC_WW_Pin1_4	787	792	PF00397	0.644
DOC_WW_Pin1_4	89	94	PF00397	0.702
LIG_14-3-3_CanoR_1	259	265	PF00244	0.715
LIG_14-3-3_CanoR_1	290	297	PF00244	0.771
LIG_14-3-3_CanoR_1	324	329	PF00244	0.523
LIG_14-3-3_CanoR_1	340	349	PF00244	0.552
LIG_14-3-3_CanoR_1	441	446	PF00244	0.657
LIG_14-3-3_CanoR_1	517	526	PF00244	0.817
LIG_14-3-3_CanoR_1	62	67	PF00244	0.648
LIG_14-3-3_CanoR_1	849	853	PF00244	0.719
LIG_14-3-3_CanoR_1	883	888	PF00244	0.755
LIG_14-3-3_CanoR_1	898	904	PF00244	0.672
LIG_14-3-3_CanoR_1	938	944	PF00244	0.819
LIG_BRCT_BRCA1_1	155	159	PF00533	0.599
LIG_BRCT_BRCA1_1	385	389	PF00533	0.534
LIG_CtBP_PxDLS_1	93	97	PF00389	0.605
LIG_FHA_1	176	182	PF00498	0.630
LIG_FHA_1	220	226	PF00498	0.822
LIG_FHA_1	413	419	PF00498	0.626
LIG_FHA_1	843	849	PF00498	0.702
LIG_FHA_2	26	32	PF00498	0.613
LIG_FHA_2	282	288	PF00498	0.594
LIG_FHA_2	310	316	PF00498	0.564
LIG_FHA_2	518	524	PF00498	0.775
LIG_FHA_2	583	589	PF00498	0.412
LIG_FHA_2	602	608	PF00498	0.626
LIG_FHA_2	719	725	PF00498	0.694
LIG_FHA_2	775	781	PF00498	0.756
LIG_HCF-1_HBM_1	655	658	PF13415	0.655
LIG_Integrin_isoDGR_2	513	515	PF01839	0.595
LIG_LIR_Apic_2	655	661	PF02991	0.759
LIG_LIR_Gen_1	412	422	PF02991	0.641
LIG_LIR_Gen_1	477	488	PF02991	0.648
LIG_LIR_Nem_3	30	36	PF02991	0.684
LIG_LIR_Nem_3	412	417	PF02991	0.628
LIG_LIR_Nem_3	477	482	PF02991	0.608
LIG_LYPXL_SIV_4	558	566	PF13949	0.561
LIG_MYND_1	141	145	PF01753	0.538
LIG_MYND_1	195	199	PF01753	0.609
LIG_NRBOX	648	654	PF00104	0.593
LIG_PDZ_Class_1	962	967	PF00595	0.523
LIG_Rb_pABgroove_1	326	334	PF01858	0.546
LIG_SH2_CRK	365	369	PF00017	0.634
LIG_SH2_CRK	414	418	PF00017	0.636
LIG_SH2_CRK	658	662	PF00017	0.792
LIG_SH2_GRB2like	216	219	PF00017	0.612
LIG_SH2_GRB2like	587	590	PF00017	0.693
LIG_SH2_PTP2	381	384	PF00017	0.523
LIG_SH2_SRC	216	219	PF00017	0.612
LIG_SH2_SRC	33	36	PF00017	0.600
LIG_SH2_STAP1	306	310	PF00017	0.553
LIG_SH2_STAP1	414	418	PF00017	0.636
LIG_SH2_STAP1	474	478	PF00017	0.665
LIG_SH2_STAP1	587	591	PF00017	0.588
LIG_SH2_STAP1	854	858	PF00017	0.706
LIG_SH2_STAT5	216	219	PF00017	0.612
LIG_SH2_STAT5	33	36	PF00017	0.624
LIG_SH2_STAT5	381	384	PF00017	0.523
LIG_SH2_STAT5	414	417	PF00017	0.633
LIG_SH3_1	664	670	PF00018	0.760
LIG_SH3_2	667	672	PF14604	0.723
LIG_SH3_2	893	898	PF14604	0.752
LIG_SH3_3	102	108	PF00018	0.693
LIG_SH3_3	125	131	PF00018	0.671
LIG_SH3_3	196	202	PF00018	0.689
LIG_SH3_3	203	209	PF00018	0.754
LIG_SH3_3	234	240	PF00018	0.679
LIG_SH3_3	446	452	PF00018	0.599
LIG_SH3_3	479	485	PF00018	0.631
LIG_SH3_3	664	670	PF00018	0.760
LIG_SH3_3	688	694	PF00018	0.663
LIG_SH3_3	890	896	PF00018	0.750
LIG_SUMO_SIM_par_1	532	538	PF11976	0.669
LIG_SUMO_SIM_par_1	572	577	PF11976	0.562
MOD_CDC14_SPxK_1	693	696	PF00782	0.699
MOD_CDK_SPxK_1	690	696	PF00069	0.701
MOD_CDK_SPxxK_3	690	697	PF00069	0.700
MOD_CK1_1	109	115	PF00069	0.529
MOD_CK1_1	117	123	PF00069	0.580
MOD_CK1_1	139	145	PF00069	0.593
MOD_CK1_1	147	153	PF00069	0.557
MOD_CK1_1	15	21	PF00069	0.711
MOD_CK1_1	157	163	PF00069	0.522
MOD_CK1_1	170	176	PF00069	0.648
MOD_CK1_1	189	195	PF00069	0.493
MOD_CK1_1	223	229	PF00069	0.710
MOD_CK1_1	247	253	PF00069	0.725
MOD_CK1_1	273	279	PF00069	0.816
MOD_CK1_1	285	291	PF00069	0.729
MOD_CK1_1	387	393	PF00069	0.541
MOD_CK1_1	490	496	PF00069	0.797
MOD_CK1_1	65	71	PF00069	0.646
MOD_CK1_1	671	677	PF00069	0.758
MOD_CK1_1	714	720	PF00069	0.821
MOD_CK1_1	769	775	PF00069	0.733
MOD_CK1_1	823	829	PF00069	0.833
MOD_CK1_1	894	900	PF00069	0.710
MOD_CK1_1	92	98	PF00069	0.607
MOD_CK2_1	131	137	PF00069	0.604
MOD_CK2_1	25	31	PF00069	0.656
MOD_CK2_1	281	287	PF00069	0.696
MOD_CK2_1	309	315	PF00069	0.564
MOD_CK2_1	517	523	PF00069	0.775
MOD_CK2_1	582	588	PF00069	0.411
MOD_CK2_1	601	607	PF00069	0.654
MOD_DYRK1A_RPxSP_1	110	114	PF00069	0.611
MOD_GlcNHglycan	116	119	PF01048	0.601
MOD_GlcNHglycan	15	18	PF01048	0.601
MOD_GlcNHglycan	156	159	PF01048	0.599
MOD_GlcNHglycan	182	186	PF01048	0.665
MOD_GlcNHglycan	246	249	PF01048	0.733
MOD_GlcNHglycan	39	42	PF01048	0.779
MOD_GlcNHglycan	438	441	PF01048	0.622
MOD_GlcNHglycan	492	495	PF01048	0.717
MOD_GlcNHglycan	5	8	PF01048	0.701
MOD_GlcNHglycan	548	551	PF01048	0.702
MOD_GlcNHglycan	715	720	PF01048	0.733
MOD_GlcNHglycan	738	741	PF01048	0.738
MOD_GlcNHglycan	771	774	PF01048	0.813
MOD_GlcNHglycan	826	829	PF01048	0.776
MOD_GlcNHglycan	877	880	PF01048	0.706
MOD_GlcNHglycan	887	890	PF01048	0.740
MOD_GlcNHglycan	905	908	PF01048	0.609
MOD_GSK3_1	106	113	PF00069	0.692
MOD_GSK3_1	12	19	PF00069	0.640
MOD_GSK3_1	139	146	PF00069	0.662
MOD_GSK3_1	153	160	PF00069	0.524
MOD_GSK3_1	219	226	PF00069	0.688
MOD_GSK3_1	242	249	PF00069	0.730
MOD_GSK3_1	268	275	PF00069	0.666
MOD_GSK3_1	281	288	PF00069	0.694
MOD_GSK3_1	3	10	PF00069	0.734
MOD_GSK3_1	305	312	PF00069	0.578
MOD_GSK3_1	383	390	PF00069	0.495
MOD_GSK3_1	468	475	PF00069	0.772
MOD_GSK3_1	489	496	PF00069	0.725
MOD_GSK3_1	578	585	PF00069	0.392
MOD_GSK3_1	624	631	PF00069	0.790
MOD_GSK3_1	668	675	PF00069	0.740
MOD_GSK3_1	676	683	PF00069	0.724
MOD_GSK3_1	707	714	PF00069	0.784
MOD_GSK3_1	734	741	PF00069	0.671
MOD_GSK3_1	820	827	PF00069	0.726
MOD_GSK3_1	844	851	PF00069	0.761
MOD_GSK3_1	858	865	PF00069	0.597
MOD_GSK3_1	894	901	PF00069	0.793
MOD_LATS_1	60	66	PF00433	0.648
MOD_LATS_1	860	866	PF00433	0.729
MOD_N-GLC_1	147	152	PF02516	0.605
MOD_N-GLC_1	223	228	PF02516	0.739
MOD_N-GLC_1	338	343	PF02516	0.646
MOD_NEK2_1	364	369	PF00069	0.637
MOD_NEK2_1	384	389	PF00069	0.614
MOD_NEK2_1	5	10	PF00069	0.696
MOD_NEK2_1	576	581	PF00069	0.571
MOD_NEK2_1	858	863	PF00069	0.783
MOD_NEK2_2	844	849	PF00069	0.680
MOD_PIKK_1	250	256	PF00454	0.750
MOD_PIKK_1	468	474	PF00454	0.777
MOD_PIKK_1	493	499	PF00454	0.708
MOD_PIKK_1	707	713	PF00454	0.610
MOD_PIKK_1	815	821	PF00454	0.742
MOD_PIKK_1	939	945	PF00454	0.745
MOD_PKA_2	109	115	PF00069	0.666
MOD_PKA_2	220	226	PF00069	0.623
MOD_PKA_2	258	264	PF00069	0.716
MOD_PKA_2	37	43	PF00069	0.592
MOD_PKA_2	431	437	PF00069	0.627
MOD_PKA_2	516	522	PF00069	0.805
MOD_PKA_2	752	758	PF00069	0.657
MOD_PKA_2	848	854	PF00069	0.721
MOD_PKA_2	897	903	PF00069	0.754
MOD_PKB_1	348	356	PF00069	0.575
MOD_PKB_1	515	523	PF00069	0.637
MOD_PKB_1	881	889	PF00069	0.756
MOD_Plk_1	147	153	PF00069	0.604
MOD_Plk_1	338	344	PF00069	0.646
MOD_Plk_4	139	145	PF00069	0.593
MOD_Plk_4	413	419	PF00069	0.668
MOD_ProDKin_1	110	116	PF00069	0.598
MOD_ProDKin_1	123	129	PF00069	0.520
MOD_ProDKin_1	136	142	PF00069	0.544
MOD_ProDKin_1	198	204	PF00069	0.696
MOD_ProDKin_1	211	217	PF00069	0.587
MOD_ProDKin_1	282	288	PF00069	0.706
MOD_ProDKin_1	450	456	PF00069	0.771
MOD_ProDKin_1	481	487	PF00069	0.636
MOD_ProDKin_1	524	530	PF00069	0.743
MOD_ProDKin_1	639	645	PF00069	0.713
MOD_ProDKin_1	672	678	PF00069	0.760
MOD_ProDKin_1	690	696	PF00069	0.513
MOD_ProDKin_1	787	793	PF00069	0.634
MOD_ProDKin_1	89	95	PF00069	0.701
MOD_SUMO_for_1	371	374	PF00179	0.527
MOD_SUMO_for_1	605	608	PF00179	0.670
MOD_SUMO_rev_2	344	349	PF00179	0.655
MOD_SUMO_rev_2	942	948	PF00179	0.695
TRG_DiLeu_BaEn_1	403	408	PF01217	0.607
TRG_DiLeu_BaEn_1	541	546	PF01217	0.674
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.629
TRG_DiLeu_LyEn_5	541	546	PF01217	0.577
TRG_ENDOCYTIC_2	33	36	PF00928	0.678
TRG_ENDOCYTIC_2	332	335	PF00928	0.518
TRG_ENDOCYTIC_2	365	368	PF00928	0.535
TRG_ENDOCYTIC_2	381	384	PF00928	0.495
TRG_ENDOCYTIC_2	414	417	PF00928	0.633
TRG_ENDOCYTIC_2	559	562	PF00928	0.570
TRG_ER_diArg_1	571	573	PF00400	0.591
TRG_ER_diArg_1	613	615	PF00400	0.704
TRG_ER_diArg_1	728	730	PF00400	0.758
TRG_ER_diArg_1	758	761	PF00400	0.638
TRG_ER_diArg_1	796	798	PF00400	0.634
TRG_ER_diArg_1	830	833	PF00400	0.751
TRG_ER_diArg_1	848	850	PF00400	0.463
TRG_ER_diArg_1	881	884	PF00400	0.803
TRG_ER_diArg_1	902	904	PF00400	0.720
TRG_ER_diArg_1	936	939	PF00400	0.745
TRG_ER_diArg_1	96	99	PF00400	0.615
TRG_NES_CRM1_1	383	398	PF08389	0.598
TRG_NLS_MonoCore_2	758	763	PF00514	0.532
TRG_NLS_MonoExtC_3	934	939	PF00514	0.744
TRG_NLS_MonoExtN_4	758	764	PF00514	0.628
TRG_NLS_MonoExtN_4	932	939	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	850	855	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T6	Leptomonas seymouri	38%	100%
A0A3Q8ICB6	Leishmania donovani	99%	100%
A4HE40	Leishmania braziliensis	56%	92%
E9AXI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q9Y9	Leishmania major	86%	98%