Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1E5_LEIIN

TriTrypDb:

LINF_250016400

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1E5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.568
CLV_C14_Caspase3-7	790	794	PF00656	0.614
CLV_NRD_NRD_1	105	107	PF00675	0.438
CLV_NRD_NRD_1	184	186	PF00675	0.474
CLV_NRD_NRD_1	255	257	PF00675	0.447
CLV_NRD_NRD_1	632	634	PF00675	0.778
CLV_NRD_NRD_1	763	765	PF00675	0.544
CLV_NRD_NRD_1	96	98	PF00675	0.378
CLV_PCSK_KEX2_1	184	186	PF00082	0.474
CLV_PCSK_KEX2_1	255	257	PF00082	0.451
CLV_PCSK_KEX2_1	763	765	PF00082	0.544
CLV_PCSK_KEX2_1	96	98	PF00082	0.378
CLV_PCSK_SKI1_1	763	767	PF00082	0.494
CLV_Separin_Metazoa	778	782	PF03568	0.335
DEG_APCC_DBOX_1	780	788	PF00400	0.519
DEG_APCC_DBOX_1	96	104	PF00400	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DEG_SCF_FBW7_2	571	576	PF00400	0.618
DEG_SIAH_1	734	742	PF03145	0.555
DEG_SPOP_SBC_1	60	64	PF00917	0.365
DEG_SPOP_SBC_1	741	745	PF00917	0.513
DOC_CYCLIN_RxL_1	761	771	PF00134	0.485
DOC_CYCLIN_RxL_1	93	104	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.510
DOC_MAPK_gen_1	620	629	PF00069	0.509
DOC_MAPK_gen_1	85	95	PF00069	0.436
DOC_MAPK_gen_1	96	105	PF00069	0.392
DOC_MAPK_HePTP_8	93	105	PF00069	0.374
DOC_MAPK_MEF2A_6	316	324	PF00069	0.501
DOC_MAPK_MEF2A_6	96	105	PF00069	0.557
DOC_MAPK_RevD_3	93	107	PF00069	0.434
DOC_PP1_RVXF_1	302	309	PF00149	0.506
DOC_PP2B_LxvP_1	220	223	PF13499	0.389
DOC_PP2B_LxvP_1	455	458	PF13499	0.349
DOC_PP4_FxxP_1	456	459	PF00568	0.437
DOC_SPAK_OSR1_1	307	311	PF12202	0.620
DOC_USP7_MATH_1	111	115	PF00917	0.558
DOC_USP7_MATH_1	120	124	PF00917	0.403
DOC_USP7_MATH_1	231	235	PF00917	0.649
DOC_USP7_MATH_1	25	29	PF00917	0.608
DOC_USP7_MATH_1	284	288	PF00917	0.691
DOC_USP7_MATH_1	30	34	PF00917	0.594
DOC_USP7_MATH_1	331	335	PF00917	0.489
DOC_USP7_MATH_1	379	383	PF00917	0.559
DOC_USP7_MATH_1	404	408	PF00917	0.572
DOC_USP7_MATH_1	440	444	PF00917	0.637
DOC_USP7_MATH_1	463	467	PF00917	0.570
DOC_USP7_MATH_1	584	588	PF00917	0.548
DOC_USP7_MATH_1	741	745	PF00917	0.617
DOC_WW_Pin1_4	256	261	PF00397	0.518
DOC_WW_Pin1_4	553	558	PF00397	0.720
DOC_WW_Pin1_4	569	574	PF00397	0.562
DOC_WW_Pin1_4	653	658	PF00397	0.501
DOC_WW_Pin1_4	659	664	PF00397	0.592
LIG_14-3-3_CanoR_1	17	23	PF00244	0.556
LIG_14-3-3_CanoR_1	280	289	PF00244	0.698
LIG_14-3-3_CanoR_1	356	360	PF00244	0.502
LIG_14-3-3_CanoR_1	399	408	PF00244	0.601
LIG_14-3-3_CanoR_1	44	53	PF00244	0.567
LIG_14-3-3_CanoR_1	474	480	PF00244	0.417
LIG_14-3-3_CanoR_1	676	680	PF00244	0.450
LIG_14-3-3_CanoR_1	763	769	PF00244	0.503
LIG_14-3-3_CanoR_1	781	791	PF00244	0.544
LIG_APCC_ABBA_1	571	576	PF00400	0.618
LIG_APCC_ABBA_1	66	71	PF00400	0.331
LIG_BRCT_BRCA1_1	174	178	PF00533	0.313
LIG_BRCT_BRCA1_1	460	464	PF00533	0.481
LIG_BRCT_BRCA1_1	647	651	PF00533	0.543
LIG_Clathr_ClatBox_1	67	71	PF01394	0.332
LIG_DLG_GKlike_1	764	772	PF00625	0.442
LIG_eIF4E_1	683	689	PF01652	0.355
LIG_FHA_1	10	16	PF00498	0.646
LIG_FHA_1	172	178	PF00498	0.487
LIG_FHA_1	269	275	PF00498	0.568
LIG_FHA_1	291	297	PF00498	0.593
LIG_FHA_1	336	342	PF00498	0.581
LIG_FHA_1	345	351	PF00498	0.414
LIG_FHA_1	507	513	PF00498	0.456
LIG_FHA_1	60	66	PF00498	0.530
LIG_FHA_1	692	698	PF00498	0.447
LIG_FHA_1	715	721	PF00498	0.614
LIG_FHA_2	437	443	PF00498	0.698
LIG_FHA_2	448	454	PF00498	0.422
LIG_FHA_2	476	482	PF00498	0.429
LIG_FHA_2	52	58	PF00498	0.653
LIG_FHA_2	617	623	PF00498	0.548
LIG_FHA_2	702	708	PF00498	0.520
LIG_FHA_2	805	811	PF00498	0.771
LIG_GBD_Chelix_1	489	497	PF00786	0.377
LIG_GBD_Chelix_1	684	692	PF00786	0.342
LIG_LIR_Apic_2	357	362	PF02991	0.559
LIG_LIR_Apic_2	407	413	PF02991	0.410
LIG_LIR_Apic_2	453	459	PF02991	0.408
LIG_LIR_Apic_2	745	751	PF02991	0.492
LIG_LIR_Gen_1	191	198	PF02991	0.563
LIG_LIR_Gen_1	234	242	PF02991	0.717
LIG_LIR_Gen_1	447	456	PF02991	0.474
LIG_LIR_Gen_1	509	519	PF02991	0.403
LIG_LIR_Gen_1	682	691	PF02991	0.400
LIG_LIR_Nem_3	191	196	PF02991	0.481
LIG_LIR_Nem_3	234	239	PF02991	0.742
LIG_LIR_Nem_3	259	264	PF02991	0.544
LIG_LIR_Nem_3	305	311	PF02991	0.630
LIG_LIR_Nem_3	447	451	PF02991	0.594
LIG_LIR_Nem_3	509	514	PF02991	0.402
LIG_LIR_Nem_3	682	686	PF02991	0.353
LIG_LIR_Nem_3	8	14	PF02991	0.676
LIG_MAD2	262	270	PF02301	0.517
LIG_MYND_1	752	756	PF01753	0.505
LIG_NRBOX	123	129	PF00104	0.423
LIG_NRBOX	450	456	PF00104	0.455
LIG_PDZ_Class_2	832	837	PF00595	0.590
LIG_Pex14_1	261	265	PF04695	0.476
LIG_Rb_LxCxE_1	206	225	PF01857	0.426
LIG_SH2_CRK	2	6	PF00017	0.623
LIG_SH2_CRK	317	321	PF00017	0.535
LIG_SH2_CRK	655	659	PF00017	0.422
LIG_SH2_CRK	699	703	PF00017	0.387
LIG_SH2_CRK	748	752	PF00017	0.545
LIG_SH2_GRB2like	2	5	PF00017	0.479
LIG_SH2_NCK_1	193	197	PF00017	0.491
LIG_SH2_NCK_1	2	6	PF00017	0.499
LIG_SH2_PTP2	448	451	PF00017	0.481
LIG_SH2_PTP2	683	686	PF00017	0.289
LIG_SH2_SRC	2	5	PF00017	0.502
LIG_SH2_SRC	699	702	PF00017	0.415
LIG_SH2_STAP1	371	375	PF00017	0.541
LIG_SH2_STAT5	371	374	PF00017	0.535
LIG_SH2_STAT5	427	430	PF00017	0.470
LIG_SH2_STAT5	448	451	PF00017	0.495
LIG_SH2_STAT5	495	498	PF00017	0.457
LIG_SH2_STAT5	628	631	PF00017	0.648
LIG_SH2_STAT5	683	686	PF00017	0.295
LIG_SH2_STAT5	701	704	PF00017	0.365
LIG_SH3_1	110	116	PF00018	0.376
LIG_SH3_1	749	755	PF00018	0.505
LIG_SH3_2	735	740	PF14604	0.532
LIG_SH3_3	110	116	PF00018	0.474
LIG_SH3_3	155	161	PF00018	0.567
LIG_SH3_3	31	37	PF00018	0.686
LIG_SH3_3	732	738	PF00018	0.585
LIG_SH3_3	749	755	PF00018	0.506
LIG_SH3_4	269	276	PF00018	0.445
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.523
LIG_SUMO_SIM_anti_2	776	781	PF11976	0.324
LIG_SUMO_SIM_par_1	427	433	PF11976	0.511
LIG_SUMO_SIM_par_1	553	564	PF11976	0.598
LIG_SUMO_SIM_par_1	99	104	PF11976	0.406
LIG_TRAF2_1	235	238	PF00917	0.654
LIG_TRAF2_1	395	398	PF00917	0.602
LIG_TRAF2_1	579	582	PF00917	0.629
LIG_TRAF2_1	822	825	PF00917	0.693
LIG_TYR_ITIM	263	268	PF00017	0.500
LIG_TYR_ITIM	697	702	PF00017	0.406
MOD_CDC14_SPxK_1	259	262	PF00782	0.557
MOD_CDK_SPxK_1	256	262	PF00069	0.555
MOD_CDK_SPxxK_3	653	660	PF00069	0.451
MOD_CK1_1	18	24	PF00069	0.540
MOD_CK1_1	191	197	PF00069	0.527
MOD_CK1_1	382	388	PF00069	0.597
MOD_CK1_1	415	421	PF00069	0.706
MOD_CK1_1	447	453	PF00069	0.498
MOD_CK1_1	465	471	PF00069	0.488
MOD_CK1_1	556	562	PF00069	0.750
MOD_CK1_1	728	734	PF00069	0.645
MOD_CK1_1	742	748	PF00069	0.574
MOD_CK1_1	828	834	PF00069	0.634
MOD_CK2_1	137	143	PF00069	0.671
MOD_CK2_1	224	230	PF00069	0.720
MOD_CK2_1	231	237	PF00069	0.653
MOD_CK2_1	331	337	PF00069	0.486
MOD_CK2_1	475	481	PF00069	0.392
MOD_CK2_1	576	582	PF00069	0.659
MOD_CK2_1	616	622	PF00069	0.605
MOD_CK2_1	701	707	PF00069	0.528
MOD_CK2_1	728	734	PF00069	0.720
MOD_CMANNOS	187	190	PF00535	0.469
MOD_Cter_Amidation	631	634	PF01082	0.625
MOD_GlcNHglycan	143	146	PF01048	0.654
MOD_GlcNHglycan	226	229	PF01048	0.703
MOD_GlcNHglycan	232	236	PF01048	0.648
MOD_GlcNHglycan	26	30	PF01048	0.573
MOD_GlcNHglycan	282	285	PF01048	0.683
MOD_GlcNHglycan	286	289	PF01048	0.659
MOD_GlcNHglycan	317	320	PF01048	0.601
MOD_GlcNHglycan	384	387	PF01048	0.543
MOD_GlcNHglycan	401	404	PF01048	0.659
MOD_GlcNHglycan	414	417	PF01048	0.444
MOD_GlcNHglycan	432	435	PF01048	0.559
MOD_GlcNHglycan	442	445	PF01048	0.543
MOD_GlcNHglycan	460	463	PF01048	0.722
MOD_GlcNHglycan	465	468	PF01048	0.560
MOD_GlcNHglycan	545	548	PF01048	0.807
MOD_GlcNHglycan	563	566	PF01048	0.498
MOD_GlcNHglycan	723	726	PF01048	0.698
MOD_GlcNHglycan	730	733	PF01048	0.661
MOD_GlcNHglycan	819	822	PF01048	0.661
MOD_GlcNHglycan	830	833	PF01048	0.720
MOD_GSK3_1	116	123	PF00069	0.382
MOD_GSK3_1	137	144	PF00069	0.557
MOD_GSK3_1	25	32	PF00069	0.667
MOD_GSK3_1	276	283	PF00069	0.671
MOD_GSK3_1	331	338	PF00069	0.563
MOD_GSK3_1	378	385	PF00069	0.618
MOD_GSK3_1	436	443	PF00069	0.572
MOD_GSK3_1	458	465	PF00069	0.741
MOD_GSK3_1	497	504	PF00069	0.562
MOD_GSK3_1	506	513	PF00069	0.435
MOD_GSK3_1	552	559	PF00069	0.780
MOD_GSK3_1	56	63	PF00069	0.497
MOD_GSK3_1	592	599	PF00069	0.545
MOD_GSK3_1	618	625	PF00069	0.694
MOD_GSK3_1	675	682	PF00069	0.417
MOD_GSK3_1	721	728	PF00069	0.685
MOD_GSK3_1	764	771	PF00069	0.514
MOD_GSK3_1	783	790	PF00069	0.490
MOD_LATS_1	550	556	PF00433	0.630
MOD_N-GLC_1	382	387	PF02516	0.509
MOD_N-GLC_1	721	726	PF02516	0.654
MOD_N-GLC_2	760	762	PF02516	0.452
MOD_NEK2_1	224	229	PF00069	0.694
MOD_NEK2_1	276	281	PF00069	0.530
MOD_NEK2_1	436	441	PF00069	0.635
MOD_NEK2_1	720	725	PF00069	0.696
MOD_NEK2_1	768	773	PF00069	0.534
MOD_NEK2_1	780	785	PF00069	0.328
MOD_NEK2_2	188	193	PF00069	0.468
MOD_OFUCOSY	360	367	PF10250	0.574
MOD_PIKK_1	111	117	PF00454	0.487
MOD_PIKK_1	172	178	PF00454	0.487
MOD_PIKK_1	335	341	PF00454	0.550
MOD_PIKK_1	484	490	PF00454	0.294
MOD_PIKK_1	584	590	PF00454	0.542
MOD_PIKK_1	742	748	PF00454	0.610
MOD_PIKK_1	768	774	PF00454	0.541
MOD_PKA_2	315	321	PF00069	0.608
MOD_PKA_2	355	361	PF00069	0.503
MOD_PKA_2	551	557	PF00069	0.672
MOD_PKA_2	622	628	PF00069	0.680
MOD_PKA_2	675	681	PF00069	0.494
MOD_PKA_2	780	786	PF00069	0.481
MOD_PKB_1	280	288	PF00069	0.531
MOD_Plk_1	231	237	PF00069	0.758
MOD_Plk_1	382	388	PF00069	0.515
MOD_Plk_1	56	62	PF00069	0.437
MOD_Plk_1	606	612	PF00069	0.707
MOD_Plk_2-3	804	810	PF00069	0.668
MOD_Plk_4	444	450	PF00069	0.500
MOD_Plk_4	61	67	PF00069	0.380
MOD_Plk_4	679	685	PF00069	0.420
MOD_ProDKin_1	256	262	PF00069	0.520
MOD_ProDKin_1	553	559	PF00069	0.719
MOD_ProDKin_1	569	575	PF00069	0.561
MOD_ProDKin_1	653	659	PF00069	0.512
MOD_SUMO_rev_2	390	395	PF00179	0.534
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.350
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.517
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.549
TRG_ENDOCYTIC_2	170	173	PF00928	0.556
TRG_ENDOCYTIC_2	183	186	PF00928	0.402
TRG_ENDOCYTIC_2	193	196	PF00928	0.514
TRG_ENDOCYTIC_2	2	5	PF00928	0.651
TRG_ENDOCYTIC_2	265	268	PF00928	0.524
TRG_ENDOCYTIC_2	317	320	PF00928	0.541
TRG_ENDOCYTIC_2	448	451	PF00928	0.588
TRG_ENDOCYTIC_2	683	686	PF00928	0.387
TRG_ENDOCYTIC_2	699	702	PF00928	0.310
TRG_ER_diArg_1	183	185	PF00400	0.473
TRG_ER_diArg_1	644	647	PF00400	0.593
TRG_ER_diArg_1	95	97	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	764	769	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUQ4	Leptomonas seymouri	39%	98%
A0A3R7LA44	Trypanosoma rangeli	25%	100%
A0A3S7WZ43	Leishmania donovani	100%	100%
A4HE39	Leishmania braziliensis	63%	99%
C9ZJW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AXI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9Z0	Leishmania major	87%	98%