LeishMANIAdb
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JmjC domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
JmjC domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I1E1_LEIIN
TriTrypDb:
LINF_250015900
Length:
776

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 503

Expansion

Sequence features

A4I1E1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1E1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 276 280 PF00656 0.788
CLV_C14_Caspase3-7 574 578 PF00656 0.785
CLV_C14_Caspase3-7 85 89 PF00656 0.791
CLV_NRD_NRD_1 444 446 PF00675 0.845
CLV_NRD_NRD_1 500 502 PF00675 0.819
CLV_NRD_NRD_1 681 683 PF00675 0.525
CLV_NRD_NRD_1 700 702 PF00675 0.568
CLV_NRD_NRD_1 704 706 PF00675 0.584
CLV_PCSK_KEX2_1 444 446 PF00082 0.845
CLV_PCSK_KEX2_1 500 502 PF00082 0.819
CLV_PCSK_KEX2_1 509 511 PF00082 0.675
CLV_PCSK_KEX2_1 693 695 PF00082 0.672
CLV_PCSK_KEX2_1 700 702 PF00082 0.557
CLV_PCSK_KEX2_1 704 706 PF00082 0.474
CLV_PCSK_KEX2_1 746 748 PF00082 0.705
CLV_PCSK_PC1ET2_1 509 511 PF00082 0.817
CLV_PCSK_PC1ET2_1 693 695 PF00082 0.672
CLV_PCSK_PC1ET2_1 746 748 PF00082 0.757
CLV_PCSK_PC7_1 700 706 PF00082 0.584
CLV_PCSK_SKI1_1 593 597 PF00082 0.798
CLV_PCSK_SKI1_1 599 603 PF00082 0.701
CLV_PCSK_SKI1_1 662 666 PF00082 0.540
CLV_PCSK_SKI1_1 758 762 PF00082 0.670
DEG_APCC_DBOX_1 17 25 PF00400 0.711
DEG_Nend_Nbox_1 1 3 PF02207 0.835
DEG_SCF_FBW7_1 613 618 PF00400 0.593
DEG_SPOP_SBC_1 628 632 PF00917 0.664
DEG_SPOP_SBC_1 640 644 PF00917 0.709
DEG_SPOP_SBC_1 676 680 PF00917 0.593
DOC_CKS1_1 286 291 PF01111 0.789
DOC_CKS1_1 600 605 PF01111 0.745
DOC_CKS1_1 95 100 PF01111 0.793
DOC_CYCLIN_yCln2_LP_2 534 537 PF00134 0.629
DOC_PP1_SILK_1 723 728 PF00149 0.639
DOC_PP2B_LxvP_1 534 537 PF13499 0.629
DOC_USP7_MATH_1 117 121 PF00917 0.624
DOC_USP7_MATH_1 128 132 PF00917 0.684
DOC_USP7_MATH_1 145 149 PF00917 0.595
DOC_USP7_MATH_1 185 189 PF00917 0.832
DOC_USP7_MATH_1 230 234 PF00917 0.628
DOC_USP7_MATH_1 250 254 PF00917 0.754
DOC_USP7_MATH_1 289 293 PF00917 0.686
DOC_USP7_MATH_1 308 312 PF00917 0.626
DOC_USP7_MATH_1 319 323 PF00917 0.685
DOC_USP7_MATH_1 336 340 PF00917 0.589
DOC_USP7_MATH_1 376 380 PF00917 0.826
DOC_USP7_MATH_1 421 425 PF00917 0.608
DOC_USP7_MATH_1 443 447 PF00917 0.839
DOC_USP7_MATH_1 46 50 PF00917 0.832
DOC_USP7_MATH_1 466 470 PF00917 0.790
DOC_USP7_MATH_1 615 619 PF00917 0.798
DOC_USP7_MATH_1 623 627 PF00917 0.667
DOC_USP7_MATH_1 640 644 PF00917 0.504
DOC_USP7_MATH_1 721 725 PF00917 0.630
DOC_USP7_MATH_1 98 102 PF00917 0.703
DOC_USP7_UBL2_3 742 746 PF12436 0.747
DOC_WW_Pin1_4 139 144 PF00397 0.657
DOC_WW_Pin1_4 181 186 PF00397 0.828
DOC_WW_Pin1_4 207 212 PF00397 0.846
DOC_WW_Pin1_4 285 290 PF00397 0.787
DOC_WW_Pin1_4 330 335 PF00397 0.655
DOC_WW_Pin1_4 372 377 PF00397 0.821
DOC_WW_Pin1_4 398 403 PF00397 0.833
DOC_WW_Pin1_4 4 9 PF00397 0.788
DOC_WW_Pin1_4 537 542 PF00397 0.820
DOC_WW_Pin1_4 599 604 PF00397 0.744
DOC_WW_Pin1_4 611 616 PF00397 0.594
DOC_WW_Pin1_4 94 99 PF00397 0.791
LIG_14-3-3_CanoR_1 465 473 PF00244 0.654
LIG_14-3-3_CanoR_1 500 508 PF00244 0.814
LIG_14-3-3_CanoR_1 510 516 PF00244 0.657
LIG_Actin_WH2_2 508 525 PF00022 0.755
LIG_BIR_III_2 279 283 PF00653 0.788
LIG_BIR_III_2 88 92 PF00653 0.790
LIG_FHA_1 155 161 PF00498 0.841
LIG_FHA_1 346 352 PF00498 0.834
LIG_FHA_2 240 246 PF00498 0.841
LIG_FHA_2 431 437 PF00498 0.796
LIG_FHA_2 566 572 PF00498 0.768
LIG_FHA_2 600 606 PF00498 0.817
LIG_GBD_Chelix_1 13 21 PF00786 0.714
LIG_LIR_Apic_2 161 165 PF02991 0.702
LIG_LIR_Apic_2 352 356 PF02991 0.694
LIG_LIR_Apic_2 678 684 PF02991 0.730
LIG_LIR_Apic_2 748 753 PF02991 0.659
LIG_LIR_Nem_3 697 702 PF02991 0.664
LIG_LIR_Nem_3 703 709 PF02991 0.546
LIG_LIR_Nem_3 754 760 PF02991 0.585
LIG_PCNA_PIPBox_1 515 524 PF02747 0.623
LIG_SH2_CRK 162 166 PF00017 0.840
LIG_SH2_CRK 353 357 PF00017 0.832
LIG_SH2_CRK 681 685 PF00017 0.649
LIG_SH2_CRK 706 710 PF00017 0.623
LIG_SH2_NCK_1 162 166 PF00017 0.840
LIG_SH2_NCK_1 353 357 PF00017 0.832
LIG_SH2_STAP1 624 628 PF00017 0.654
LIG_SH2_STAP1 702 706 PF00017 0.647
LIG_SH2_STAT5 427 430 PF00017 0.580
LIG_SH2_STAT5 548 551 PF00017 0.798
LIG_SH3_1 39 45 PF00018 0.727
LIG_SH3_3 254 260 PF00018 0.859
LIG_SH3_3 39 45 PF00018 0.727
LIG_SH3_3 425 431 PF00018 0.585
LIG_SH3_3 535 541 PF00018 0.635
LIG_SH3_3 597 603 PF00018 0.741
LIG_SH3_3 63 69 PF00018 0.726
LIG_SH3_4 742 749 PF00018 0.746
LIG_TRAF2_1 136 139 PF00917 0.615
LIG_TRAF2_1 260 263 PF00917 0.792
LIG_TRAF2_1 284 287 PF00917 0.654
LIG_TRAF2_1 327 330 PF00917 0.650
LIG_TRAF2_1 69 72 PF00917 0.792
LIG_TRAF2_1 93 96 PF00917 0.651
MOD_CDC14_SPxK_1 210 213 PF00782 0.780
MOD_CDC14_SPxK_1 401 404 PF00782 0.768
MOD_CDK_SPK_2 599 604 PF00069 0.744
MOD_CDK_SPxK_1 207 213 PF00069 0.848
MOD_CDK_SPxK_1 398 404 PF00069 0.835
MOD_CK1_1 181 187 PF00069 0.828
MOD_CK1_1 197 203 PF00069 0.573
MOD_CK1_1 3 9 PF00069 0.792
MOD_CK1_1 372 378 PF00069 0.821
MOD_CK1_1 388 394 PF00069 0.562
MOD_CK1_1 47 53 PF00069 0.844
MOD_CK1_1 540 546 PF00069 0.618
MOD_CK1_1 554 560 PF00069 0.594
MOD_CK1_1 627 633 PF00069 0.727
MOD_CK1_1 766 772 PF00069 0.642
MOD_CK2_1 133 139 PF00069 0.654
MOD_CK2_1 145 151 PF00069 0.679
MOD_CK2_1 215 221 PF00069 0.783
MOD_CK2_1 239 245 PF00069 0.837
MOD_CK2_1 324 330 PF00069 0.677
MOD_CK2_1 336 342 PF00069 0.652
MOD_CK2_1 406 412 PF00069 0.769
MOD_CK2_1 430 436 PF00069 0.805
MOD_CK2_1 443 449 PF00069 0.658
MOD_CK2_1 554 560 PF00069 0.730
MOD_CK2_1 565 571 PF00069 0.742
MOD_CK2_1 599 605 PF00069 0.814
MOD_CK2_1 6 12 PF00069 0.549
MOD_CK2_1 745 751 PF00069 0.679
MOD_GlcNHglycan 119 122 PF01048 0.863
MOD_GlcNHglycan 129 133 PF01048 0.703
MOD_GlcNHglycan 147 150 PF01048 0.623
MOD_GlcNHglycan 165 168 PF01048 0.733
MOD_GlcNHglycan 180 183 PF01048 0.594
MOD_GlcNHglycan 194 197 PF01048 0.618
MOD_GlcNHglycan 205 208 PF01048 0.666
MOD_GlcNHglycan 228 231 PF01048 0.764
MOD_GlcNHglycan 232 235 PF01048 0.699
MOD_GlcNHglycan 310 313 PF01048 0.868
MOD_GlcNHglycan 320 324 PF01048 0.705
MOD_GlcNHglycan 338 341 PF01048 0.619
MOD_GlcNHglycan 356 359 PF01048 0.722
MOD_GlcNHglycan 371 374 PF01048 0.588
MOD_GlcNHglycan 385 388 PF01048 0.607
MOD_GlcNHglycan 396 399 PF01048 0.656
MOD_GlcNHglycan 419 422 PF01048 0.744
MOD_GlcNHglycan 423 426 PF01048 0.679
MOD_GlcNHglycan 482 485 PF01048 0.797
MOD_GlcNHglycan 494 498 PF01048 0.566
MOD_GlcNHglycan 573 576 PF01048 0.729
MOD_GlcNHglycan 652 655 PF01048 0.682
MOD_GlcNHglycan 684 687 PF01048 0.697
MOD_GlcNHglycan 711 715 PF01048 0.633
MOD_GlcNHglycan 765 768 PF01048 0.420
MOD_GSK3_1 141 148 PF00069 0.789
MOD_GSK3_1 154 161 PF00069 0.653
MOD_GSK3_1 177 184 PF00069 0.833
MOD_GSK3_1 194 201 PF00069 0.563
MOD_GSK3_1 203 210 PF00069 0.665
MOD_GSK3_1 212 219 PF00069 0.568
MOD_GSK3_1 226 233 PF00069 0.701
MOD_GSK3_1 285 292 PF00069 0.789
MOD_GSK3_1 3 10 PF00069 0.598
MOD_GSK3_1 332 339 PF00069 0.782
MOD_GSK3_1 345 352 PF00069 0.646
MOD_GSK3_1 368 375 PF00069 0.826
MOD_GSK3_1 385 392 PF00069 0.552
MOD_GSK3_1 394 401 PF00069 0.655
MOD_GSK3_1 403 410 PF00069 0.553
MOD_GSK3_1 417 424 PF00069 0.682
MOD_GSK3_1 489 496 PF00069 0.625
MOD_GSK3_1 547 554 PF00069 0.604
MOD_GSK3_1 611 618 PF00069 0.794
MOD_GSK3_1 623 630 PF00069 0.618
MOD_GSK3_1 721 728 PF00069 0.636
MOD_GSK3_1 763 770 PF00069 0.419
MOD_GSK3_1 94 101 PF00069 0.791
MOD_N-GLC_1 192 197 PF02516 0.842
MOD_N-GLC_1 383 388 PF02516 0.833
MOD_N-GLC_1 526 531 PF02516 0.617
MOD_NEK2_1 107 112 PF00069 0.789
MOD_NEK2_1 178 183 PF00069 0.835
MOD_NEK2_1 194 199 PF00069 0.583
MOD_NEK2_1 298 303 PF00069 0.789
MOD_NEK2_1 31 36 PF00069 0.483
MOD_NEK2_1 369 374 PF00069 0.829
MOD_NEK2_1 385 390 PF00069 0.572
MOD_NEK2_1 482 487 PF00069 0.758
MOD_NEK2_1 551 556 PF00069 0.665
MOD_NEK2_1 582 587 PF00069 0.754
MOD_NEK2_1 641 646 PF00069 0.759
MOD_NEK2_1 649 654 PF00069 0.551
MOD_NEK2_2 185 190 PF00069 0.834
MOD_NEK2_2 376 381 PF00069 0.828
MOD_NEK2_2 547 552 PF00069 0.599
MOD_PIKK_1 115 121 PF00454 0.857
MOD_PIKK_1 134 140 PF00454 0.556
MOD_PIKK_1 194 200 PF00454 0.831
MOD_PIKK_1 306 312 PF00454 0.864
MOD_PIKK_1 325 331 PF00454 0.558
MOD_PIKK_1 385 391 PF00454 0.821
MOD_PIKK_1 466 472 PF00454 0.733
MOD_PIKK_1 540 546 PF00454 0.597
MOD_PKA_1 500 506 PF00069 0.814
MOD_PKA_1 682 688 PF00069 0.512
MOD_PKA_1 700 706 PF00069 0.559
MOD_PKA_2 212 218 PF00069 0.851
MOD_PKA_2 403 409 PF00069 0.835
MOD_PKA_2 443 449 PF00069 0.825
MOD_PKA_2 500 506 PF00069 0.814
MOD_PKA_2 700 706 PF00069 0.654
MOD_Plk_1 107 113 PF00069 0.791
MOD_Plk_1 185 191 PF00069 0.838
MOD_Plk_1 298 304 PF00069 0.791
MOD_Plk_1 376 382 PF00069 0.832
MOD_Plk_1 565 571 PF00069 0.736
MOD_Plk_1 694 700 PF00069 0.662
MOD_Plk_1 710 716 PF00069 0.379
MOD_Plk_2-3 52 58 PF00069 0.650
MOD_Plk_4 547 553 PF00069 0.598
MOD_Plk_4 584 590 PF00069 0.713
MOD_Plk_4 624 630 PF00069 0.548
MOD_Plk_4 694 700 PF00069 0.603
MOD_Plk_4 721 727 PF00069 0.633
MOD_ProDKin_1 139 145 PF00069 0.656
MOD_ProDKin_1 181 187 PF00069 0.828
MOD_ProDKin_1 207 213 PF00069 0.848
MOD_ProDKin_1 285 291 PF00069 0.789
MOD_ProDKin_1 330 336 PF00069 0.653
MOD_ProDKin_1 372 378 PF00069 0.821
MOD_ProDKin_1 398 404 PF00069 0.835
MOD_ProDKin_1 4 10 PF00069 0.783
MOD_ProDKin_1 537 543 PF00069 0.816
MOD_ProDKin_1 599 605 PF00069 0.744
MOD_ProDKin_1 611 617 PF00069 0.593
MOD_ProDKin_1 94 100 PF00069 0.792
MOD_SUMO_rev_2 276 282 PF00179 0.786
MOD_SUMO_rev_2 737 744 PF00179 0.721
MOD_SUMO_rev_2 85 91 PF00179 0.791
TRG_DiLeu_BaEn_2 578 584 PF01217 0.770
TRG_ENDOCYTIC_2 548 551 PF00928 0.672
TRG_ENDOCYTIC_2 706 709 PF00928 0.632
TRG_ER_diArg_1 443 445 PF00400 0.846
TRG_ER_diArg_1 500 502 PF00400 0.819
TRG_ER_diArg_1 699 701 PF00400 0.670
TRG_ER_diArg_1 704 706 PF00400 0.568
TRG_Pf-PMV_PEXEL_1 105 109 PF00026 0.793
TRG_Pf-PMV_PEXEL_1 296 300 PF00026 0.793
TRG_Pf-PMV_PEXEL_1 500 504 PF00026 0.816
TRG_Pf-PMV_PEXEL_1 567 571 PF00026 0.825
TRG_Pf-PMV_PEXEL_1 593 597 PF00026 0.700
TRG_Pf-PMV_PEXEL_1 707 711 PF00026 0.627
TRG_Pf-PMV_PEXEL_1 759 763 PF00026 0.664

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WZ10 Leishmania donovani 98% 80%
E9AXH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 97%
Q4Q9Z4 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS