ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies)/Ankyrin repeat - putative

Species:

Leishmania infantum

UniProt:

A4I1D4_LEIIN

TriTrypDb:

LINF_250015100

Length:

262

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.437
CLV_PCSK_SKI1_1	165	169	PF00082	0.413
DEG_APCC_DBOX_1	238	246	PF00400	0.494
DEG_SPOP_SBC_1	118	122	PF00917	0.550
DOC_CDC14_PxL_1	1	9	PF14671	0.504
DOC_CKS1_1	95	100	PF01111	0.475
DOC_CYCLIN_RxL_1	162	170	PF00134	0.387
DOC_PP4_FxxP_1	95	98	PF00568	0.411
DOC_USP7_MATH_1	101	105	PF00917	0.591
DOC_USP7_MATH_1	118	122	PF00917	0.485
DOC_USP7_MATH_1	125	129	PF00917	0.627
DOC_USP7_MATH_1	142	146	PF00917	0.175
DOC_USP7_MATH_1	177	181	PF00917	0.307
DOC_USP7_MATH_1	254	258	PF00917	0.468
DOC_WW_Pin1_4	114	119	PF00397	0.380
DOC_WW_Pin1_4	123	128	PF00397	0.712
DOC_WW_Pin1_4	147	152	PF00397	0.245
DOC_WW_Pin1_4	26	31	PF00397	0.449
DOC_WW_Pin1_4	94	99	PF00397	0.406
LIG_14-3-3_CanoR_1	41	45	PF00244	0.320
LIG_14-3-3_CanoR_1	53	61	PF00244	0.303
LIG_14-3-3_CanoR_1	63	68	PF00244	0.268
LIG_14-3-3_CanoR_1	80	90	PF00244	0.371
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BRCT_BRCA1_1	215	219	PF00533	0.496
LIG_EH1_1	195	203	PF00400	0.365
LIG_FHA_1	11	17	PF00498	0.402
LIG_FHA_1	54	60	PF00498	0.314
LIG_FHA_2	182	188	PF00498	0.317
LIG_LIR_Apic_2	92	98	PF02991	0.191
LIG_LIR_Gen_1	227	237	PF02991	0.500
LIG_LIR_Nem_3	227	232	PF02991	0.504
LIG_PCNA_PIPBox_1	160	169	PF02747	0.273
LIG_SH2_NCK_1	116	120	PF00017	0.688
LIG_SH2_PTP2	229	232	PF00017	0.462
LIG_SH2_SRC	229	232	PF00017	0.575
LIG_SH2_STAT5	116	119	PF00017	0.688
LIG_SH2_STAT5	166	169	PF00017	0.273
LIG_SH2_STAT5	229	232	PF00017	0.530
LIG_SH2_STAT5	35	38	PF00017	0.404
LIG_TYR_ITIM	164	169	PF00017	0.273
MOD_CK1_1	121	127	PF00069	0.579
MOD_CK1_1	128	134	PF00069	0.431
MOD_GlcNHglycan	104	107	PF01048	0.588
MOD_GlcNHglycan	123	126	PF01048	0.531
MOD_GlcNHglycan	144	147	PF01048	0.356
MOD_GlcNHglycan	157	160	PF01048	0.423
MOD_GlcNHglycan	20	24	PF01048	0.439
MOD_GlcNHglycan	224	227	PF01048	0.506
MOD_GlcNHglycan	83	86	PF01048	0.362
MOD_GlcNHglycan	99	102	PF01048	0.417
MOD_GSK3_1	110	117	PF00069	0.504
MOD_GSK3_1	119	126	PF00069	0.647
MOD_GSK3_1	177	184	PF00069	0.352
MOD_GSK3_1	218	225	PF00069	0.449
MOD_GSK3_1	3	10	PF00069	0.561
MOD_GSK3_1	59	66	PF00069	0.393
MOD_GSK3_1	89	96	PF00069	0.315
MOD_GSK3_1	97	104	PF00069	0.384
MOD_N-GLC_1	202	207	PF02516	0.396
MOD_N-GLC_1	213	218	PF02516	0.365
MOD_N-GLC_1	26	31	PF02516	0.472
MOD_N-GLC_1	33	38	PF02516	0.456
MOD_NEK2_1	167	172	PF00069	0.343
MOD_NEK2_1	202	207	PF00069	0.374
MOD_NEK2_1	59	64	PF00069	0.359
MOD_NEK2_1	7	12	PF00069	0.435
MOD_PIKK_1	10	16	PF00454	0.339
MOD_PIKK_1	219	225	PF00454	0.540
MOD_PIKK_1	54	60	PF00454	0.442
MOD_PKA_2	110	116	PF00069	0.669
MOD_PKA_2	177	183	PF00069	0.321
MOD_PKA_2	40	46	PF00069	0.300
MOD_Plk_1	19	25	PF00069	0.477
MOD_Plk_1	202	208	PF00069	0.411
MOD_Plk_1	254	260	PF00069	0.489
MOD_Plk_4	125	131	PF00069	0.612
MOD_Plk_4	40	46	PF00069	0.245
MOD_Plk_4	89	95	PF00069	0.210
MOD_ProDKin_1	114	120	PF00069	0.381
MOD_ProDKin_1	123	129	PF00069	0.698
MOD_ProDKin_1	147	153	PF00069	0.245
MOD_ProDKin_1	26	32	PF00069	0.444
MOD_ProDKin_1	94	100	PF00069	0.417
TRG_ENDOCYTIC_2	166	169	PF00928	0.345
TRG_ENDOCYTIC_2	229	232	PF00928	0.510
TRG_NES_CRM1_1	187	199	PF08389	0.321
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I922	Leptomonas seymouri	62%	100%
A0A0S4IRG3	Bodo saltans	30%	100%
A0A1X0NNH1	Trypanosomatidae	36%	100%
A0A3Q8ICG2	Leishmania donovani	100%	100%
A0A422NXA4	Trypanosoma rangeli	36%	100%
A4HE28	Leishmania braziliensis	82%	100%
C9ZKX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AXH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QA01	Leishmania major	93%	100%
Q6P6B7	Homo sapiens	29%	73%
V5BBP8	Trypanosoma cruzi	37%	100%