SLBP_RNA_bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone RNA hairpin-binding protein RNA-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I1D3_LEIIN

TriTrypDb:

LINF_250015000

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071204	histone pre-mRNA 3'end processing complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I1D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1D3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0008152	metabolic process	1	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0036002	pre-mRNA binding	5	1
GO:0071207	histone pre-mRNA stem-loop binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.764
CLV_NRD_NRD_1	165	167	PF00675	0.256
CLV_NRD_NRD_1	220	222	PF00675	0.393
CLV_NRD_NRD_1	224	226	PF00675	0.354
CLV_NRD_NRD_1	252	254	PF00675	0.553
CLV_NRD_NRD_1	411	413	PF00675	0.827
CLV_NRD_NRD_1	692	694	PF00675	0.680
CLV_NRD_NRD_1	794	796	PF00675	0.586
CLV_NRD_NRD_1	94	96	PF00675	0.713
CLV_PCSK_KEX2_1	164	166	PF00082	0.393
CLV_PCSK_KEX2_1	186	188	PF00082	0.393
CLV_PCSK_KEX2_1	213	215	PF00082	0.393
CLV_PCSK_KEX2_1	224	226	PF00082	0.286
CLV_PCSK_KEX2_1	252	254	PF00082	0.553
CLV_PCSK_KEX2_1	411	413	PF00082	0.827
CLV_PCSK_KEX2_1	692	694	PF00082	0.680
CLV_PCSK_KEX2_1	94	96	PF00082	0.713
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.393
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.393
CLV_PCSK_PC7_1	688	694	PF00082	0.598
CLV_PCSK_SKI1_1	224	228	PF00082	0.393
CLV_PCSK_SKI1_1	296	300	PF00082	0.660
CLV_PCSK_SKI1_1	795	799	PF00082	0.736
CLV_Separin_Metazoa	262	266	PF03568	0.641
DEG_COP1_1	379	387	PF00400	0.694
DEG_Nend_UBRbox_3	1	3	PF02207	0.755
DOC_CKS1_1	825	830	PF01111	0.797
DOC_CYCLIN_RxL_1	473	484	PF00134	0.682
DOC_CYCLIN_RxL_1	792	800	PF00134	0.674
DOC_MAPK_gen_1	164	175	PF00069	0.593
DOC_MAPK_gen_1	210	220	PF00069	0.586
DOC_MAPK_gen_1	265	273	PF00069	0.641
DOC_MAPK_gen_1	411	417	PF00069	0.793
DOC_MAPK_gen_1	781	791	PF00069	0.694
DOC_MAPK_MEF2A_6	265	273	PF00069	0.641
DOC_PP1_RVXF_1	169	176	PF00149	0.593
DOC_PP2B_LxvP_1	203	206	PF13499	0.593
DOC_PP2B_LxvP_1	415	418	PF13499	0.691
DOC_PP2B_LxvP_1	492	495	PF13499	0.642
DOC_PP2B_LxvP_1	504	507	PF13499	0.742
DOC_PP2B_LxvP_1	552	555	PF13499	0.705
DOC_PP2B_LxvP_1	636	639	PF13499	0.669
DOC_PP4_FxxP_1	510	513	PF00568	0.653
DOC_USP7_MATH_1	136	140	PF00917	0.685
DOC_USP7_MATH_1	143	147	PF00917	0.639
DOC_USP7_MATH_1	284	288	PF00917	0.594
DOC_USP7_MATH_1	4	8	PF00917	0.603
DOC_USP7_MATH_1	416	420	PF00917	0.694
DOC_USP7_MATH_1	421	425	PF00917	0.648
DOC_USP7_MATH_1	460	464	PF00917	0.720
DOC_USP7_MATH_1	495	499	PF00917	0.699
DOC_USP7_MATH_1	538	542	PF00917	0.720
DOC_USP7_MATH_1	611	615	PF00917	0.724
DOC_USP7_MATH_1	616	620	PF00917	0.701
DOC_USP7_MATH_1	682	686	PF00917	0.720
DOC_WW_Pin1_4	102	107	PF00397	0.791
DOC_WW_Pin1_4	132	137	PF00397	0.634
DOC_WW_Pin1_4	139	144	PF00397	0.665
DOC_WW_Pin1_4	151	156	PF00397	0.625
DOC_WW_Pin1_4	201	206	PF00397	0.593
DOC_WW_Pin1_4	28	33	PF00397	0.766
DOC_WW_Pin1_4	323	328	PF00397	0.692
DOC_WW_Pin1_4	404	409	PF00397	0.773
DOC_WW_Pin1_4	417	422	PF00397	0.610
DOC_WW_Pin1_4	427	432	PF00397	0.661
DOC_WW_Pin1_4	43	48	PF00397	0.560
DOC_WW_Pin1_4	436	441	PF00397	0.501
DOC_WW_Pin1_4	444	449	PF00397	0.590
DOC_WW_Pin1_4	511	516	PF00397	0.751
DOC_WW_Pin1_4	526	531	PF00397	0.529
DOC_WW_Pin1_4	54	59	PF00397	0.644
DOC_WW_Pin1_4	566	571	PF00397	0.623
DOC_WW_Pin1_4	626	631	PF00397	0.723
DOC_WW_Pin1_4	70	75	PF00397	0.564
DOC_WW_Pin1_4	703	708	PF00397	0.696
DOC_WW_Pin1_4	717	722	PF00397	0.559
DOC_WW_Pin1_4	789	794	PF00397	0.749
DOC_WW_Pin1_4	820	825	PF00397	0.769
LIG_14-3-3_CanoR_1	164	173	PF00244	0.547
LIG_14-3-3_CanoR_1	253	263	PF00244	0.600
LIG_14-3-3_CanoR_1	355	360	PF00244	0.644
LIG_14-3-3_CanoR_1	451	458	PF00244	0.580
LIG_14-3-3_CanoR_1	476	481	PF00244	0.770
LIG_14-3-3_CanoR_1	537	543	PF00244	0.540
LIG_14-3-3_CanoR_1	61	70	PF00244	0.691
LIG_14-3-3_CanoR_1	676	682	PF00244	0.668
LIG_14-3-3_CanoR_1	692	698	PF00244	0.569
LIG_14-3-3_CanoR_1	716	721	PF00244	0.698
LIG_14-3-3_CanoR_1	729	735	PF00244	0.599
LIG_14-3-3_CanoR_1	767	773	PF00244	0.589
LIG_14-3-3_CanoR_1	79	85	PF00244	0.566
LIG_Actin_WH2_2	181	198	PF00022	0.593
LIG_Actin_WH2_2	282	298	PF00022	0.657
LIG_BRCT_BRCA1_1	104	108	PF00533	0.620
LIG_BRCT_BRCA1_1	256	260	PF00533	0.582
LIG_BRCT_BRCA1_1	602	606	PF00533	0.614
LIG_BRCT_BRCA1_1	769	773	PF00533	0.620
LIG_CSL_BTD_1	521	524	PF09270	0.665
LIG_CtBP_PxDLS_1	403	407	PF00389	0.707
LIG_EVH1_2	205	209	PF00568	0.467
LIG_EVH1_2	506	510	PF00568	0.733
LIG_FHA_1	132	138	PF00498	0.581
LIG_FHA_1	498	504	PF00498	0.749
LIG_FHA_1	512	518	PF00498	0.573
LIG_FHA_1	626	632	PF00498	0.723
LIG_FHA_1	747	753	PF00498	0.724
LIG_FHA_1	798	804	PF00498	0.687
LIG_FHA_1	833	839	PF00498	0.701
LIG_Integrin_RGD_1	114	116	PF01839	0.722
LIG_LIR_Gen_1	179	190	PF02991	0.593
LIG_LIR_Gen_1	231	239	PF02991	0.664
LIG_LIR_Gen_1	257	267	PF02991	0.598
LIG_LIR_Gen_1	302	313	PF02991	0.667
LIG_LIR_Gen_1	669	679	PF02991	0.729
LIG_LIR_Gen_1	7	15	PF02991	0.722
LIG_LIR_Nem_3	231	235	PF02991	0.634
LIG_LIR_Nem_3	302	308	PF02991	0.660
LIG_LIR_Nem_3	7	11	PF02991	0.694
LIG_Pex14_2	230	234	PF04695	0.678
LIG_PTAP_UEV_1	384	389	PF05743	0.684
LIG_SH2_GRB2like	182	185	PF00017	0.593
LIG_SH2_PTP2	232	235	PF00017	0.612
LIG_SH2_STAT5	177	180	PF00017	0.593
LIG_SH2_STAT5	182	185	PF00017	0.544
LIG_SH2_STAT5	232	235	PF00017	0.670
LIG_SH3_3	199	205	PF00018	0.593
LIG_SH3_3	382	388	PF00018	0.693
LIG_SH3_3	407	413	PF00018	0.766
LIG_SH3_3	415	421	PF00018	0.662
LIG_SH3_3	423	429	PF00018	0.579
LIG_SH3_3	46	52	PF00018	0.775
LIG_SH3_3	500	506	PF00018	0.732
LIG_SH3_3	573	579	PF00018	0.762
LIG_SH3_3	624	630	PF00018	0.627
LIG_SH3_3	745	751	PF00018	0.616
LIG_SH3_3	82	88	PF00018	0.697
LIG_SH3_3	839	845	PF00018	0.724
LIG_SUMO_SIM_par_1	401	407	PF11976	0.705
LIG_TRAF2_1	290	293	PF00917	0.656
LIG_WW_2	413	416	PF00397	0.788
MOD_CDC14_SPxK_1	409	412	PF00782	0.788
MOD_CDK_SPK_2	406	411	PF00069	0.779
MOD_CDK_SPxK_1	406	412	PF00069	0.782
MOD_CDK_SPxK_1	436	442	PF00069	0.677
MOD_CDK_SPxK_1	70	76	PF00069	0.728
MOD_CDK_SPxK_1	789	795	PF00069	0.749
MOD_CDK_SPxxK_3	404	411	PF00069	0.778
MOD_CDK_SPxxK_3	427	434	PF00069	0.630
MOD_CDK_SPxxK_3	444	451	PF00069	0.589
MOD_CDK_SPxxK_3	54	61	PF00069	0.730
MOD_CDK_SPxxK_3	566	573	PF00069	0.567
MOD_CDK_SPxxK_3	789	796	PF00069	0.602
MOD_CDK_SPxxK_3	824	831	PF00069	0.796
MOD_CK1_1	139	145	PF00069	0.659
MOD_CK1_1	156	162	PF00069	0.558
MOD_CK1_1	307	313	PF00069	0.674
MOD_CK1_1	315	321	PF00069	0.593
MOD_CK1_1	419	425	PF00069	0.726
MOD_CK1_1	427	433	PF00069	0.646
MOD_CK1_1	463	469	PF00069	0.724
MOD_CK1_1	481	487	PF00069	0.568
MOD_CK1_1	511	517	PF00069	0.604
MOD_CK1_1	541	547	PF00069	0.630
MOD_CK1_1	596	602	PF00069	0.593
MOD_CK1_1	614	620	PF00069	0.695
MOD_CK1_1	656	662	PF00069	0.705
MOD_CK1_1	677	683	PF00069	0.671
MOD_CK1_1	7	13	PF00069	0.620
MOD_CK2_1	156	162	PF00069	0.730
MOD_CK2_1	164	170	PF00069	0.362
MOD_CK2_1	323	329	PF00069	0.671
MOD_CK2_1	717	723	PF00069	0.694
MOD_Cter_Amidation	162	165	PF01082	0.295
MOD_DYRK1A_RPxSP_1	43	47	PF00069	0.700
MOD_GlcNHglycan	121	124	PF01048	0.777
MOD_GlcNHglycan	155	158	PF01048	0.677
MOD_GlcNHglycan	196	199	PF01048	0.470
MOD_GlcNHglycan	282	285	PF01048	0.700
MOD_GlcNHglycan	314	317	PF01048	0.696
MOD_GlcNHglycan	338	341	PF01048	0.656
MOD_GlcNHglycan	385	388	PF01048	0.792
MOD_GlcNHglycan	462	465	PF01048	0.703
MOD_GlcNHglycan	470	473	PF01048	0.691
MOD_GlcNHglycan	480	483	PF01048	0.561
MOD_GlcNHglycan	497	500	PF01048	0.507
MOD_GlcNHglycan	510	513	PF01048	0.605
MOD_GlcNHglycan	58	61	PF01048	0.732
MOD_GlcNHglycan	595	598	PF01048	0.732
MOD_GlcNHglycan	676	679	PF01048	0.758
MOD_GlcNHglycan	694	697	PF01048	0.528
MOD_GlcNHglycan	730	733	PF01048	0.738
MOD_GlcNHglycan	736	739	PF01048	0.643
MOD_GlcNHglycan	741	744	PF01048	0.600
MOD_GlcNHglycan	786	789	PF01048	0.628
MOD_GlcNHglycan	828	831	PF01048	0.733
MOD_GSK3_1	131	138	PF00069	0.619
MOD_GSK3_1	139	146	PF00069	0.586
MOD_GSK3_1	176	183	PF00069	0.470
MOD_GSK3_1	19	26	PF00069	0.603
MOD_GSK3_1	280	287	PF00069	0.582
MOD_GSK3_1	379	386	PF00069	0.729
MOD_GSK3_1	39	46	PF00069	0.669
MOD_GSK3_1	417	424	PF00069	0.719
MOD_GSK3_1	476	483	PF00069	0.657
MOD_GSK3_1	524	531	PF00069	0.613
MOD_GSK3_1	592	599	PF00069	0.531
MOD_GSK3_1	670	677	PF00069	0.664
MOD_GSK3_1	820	827	PF00069	0.767
MOD_NEK2_1	194	199	PF00069	0.486
MOD_NEK2_1	209	214	PF00069	0.331
MOD_NEK2_1	39	44	PF00069	0.764
MOD_NEK2_1	478	483	PF00069	0.735
MOD_NEK2_1	497	502	PF00069	0.494
MOD_NEK2_1	782	787	PF00069	0.753
MOD_NEK2_1	797	802	PF00069	0.546
MOD_NEK2_2	304	309	PF00069	0.668
MOD_PIKK_1	164	170	PF00454	0.406
MOD_PIKK_1	470	476	PF00454	0.759
MOD_PIKK_1	61	67	PF00454	0.745
MOD_PIKK_1	656	662	PF00454	0.784
MOD_PIKK_1	782	788	PF00454	0.754
MOD_PIKK_1	80	86	PF00454	0.557
MOD_PKA_1	164	170	PF00069	0.406
MOD_PKA_1	692	698	PF00069	0.685
MOD_PKA_2	164	170	PF00069	0.406
MOD_PKA_2	354	360	PF00069	0.644
MOD_PKA_2	435	441	PF00069	0.587
MOD_PKA_2	450	456	PF00069	0.657
MOD_PKA_2	661	667	PF00069	0.713
MOD_PKA_2	691	697	PF00069	0.778
MOD_PKA_2	715	721	PF00069	0.739
MOD_PKA_2	728	734	PF00069	0.623
MOD_PKA_2	832	838	PF00069	0.717
MOD_Plk_4	768	774	PF00069	0.603
MOD_ProDKin_1	102	108	PF00069	0.794
MOD_ProDKin_1	132	138	PF00069	0.635
MOD_ProDKin_1	139	145	PF00069	0.668
MOD_ProDKin_1	151	157	PF00069	0.622
MOD_ProDKin_1	201	207	PF00069	0.470
MOD_ProDKin_1	28	34	PF00069	0.766
MOD_ProDKin_1	323	329	PF00069	0.690
MOD_ProDKin_1	404	410	PF00069	0.773
MOD_ProDKin_1	417	423	PF00069	0.611
MOD_ProDKin_1	427	433	PF00069	0.661
MOD_ProDKin_1	43	49	PF00069	0.562
MOD_ProDKin_1	436	442	PF00069	0.502
MOD_ProDKin_1	444	450	PF00069	0.588
MOD_ProDKin_1	511	517	PF00069	0.755
MOD_ProDKin_1	526	532	PF00069	0.527
MOD_ProDKin_1	54	60	PF00069	0.645
MOD_ProDKin_1	566	572	PF00069	0.623
MOD_ProDKin_1	626	632	PF00069	0.723
MOD_ProDKin_1	70	76	PF00069	0.563
MOD_ProDKin_1	703	709	PF00069	0.695
MOD_ProDKin_1	717	723	PF00069	0.559
MOD_ProDKin_1	789	795	PF00069	0.749
MOD_ProDKin_1	820	826	PF00069	0.769
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.470
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.389
TRG_ENDOCYTIC_2	182	185	PF00928	0.470
TRG_ENDOCYTIC_2	232	235	PF00928	0.647
TRG_ENDOCYTIC_2	305	308	PF00928	0.688
TRG_ENDOCYTIC_2	562	565	PF00928	0.742
TRG_ENDOCYTIC_2	632	635	PF00928	0.672
TRG_ER_diArg_1	164	166	PF00400	0.470
TRG_ER_diArg_1	223	225	PF00400	0.470
TRG_ER_diArg_1	410	412	PF00400	0.825
TRG_NLS_MonoExtC_3	220	225	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	750	755	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF88	Leishmania donovani	99%	100%
A4HE27	Leishmania braziliensis	62%	97%
E9AXH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA02	Leishmania major	88%	100%