Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin type peptidyl-prolyl cis-trans isomerase

Species:

Leishmania infantum

UniProt:

A4I1D2_LEIIN

TriTrypDb:

LINF_250014900

Length:

177

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, Peptidyl-prolyl cis-trans isomerase CYPA

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0005929	cilium	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Phosphorylation

Amastigote: 97
Promastigote/Amastigote: 4

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1D2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006457	protein folding	2	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.341
DOC_MAPK_MEF2A_6	15	22	PF00069	0.393
DOC_PP1_RVXF_1	136	143	PF00149	0.247
DOC_USP7_MATH_1	157	161	PF00917	0.265
DOC_USP7_MATH_1	94	98	PF00917	0.305
DOC_WW_Pin1_4	1	6	PF00397	0.381
LIG_14-3-3_CanoR_1	161	171	PF00244	0.421
LIG_14-3-3_CanoR_1	29	33	PF00244	0.281
LIG_APCC_ABBA_1	32	37	PF00400	0.247
LIG_BIR_II_1	1	5	PF00653	0.361
LIG_BIR_III_2	37	41	PF00653	0.247
LIG_BRCT_BRCA1_1	122	126	PF00533	0.247
LIG_FHA_1	130	136	PF00498	0.247
LIG_FHA_1	29	35	PF00498	0.281
LIG_LIR_Gen_1	147	157	PF02991	0.341
LIG_LIR_Nem_3	147	152	PF02991	0.341
LIG_LIR_Nem_3	4	10	PF02991	0.347
LIG_LIR_Nem_3	44	49	PF02991	0.251
LIG_LYPXL_yS_3	7	10	PF13949	0.436
LIG_MLH1_MIPbox_1	122	126	PF16413	0.247
LIG_PTB_Apo_2	57	64	PF02174	0.268
LIG_SH2_CRK	149	153	PF00017	0.276
LIG_SH2_GRB2like	58	61	PF00017	0.268
LIG_SH2_STAT5	3	6	PF00017	0.518
LIG_SH3_3	2	8	PF00018	0.371
MOD_CK1_1	162	168	PF00069	0.341
MOD_GlcNHglycan	161	164	PF01048	0.276
MOD_GSK3_1	126	133	PF00069	0.344
MOD_GSK3_1	157	164	PF00069	0.254
MOD_GSK3_1	80	87	PF00069	0.260
MOD_N-GLC_1	120	125	PF02516	0.247
MOD_N-GLC_1	80	85	PF02516	0.247
MOD_NEK2_1	126	131	PF00069	0.247
MOD_NEK2_2	84	89	PF00069	0.247
MOD_PIKK_1	120	126	PF00454	0.247
MOD_PKA_2	28	34	PF00069	0.281
MOD_Plk_1	94	100	PF00069	0.247
MOD_Plk_4	130	136	PF00069	0.341
MOD_Plk_4	84	90	PF00069	0.247
MOD_ProDKin_1	1	7	PF00069	0.372
MOD_SUMO_rev_2	133	140	PF00179	0.341
TRG_ENDOCYTIC_2	149	152	PF00928	0.341
TRG_ENDOCYTIC_2	7	10	PF00928	0.375
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A075B759	Homo sapiens	61%	100%
A0A075B767	Homo sapiens	61%	100%
A0A0B4J2A2	Homo sapiens	62%	100%
A0A0N0P364	Leptomonas seymouri	49%	77%
A0A0N0P839	Leptomonas seymouri	69%	90%
A0A0N1I0P5	Leptomonas seymouri	90%	99%
A0A0N1I6E6	Leptomonas seymouri	61%	93%
A0A0N1PC19	Leptomonas seymouri	37%	88%
A0A0N1PDY0	Leptomonas seymouri	31%	72%
A0A0S4J0W0	Bodo saltans	55%	72%
A0A0S4J351	Bodo saltans	40%	66%
A0A0S4J378	Bodo saltans	60%	96%
A0A0S4J465	Bodo saltans	28%	73%
A0A0S4J4A4	Bodo saltans	73%	96%
A0A0S4J7K8	Bodo saltans	80%	100%
A0A0S4J8W7	Bodo saltans	51%	77%
A0A0S4J9U9	Bodo saltans	33%	85%
A0A0S4JID7	Bodo saltans	55%	79%
A0A0S4JQ48	Bodo saltans	28%	98%
A0A0S4KDV3	Bodo saltans	38%	94%
A0A0S4KGS8	Bodo saltans	36%	72%
A0A0S4KLH0	Bodo saltans	69%	89%
A0A1X0NJS0	Trypanosomatidae	58%	93%
A0A1X0NTQ9	Trypanosomatidae	59%	77%
A0A1X0NTS4	Trypanosomatidae	52%	77%
A0A1X0NXG7	Trypanosomatidae	69%	68%
A0A1X0P184	Trypanosomatidae	71%	90%
A0A1X0P2K2	Trypanosomatidae	34%	67%
A0A1X0P4X3	Trypanosomatidae	36%	96%
A0A1X0P5F9	Trypanosomatidae	82%	100%
A0A1X0P6P3	Trypanosomatidae	38%	99%
A0A3Q8ICB3	Leishmania donovani	50%	77%
A0A3R7MP70	Trypanosoma rangeli	38%	97%
A0A3R7NMR3	Trypanosoma rangeli	80%	100%
A0A3R7RC31	Trypanosoma rangeli	69%	90%
A0A3R7RE54	Trypanosoma rangeli	67%	69%
A0A3R7RI88	Trypanosoma rangeli	58%	93%
A0A3S5H5N2	Leishmania donovani	61%	95%
A0A3S5H7U6	Leishmania donovani	71%	69%
A0A3S5IQL2	Trypanosoma rangeli	32%	68%
A0A3S7WYY5	Leishmania donovani	100%	100%
A0A3S7X410	Leishmania donovani	56%	77%
A0A3S7XB52	Leishmania donovani	41%	67%
A0A422N1Z9	Trypanosoma rangeli	55%	79%
A0A422N490	Trypanosoma rangeli	52%	77%
A0A422NR67	Trypanosoma rangeli	36%	99%
A4H4H8	Leishmania braziliensis	56%	100%
A4HCI8	Leishmania braziliensis	49%	100%
A4HE26	Leishmania braziliensis	90%	100%
A4HHU7	Leishmania braziliensis	32%	100%
A4HIW9	Leishmania braziliensis	55%	100%
A4HLM4	Leishmania braziliensis	71%	100%
A4HPH9	Leishmania braziliensis	39%	100%
A4HSQ3	Leishmania infantum	61%	100%
A4I004	Leishmania infantum	50%	100%
A4I4Z7	Leishmania infantum	32%	72%
A4I698	Leishmania infantum	56%	77%
A4I935	Leishmania infantum	71%	69%
A4IDA1	Leishmania infantum	41%	67%
B3A0R0	Lottia gigantea	58%	86%
C9ZIV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	90%
C9ZNS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	75%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	68%
C9ZRQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	79%
C9ZSQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	77%
C9ZT99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	89%
C9ZYX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
D0A5M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0A8E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
D4AY02	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	62%	78%
E9AKP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AXG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
F5H284	Homo sapiens	61%	100%
O00060	Uromyces fabae	62%	100%
O00845	Paramecium primaurelia	54%	100%
O02614	Leishmania major	97%	100%
O25982	Helicobacter pylori (strain ATCC 700392 / 26695)	37%	100%
O43447	Homo sapiens	51%	100%
O49605	Arabidopsis thaliana	45%	79%
O49886	Lupinus luteus	66%	100%
O53021	Dickeya dadantii (strain 3937)	31%	93%
O66105	Treponema pallidum (strain Nichols)	50%	82%
O74729	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
O93826	Arthroderma benhamiae	62%	78%
O94273	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	88%
P0AFL3	Escherichia coli (strain K12)	34%	93%
P0AFL4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	34%	93%
P0AFL5	Escherichia coli O157:H7	34%	93%
P0C1H7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	68%	100%
P0C1H8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	64%	100%
P0C1H9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	56%	85%
P0C1I0	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	55%	85%
P0C1I3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	53%	99%
P0C1I4	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	56%	100%
P0C1I5	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	50%	100%
P0C1I7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	57%	100%
P0C1I8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	57%	100%
P0CP78	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	60%	77%
P0CP79	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	60%	77%
P0CP82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	54%	99%
P0CP83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	54%	99%
P0CP84	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	49%	100%
P0CP85	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	49%	100%
P0CP86	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	47%	100%
P0CP87	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	47%	100%
P0DN26	Homo sapiens	61%	100%
P0DN37	Homo sapiens	61%	100%
P10111	Rattus norvegicus	69%	100%
P10255	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	60%	79%
P14088	Echinococcus granulosus	71%	100%
P14832	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	67%	100%
P14851	Cricetulus griseus	68%	100%
P15425	Drosophila melanogaster	47%	75%
P17742	Mus musculus	68%	100%
P18253	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	65%	100%
P20753	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	93%
P21568	Solanum lycopersicum	70%	100%
P21569	Zea mays	68%	100%
P22011	Candida albicans (strain SC5314 / ATCC MYA-2876)	64%	100%
P23284	Homo sapiens	58%	82%
P23285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	86%
P23869	Escherichia coli (strain K12)	33%	100%
P24367	Gallus gallus	58%	86%
P24368	Rattus norvegicus	60%	82%
P24369	Mus musculus	61%	82%
P24525	Brassica napus	67%	100%
P25007	Drosophila melanogaster	67%	78%
P25719	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	97%
P28517	Calliphora vicina	45%	76%
P29117	Rattus norvegicus	69%	86%
P29820	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	38%	100%
P30404	Bos taurus	69%	85%
P30405	Homo sapiens	70%	86%
P30412	Mus musculus	60%	83%
P34790	Arabidopsis thaliana	69%	100%
P34791	Arabidopsis thaliana	61%	68%
P34887	Allium cepa	72%	100%
P35137	Bacillus subtilis (strain 168)	36%	100%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	79%
P35627	Unspecified eudicot DB-1992	63%	100%
P42693	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	31%	94%
P44499	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
P45877	Homo sapiens	59%	83%
P52009	Caenorhabditis elegans	65%	92%
P52010	Caenorhabditis elegans	63%	100%
P52011	Caenorhabditis elegans	65%	100%
P52013	Caenorhabditis elegans	58%	87%
P52014	Caenorhabditis elegans	54%	88%
P52015	Caenorhabditis elegans	65%	100%
P52017	Caenorhabditis elegans	44%	100%
P52018	Caenorhabditis elegans	55%	97%
P54985	Blattella germanica	67%	100%
P62935	Bos taurus	69%	100%
P62936	Sus scrofa	69%	100%
P62937	Homo sapiens	70%	100%
P62938	Chlorocebus aethiops	70%	100%
P62940	Macaca mulatta	70%	100%
P62941	Papio anubis	70%	100%
P65763	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	35%	97%
P73789	Synechocystis sp. (strain PCC 6803 / Kazusa)	62%	100%
P77949	Streptomyces anulatus	46%	100%
P80311	Bos taurus	58%	82%
P83221	Streptomyces antibioticus	34%	100%
P84343	Neospora caninum	53%	99%
P87051	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
P91791	Hemicentrotus pulcherrimus	67%	100%
P9WHW2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	97%
P9WHW3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	97%
Q01490	Orpinomyces sp. (strain PC-2)	61%	87%
Q06118	Streptomyces anulatus	64%	100%
Q08E11	Bos taurus	61%	83%
Q0P5D0	Bos taurus	51%	100%
Q0ZQK3	Saguinus oedipus	69%	100%
Q0ZQK6	Symphalangus syndactylus	70%	100%
Q0ZQK7	Nomascus leucogenys	70%	100%
Q0ZQK8	Hylobates lar	70%	100%
Q0ZQL0	Gorilla gorilla gorilla	70%	100%
Q0ZQL1	Pan troglodytes	70%	100%
Q0ZQL2	Pan paniscus	70%	100%
Q26516	Schistosoma japonicum	65%	99%
Q26551	Schistosoma mansoni	51%	83%
Q26565	Schistosoma mansoni	60%	100%
Q27774	Schistosoma japonicum	51%	83%
Q2FIC1	Staphylococcus aureus (strain USA300)	39%	90%
Q2FZU9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	39%	90%
Q2TZ33	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	52%	98%
Q2U6U0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	51%	100%
Q2UGK2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	60%	92%
Q2YPY5	Brucella abortus (strain 2308)	30%	90%
Q2YWT2	Staphylococcus aureus (strain bovine RF122 / ET3-1)	39%	90%
Q38867	Arabidopsis thaliana	66%	100%
Q38900	Arabidopsis thaliana	68%	100%
Q39613	Catharanthus roseus	70%	100%
Q41651	Vicia faba	62%	71%
Q42406	Arabidopsis thaliana	66%	100%
Q49W93	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	41%	90%
Q4I1Y1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	52%	100%
Q4I5R9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	59%	71%
Q4IPB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	45%	100%
Q4IPH4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	58%	97%
Q4L4W9	Staphylococcus haemolyticus (strain JCSC1435)	42%	89%
Q4P6X6	Ustilago maydis (strain 521 / FGSC 9021)	54%	100%
Q4PCH8	Ustilago maydis (strain 521 / FGSC 9021)	43%	100%
Q4Q1A6	Leishmania major	41%	67%
Q4Q424	Leishmania major	71%	100%
Q4Q6Q9	Leishmania major	56%	100%
Q4Q7V7	Leishmania major	32%	100%
Q4QBK2	Leishmania major	50%	100%
Q4QJ67	Leishmania major	60%	100%
Q4WCM6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	54%	98%
Q4WCR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	51%	100%
Q4WMB6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	83%
Q4WP12	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	59%	85%
Q54E95	Dictyostelium discoideum	47%	100%
Q54SM3	Dictyostelium discoideum	68%	99%
Q57D43	Brucella abortus biovar 1 (strain 9-941)	30%	90%
Q5AQL0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	51%	97%
Q5ASQ0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	53%	100%
Q5B4R3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	59%	83%
Q5BAH7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	84%
Q5E992	Bos taurus	45%	100%
Q5HHD1	Staphylococcus aureus (strain COL)	39%	90%
Q5HQK8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	42%	90%
Q5R8S7	Pongo pygmaeus	70%	100%
Q5UP71	Acanthamoeba polyphaga mimivirus	29%	76%
Q5ZLV2	Gallus gallus	45%	100%
Q6C4W6	Yarrowia lipolytica (strain CLIB 122 / E 150)	56%	78%
Q6DTV9	Aotus trivirgatus	69%	100%
Q6GAX2	Staphylococcus aureus (strain MSSA476)	39%	90%
Q6GID4	Staphylococcus aureus (strain MRSA252)	39%	90%
Q6MWS8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q7A1C0	Staphylococcus aureus (strain MW2)	39%	90%
Q7A6I1	Staphylococcus aureus (strain N315)	39%	90%
Q7SF72	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	55%	100%
Q7SG06	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	97%
Q812D3	Rattus norvegicus	45%	100%
Q8CT84	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	42%	90%
Q8G0J9	Brucella suis biovar 1 (strain 1330)	31%	90%
Q8HXS3	Felis catus	68%	100%
Q8L8W5	Arabidopsis thaliana	58%	78%
Q8LDP4	Arabidopsis thaliana	61%	88%
Q8SRE1	Encephalitozoon cuniculi (strain GB-M1)	52%	100%
Q8W171	Glycine max	69%	100%
Q8X166	Aspergillus niger	60%	83%
Q8X191	Aspergillus niger	49%	100%
Q8YHB5	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	31%	90%
Q94A16	Arabidopsis thaliana	30%	77%
Q99KR7	Mus musculus	68%	86%
Q99VD4	Staphylococcus aureus (strain Mu50 / ATCC 700699)	39%	90%
Q9ASS6	Arabidopsis thaliana	64%	68%
Q9C835	Arabidopsis thaliana	30%	75%
Q9CDE9	Mycobacterium leprae (strain TN)	36%	97%
Q9D0W5	Mus musculus	45%	100%
Q9D6L8	Mus musculus	45%	100%
Q9D868	Mus musculus	55%	94%
Q9H2H8	Homo sapiens	45%	100%
Q9LIK6	Arabidopsis thaliana	41%	76%
Q9LPC7	Arabidopsis thaliana	46%	100%
Q9NI62	Dictyostelium discoideum	48%	100%
Q9SIH1	Arabidopsis thaliana	47%	100%
Q9SKQ0	Arabidopsis thaliana	66%	100%
Q9SP02	Arabidopsis thaliana	60%	87%
Q9TTC6	Oryctolagus cuniculus	69%	100%
Q9TW32	Dictyostelium discoideum	61%	90%
Q9UA41	Dictyostelium discoideum	55%	100%
Q9Y3C6	Homo sapiens	45%	100%
Q9Y536	Homo sapiens	61%	100%
Q9ZJH5	Helicobacter pylori (strain J99 / ATCC 700824)	44%	100%
Q9ZVJ4	Arabidopsis thaliana	54%	89%
V5B2A0	Trypanosoma cruzi	66%	69%
V5BGX2	Trypanosoma cruzi	34%	67%
V5BHF5	Trypanosoma cruzi	70%	90%
V5BM49	Trypanosoma cruzi	42%	72%
V5BTK6	Trypanosoma cruzi	37%	99%
V5D532	Trypanosoma cruzi	56%	91%