LeishMANIAdb
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Non-specific serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Non-specific serine/threonine protein kinase
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4I1C8_LEIIN
TriTrypDb:
LINF_250014500
Length:
292

Annotations

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000408 EKC/KEOPS complex 2 1
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I1C8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1C8

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006399 tRNA metabolic process 7 12
GO:0006468 protein phosphorylation 5 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008033 tRNA processing 8 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0004674 protein serine/threonine kinase activity 4 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0106310 protein serine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 197 201 PF00656 0.684
CLV_NRD_NRD_1 285 287 PF00675 0.440
CLV_NRD_NRD_1 68 70 PF00675 0.520
CLV_PCSK_FUR_1 66 70 PF00082 0.550
CLV_PCSK_KEX2_1 287 289 PF00082 0.495
CLV_PCSK_KEX2_1 51 53 PF00082 0.503
CLV_PCSK_KEX2_1 68 70 PF00082 0.423
CLV_PCSK_PC1ET2_1 287 289 PF00082 0.525
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.530
CLV_PCSK_SKI1_1 108 112 PF00082 0.401
CLV_PCSK_SKI1_1 23 27 PF00082 0.476
CLV_PCSK_SKI1_1 48 52 PF00082 0.459
CLV_PCSK_SKI1_1 76 80 PF00082 0.496
CLV_Separin_Fungi 18 24 PF03568 0.455
DEG_SCF_FBW7_1 135 142 PF00400 0.702
DOC_CDC14_PxL_1 38 46 PF14671 0.413
DOC_CKS1_1 136 141 PF01111 0.708
DOC_PP1_RVXF_1 21 27 PF00149 0.479
DOC_USP7_MATH_1 12 16 PF00917 0.630
DOC_USP7_MATH_1 139 143 PF00917 0.726
DOC_USP7_MATH_1 201 205 PF00917 0.687
DOC_USP7_MATH_1 242 246 PF00917 0.358
DOC_USP7_MATH_1 252 256 PF00917 0.366
DOC_WW_Pin1_4 135 140 PF00397 0.732
DOC_WW_Pin1_4 147 152 PF00397 0.449
LIG_14-3-3_CanoR_1 241 250 PF00244 0.358
LIG_14-3-3_CanoR_1 286 291 PF00244 0.520
LIG_BIR_II_1 1 5 PF00653 0.732
LIG_eIF4E_1 92 98 PF01652 0.507
LIG_FHA_1 14 20 PF00498 0.555
LIG_FHA_1 151 157 PF00498 0.456
LIG_FHA_1 203 209 PF00498 0.568
LIG_FHA_1 93 99 PF00498 0.474
LIG_FHA_2 104 110 PF00498 0.392
LIG_FHA_2 209 215 PF00498 0.486
LIG_FHA_2 65 71 PF00498 0.425
LIG_LIR_Apic_2 37 42 PF02991 0.382
LIG_LIR_Gen_1 95 103 PF02991 0.475
LIG_LIR_Nem_3 219 223 PF02991 0.375
LIG_SH2_CRK 39 43 PF00017 0.415
LIG_SH2_GRB2like 92 95 PF00017 0.499
LIG_SH2_STAT3 118 121 PF00017 0.508
LIG_SH2_STAT5 237 240 PF00017 0.355
LIG_SH2_STAT5 249 252 PF00017 0.370
LIG_SH2_STAT5 35 38 PF00017 0.372
LIG_SH2_STAT5 92 95 PF00017 0.464
LIG_SUMO_SIM_anti_2 213 219 PF11976 0.386
LIG_SUMO_SIM_par_1 213 219 PF11976 0.353
LIG_TRAF2_1 228 231 PF00917 0.359
LIG_WRC_WIRS_1 35 40 PF05994 0.300
LIG_WRC_WIRS_1 93 98 PF05994 0.477
MOD_CK1_1 15 21 PF00069 0.575
MOD_CK1_1 150 156 PF00069 0.453
MOD_CK2_1 103 109 PF00069 0.437
MOD_CK2_1 225 231 PF00069 0.404
MOD_CK2_1 54 60 PF00069 0.462
MOD_CK2_1 64 70 PF00069 0.375
MOD_Cter_Amidation 284 287 PF01082 0.453
MOD_GlcNHglycan 128 131 PF01048 0.750
MOD_GlcNHglycan 141 144 PF01048 0.642
MOD_GlcNHglycan 250 253 PF01048 0.444
MOD_GlcNHglycan 263 266 PF01048 0.446
MOD_GSK3_1 120 127 PF00069 0.577
MOD_GSK3_1 135 142 PF00069 0.653
MOD_GSK3_1 221 228 PF00069 0.505
MOD_GSK3_1 248 255 PF00069 0.495
MOD_NEK2_1 1 6 PF00069 0.749
MOD_NEK2_1 156 161 PF00069 0.398
MOD_NEK2_1 177 182 PF00069 0.343
MOD_NEK2_1 202 207 PF00069 0.656
MOD_NEK2_2 34 39 PF00069 0.455
MOD_PIKK_1 61 67 PF00454 0.526
MOD_PKA_1 286 292 PF00069 0.529
MOD_PKB_1 284 292 PF00069 0.503
MOD_PKB_1 52 60 PF00069 0.553
MOD_Plk_4 34 40 PF00069 0.430
MOD_Plk_4 92 98 PF00069 0.394
MOD_ProDKin_1 135 141 PF00069 0.726
MOD_ProDKin_1 147 153 PF00069 0.436
TRG_DiLeu_BaEn_1 20 25 PF01217 0.486
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.488
TRG_DiLeu_LyEn_5 20 25 PF01217 0.486
TRG_ENDOCYTIC_2 35 38 PF00928 0.390
TRG_ER_diArg_1 281 284 PF00400 0.437
TRG_ER_diArg_1 66 69 PF00400 0.503
TRG_NLS_Bipartite_1 269 290 PF00514 0.547
TRG_NLS_MonoExtN_4 284 290 PF00514 0.485
TRG_Pf-PMV_PEXEL_1 23 27 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 86 91 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P733 Leptomonas seymouri 62% 96%
A0A0S4J0K1 Bodo saltans 38% 100%
A0A1X0P554 Trypanosomatidae 46% 100%
A0A3R7L6S7 Trypanosoma rangeli 45% 100%
A0A3S7WZ44 Leishmania donovani 100% 100%
A1CLD2 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 38% 100%
A4HE22 Leishmania braziliensis 83% 100%
D0A5M3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AXG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P0CP72 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 34% 100%
P0CP73 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 34% 100%
P53323 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q1EBD3 Coccidioides immitis (strain RS) 35% 100%
Q2HGY8 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 37% 100%
Q2U3T8 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 35% 100%
Q4HYC1 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 32% 100%
Q4QA07 Leishmania major 96% 100%
Q4WYU4 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 36% 100%
Q54W07 Dictyostelium discoideum 35% 100%
Q5AGC7 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 99%
Q5BAB7 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 36% 100%
Q6BHA8 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 28% 100%
Q6C2A3 Yarrowia lipolytica (strain CLIB 122 / E 150) 34% 100%
Q6CXB9 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 28% 100%
Q6FTW0 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 100%
Q74Z75 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 33% 100%
Q96S44 Homo sapiens 37% 100%
Q99PW4 Mus musculus 36% 100%
Q9P7N1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
Q9UYB9 Pyrococcus abyssi (strain GE5 / Orsay) 30% 100%
V5BXG1 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS