Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1C6_LEIIN

TriTrypDb:

LINF_250014200

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.510
CLV_NRD_NRD_1	178	180	PF00675	0.601
CLV_NRD_NRD_1	210	212	PF00675	0.625
CLV_NRD_NRD_1	222	224	PF00675	0.634
CLV_NRD_NRD_1	258	260	PF00675	0.543
CLV_NRD_NRD_1	339	341	PF00675	0.720
CLV_NRD_NRD_1	359	361	PF00675	0.717
CLV_NRD_NRD_1	9	11	PF00675	0.490
CLV_PCSK_FUR_1	123	127	PF00082	0.340
CLV_PCSK_KEX2_1	123	125	PF00082	0.484
CLV_PCSK_KEX2_1	178	180	PF00082	0.601
CLV_PCSK_KEX2_1	183	185	PF00082	0.593
CLV_PCSK_KEX2_1	210	212	PF00082	0.586
CLV_PCSK_KEX2_1	221	223	PF00082	0.601
CLV_PCSK_KEX2_1	339	341	PF00082	0.720
CLV_PCSK_KEX2_1	52	54	PF00082	0.509
CLV_PCSK_KEX2_1	8	10	PF00082	0.499
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.430
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.561
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.565
CLV_PCSK_PC7_1	179	185	PF00082	0.603
CLV_PCSK_SKI1_1	10	14	PF00082	0.493
CLV_PCSK_SKI1_1	102	106	PF00082	0.687
CLV_PCSK_SKI1_1	126	130	PF00082	0.447
CLV_PCSK_SKI1_1	178	182	PF00082	0.564
CLV_PCSK_SKI1_1	222	226	PF00082	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_CYCLIN_RxL_1	123	134	PF00134	0.447
DOC_CYCLIN_RxL_1	206	218	PF00134	0.580
DOC_MAPK_gen_1	123	131	PF00069	0.414
DOC_MAPK_gen_1	339	347	PF00069	0.527
DOC_MAPK_gen_1	51	59	PF00069	0.452
DOC_USP7_MATH_1	243	247	PF00917	0.491
DOC_USP7_MATH_1	296	300	PF00917	0.703
DOC_USP7_MATH_1	303	307	PF00917	0.736
DOC_USP7_MATH_1	372	376	PF00917	0.597
DOC_USP7_MATH_1	77	81	PF00917	0.554
DOC_USP7_UBL2_3	249	253	PF12436	0.519
DOC_USP7_UBL2_3	357	361	PF12436	0.693
DOC_WW_Pin1_4	132	137	PF00397	0.504
DOC_WW_Pin1_4	267	272	PF00397	0.740
LIG_14-3-3_CanoR_1	132	136	PF00244	0.429
LIG_14-3-3_CanoR_1	178	187	PF00244	0.646
LIG_14-3-3_CanoR_1	222	232	PF00244	0.510
LIG_14-3-3_CanoR_1	259	269	PF00244	0.620
LIG_14-3-3_CanoR_1	339	347	PF00244	0.681
LIG_BRCT_BRCA1_1	262	266	PF00533	0.545
LIG_BRCT_BRCA1_1	337	341	PF00533	0.683
LIG_FHA_1	141	147	PF00498	0.364
LIG_FHA_1	191	197	PF00498	0.567
LIG_FHA_1	224	230	PF00498	0.550
LIG_FHA_1	295	301	PF00498	0.623
LIG_FHA_1	86	92	PF00498	0.500
LIG_FHA_1	96	102	PF00498	0.702
LIG_FHA_2	200	206	PF00498	0.499
LIG_FHA_2	313	319	PF00498	0.636
LIG_GBD_Chelix_1	261	269	PF00786	0.555
LIG_LIR_Apic_2	193	198	PF02991	0.558
LIG_LIR_Gen_1	263	274	PF02991	0.655
LIG_LIR_Gen_1	370	378	PF02991	0.496
LIG_LIR_Nem_3	112	118	PF02991	0.356
LIG_LIR_Nem_3	143	148	PF02991	0.490
LIG_LIR_Nem_3	174	180	PF02991	0.603
LIG_LIR_Nem_3	255	261	PF02991	0.509
LIG_LIR_Nem_3	263	269	PF02991	0.587
LIG_LIR_Nem_3	370	376	PF02991	0.538
LIG_LIR_Nem_3	45	49	PF02991	0.492
LIG_PDZ_Class_2	373	378	PF00595	0.519
LIG_Pex14_1	7	11	PF04695	0.578
LIG_Pex14_2	116	120	PF04695	0.347
LIG_SH2_CRK	177	181	PF00017	0.602
LIG_SH2_CRK	258	262	PF00017	0.466
LIG_SH2_CRK	373	377	PF00017	0.518
LIG_SH2_PTP2	195	198	PF00017	0.474
LIG_SH2_SRC	195	198	PF00017	0.607
LIG_SH2_STAT5	115	118	PF00017	0.343
LIG_SH2_STAT5	127	130	PF00017	0.403
LIG_SH2_STAT5	139	142	PF00017	0.487
LIG_SH2_STAT5	145	148	PF00017	0.420
LIG_SH2_STAT5	149	152	PF00017	0.425
LIG_SH2_STAT5	195	198	PF00017	0.631
LIG_SH2_STAT5	63	66	PF00017	0.392
LIG_SH3_2	74	79	PF14604	0.577
LIG_SH3_3	268	274	PF00018	0.616
LIG_SH3_3	71	77	PF00018	0.480
LIG_SUMO_SIM_par_1	127	135	PF11976	0.484
LIG_SUMO_SIM_par_1	86	93	PF11976	0.450
LIG_SxIP_EBH_1	40	53	PF03271	0.500
LIG_TRAF2_1	119	122	PF00917	0.406
LIG_TRAF2_1	254	257	PF00917	0.547
LIG_TYR_ITIM	175	180	PF00017	0.562
MOD_CK1_1	106	112	PF00069	0.417
MOD_CK1_1	190	196	PF00069	0.545
MOD_CK1_1	239	245	PF00069	0.537
MOD_CK1_1	333	339	PF00069	0.701
MOD_CK1_1	97	103	PF00069	0.654
MOD_CK2_1	116	122	PF00069	0.403
MOD_CK2_1	199	205	PF00069	0.503
MOD_CK2_1	251	257	PF00069	0.592
MOD_CK2_1	261	267	PF00069	0.671
MOD_CK2_1	285	291	PF00069	0.550
MOD_CK2_1	87	93	PF00069	0.532
MOD_GlcNHglycan	152	156	PF01048	0.483
MOD_GlcNHglycan	226	229	PF01048	0.514
MOD_GlcNHglycan	243	246	PF01048	0.635
MOD_GlcNHglycan	30	33	PF01048	0.469
MOD_GlcNHglycan	305	308	PF01048	0.660
MOD_GlcNHglycan	335	338	PF01048	0.789
MOD_GlcNHglycan	353	356	PF01048	0.662
MOD_GlcNHglycan	66	71	PF01048	0.547
MOD_GSK3_1	102	109	PF00069	0.573
MOD_GSK3_1	183	190	PF00069	0.561
MOD_GSK3_1	239	246	PF00069	0.520
MOD_GSK3_1	312	319	PF00069	0.745
MOD_GSK3_1	329	336	PF00069	0.691
MOD_GSK3_1	367	374	PF00069	0.574
MOD_GSK3_1	83	90	PF00069	0.496
MOD_GSK3_1	93	100	PF00069	0.584
MOD_N-GLC_1	106	111	PF02516	0.474
MOD_NEK2_1	130	135	PF00069	0.479
MOD_NEK2_1	141	146	PF00069	0.388
MOD_NEK2_1	224	229	PF00069	0.449
MOD_NEK2_1	329	334	PF00069	0.692
MOD_NEK2_1	341	346	PF00069	0.698
MOD_NEK2_2	372	377	PF00069	0.681
MOD_PK_1	285	291	PF00069	0.690
MOD_PKA_1	178	184	PF00069	0.644
MOD_PKA_1	339	345	PF00069	0.527
MOD_PKA_2	131	137	PF00069	0.489
MOD_PKA_2	178	184	PF00069	0.644
MOD_PKA_2	329	335	PF00069	0.574
MOD_PKA_2	339	345	PF00069	0.510
MOD_PKB_1	221	229	PF00069	0.513
MOD_Plk_1	285	291	PF00069	0.708
MOD_Plk_2-3	199	205	PF00069	0.492
MOD_Plk_2-3	87	93	PF00069	0.485
MOD_Plk_4	109	115	PF00069	0.502
MOD_Plk_4	141	147	PF00069	0.412
MOD_Plk_4	183	189	PF00069	0.594
MOD_Plk_4	190	196	PF00069	0.519
MOD_Plk_4	261	267	PF00069	0.684
MOD_Plk_4	341	347	PF00069	0.535
MOD_Plk_4	42	48	PF00069	0.483
MOD_ProDKin_1	132	138	PF00069	0.505
MOD_ProDKin_1	267	273	PF00069	0.739
MOD_SUMO_for_1	363	366	PF00179	0.606
MOD_SUMO_rev_2	275	281	PF00179	0.586
TRG_ENDOCYTIC_2	113	116	PF00928	0.357
TRG_ENDOCYTIC_2	127	130	PF00928	0.391
TRG_ENDOCYTIC_2	145	148	PF00928	0.493
TRG_ENDOCYTIC_2	177	180	PF00928	0.588
TRG_ENDOCYTIC_2	258	261	PF00928	0.467
TRG_ENDOCYTIC_2	373	376	PF00928	0.564
TRG_ER_diArg_1	123	126	PF00400	0.529
TRG_ER_diArg_1	177	179	PF00400	0.601
TRG_ER_diArg_1	209	211	PF00400	0.625
TRG_ER_diArg_1	221	223	PF00400	0.650
TRG_ER_diArg_1	339	341	PF00400	0.719
TRG_ER_diArg_1	7	10	PF00400	0.517
TRG_NLS_MonoExtC_3	50	56	PF00514	0.566
TRG_NLS_MonoExtN_4	123	128	PF00514	0.382
TRG_NLS_MonoExtN_4	48	55	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI8	Leptomonas seymouri	51%	92%
A0A1X0P4C2	Trypanosomatidae	31%	100%
A0A3S7WYY8	Leishmania donovani	99%	100%
A0A422MPP3	Trypanosoma rangeli	34%	100%
A4HE19	Leishmania braziliensis	68%	100%
E9AXG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QA10	Leishmania major	84%	100%
V5BXG5	Trypanosoma cruzi	35%	100%