Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1C3_LEIIN

TriTrypDb:

LINF_250013900

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.632
CLV_C14_Caspase3-7	460	464	PF00656	0.392
CLV_C14_Caspase3-7	542	546	PF00656	0.573
CLV_C14_Caspase3-7	628	632	PF00656	0.477
CLV_C14_Caspase3-7	734	738	PF00656	0.654
CLV_NRD_NRD_1	220	222	PF00675	0.501
CLV_NRD_NRD_1	426	428	PF00675	0.606
CLV_NRD_NRD_1	443	445	PF00675	0.397
CLV_NRD_NRD_1	644	646	PF00675	0.514
CLV_NRD_NRD_1	696	698	PF00675	0.531
CLV_NRD_NRD_1	834	836	PF00675	0.611
CLV_NRD_NRD_1	963	965	PF00675	0.706
CLV_PCSK_KEX2_1	220	222	PF00082	0.501
CLV_PCSK_KEX2_1	426	428	PF00082	0.606
CLV_PCSK_KEX2_1	443	445	PF00082	0.397
CLV_PCSK_KEX2_1	501	503	PF00082	0.411
CLV_PCSK_KEX2_1	644	646	PF00082	0.514
CLV_PCSK_KEX2_1	696	698	PF00082	0.531
CLV_PCSK_KEX2_1	834	836	PF00082	0.607
CLV_PCSK_KEX2_1	963	965	PF00082	0.706
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.492
CLV_PCSK_SKI1_1	179	183	PF00082	0.541
CLV_PCSK_SKI1_1	377	381	PF00082	0.655
CLV_PCSK_SKI1_1	426	430	PF00082	0.488
CLV_PCSK_SKI1_1	473	477	PF00082	0.363
CLV_PCSK_SKI1_1	644	648	PF00082	0.515
CLV_PCSK_SKI1_1	706	710	PF00082	0.455
DEG_SPOP_SBC_1	626	630	PF00917	0.380
DEG_SPOP_SBC_1	725	729	PF00917	0.599
DEG_SPOP_SBC_1	79	83	PF00917	0.628
DOC_CKS1_1	182	187	PF01111	0.605
DOC_CKS1_1	21	26	PF01111	0.553
DOC_CKS1_1	372	377	PF01111	0.700
DOC_CYCLIN_RxL_1	176	187	PF00134	0.621
DOC_CYCLIN_RxL_1	421	432	PF00134	0.483
DOC_CYCLIN_RxL_1	641	649	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	251	254	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.378
DOC_CYCLIN_yCln2_LP_2	608	614	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	785	791	PF00134	0.573
DOC_MAPK_gen_1	339	348	PF00069	0.613
DOC_MAPK_gen_1	48	54	PF00069	0.615
DOC_MAPK_MEF2A_6	1002	1010	PF00069	0.550
DOC_MAPK_MEF2A_6	881	890	PF00069	0.465
DOC_MAPK_NFAT4_5	881	889	PF00069	0.483
DOC_PP1_RVXF_1	299	305	PF00149	0.579
DOC_PP1_RVXF_1	47	54	PF00149	0.541
DOC_PP1_RVXF_1	471	477	PF00149	0.369
DOC_PP2B_LxvP_1	183	186	PF13499	0.553
DOC_PP2B_LxvP_1	251	254	PF13499	0.656
DOC_PP2B_LxvP_1	574	577	PF13499	0.419
DOC_PP2B_LxvP_1	785	788	PF13499	0.538
DOC_PP2B_LxvP_1	789	792	PF13499	0.461
DOC_PP4_FxxP_1	54	57	PF00568	0.554
DOC_PP4_MxPP_1	29	32	PF00568	0.701
DOC_USP7_MATH_1	205	209	PF00917	0.754
DOC_USP7_MATH_1	317	321	PF00917	0.684
DOC_USP7_MATH_1	335	339	PF00917	0.511
DOC_USP7_MATH_1	721	725	PF00917	0.525
DOC_USP7_MATH_1	726	730	PF00917	0.599
DOC_USP7_MATH_1	735	739	PF00917	0.617
DOC_USP7_MATH_1	79	83	PF00917	0.649
DOC_USP7_MATH_1	908	912	PF00917	0.760
DOC_USP7_MATH_1	942	946	PF00917	0.515
DOC_USP7_MATH_1	967	971	PF00917	0.621
DOC_WW_Pin1_4	100	105	PF00397	0.706
DOC_WW_Pin1_4	181	186	PF00397	0.600
DOC_WW_Pin1_4	20	25	PF00397	0.582
DOC_WW_Pin1_4	371	376	PF00397	0.622
DOC_WW_Pin1_4	524	529	PF00397	0.466
DOC_WW_Pin1_4	689	694	PF00397	0.555
DOC_WW_Pin1_4	736	741	PF00397	0.605
DOC_WW_Pin1_4	766	771	PF00397	0.508
DOC_WW_Pin1_4	915	920	PF00397	0.616
DOC_WW_Pin1_4	970	975	PF00397	0.672
LIG_14-3-3_CanoR_1	288	293	PF00244	0.615
LIG_14-3-3_CanoR_1	341	349	PF00244	0.612
LIG_14-3-3_CanoR_1	446	453	PF00244	0.405
LIG_14-3-3_CanoR_1	578	583	PF00244	0.447
LIG_14-3-3_CanoR_1	835	844	PF00244	0.508
LIG_14-3-3_CanoR_1	85	89	PF00244	0.593
LIG_14-3-3_CanoR_1	896	903	PF00244	0.639
LIG_14-3-3_CanoR_1	977	986	PF00244	0.609
LIG_Actin_WH2_2	790	808	PF00022	0.501
LIG_AP2alpha_1	482	486	PF02296	0.341
LIG_APCC_Cbox_2	484	490	PF00515	0.354
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_deltaCOP1_diTrp_1	128	133	PF00928	0.586
LIG_deltaCOP1_diTrp_1	701	708	PF00928	0.458
LIG_eIF4E_1	177	183	PF01652	0.539
LIG_FHA_1	124	130	PF00498	0.674
LIG_FHA_1	171	177	PF00498	0.539
LIG_FHA_1	276	282	PF00498	0.522
LIG_FHA_1	327	333	PF00498	0.727
LIG_FHA_1	341	347	PF00498	0.577
LIG_FHA_1	556	562	PF00498	0.374
LIG_FHA_1	569	575	PF00498	0.507
LIG_FHA_1	587	593	PF00498	0.464
LIG_FHA_1	641	647	PF00498	0.507
LIG_FHA_1	707	713	PF00498	0.453
LIG_FHA_1	839	845	PF00498	0.623
LIG_FHA_1	84	90	PF00498	0.781
LIG_FHA_1	951	957	PF00498	0.626
LIG_FHA_2	112	118	PF00498	0.633
LIG_FHA_2	202	208	PF00498	0.641
LIG_FHA_2	328	334	PF00498	0.700
LIG_FHA_2	36	42	PF00498	0.582
LIG_FHA_2	614	620	PF00498	0.412
LIG_FHA_2	690	696	PF00498	0.484
LIG_FHA_2	920	926	PF00498	0.632
LIG_LIR_Gen_1	166	176	PF02991	0.531
LIG_LIR_Gen_1	178	186	PF02991	0.543
LIG_LIR_Gen_1	3	13	PF02991	0.610
LIG_LIR_Gen_1	484	494	PF02991	0.446
LIG_LIR_Gen_1	594	605	PF02991	0.369
LIG_LIR_Gen_1	616	626	PF02991	0.428
LIG_LIR_Gen_1	701	708	PF02991	0.458
LIG_LIR_Gen_1	760	771	PF02991	0.569
LIG_LIR_Nem_3	166	171	PF02991	0.570
LIG_LIR_Nem_3	174	180	PF02991	0.632
LIG_LIR_Nem_3	3	9	PF02991	0.605
LIG_LIR_Nem_3	484	489	PF02991	0.423
LIG_LIR_Nem_3	594	600	PF02991	0.380
LIG_LIR_Nem_3	601	605	PF02991	0.355
LIG_LIR_Nem_3	616	621	PF02991	0.338
LIG_LIR_Nem_3	631	637	PF02991	0.466
LIG_LIR_Nem_3	701	705	PF02991	0.452
LIG_LIR_Nem_3	760	766	PF02991	0.601
LIG_LIR_Nem_3	877	883	PF02991	0.518
LIG_LIR_Nem_3	985	990	PF02991	0.518
LIG_MYND_1	944	948	PF01753	0.527
LIG_NRBOX	424	430	PF00104	0.533
LIG_NRBOX	885	891	PF00104	0.436
LIG_PDZ_Class_3	1016	1021	PF00595	0.529
LIG_Pex14_2	482	486	PF04695	0.341
LIG_REV1ctd_RIR_1	495	506	PF16727	0.473
LIG_RPA_C_Fungi	334	346	PF08784	0.644
LIG_SH2_CRK	1013	1017	PF00017	0.513
LIG_SH2_CRK	477	481	PF00017	0.345
LIG_SH2_CRK	634	638	PF00017	0.542
LIG_SH2_CRK	880	884	PF00017	0.675
LIG_SH2_NCK_1	168	172	PF00017	0.528
LIG_SH2_NCK_1	477	481	PF00017	0.345
LIG_SH2_SRC	331	334	PF00017	0.592
LIG_SH2_SRC	468	471	PF00017	0.402
LIG_SH2_STAP1	177	181	PF00017	0.539
LIG_SH2_STAP1	271	275	PF00017	0.510
LIG_SH2_STAP1	477	481	PF00017	0.345
LIG_SH2_STAT3	434	437	PF00017	0.498
LIG_SH2_STAT3	500	503	PF00017	0.397
LIG_SH2_STAT5	162	165	PF00017	0.494
LIG_SH2_STAT5	180	183	PF00017	0.537
LIG_SH2_STAT5	260	263	PF00017	0.584
LIG_SH2_STAT5	271	274	PF00017	0.469
LIG_SH2_STAT5	331	334	PF00017	0.707
LIG_SH2_STAT5	468	471	PF00017	0.402
LIG_SH2_STAT5	477	480	PF00017	0.342
LIG_SH2_STAT5	952	955	PF00017	0.630
LIG_SH3_1	369	375	PF00018	0.654
LIG_SH3_2	372	377	PF14604	0.652
LIG_SH3_3	249	255	PF00018	0.586
LIG_SH3_3	369	375	PF00018	0.662
LIG_SH3_3	522	528	PF00018	0.633
LIG_SH3_3	608	614	PF00018	0.413
LIG_SH3_3	794	800	PF00018	0.563
LIG_SH3_3	938	944	PF00018	0.641
LIG_SH3_3	945	951	PF00018	0.609
LIG_SH3_5	256	260	PF00018	0.555
LIG_Sin3_3	277	284	PF02671	0.593
LIG_Sin3_3	775	782	PF02671	0.548
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.342
LIG_SUMO_SIM_anti_2	885	891	PF11976	0.461
LIG_SUMO_SIM_par_1	455	461	PF11976	0.388
LIG_SUMO_SIM_par_1	613	619	PF11976	0.417
LIG_TRAF2_1	125	128	PF00917	0.676
LIG_TRAF2_1	284	287	PF00917	0.527
LIG_TRAF2_1	38	41	PF00917	0.584
LIG_TRAF2_1	509	512	PF00917	0.517
LIG_TRAF2_1	668	671	PF00917	0.586
LIG_TRAF2_1	751	754	PF00917	0.692
LIG_TRAF2_1	845	848	PF00917	0.537
LIG_UBA3_1	986	995	PF00899	0.503
LIG_WRC_WIRS_1	553	558	PF05994	0.433
LIG_WW_3	575	579	PF00397	0.415
MOD_CDK_SPK_2	736	741	PF00069	0.650
MOD_CDK_SPK_2	970	975	PF00069	0.644
MOD_CDK_SPxK_1	371	377	PF00069	0.624
MOD_CDK_SPxxK_3	181	188	PF00069	0.607
MOD_CDK_SPxxK_3	689	696	PF00069	0.544
MOD_CDK_SPxxK_3	970	977	PF00069	0.641
MOD_CK1_1	1001	1007	PF00069	0.548
MOD_CK1_1	103	109	PF00069	0.454
MOD_CK1_1	187	193	PF00069	0.656
MOD_CK1_1	310	316	PF00069	0.588
MOD_CK1_1	370	376	PF00069	0.623
MOD_CK1_1	555	561	PF00069	0.427
MOD_CK1_1	640	646	PF00069	0.508
MOD_CK1_1	724	730	PF00069	0.586
MOD_CK1_1	731	737	PF00069	0.631
MOD_CK1_1	83	89	PF00069	0.599
MOD_CK1_1	895	901	PF00069	0.667
MOD_CK1_1	970	976	PF00069	0.670
MOD_CK2_1	111	117	PF00069	0.634
MOD_CK2_1	122	128	PF00069	0.767
MOD_CK2_1	163	169	PF00069	0.508
MOD_CK2_1	209	215	PF00069	0.536
MOD_CK2_1	22	28	PF00069	0.694
MOD_CK2_1	229	235	PF00069	0.416
MOD_CK2_1	309	315	PF00069	0.661
MOD_CK2_1	327	333	PF00069	0.511
MOD_CK2_1	35	41	PF00069	0.519
MOD_CK2_1	405	411	PF00069	0.613
MOD_CK2_1	506	512	PF00069	0.492
MOD_CK2_1	613	619	PF00069	0.417
MOD_CK2_1	919	925	PF00069	0.585
MOD_CMANNOS	130	133	PF00535	0.581
MOD_CMANNOS	442	445	PF00535	0.395
MOD_DYRK1A_RPxSP_1	524	528	PF00069	0.450
MOD_GlcNHglycan	16	19	PF01048	0.594
MOD_GlcNHglycan	173	176	PF01048	0.674
MOD_GlcNHglycan	189	192	PF01048	0.581
MOD_GlcNHglycan	207	210	PF01048	0.470
MOD_GlcNHglycan	231	234	PF01048	0.627
MOD_GlcNHglycan	24	27	PF01048	0.614
MOD_GlcNHglycan	319	322	PF01048	0.611
MOD_GlcNHglycan	333	336	PF01048	0.626
MOD_GlcNHglycan	343	346	PF01048	0.564
MOD_GlcNHglycan	357	360	PF01048	0.620
MOD_GlcNHglycan	369	372	PF01048	0.582
MOD_GlcNHglycan	393	396	PF01048	0.635
MOD_GlcNHglycan	439	442	PF01048	0.461
MOD_GlcNHglycan	449	452	PF01048	0.415
MOD_GlcNHglycan	541	544	PF01048	0.668
MOD_GlcNHglycan	64	67	PF01048	0.802
MOD_GlcNHglycan	678	681	PF01048	0.564
MOD_GlcNHglycan	71	74	PF01048	0.644
MOD_GlcNHglycan	723	726	PF01048	0.556
MOD_GlcNHglycan	728	731	PF01048	0.614
MOD_GlcNHglycan	733	736	PF01048	0.623
MOD_GlcNHglycan	824	827	PF01048	0.657
MOD_GlcNHglycan	899	903	PF01048	0.562
MOD_GlcNHglycan	95	99	PF01048	0.720
MOD_GlcNHglycan	969	972	PF01048	0.701
MOD_GlcNHglycan	979	982	PF01048	0.538
MOD_GSK3_1	100	107	PF00069	0.738
MOD_GSK3_1	201	208	PF00069	0.588
MOD_GSK3_1	211	218	PF00069	0.616
MOD_GSK3_1	265	272	PF00069	0.492
MOD_GSK3_1	288	295	PF00069	0.584
MOD_GSK3_1	303	310	PF00069	0.525
MOD_GSK3_1	317	324	PF00069	0.515
MOD_GSK3_1	327	334	PF00069	0.613
MOD_GSK3_1	335	342	PF00069	0.684
MOD_GSK3_1	367	374	PF00069	0.611
MOD_GSK3_1	520	527	PF00069	0.481
MOD_GSK3_1	586	593	PF00069	0.459
MOD_GSK3_1	633	640	PF00069	0.481
MOD_GSK3_1	721	728	PF00069	0.557
MOD_GSK3_1	731	738	PF00069	0.654
MOD_GSK3_1	79	86	PF00069	0.639
MOD_GSK3_1	816	823	PF00069	0.652
MOD_GSK3_1	869	876	PF00069	0.748
MOD_GSK3_1	915	922	PF00069	0.588
MOD_GSK3_1	942	949	PF00069	0.665
MOD_GSK3_1	950	957	PF00069	0.574
MOD_GSK3_1	966	973	PF00069	0.589
MOD_N-GLC_1	317	322	PF02516	0.608
MOD_N-GLC_1	837	842	PF02516	0.543
MOD_NEK2_1	111	116	PF00069	0.664
MOD_NEK2_1	120	125	PF00069	0.582
MOD_NEK2_1	151	156	PF00069	0.469
MOD_NEK2_1	163	168	PF00069	0.503
MOD_NEK2_1	170	175	PF00069	0.537
MOD_NEK2_1	229	234	PF00069	0.615
MOD_NEK2_1	269	274	PF00069	0.503
MOD_NEK2_1	275	280	PF00069	0.517
MOD_NEK2_1	294	299	PF00069	0.534
MOD_NEK2_1	302	307	PF00069	0.534
MOD_NEK2_1	428	433	PF00069	0.603
MOD_NEK2_1	520	525	PF00069	0.600
MOD_NEK2_1	539	544	PF00069	0.717
MOD_NEK2_1	566	571	PF00069	0.353
MOD_NEK2_1	625	630	PF00069	0.477
MOD_NEK2_1	633	638	PF00069	0.557
MOD_NEK2_1	80	85	PF00069	0.578
MOD_NEK2_1	869	874	PF00069	0.606
MOD_NEK2_1	884	889	PF00069	0.541
MOD_NEK2_2	104	109	PF00069	0.579
MOD_PIKK_1	123	129	PF00454	0.678
MOD_PIKK_1	333	339	PF00454	0.699
MOD_PIKK_1	414	420	PF00454	0.477
MOD_PIKK_1	555	561	PF00454	0.351
MOD_PKA_2	1001	1007	PF00069	0.548
MOD_PKA_2	111	117	PF00069	0.666
MOD_PKA_2	200	206	PF00069	0.535
MOD_PKA_2	340	346	PF00069	0.593
MOD_PKA_2	523	529	PF00069	0.658
MOD_PKA_2	84	90	PF00069	0.563
MOD_PKA_2	869	875	PF00069	0.579
MOD_PKA_2	895	901	PF00069	0.542
MOD_PKB_1	339	347	PF00069	0.615
MOD_PKB_1	444	452	PF00069	0.385
MOD_PKB_1	704	712	PF00069	0.457
MOD_PKB_1	975	983	PF00069	0.639
MOD_Plk_1	429	435	PF00069	0.550
MOD_Plk_1	884	890	PF00069	0.458
MOD_Plk_1	892	898	PF00069	0.504
MOD_Plk_4	247	253	PF00069	0.544
MOD_Plk_4	327	333	PF00069	0.625
MOD_Plk_4	405	411	PF00069	0.654
MOD_Plk_4	429	435	PF00069	0.538
MOD_Plk_4	552	558	PF00069	0.439
MOD_Plk_4	613	619	PF00069	0.417
MOD_Plk_4	84	90	PF00069	0.580
MOD_Plk_4	884	890	PF00069	0.462
MOD_ProDKin_1	100	106	PF00069	0.707
MOD_ProDKin_1	181	187	PF00069	0.602
MOD_ProDKin_1	20	26	PF00069	0.584
MOD_ProDKin_1	371	377	PF00069	0.624
MOD_ProDKin_1	524	530	PF00069	0.471
MOD_ProDKin_1	689	695	PF00069	0.547
MOD_ProDKin_1	736	742	PF00069	0.606
MOD_ProDKin_1	766	772	PF00069	0.504
MOD_ProDKin_1	915	921	PF00069	0.614
MOD_ProDKin_1	970	976	PF00069	0.670
MOD_SUMO_rev_2	753	759	PF00179	0.652
TRG_DiLeu_BaEn_1	178	183	PF01217	0.536
TRG_DiLeu_BaEn_1	601	606	PF01217	0.362
TRG_DiLeu_BaEn_1	885	890	PF01217	0.440
TRG_DiLeu_BaEn_2	551	557	PF01217	0.400
TRG_DiLeu_BaEn_3	594	600	PF01217	0.456
TRG_DiLeu_BaEn_4	753	759	PF01217	0.570
TRG_DiLeu_BaEn_4	847	853	PF01217	0.629
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.594
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.528
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.512
TRG_ENDOCYTIC_2	1013	1016	PF00928	0.514
TRG_ENDOCYTIC_2	168	171	PF00928	0.532
TRG_ENDOCYTIC_2	180	183	PF00928	0.537
TRG_ENDOCYTIC_2	477	480	PF00928	0.342
TRG_ENDOCYTIC_2	634	637	PF00928	0.538
TRG_ENDOCYTIC_2	880	883	PF00928	0.522
TRG_ER_diArg_1	219	221	PF00400	0.493
TRG_ER_diArg_1	425	427	PF00400	0.599
TRG_ER_diArg_1	442	444	PF00400	0.400
TRG_ER_diArg_1	577	580	PF00400	0.419
TRG_ER_diArg_1	644	646	PF00400	0.514
TRG_ER_diArg_1	703	706	PF00400	0.621
TRG_ER_diArg_1	974	977	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	881	885	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	989	993	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D6	Leptomonas seymouri	52%	97%
A0A3Q8ID75	Leishmania donovani	99%	100%
A4HE16	Leishmania braziliensis	80%	100%
E9AXF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QA13	Leishmania major	93%	100%