Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1C0_LEIIN

TriTrypDb:

LINF_250013600

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Phosphorylation

Amastigote: 297
Promastigote: 295

Expansion

Sequence features

A4I1C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.532
CLV_NRD_NRD_1	57	59	PF00675	0.719
CLV_PCSK_FUR_1	211	215	PF00082	0.495
CLV_PCSK_KEX2_1	210	212	PF00082	0.534
CLV_PCSK_KEX2_1	213	215	PF00082	0.514
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.500
CLV_PCSK_SKI1_1	141	145	PF00082	0.592
CLV_PCSK_SKI1_1	77	81	PF00082	0.689
DOC_CKS1_1	69	74	PF01111	0.372
DOC_CYCLIN_yCln2_LP_2	116	119	PF00134	0.396
DOC_MAPK_gen_1	58	65	PF00069	0.478
DOC_MAPK_MEF2A_6	58	67	PF00069	0.395
DOC_PP2B_LxvP_1	116	119	PF13499	0.431
DOC_USP7_MATH_1	119	123	PF00917	0.495
DOC_USP7_MATH_1	19	23	PF00917	0.471
DOC_USP7_MATH_1	203	207	PF00917	0.556
DOC_USP7_MATH_1	47	51	PF00917	0.435
DOC_USP7_MATH_1	87	91	PF00917	0.493
DOC_WW_Pin1_4	278	283	PF00397	0.700
DOC_WW_Pin1_4	292	297	PF00397	0.766
DOC_WW_Pin1_4	65	70	PF00397	0.413
LIG_Actin_WH2_2	125	143	PF00022	0.407
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_FHA_1	102	108	PF00498	0.469
LIG_FHA_1	135	141	PF00498	0.421
LIG_FHA_1	33	39	PF00498	0.381
LIG_FHA_1	52	58	PF00498	0.444
LIG_FHA_2	137	143	PF00498	0.376
LIG_LIR_Apic_2	255	259	PF02991	0.753
LIG_LIR_Nem_3	129	134	PF02991	0.434
LIG_PTB_Apo_2	106	113	PF02174	0.391
LIG_SH2_CRK	256	260	PF00017	0.829
LIG_SH2_GRB2like	269	272	PF00017	0.782
LIG_SH2_STAT3	225	228	PF00017	0.765
LIG_SH2_STAT3	272	275	PF00017	0.787
LIG_SH2_STAT3	33	36	PF00017	0.424
LIG_SH3_3	220	226	PF00018	0.732
LIG_SH3_3	232	238	PF00018	0.722
LIG_SH3_3	257	263	PF00018	0.749
LIG_SH3_3	66	72	PF00018	0.374
LIG_SUMO_SIM_anti_2	21	28	PF11976	0.395
LIG_TRAF2_1	53	56	PF00917	0.488
LIG_WW_1	259	262	PF00397	0.707
MOD_CK1_1	22	28	PF00069	0.392
MOD_CK1_1	68	74	PF00069	0.420
MOD_CK2_1	203	209	PF00069	0.566
MOD_GlcNHglycan	12	15	PF01048	0.708
MOD_GlcNHglycan	145	148	PF01048	0.653
MOD_GlcNHglycan	154	159	PF01048	0.625
MOD_GlcNHglycan	200	203	PF01048	0.412
MOD_GlcNHglycan	205	208	PF01048	0.462
MOD_GlcNHglycan	272	275	PF01048	0.565
MOD_GlcNHglycan	49	52	PF01048	0.631
MOD_GlcNHglycan	89	92	PF01048	0.715
MOD_GSK3_1	290	297	PF00069	0.728
MOD_GSK3_1	47	54	PF00069	0.439
MOD_GSK3_1	6	13	PF00069	0.518
MOD_N-GLC_1	270	275	PF02516	0.560
MOD_NEK2_1	134	139	PF00069	0.423
MOD_NEK2_1	198	203	PF00069	0.412
MOD_PIKK_1	32	38	PF00454	0.380
MOD_PK_1	6	12	PF00069	0.392
MOD_PKA_1	213	219	PF00069	0.659
MOD_PKA_2	170	176	PF00069	0.342
MOD_PKA_2	213	219	PF00069	0.684
MOD_PKB_1	211	219	PF00069	0.659
MOD_Plk_1	29	35	PF00069	0.490
MOD_Plk_4	19	25	PF00069	0.429
MOD_ProDKin_1	278	284	PF00069	0.701
MOD_ProDKin_1	292	298	PF00069	0.766
MOD_ProDKin_1	65	71	PF00069	0.410
MOD_SUMO_rev_2	281	290	PF00179	0.698
TRG_DiLeu_BaEn_1	162	167	PF01217	0.380
TRG_DiLeu_BaEn_4	55	61	PF01217	0.411
TRG_ER_diArg_1	211	214	PF00400	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IN96	Leishmania donovani	100%	100%
A4HE13	Leishmania braziliensis	54%	99%
E9AXF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA16	Leishmania major	92%	100%