Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1B8_LEIIN

TriTrypDb:

LINF_250013400

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1B8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.563
CLV_NRD_NRD_1	15	17	PF00675	0.553
CLV_NRD_NRD_1	269	271	PF00675	0.527
CLV_PCSK_KEX2_1	15	17	PF00082	0.553
CLV_PCSK_KEX2_1	268	270	PF00082	0.532
CLV_PCSK_SKI1_1	134	138	PF00082	0.468
CLV_PCSK_SKI1_1	245	249	PF00082	0.636
CLV_PCSK_SKI1_1	88	92	PF00082	0.554
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_SPOP_SBC_1	59	63	PF00917	0.640
DOC_CYCLIN_RxL_1	179	188	PF00134	0.559
DOC_CYCLIN_RxL_1	85	93	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.454
DOC_MAPK_MEF2A_6	120	129	PF00069	0.633
DOC_MAPK_MEF2A_6	284	292	PF00069	0.377
DOC_PP1_RVXF_1	180	187	PF00149	0.568
DOC_PP2B_LxvP_1	285	288	PF13499	0.421
DOC_USP7_MATH_1	162	166	PF00917	0.612
DOC_USP7_MATH_1	29	33	PF00917	0.648
DOC_USP7_MATH_1	58	62	PF00917	0.738
DOC_WW_Pin1_4	119	124	PF00397	0.699
DOC_WW_Pin1_4	163	168	PF00397	0.710
DOC_WW_Pin1_4	169	174	PF00397	0.662
DOC_WW_Pin1_4	342	347	PF00397	0.638
DOC_WW_Pin1_4	64	69	PF00397	0.661
LIG_14-3-3_CanoR_1	175	181	PF00244	0.566
LIG_14-3-3_CanoR_1	245	250	PF00244	0.628
LIG_Actin_WH2_2	200	218	PF00022	0.541
LIG_APCC_ABBA_1	140	145	PF00400	0.356
LIG_BIR_III_4	93	97	PF00653	0.466
LIG_BRCT_BRCA1_1	165	169	PF00533	0.659
LIG_CaM_NSCaTE_8	223	230	PF13499	0.506
LIG_Clathr_ClatBox_1	204	208	PF01394	0.541
LIG_Clathr_ClatBox_1	302	306	PF01394	0.497
LIG_eIF4E_1	199	205	PF01652	0.511
LIG_eIF4E_1	42	48	PF01652	0.515
LIG_FHA_1	41	47	PF00498	0.530
LIG_HCF-1_HBM_1	196	199	PF13415	0.513
LIG_LIR_Gen_1	145	152	PF02991	0.492
LIG_LIR_Nem_3	145	150	PF02991	0.411
LIG_LIR_Nem_3	193	198	PF02991	0.535
LIG_LIR_Nem_3	339	344	PF02991	0.560
LIG_MYND_1	342	346	PF01753	0.637
LIG_NRBOX	200	206	PF00104	0.466
LIG_NRBOX	86	92	PF00104	0.491
LIG_Pex14_1	195	199	PF04695	0.380
LIG_SH2_CRK	73	77	PF00017	0.476
LIG_SH2_SRC	143	146	PF00017	0.401
LIG_SH2_STAP1	152	156	PF00017	0.620
LIG_SH2_STAP1	42	46	PF00017	0.581
LIG_SH2_STAT3	78	81	PF00017	0.483
LIG_SH2_STAT5	143	146	PF00017	0.423
LIG_SH2_STAT5	152	155	PF00017	0.593
LIG_SH2_STAT5	199	202	PF00017	0.514
LIG_SH2_STAT5	42	45	PF00017	0.584
LIG_SH2_STAT5	78	81	PF00017	0.483
LIG_SH3_3	118	124	PF00018	0.615
LIG_SH3_3	230	236	PF00018	0.647
LIG_SH3_3	47	53	PF00018	0.595
LIG_SUMO_SIM_par_1	300	307	PF11976	0.487
LIG_SxIP_EBH_1	322	332	PF03271	0.498
MOD_CDC14_SPxK_1	172	175	PF00782	0.586
MOD_CDK_SPK_2	342	347	PF00069	0.533
MOD_CDK_SPxK_1	169	175	PF00069	0.593
MOD_CK1_1	165	171	PF00069	0.603
MOD_CK1_1	37	43	PF00069	0.632
MOD_CK1_1	5	11	PF00069	0.541
MOD_CK1_1	62	68	PF00069	0.721
MOD_CK2_1	175	181	PF00069	0.576
MOD_CK2_1	190	196	PF00069	0.428
MOD_GlcNHglycan	112	115	PF01048	0.735
MOD_GlcNHglycan	154	157	PF01048	0.688
MOD_GlcNHglycan	316	319	PF01048	0.710
MOD_GlcNHglycan	323	326	PF01048	0.635
MOD_GlcNHglycan	62	65	PF01048	0.731
MOD_GSK3_1	150	157	PF00069	0.582
MOD_GSK3_1	165	172	PF00069	0.602
MOD_GSK3_1	207	214	PF00069	0.560
MOD_GSK3_1	23	30	PF00069	0.743
MOD_GSK3_1	31	38	PF00069	0.750
MOD_GSK3_1	58	65	PF00069	0.737
MOD_NEK2_1	150	155	PF00069	0.678
MOD_NEK2_1	207	212	PF00069	0.494
MOD_NEK2_1	293	298	PF00069	0.491
MOD_PIKK_1	207	213	PF00454	0.557
MOD_PIKK_1	23	29	PF00454	0.753
MOD_PIKK_1	237	243	PF00454	0.721
MOD_PIKK_1	253	259	PF00454	0.293
MOD_PIKK_1	66	72	PF00454	0.588
MOD_PKA_2	321	327	PF00069	0.538
MOD_PKB_1	268	276	PF00069	0.498
MOD_Plk_1	207	213	PF00069	0.557
MOD_Plk_1	38	44	PF00069	0.606
MOD_Plk_4	165	171	PF00069	0.699
MOD_Plk_4	5	11	PF00069	0.630
MOD_ProDKin_1	119	125	PF00069	0.682
MOD_ProDKin_1	163	169	PF00069	0.711
MOD_ProDKin_1	64	70	PF00069	0.649
MOD_SUMO_for_1	236	239	PF00179	0.709
MOD_SUMO_rev_2	20	25	PF00179	0.586
TRG_DiLeu_BaEn_1	6	11	PF01217	0.541
TRG_ENDOCYTIC_2	198	201	PF00928	0.509
TRG_ER_diArg_1	14	16	PF00400	0.534
TRG_ER_diArg_1	268	270	PF00400	0.479
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T2	Leptomonas seymouri	34%	97%
A0A3Q8IF78	Leishmania donovani	97%	98%
A0A3R7K7C7	Trypanosoma rangeli	32%	100%
A4HE11	Leishmania braziliensis	71%	100%
D0A5L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AXF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QA18	Leishmania major	92%	100%