Well-conserved EIF5A protein, with two copies in L. infantum only
Translation, eukaryotic initiation factor 5a EIF5A2
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 1 |
| NetGPI | no | yes: 0, no: 1 |
Related structures:
AlphaFold database: A4I1B5
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006417 | regulation of translation | 6 | 2 |
| GO:0006448 | regulation of translational elongation | 7 | 2 |
| GO:0006449 | regulation of translational termination | 6 | 2 |
| GO:0009889 | regulation of biosynthetic process | 4 | 2 |
| GO:0009891 | positive regulation of biosynthetic process | 5 | 2 |
| GO:0009893 | positive regulation of metabolic process | 4 | 2 |
| GO:0010468 | regulation of gene expression | 5 | 2 |
| GO:0010556 | regulation of macromolecule biosynthetic process | 5 | 2 |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 6 | 2 |
| GO:0010604 | positive regulation of macromolecule metabolic process | 5 | 2 |
| GO:0010608 | post-transcriptional regulation of gene expression | 6 | 2 |
| GO:0010628 | positive regulation of gene expression | 6 | 2 |
| GO:0019222 | regulation of metabolic process | 3 | 2 |
| GO:0031323 | regulation of cellular metabolic process | 4 | 2 |
| GO:0031325 | positive regulation of cellular metabolic process | 5 | 2 |
| GO:0031326 | regulation of cellular biosynthetic process | 5 | 2 |
| GO:0031328 | positive regulation of cellular biosynthetic process | 6 | 2 |
| GO:0034248 | regulation of amide metabolic process | 5 | 2 |
| GO:0034250 | positive regulation of amide metabolic process | 6 | 2 |
| GO:0043243 | positive regulation of protein-containing complex disassembly | 6 | 2 |
| GO:0043244 | regulation of protein-containing complex disassembly | 5 | 2 |
| GO:0045727 | positive regulation of translation | 7 | 2 |
| GO:0045901 | positive regulation of translational elongation | 8 | 2 |
| GO:0045905 | positive regulation of translational termination | 7 | 2 |
| GO:0048518 | positive regulation of biological process | 3 | 2 |
| GO:0048522 | positive regulation of cellular process | 4 | 2 |
| GO:0050789 | regulation of biological process | 2 | 2 |
| GO:0050794 | regulation of cellular process | 3 | 2 |
| GO:0051128 | regulation of cellular component organization | 4 | 2 |
| GO:0051130 | positive regulation of cellular component organization | 5 | 2 |
| GO:0051171 | regulation of nitrogen compound metabolic process | 4 | 2 |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 5 | 2 |
| GO:0051246 | regulation of protein metabolic process | 5 | 2 |
| GO:0051247 | positive regulation of protein metabolic process | 6 | 2 |
| GO:0060255 | regulation of macromolecule metabolic process | 4 | 2 |
| GO:0065007 | biological regulation | 1 | 2 |
| GO:0080090 | regulation of primary metabolic process | 4 | 2 |
| GO:2000112 | obsolete regulation of cellular macromolecule biosynthetic process | 6 | 2 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 2 |
| GO:0003723 | RNA binding | 4 | 2 |
| GO:0003743 | translation initiation factor activity | 4 | 2 |
| GO:0003746 | translation elongation factor activity | 4 | 2 |
| GO:0005488 | binding | 1 | 2 |
| GO:0008135 | translation factor activity, RNA binding | 3 | 2 |
| GO:0043021 | ribonucleoprotein complex binding | 3 | 2 |
| GO:0043022 | ribosome binding | 4 | 2 |
| GO:0044877 | protein-containing complex binding | 2 | 2 |
| GO:0045182 | translation regulator activity | 1 | 2 |
| GO:0090079 | translation regulator activity, nucleic acid binding | 2 | 2 |
| GO:0097159 | organic cyclic compound binding | 2 | 2 |
| GO:1901363 | heterocyclic compound binding | 2 | 2 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 12 | 14 | PF00675 | 0.385 |
| CLV_PCSK_KEX2_1 | 14 | 16 | PF00082 | 0.381 |
| CLV_PCSK_PC1ET2_1 | 14 | 16 | PF00082 | 0.381 |
| CLV_PCSK_SKI1_1 | 179 | 183 | PF00082 | 0.224 |
| CLV_PCSK_SKI1_1 | 233 | 237 | PF00082 | 0.224 |
| CLV_PCSK_SKI1_1 | 7 | 11 | PF00082 | 0.387 |
| CLV_PCSK_SKI1_1 | 82 | 86 | PF00082 | 0.316 |
| DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.589 |
| DOC_MAPK_FxFP_2 | 8 | 11 | PF00069 | 0.586 |
| DOC_MAPK_gen_1 | 120 | 127 | PF00069 | 0.472 |
| DOC_MAPK_gen_1 | 130 | 139 | PF00069 | 0.477 |
| DOC_MAPK_gen_1 | 26 | 35 | PF00069 | 0.224 |
| DOC_MAPK_HePTP_8 | 127 | 139 | PF00069 | 0.479 |
| DOC_MAPK_MEF2A_6 | 130 | 139 | PF00069 | 0.477 |
| DOC_MAPK_MEF2A_6 | 233 | 240 | PF00069 | 0.425 |
| DOC_MAPK_MEF2A_6 | 26 | 35 | PF00069 | 0.224 |
| DOC_MAPK_NFAT4_5 | 28 | 36 | PF00069 | 0.224 |
| DOC_PP2B_LxvP_1 | 213 | 216 | PF13499 | 0.425 |
| DOC_PP4_FxxP_1 | 8 | 11 | PF00568 | 0.586 |
| DOC_USP7_MATH_1 | 148 | 152 | PF00917 | 0.471 |
| DOC_USP7_MATH_2 | 190 | 196 | PF00917 | 0.425 |
| LIG_BRCT_BRCA1_1 | 53 | 57 | PF00533 | 0.224 |
| LIG_eIF4E_1 | 75 | 81 | PF01652 | 0.512 |
| LIG_FHA_1 | 109 | 115 | PF00498 | 0.509 |
| LIG_FHA_1 | 168 | 174 | PF00498 | 0.514 |
| LIG_FHA_1 | 180 | 186 | PF00498 | 0.425 |
| LIG_FHA_1 | 243 | 249 | PF00498 | 0.425 |
| LIG_FHA_1 | 28 | 34 | PF00498 | 0.224 |
| LIG_FHA_2 | 89 | 95 | PF00498 | 0.568 |
| LIG_Integrin_isoDGR_2 | 128 | 130 | PF01839 | 0.299 |
| LIG_LIR_Apic_2 | 109 | 115 | PF02991 | 0.509 |
| LIG_LIR_Gen_1 | 180 | 190 | PF02991 | 0.425 |
| LIG_LIR_Gen_1 | 87 | 96 | PF02991 | 0.566 |
| LIG_LIR_LC3C_4 | 234 | 238 | PF02991 | 0.425 |
| LIG_LIR_Nem_3 | 180 | 186 | PF02991 | 0.425 |
| LIG_NRBOX | 30 | 36 | PF00104 | 0.224 |
| LIG_NRBOX | 76 | 82 | PF00104 | 0.507 |
| LIG_PCNA_PIPBox_1 | 40 | 49 | PF02747 | 0.337 |
| LIG_PCNA_yPIPBox_3 | 36 | 47 | PF02747 | 0.224 |
| LIG_Pex14_2 | 177 | 181 | PF04695 | 0.425 |
| LIG_PTB_Apo_2 | 69 | 76 | PF02174 | 0.547 |
| LIG_PTB_Phospho_1 | 69 | 75 | PF10480 | 0.551 |
| LIG_SH2_GRB2like | 70 | 73 | PF00017 | 0.553 |
| LIG_SH2_PTP2 | 124 | 127 | PF00017 | 0.452 |
| LIG_SH2_STAT5 | 124 | 127 | PF00017 | 0.452 |
| LIG_SH2_STAT5 | 75 | 78 | PF00017 | 0.517 |
| LIG_SH3_3 | 170 | 176 | PF00018 | 0.500 |
| LIG_SH3_3 | 191 | 197 | PF00018 | 0.425 |
| LIG_SUMO_SIM_anti_2 | 198 | 206 | PF11976 | 0.425 |
| LIG_SUMO_SIM_anti_2 | 234 | 241 | PF11976 | 0.425 |
| LIG_SUMO_SIM_par_1 | 133 | 138 | PF11976 | 0.482 |
| LIG_SUMO_SIM_par_1 | 234 | 241 | PF11976 | 0.425 |
| LIG_WRC_WIRS_1 | 178 | 183 | PF05994 | 0.425 |
| LIG_WRC_WIRS_1 | 86 | 91 | PF05994 | 0.549 |
| MOD_CK1_1 | 195 | 201 | PF00069 | 0.425 |
| MOD_CK1_1 | 88 | 94 | PF00069 | 0.563 |
| MOD_CK2_1 | 228 | 234 | PF00069 | 0.425 |
| MOD_GlcNHglycan | 230 | 233 | PF01048 | 0.224 |
| MOD_GlcNHglycan | 240 | 243 | PF01048 | 0.224 |
| MOD_GSK3_1 | 135 | 142 | PF00069 | 0.501 |
| MOD_GSK3_1 | 148 | 155 | PF00069 | 0.469 |
| MOD_GSK3_1 | 177 | 184 | PF00069 | 0.425 |
| MOD_GSK3_1 | 238 | 245 | PF00069 | 0.425 |
| MOD_GSK3_1 | 84 | 91 | PF00069 | 0.540 |
| MOD_N-GLC_1 | 106 | 111 | PF02516 | 0.347 |
| MOD_NEK2_1 | 137 | 142 | PF00069 | 0.503 |
| MOD_NEK2_1 | 177 | 182 | PF00069 | 0.425 |
| MOD_NEK2_1 | 85 | 90 | PF00069 | 0.540 |
| MOD_PIKK_1 | 220 | 226 | PF00454 | 0.425 |
| MOD_Plk_1 | 135 | 141 | PF00069 | 0.501 |
| MOD_Plk_4 | 148 | 154 | PF00069 | 0.468 |
| MOD_Plk_4 | 181 | 187 | PF00069 | 0.425 |
| MOD_Plk_4 | 198 | 204 | PF00069 | 0.425 |
| TRG_ENDOCYTIC_2 | 124 | 127 | PF00928 | 0.452 |
| TRG_ENDOCYTIC_2 | 183 | 186 | PF00928 | 0.425 |
| TRG_NLS_MonoExtN_4 | 11 | 17 | PF00514 | 0.579 |
| TRG_Pf-PMV_PEXEL_1 | 36 | 40 | PF00026 | 0.224 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0B9S8 | METTP | 33% | 100% |
| A1RS27 | PYRIL | 45% | 100% |
| A1RX88 | THEPD | 35% | 100% |
| A2BNB6 | HYPBU | 32% | 100% |
| A3CU49 | METMJ | 36% | 100% |
| A3DNK3 | STAMF | 33% | 100% |
| A3MTA0 | PYRCJ | 44% | 100% |
| A4FXY5 | METM5 | 37% | 100% |
| A4GVE9 | LEIDO | 100% | 100% |
| A4WLN5 | PYRAR | 44% | 100% |
| A4YHK9 | METS5 | 32% | 100% |
| A5ULK4 | METS3 | 32% | 100% |
| A6UNS4 | METVS | 33% | 100% |
| A6UVH4 | META3 | 33% | 100% |
| A6VFP3 | METM7 | 34% | 100% |
| A7I807 | METB6 | 31% | 100% |
| A8ABK3 | IGNH4 | 42% | 100% |
| A8MD73 | CALMQ | 40% | 100% |
| A9AAZ2 | METM6 | 34% | 100% |
| B1L7A5 | KORCO | 36% | 100% |
| B1Y9U5 | PYRNV | 47% | 100% |
| B6YTM4 | THEON | 33% | 100% |
| B8D4W8 | DESA1 | 29% | 100% |
| B8GEC0 | METPE | 38% | 100% |
| C3MPN5 | SULIL | 33% | 100% |
| C3MYM9 | SULIM | 33% | 100% |
| C3N5B1 | SULIA | 33% | 100% |
| C3NDW5 | SULIY | 33% | 100% |
| C3NHT8 | SULIN | 33% | 100% |
| C4KGX7 | SULIK | 33% | 100% |
| C5A5M5 | THEGJ | 32% | 100% |
| C6A117 | THESM | 32% | 100% |
| E9AXF0 | LEIMU | 98% | 100% |
| O26955 | METTH | 31% | 100% |
| O29612 | ARCFU | 32% | 100% |
| O50089 | PYRHO | 30% | 100% |
| O94083 | CANAL | 45% | 100% |
| P10160 | RABIT | 45% | 100% |
| P13651 | DICDI | 47% | 100% |
| P19211 | YEAST | 50% | 100% |
| P23301 | YEAST | 48% | 100% |
| P24922 | NICPL | 48% | 100% |
| P26564 | MEDSA | 47% | 100% |
| P28461 | SULAC | 33% | 100% |
| P34563 | CAEEL | 44% | 100% |
| P38672 | NEUCR | 48% | 100% |
| P56289 | SCHPO | 46% | 100% |
| P56333 | SOLTU | 47% | 100% |
| P56335 | SOLTU | 47% | 100% |
| P56336 | SOLTU | 49% | 100% |
| P56337 | SOLTU | 46% | 100% |
| P56635 | PYRAE | 45% | 100% |
| P62924 | SPOEX | 47% | 100% |
| P62925 | SPOFR | 47% | 100% |
| P63241 | HUMAN | 44% | 100% |
| P63242 | MOUSE | 44% | 100% |
| P69039 | NICPL | 46% | 100% |
| P69040 | TOBAC | 46% | 100% |
| P80639 | MAIZE | 47% | 100% |
| P87252 | NEUCR | 29% | 100% |
| Q07460 | CHICK | 44% | 100% |
| Q09121 | CHICK | 44% | 100% |
| Q0W941 | METAR | 30% | 100% |
| Q12UU7 | METBU | 32% | 100% |
| Q20751 | CAEEL | 46% | 100% |
| Q26571 | SCHMA | 56% | 100% |
| Q2FQ93 | METHJ | 31% | 100% |
| Q2NEM4 | METST | 32% | 100% |
| Q387H6 | TRYB2 | 77% | 100% |
| Q3T1J1 | RAT | 44% | 100% |
| Q58625 | METJA | 39% | 100% |
| Q5JI42 | THEKO | 32% | 100% |
| Q5R898 | PONAB | 45% | 100% |
| Q6EWQ7 | BOVIN | 44% | 100% |
| Q6IS14 | HUMAN | 43% | 100% |
| Q6L150 | PICTO | 34% | 100% |
| Q6LYN8 | METMP | 38% | 100% |
| Q8BGY2 | MOUSE | 45% | 100% |
| Q8TXD5 | METKA | 33% | 100% |
| Q8U1E4 | PYRFU | 29% | 100% |
| Q93VP3 | ARATH | 46% | 100% |
| Q945F4 | MEDSA | 48% | 100% |
| Q971T0 | SULTO | 36% | 100% |
| Q97BB9 | THEVO | 31% | 100% |
| Q97ZE8 | SACS2 | 34% | 100% |
| Q9AXJ4 | MANES | 45% | 100% |
| Q9AXQ3 | SOLLC | 46% | 100% |
| Q9AXQ4 | SOLLC | 48% | 100% |
| Q9AXQ5 | SOLLC | 46% | 100% |
| Q9AXQ6 | SOLLC | 46% | 100% |
| Q9AXQ7 | DIACA | 46% | 100% |
| Q9C505 | ARATH | 49% | 100% |
| Q9GU68 | DROME | 43% | 100% |
| Q9GZV4 | HUMAN | 45% | 100% |
| Q9HJB1 | THEAC | 36% | 100% |
| Q9SC12 | SENVE | 48% | 100% |
| Q9UST4 | SCHPO | 47% | 100% |
| Q9V0M2 | PYRAB | 30% | 100% |
| Q9XI91 | ARATH | 49% | 100% |
| Q9YA53 | AERPE | 41% | 100% |