Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1B1_LEIIN

TriTrypDb:

LINF_250012400

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.518
CLV_NRD_NRD_1	273	275	PF00675	0.586
CLV_NRD_NRD_1	366	368	PF00675	0.613
CLV_NRD_NRD_1	38	40	PF00675	0.724
CLV_NRD_NRD_1	97	99	PF00675	0.415
CLV_PCSK_FUR_1	364	368	PF00082	0.682
CLV_PCSK_FUR_1	506	510	PF00082	0.607
CLV_PCSK_KEX2_1	185	187	PF00082	0.535
CLV_PCSK_KEX2_1	273	275	PF00082	0.582
CLV_PCSK_KEX2_1	366	368	PF00082	0.685
CLV_PCSK_KEX2_1	508	510	PF00082	0.605
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.500
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.605
CLV_PCSK_SKI1_1	14	18	PF00082	0.605
CLV_PCSK_SKI1_1	173	177	PF00082	0.427
CLV_PCSK_SKI1_1	203	207	PF00082	0.551
CLV_PCSK_SKI1_1	248	252	PF00082	0.535
CLV_PCSK_SKI1_1	387	391	PF00082	0.647
CLV_PCSK_SKI1_1	78	82	PF00082	0.401
CLV_PCSK_SKI1_1	98	102	PF00082	0.268
DEG_APCC_DBOX_1	172	180	PF00400	0.432
DEG_APCC_DBOX_1	247	255	PF00400	0.504
DEG_SPOP_SBC_1	308	312	PF00917	0.555
DEG_SPOP_SBC_1	65	69	PF00917	0.462
DOC_CDC14_PxL_1	333	341	PF14671	0.471
DOC_CKS1_1	458	463	PF01111	0.595
DOC_MAPK_MEF2A_6	387	394	PF00069	0.567
DOC_USP7_MATH_1	111	115	PF00917	0.471
DOC_USP7_MATH_1	197	201	PF00917	0.624
DOC_USP7_MATH_1	205	209	PF00917	0.519
DOC_USP7_MATH_1	23	27	PF00917	0.562
DOC_USP7_MATH_1	253	257	PF00917	0.552
DOC_USP7_MATH_1	269	273	PF00917	0.581
DOC_USP7_MATH_1	291	295	PF00917	0.691
DOC_USP7_MATH_1	309	313	PF00917	0.574
DOC_USP7_MATH_1	349	353	PF00917	0.534
DOC_USP7_MATH_1	484	488	PF00917	0.760
DOC_USP7_MATH_1	496	500	PF00917	0.587
DOC_USP7_MATH_1	65	69	PF00917	0.558
DOC_USP7_UBL2_3	181	185	PF12436	0.556
DOC_WW_Pin1_4	28	33	PF00397	0.578
DOC_WW_Pin1_4	312	317	PF00397	0.679
DOC_WW_Pin1_4	394	399	PF00397	0.480
DOC_WW_Pin1_4	448	453	PF00397	0.622
DOC_WW_Pin1_4	457	462	PF00397	0.633
DOC_WW_Pin1_4	463	468	PF00397	0.694
LIG_14-3-3_CanoR_1	359	363	PF00244	0.598
LIG_14-3-3_CanoR_1	453	457	PF00244	0.580
LIG_14-3-3_CanoR_1	509	515	PF00244	0.514
LIG_14-3-3_CanoR_1	78	84	PF00244	0.446
LIG_14-3-3_CanoR_1	98	104	PF00244	0.341
LIG_Actin_WH2_2	136	152	PF00022	0.482
LIG_Actin_WH2_2	319	334	PF00022	0.498
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BIR_III_2	290	294	PF00653	0.612
LIG_BRCT_BRCA1_1	231	235	PF00533	0.559
LIG_BRCT_BRCA1_1	293	297	PF00533	0.634
LIG_BRCT_BRCA1_1	497	501	PF00533	0.565
LIG_FHA_1	158	164	PF00498	0.387
LIG_FHA_1	345	351	PF00498	0.549
LIG_FHA_1	378	384	PF00498	0.670
LIG_FHA_1	453	459	PF00498	0.600
LIG_FHA_1	509	515	PF00498	0.563
LIG_FHA_2	395	401	PF00498	0.520
LIG_FHA_2	49	55	PF00498	0.611
LIG_Integrin_isoDGR_2	37	39	PF01839	0.552
LIG_LIR_Gen_1	101	112	PF02991	0.357
LIG_LIR_Gen_1	232	243	PF02991	0.549
LIG_LIR_Gen_1	54	63	PF02991	0.380
LIG_LIR_Nem_3	101	107	PF02991	0.401
LIG_LIR_Nem_3	232	238	PF02991	0.580
LIG_LIR_Nem_3	499	505	PF02991	0.564
LIG_LIR_Nem_3	54	59	PF02991	0.392
LIG_MLH1_MIPbox_1	498	502	PF16413	0.553
LIG_Pex14_2	401	405	PF04695	0.526
LIG_Pex14_2	497	501	PF04695	0.637
LIG_SH2_CRK	431	435	PF00017	0.535
LIG_SH2_NCK_1	431	435	PF00017	0.556
LIG_SH2_SRC	167	170	PF00017	0.384
LIG_SH2_STAT5	104	107	PF00017	0.386
LIG_SH2_STAT5	155	158	PF00017	0.377
LIG_SH2_STAT5	167	170	PF00017	0.461
LIG_SH2_STAT5	356	359	PF00017	0.598
LIG_SH2_STAT5	517	520	PF00017	0.649
LIG_SH2_STAT5	532	535	PF00017	0.429
LIG_SH3_3	259	265	PF00018	0.511
LIG_SH3_3	424	430	PF00018	0.643
LIG_SH3_3	474	480	PF00018	0.677
LIG_TRAF2_1	52	55	PF00917	0.510
MOD_CDK_SPK_2	448	453	PF00069	0.613
MOD_CK1_1	102	108	PF00069	0.294
MOD_CK1_1	189	195	PF00069	0.566
MOD_CK1_1	196	202	PF00069	0.583
MOD_CK1_1	263	269	PF00069	0.609
MOD_CK1_1	312	318	PF00069	0.684
MOD_CK1_1	377	383	PF00069	0.674
MOD_CK1_1	451	457	PF00069	0.590
MOD_CK1_1	466	472	PF00069	0.628
MOD_CK1_1	495	501	PF00069	0.585
MOD_CK1_1	513	519	PF00069	0.547
MOD_CK1_1	67	73	PF00069	0.594
MOD_CK2_1	171	177	PF00069	0.462
MOD_CK2_1	332	338	PF00069	0.454
MOD_CK2_1	369	375	PF00069	0.566
MOD_CK2_1	394	400	PF00069	0.469
MOD_CK2_1	48	54	PF00069	0.520
MOD_CK2_1	525	531	PF00069	0.485
MOD_Cter_Amidation	37	40	PF01082	0.556
MOD_GlcNHglycan	109	112	PF01048	0.345
MOD_GlcNHglycan	160	163	PF01048	0.439
MOD_GlcNHglycan	173	176	PF01048	0.347
MOD_GlcNHglycan	193	196	PF01048	0.633
MOD_GlcNHglycan	199	202	PF01048	0.650
MOD_GlcNHglycan	262	265	PF01048	0.566
MOD_GlcNHglycan	293	296	PF01048	0.555
MOD_GlcNHglycan	305	308	PF01048	0.496
MOD_GlcNHglycan	311	314	PF01048	0.648
MOD_GlcNHglycan	338	342	PF01048	0.535
MOD_GlcNHglycan	352	355	PF01048	0.504
MOD_GlcNHglycan	371	374	PF01048	0.781
MOD_GlcNHglycan	421	424	PF01048	0.546
MOD_GlcNHglycan	438	441	PF01048	0.689
MOD_GlcNHglycan	486	489	PF01048	0.658
MOD_GlcNHglycan	494	497	PF01048	0.574
MOD_GlcNHglycan	498	501	PF01048	0.504
MOD_GlcNHglycan	51	54	PF01048	0.536
MOD_GlcNHglycan	69	72	PF01048	0.552
MOD_GSK3_1	107	114	PF00069	0.388
MOD_GSK3_1	187	194	PF00069	0.550
MOD_GSK3_1	23	30	PF00069	0.590
MOD_GSK3_1	230	237	PF00069	0.582
MOD_GSK3_1	253	260	PF00069	0.495
MOD_GSK3_1	303	310	PF00069	0.690
MOD_GSK3_1	369	376	PF00069	0.653
MOD_GSK3_1	43	50	PF00069	0.713
MOD_GSK3_1	444	451	PF00069	0.644
MOD_GSK3_1	452	459	PF00069	0.578
MOD_GSK3_1	463	470	PF00069	0.644
MOD_GSK3_1	479	486	PF00069	0.664
MOD_GSK3_1	492	499	PF00069	0.653
MOD_GSK3_1	509	516	PF00069	0.677
MOD_GSK3_1	532	539	PF00069	0.551
MOD_GSK3_1	67	74	PF00069	0.414
MOD_GSK3_1	98	105	PF00069	0.539
MOD_LATS_1	330	336	PF00433	0.479
MOD_N-GLC_1	318	323	PF02516	0.573
MOD_N-GLC_1	369	374	PF02516	0.699
MOD_N-GLC_1	467	472	PF02516	0.599
MOD_N-GLC_1	520	525	PF02516	0.580
MOD_NEK2_1	107	112	PF00069	0.382
MOD_NEK2_1	229	234	PF00069	0.616
MOD_NEK2_1	279	284	PF00069	0.615
MOD_NEK2_1	331	336	PF00069	0.445
MOD_NEK2_1	79	84	PF00069	0.414
MOD_NEK2_2	243	248	PF00069	0.517
MOD_PIKK_1	279	285	PF00454	0.615
MOD_PIKK_1	93	99	PF00454	0.422
MOD_PK_1	332	338	PF00069	0.454
MOD_PKA_1	508	514	PF00069	0.575
MOD_PKA_1	98	104	PF00069	0.384
MOD_PKA_2	187	193	PF00069	0.523
MOD_PKA_2	291	297	PF00069	0.563
MOD_PKA_2	358	364	PF00069	0.584
MOD_PKA_2	452	458	PF00069	0.601
MOD_PKA_2	484	490	PF00069	0.667
MOD_PKA_2	508	514	PF00069	0.575
MOD_PKA_2	91	97	PF00069	0.457
MOD_PKB_1	184	192	PF00069	0.530
MOD_Plk_1	230	236	PF00069	0.536
MOD_Plk_1	520	526	PF00069	0.588
MOD_Plk_2-3	358	364	PF00069	0.562
MOD_Plk_4	429	435	PF00069	0.535
MOD_Plk_4	513	519	PF00069	0.586
MOD_Plk_4	71	77	PF00069	0.510
MOD_Plk_4	79	85	PF00069	0.375
MOD_Plk_4	99	105	PF00069	0.400
MOD_ProDKin_1	28	34	PF00069	0.581
MOD_ProDKin_1	312	318	PF00069	0.684
MOD_ProDKin_1	394	400	PF00069	0.478
MOD_ProDKin_1	448	454	PF00069	0.619
MOD_ProDKin_1	457	463	PF00069	0.635
MOD_ProDKin_1	467	473	PF00069	0.757
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.369
TRG_ENDOCYTIC_2	104	107	PF00928	0.357
TRG_ENDOCYTIC_2	431	434	PF00928	0.541
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM3	Leptomonas seymouri	49%	98%
A0A3Q8ID86	Leishmania donovani	100%	100%
A4HE00	Leishmania braziliensis	78%	100%
E9AXE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA25	Leishmania major	95%	100%