Putative epsin

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative epsin

Gene product:

epsin - putative

Species:

Leishmania infantum

UniProt:

A4I1A8_LEIIN

TriTrypDb:

LINF_250012000

Length:

559

Annotations

Annotations by Jardim et al.

Membrane associated proteins, epsin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030117	membrane coat	3	1
GO:0030118	clathrin coat	4	1
GO:0030120	vesicle coat	4	1
GO:0030125	clathrin vesicle coat	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 536, 538

Expansion

Sequence features

A4I1A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1A8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0030276	clathrin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.461
CLV_C14_Caspase3-7	387	391	PF00656	0.610
CLV_NRD_NRD_1	245	247	PF00675	0.631
CLV_NRD_NRD_1	295	297	PF00675	0.588
CLV_PCSK_FUR_1	293	297	PF00082	0.608
CLV_PCSK_KEX2_1	245	247	PF00082	0.631
CLV_PCSK_KEX2_1	295	297	PF00082	0.588
CLV_PCSK_PC7_1	241	247	PF00082	0.620
CLV_PCSK_SKI1_1	77	81	PF00082	0.300
DEG_Nend_UBRbox_3	1	3	PF02207	0.567
DOC_CYCLIN_RxL_1	73	83	PF00134	0.300
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.503
DOC_MAPK_gen_1	293	301	PF00069	0.654
DOC_MAPK_MEF2A_6	230	239	PF00069	0.602
DOC_PP2B_LxvP_1	330	333	PF13499	0.550
DOC_PP4_FxxP_1	331	334	PF00568	0.623
DOC_PP4_FxxP_1	336	339	PF00568	0.622
DOC_USP7_MATH_1	18	22	PF00917	0.467
DOC_USP7_MATH_1	205	209	PF00917	0.743
DOC_USP7_MATH_1	344	348	PF00917	0.586
DOC_USP7_MATH_1	350	354	PF00917	0.473
DOC_USP7_MATH_1	399	403	PF00917	0.777
DOC_USP7_MATH_1	432	436	PF00917	0.770
DOC_USP7_MATH_1	489	493	PF00917	0.840
DOC_USP7_MATH_1	532	536	PF00917	0.728
DOC_WW_Pin1_4	167	172	PF00397	0.532
DOC_WW_Pin1_4	209	214	PF00397	0.679
DOC_WW_Pin1_4	309	314	PF00397	0.628
LIG_14-3-3_CanoR_1	105	113	PF00244	0.300
LIG_14-3-3_CanoR_1	194	199	PF00244	0.711
LIG_14-3-3_CanoR_1	246	254	PF00244	0.514
LIG_AP2alpha_2	349	351	PF02296	0.445
LIG_AP2alpha_2	472	474	PF02296	0.630
LIG_APCC_Cbox_2	91	97	PF00515	0.395
LIG_BIR_III_4	390	394	PF00653	0.643
LIG_BRCT_BRCA1_1	107	111	PF00533	0.300
LIG_Clathr_ClatBox_1	79	83	PF01394	0.300
LIG_deltaCOP1_diTrp_1	390	398	PF00928	0.585
LIG_EVH1_1	318	322	PF00568	0.545
LIG_FHA_1	2	8	PF00498	0.534
LIG_FHA_1	322	328	PF00498	0.615
LIG_FHA_2	17	23	PF00498	0.431
LIG_FHA_2	222	228	PF00498	0.496
LIG_FHA_2	273	279	PF00498	0.616
LIG_FHA_2	29	35	PF00498	0.267
LIG_FHA_2	385	391	PF00498	0.606
LIG_GBD_Chelix_1	132	140	PF00786	0.417
LIG_GBD_Chelix_1	148	156	PF00786	0.573
LIG_LIR_Apic_2	110	116	PF02991	0.417
LIG_LIR_Apic_2	328	334	PF02991	0.585
LIG_LIR_Apic_2	367	371	PF02991	0.625
LIG_LIR_Apic_2	390	395	PF02991	0.778
LIG_LIR_Apic_2	437	443	PF02991	0.776
LIG_LIR_Apic_2	472	477	PF02991	0.621
LIG_LIR_Apic_2	518	524	PF02991	0.709
LIG_LIR_Gen_1	21	30	PF02991	0.304
LIG_LIR_Gen_1	349	355	PF02991	0.446
LIG_LIR_Nem_3	12	16	PF02991	0.402
LIG_LIR_Nem_3	21	26	PF02991	0.268
LIG_LIR_Nem_3	349	354	PF02991	0.451
LIG_LIR_Nem_3	492	498	PF02991	0.686
LIG_Pex14_1	495	499	PF04695	0.567
LIG_Pex14_1	72	76	PF04695	0.300
LIG_SH2_CRK	113	117	PF00017	0.417
LIG_SH2_CRK	499	503	PF00017	0.555
LIG_SH2_CRK	76	80	PF00017	0.300
LIG_SH2_GRB2like	113	116	PF00017	0.417
LIG_SH2_PTP2	23	26	PF00017	0.359
LIG_SH2_STAP1	258	262	PF00017	0.586
LIG_SH2_STAT5	113	116	PF00017	0.303
LIG_SH2_STAT5	23	26	PF00017	0.359
LIG_SH2_STAT5	93	96	PF00017	0.423
LIG_SH3_1	35	41	PF00018	0.364
LIG_SH3_3	296	302	PF00018	0.747
LIG_SH3_3	311	317	PF00018	0.641
LIG_SH3_3	338	344	PF00018	0.733
LIG_SH3_3	35	41	PF00018	0.338
LIG_SH3_3	406	412	PF00018	0.617
LIG_SH3_3	413	419	PF00018	0.538
LIG_SH3_3	482	488	PF00018	0.668
LIG_SUMO_SIM_anti_2	21	29	PF11976	0.278
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.300
LIG_SUMO_SIM_par_1	78	83	PF11976	0.301
LIG_TRAF2_1	224	227	PF00917	0.499
LIG_TRAF2_1	326	329	PF00917	0.558
LIG_TRAF2_2	467	472	PF00917	0.558
LIG_TRAF2_2	514	519	PF00917	0.625
LIG_WRC_WIRS_1	351	356	PF05994	0.499
MOD_CDK_SPxK_1	309	315	PF00069	0.733
MOD_CK1_1	170	176	PF00069	0.643
MOD_CK1_1	208	214	PF00069	0.633
MOD_CK1_1	247	253	PF00069	0.604
MOD_CK1_1	300	306	PF00069	0.607
MOD_CK1_1	458	464	PF00069	0.741
MOD_CK1_1	491	497	PF00069	0.765
MOD_CK1_1	535	541	PF00069	0.612
MOD_CK2_1	121	127	PF00069	0.300
MOD_CK2_1	16	22	PF00069	0.350
MOD_CK2_1	221	227	PF00069	0.530
MOD_CK2_1	28	34	PF00069	0.300
MOD_CK2_1	6	12	PF00069	0.439
MOD_GlcNHglycan	167	170	PF01048	0.650
MOD_GlcNHglycan	172	175	PF01048	0.705
MOD_GlcNHglycan	182	185	PF01048	0.539
MOD_GlcNHglycan	246	249	PF01048	0.526
MOD_GlcNHglycan	346	349	PF01048	0.685
MOD_GlcNHglycan	358	361	PF01048	0.732
MOD_GlcNHglycan	430	433	PF01048	0.630
MOD_GlcNHglycan	457	460	PF01048	0.667
MOD_GlcNHglycan	510	513	PF01048	0.754
MOD_GlcNHglycan	537	540	PF01048	0.664
MOD_GSK3_1	103	110	PF00069	0.356
MOD_GSK3_1	154	161	PF00069	0.592
MOD_GSK3_1	18	25	PF00069	0.310
MOD_GSK3_1	205	212	PF00069	0.669
MOD_GSK3_1	217	224	PF00069	0.697
MOD_GSK3_1	303	310	PF00069	0.656
MOD_GSK3_1	350	357	PF00069	0.507
MOD_GSK3_1	428	435	PF00069	0.633
MOD_N-GLC_1	1	6	PF02516	0.547
MOD_N-GLC_1	158	163	PF02516	0.647
MOD_N-GLC_1	455	460	PF02516	0.661
MOD_NEK2_1	1	6	PF00069	0.547
MOD_NEK2_1	103	108	PF00069	0.319
MOD_NEK2_1	111	116	PF00069	0.283
MOD_NEK2_1	257	262	PF00069	0.491
MOD_NEK2_1	354	359	PF00069	0.507
MOD_NEK2_1	517	522	PF00069	0.809
MOD_NEK2_1	533	538	PF00069	0.587
MOD_PIKK_1	1	7	PF00454	0.546
MOD_PIKK_1	334	340	PF00454	0.596
MOD_PIKK_1	445	451	PF00454	0.758
MOD_PKA_2	244	250	PF00069	0.557
MOD_PKB_1	192	200	PF00069	0.545
MOD_Plk_1	68	74	PF00069	0.359
MOD_Plk_4	107	113	PF00069	0.387
MOD_Plk_4	214	220	PF00069	0.544
MOD_Plk_4	22	28	PF00069	0.389
MOD_Plk_4	350	356	PF00069	0.535
MOD_Plk_4	75	81	PF00069	0.346
MOD_ProDKin_1	167	173	PF00069	0.531
MOD_ProDKin_1	209	215	PF00069	0.679
MOD_ProDKin_1	309	315	PF00069	0.631
TRG_AP2beta_CARGO_1	349	358	PF09066	0.438
TRG_DiLeu_BaEn_1	96	101	PF01217	0.417
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.380
TRG_ENDOCYTIC_2	178	181	PF00928	0.752
TRG_ENDOCYTIC_2	23	26	PF00928	0.359
TRG_ENDOCYTIC_2	76	79	PF00928	0.300
TRG_ER_diArg_1	262	265	PF00400	0.495
TRG_ER_diArg_1	293	296	PF00400	0.550
TRG_ER_diArg_1	61	64	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI1	Leptomonas seymouri	53%	100%
A0A1X0P4K8	Trypanosomatidae	35%	100%
A0A3Q8IDD0	Leishmania donovani	98%	100%
A0A422NX91	Trypanosoma rangeli	43%	100%
A4HDZ7	Leishmania braziliensis	60%	96%
E9AXE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	88%
O95208	Homo sapiens	27%	87%
Q4QA28	Leishmania major	75%	96%
Q8CHU3	Mus musculus	27%	94%
Q9Z1Z3	Rattus norvegicus	26%	96%
V5BXH3	Trypanosoma cruzi	43%	100%