Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania infantum

UniProt:

A4I1A6_LEIIN

TriTrypDb:

LINF_250011800

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.580
CLV_C14_Caspase3-7	334	338	PF00656	0.448
CLV_NRD_NRD_1	145	147	PF00675	0.516
CLV_NRD_NRD_1	191	193	PF00675	0.487
CLV_NRD_NRD_1	305	307	PF00675	0.644
CLV_NRD_NRD_1	321	323	PF00675	0.486
CLV_NRD_NRD_1	407	409	PF00675	0.539
CLV_PCSK_FUR_1	189	193	PF00082	0.502
CLV_PCSK_KEX2_1	145	147	PF00082	0.514
CLV_PCSK_KEX2_1	191	193	PF00082	0.487
CLV_PCSK_KEX2_1	305	307	PF00082	0.587
CLV_PCSK_KEX2_1	407	409	PF00082	0.539
CLV_PCSK_SKI1_1	349	353	PF00082	0.483
CLV_PCSK_SKI1_1	511	515	PF00082	0.430
CLV_PCSK_SKI1_1	569	573	PF00082	0.603
CLV_PCSK_SKI1_1	619	623	PF00082	0.360
CLV_PCSK_SKI1_1	644	648	PF00082	0.476
CLV_PCSK_SKI1_1	651	655	PF00082	0.462
DEG_APCC_DBOX_1	348	356	PF00400	0.443
DEG_SCF_FBW7_2	73	80	PF00400	0.511
DEG_SIAH_1	478	486	PF03145	0.494
DEG_SPOP_SBC_1	369	373	PF00917	0.611
DEG_SPOP_SBC_1	376	380	PF00917	0.503
DEG_SPOP_SBC_1	608	612	PF00917	0.503
DEG_SPOP_SBC_1	67	71	PF00917	0.542
DOC_CDC14_PxL_1	304	312	PF14671	0.464
DOC_CDC14_PxL_1	486	494	PF14671	0.499
DOC_CKS1_1	174	179	PF01111	0.437
DOC_CKS1_1	74	79	PF01111	0.507
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.431
DOC_MAPK_gen_1	189	198	PF00069	0.479
DOC_MAPK_gen_1	305	312	PF00069	0.529
DOC_MAPK_MEF2A_6	191	200	PF00069	0.461
DOC_MAPK_MEF2A_6	305	312	PF00069	0.515
DOC_MAPK_MEF2A_6	511	520	PF00069	0.475
DOC_PP1_RVXF_1	148	155	PF00149	0.602
DOC_PP1_RVXF_1	242	249	PF00149	0.487
DOC_PP2B_LxvP_1	171	174	PF13499	0.472
DOC_PP2B_LxvP_1	367	370	PF13499	0.497
DOC_USP7_MATH_1	293	297	PF00917	0.597
DOC_USP7_MATH_1	370	374	PF00917	0.664
DOC_USP7_MATH_1	381	385	PF00917	0.440
DOC_USP7_MATH_1	440	444	PF00917	0.719
DOC_USP7_MATH_1	479	483	PF00917	0.629
DOC_USP7_MATH_1	491	495	PF00917	0.393
DOC_USP7_MATH_1	608	612	PF00917	0.552
DOC_USP7_MATH_1	66	70	PF00917	0.627
DOC_WW_Pin1_4	173	178	PF00397	0.434
DOC_WW_Pin1_4	473	478	PF00397	0.579
DOC_WW_Pin1_4	500	505	PF00397	0.437
DOC_WW_Pin1_4	604	609	PF00397	0.515
DOC_WW_Pin1_4	73	78	PF00397	0.509
LIG_14-3-3_CanoR_1	150	155	PF00244	0.614
LIG_14-3-3_CanoR_1	159	168	PF00244	0.641
LIG_14-3-3_CanoR_1	189	199	PF00244	0.528
LIG_14-3-3_CanoR_1	354	360	PF00244	0.492
LIG_14-3-3_CanoR_1	431	435	PF00244	0.628
LIG_14-3-3_CanoR_1	439	445	PF00244	0.644
LIG_14-3-3_CanoR_1	511	516	PF00244	0.425
LIG_14-3-3_CanoR_1	606	616	PF00244	0.538
LIG_Actin_WH2_2	234	252	PF00022	0.489
LIG_Actin_WH2_2	308	324	PF00022	0.531
LIG_Actin_WH2_2	391	409	PF00022	0.482
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BIR_III_4	456	460	PF00653	0.640
LIG_BRCT_BRCA1_1	493	497	PF00533	0.465
LIG_FHA_1	191	197	PF00498	0.434
LIG_FHA_1	202	208	PF00498	0.461
LIG_FHA_1	220	226	PF00498	0.555
LIG_FHA_1	328	334	PF00498	0.503
LIG_FHA_1	445	451	PF00498	0.704
LIG_FHA_1	54	60	PF00498	0.800
LIG_FHA_1	572	578	PF00498	0.490
LIG_FHA_1	658	664	PF00498	0.389
LIG_FHA_2	161	167	PF00498	0.556
LIG_FHA_2	290	296	PF00498	0.588
LIG_FHA_2	342	348	PF00498	0.565
LIG_FHA_2	421	427	PF00498	0.579
LIG_FHA_2	465	471	PF00498	0.590
LIG_FHA_2	82	88	PF00498	0.599
LIG_LIR_Gen_1	17	26	PF02991	0.465
LIG_LIR_Gen_1	494	502	PF02991	0.464
LIG_LIR_Nem_3	17	23	PF02991	0.409
LIG_LIR_Nem_3	494	498	PF02991	0.436
LIG_LIR_Nem_3	574	578	PF02991	0.417
LIG_PCNA_yPIPBox_3	349	360	PF02747	0.425
LIG_PTAP_UEV_1	47	52	PF05743	0.584
LIG_REV1ctd_RIR_1	495	503	PF16727	0.483
LIG_SH2_STAT5	125	128	PF00017	0.462
LIG_SH2_STAT5	223	226	PF00017	0.462
LIG_SH2_STAT5	399	402	PF00017	0.517
LIG_SH3_3	171	177	PF00018	0.497
LIG_SH3_3	179	185	PF00018	0.432
LIG_SH3_3	310	316	PF00018	0.509
LIG_SH3_3	415	421	PF00018	0.542
LIG_SH3_3	45	51	PF00018	0.612
LIG_SUMO_SIM_anti_2	193	200	PF11976	0.358
LIG_SUMO_SIM_anti_2	620	625	PF11976	0.423
LIG_SUMO_SIM_par_1	329	334	PF11976	0.558
LIG_SUMO_SIM_par_1	80	87	PF11976	0.545
LIG_TRAF2_1	345	348	PF00917	0.504
LIG_TRAF2_1	77	80	PF00917	0.523
LIG_WRC_WIRS_1	492	497	PF05994	0.460
LIG_WRC_WIRS_1	572	577	PF05994	0.447
MOD_CAAXbox	662	665	PF01239	0.435
MOD_CK1_1	190	196	PF00069	0.630
MOD_CK1_1	271	277	PF00069	0.572
MOD_CK1_1	368	374	PF00069	0.572
MOD_CK1_1	380	386	PF00069	0.527
MOD_CK1_1	433	439	PF00069	0.604
MOD_CK1_1	464	470	PF00069	0.637
MOD_CK1_1	95	101	PF00069	0.540
MOD_CK2_1	341	347	PF00069	0.582
MOD_CK2_1	440	446	PF00069	0.657
MOD_CK2_1	81	87	PF00069	0.587
MOD_CMANNOS	273	276	PF00535	0.512
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.480
MOD_GlcNHglycan	212	215	PF01048	0.623
MOD_GlcNHglycan	251	255	PF01048	0.448
MOD_GlcNHglycan	278	281	PF01048	0.517
MOD_GlcNHglycan	295	298	PF01048	0.625
MOD_GlcNHglycan	339	342	PF01048	0.478
MOD_GlcNHglycan	367	370	PF01048	0.684
MOD_GlcNHglycan	372	375	PF01048	0.606
MOD_GlcNHglycan	379	382	PF01048	0.473
MOD_GlcNHglycan	383	386	PF01048	0.411
MOD_GlcNHglycan	442	445	PF01048	0.641
MOD_GlcNHglycan	464	467	PF01048	0.523
MOD_GlcNHglycan	507	510	PF01048	0.495
MOD_GlcNHglycan	581	584	PF01048	0.682
MOD_GlcNHglycan	587	590	PF01048	0.703
MOD_GlcNHglycan	601	604	PF01048	0.399
MOD_GlcNHglycan	70	73	PF01048	0.555
MOD_GlcNHglycan	94	97	PF01048	0.607
MOD_GSK3_1	201	208	PF00069	0.496
MOD_GSK3_1	215	222	PF00069	0.657
MOD_GSK3_1	271	278	PF00069	0.556
MOD_GSK3_1	289	296	PF00069	0.558
MOD_GSK3_1	327	334	PF00069	0.514
MOD_GSK3_1	337	344	PF00069	0.529
MOD_GSK3_1	365	372	PF00069	0.599
MOD_GSK3_1	376	383	PF00069	0.467
MOD_GSK3_1	440	447	PF00069	0.633
MOD_GSK3_1	581	588	PF00069	0.543
MOD_GSK3_1	604	611	PF00069	0.570
MOD_GSK3_1	83	90	PF00069	0.560
MOD_GSK3_1	91	98	PF00069	0.547
MOD_N-GLC_1	327	332	PF02516	0.493
MOD_N-GLC_1	473	478	PF02516	0.573
MOD_NEK2_1	210	215	PF00069	0.572
MOD_NEK2_1	355	360	PF00069	0.508
MOD_NEK2_1	377	382	PF00069	0.440
MOD_NEK2_1	406	411	PF00069	0.536
MOD_NEK2_1	497	502	PF00069	0.427
MOD_NEK2_1	68	73	PF00069	0.560
MOD_NEK2_1	92	97	PF00069	0.528
MOD_NEK2_2	280	285	PF00069	0.542
MOD_NEK2_2	35	40	PF00069	0.424
MOD_OFUCOSY	33	39	PF10250	0.422
MOD_PIKK_1	430	436	PF00454	0.665
MOD_PKA_2	190	196	PF00069	0.525
MOD_PKA_2	381	387	PF00069	0.553
MOD_PKA_2	406	412	PF00069	0.594
MOD_PKA_2	430	436	PF00069	0.620
MOD_PKB_1	604	612	PF00069	0.484
MOD_PKB_1	642	650	PF00069	0.504
MOD_Plk_1	234	240	PF00069	0.401
MOD_Plk_1	327	333	PF00069	0.488
MOD_Plk_1	414	420	PF00069	0.561
MOD_Plk_1	459	465	PF00069	0.528
MOD_Plk_4	107	113	PF00069	0.489
MOD_Plk_4	226	232	PF00069	0.427
MOD_Plk_4	268	274	PF00069	0.647
MOD_Plk_4	280	286	PF00069	0.562
MOD_Plk_4	308	314	PF00069	0.548
MOD_Plk_4	327	333	PF00069	0.526
MOD_Plk_4	355	361	PF00069	0.388
MOD_Plk_4	464	470	PF00069	0.553
MOD_Plk_4	479	485	PF00069	0.429
MOD_ProDKin_1	173	179	PF00069	0.438
MOD_ProDKin_1	473	479	PF00069	0.577
MOD_ProDKin_1	500	506	PF00069	0.432
MOD_ProDKin_1	604	610	PF00069	0.514
MOD_ProDKin_1	73	79	PF00069	0.516
MOD_SUMO_for_1	636	639	PF00179	0.458
TRG_DiLeu_BaEn_4	347	353	PF01217	0.486
TRG_ER_diArg_1	188	191	PF00400	0.513
TRG_ER_diArg_1	304	306	PF00400	0.690
TRG_ER_diArg_1	406	408	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP2	Leptomonas seymouri	45%	100%
A0A3S7WYX9	Leishmania donovani	100%	100%
A4HEF3	Leishmania braziliensis	68%	99%
D0A5J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AXE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QA30	Leishmania major	87%	100%