Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1A4_LEIIN

TriTrypDb:

LINF_250011600

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4I1A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.303
CLV_NRD_NRD_1	8	10	PF00675	0.430
CLV_PCSK_FUR_1	231	235	PF00082	0.362
CLV_PCSK_KEX2_1	217	219	PF00082	0.302
CLV_PCSK_KEX2_1	233	235	PF00082	0.366
CLV_PCSK_KEX2_1	8	10	PF00082	0.431
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.327
CLV_PCSK_SKI1_1	256	260	PF00082	0.324
DOC_CYCLIN_RxL_1	253	261	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.661
DOC_MAPK_gen_1	253	262	PF00069	0.499
DOC_MAPK_gen_1	5	14	PF00069	0.630
DOC_MAPK_MEF2A_6	253	262	PF00069	0.516
DOC_MAPK_MEF2A_6	274	282	PF00069	0.528
DOC_MAPK_MEF2A_6	59	66	PF00069	0.679
DOC_MAPK_MEF2A_6	83	92	PF00069	0.612
DOC_PP4_FxxP_1	45	48	PF00568	0.690
LIG_14-3-3_CanoR_1	157	163	PF00244	0.528
LIG_14-3-3_CanoR_1	217	221	PF00244	0.497
LIG_Actin_WH2_2	39	55	PF00022	0.695
LIG_ActinCP_TwfCPI_2	45	53	PF01115	0.700
LIG_eIF4E_1	23	29	PF01652	0.642
LIG_EVH1_2	62	66	PF00568	0.670
LIG_LIR_Gen_1	166	177	PF02991	0.500
LIG_LIR_Nem_3	15	20	PF02991	0.639
LIG_LIR_Nem_3	166	172	PF02991	0.488
LIG_LIR_Nem_3	219	223	PF02991	0.474
LIG_LIR_Nem_3	292	298	PF02991	0.334
LIG_PCNA_yPIPBox_3	233	246	PF02747	0.538
LIG_SH2_CRK	223	227	PF00017	0.468
LIG_SH2_GRB2like	295	298	PF00017	0.535
LIG_SH2_STAP1	169	173	PF00017	0.484
LIG_SH2_STAP1	201	205	PF00017	0.470
LIG_SH2_STAT5	195	198	PF00017	0.483
LIG_SH3_2	48	53	PF14604	0.642
LIG_SH3_3	174	180	PF00018	0.542
LIG_SH3_3	21	27	PF00018	0.588
LIG_SH3_3	45	51	PF00018	0.633
LIG_SH3_3	57	63	PF00018	0.616
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.633
LIG_SUMO_SIM_par_1	70	76	PF11976	0.633
LIG_TYR_ITIM	221	226	PF00017	0.317
LIG_UBA3_1	226	233	PF00899	0.341
LIG_UBA3_1	242	248	PF00899	0.459
MOD_CK1_1	118	124	PF00069	0.442
MOD_CK1_1	149	155	PF00069	0.439
MOD_Cter_Amidation	231	234	PF01082	0.404
MOD_GlcNHglycan	136	139	PF01048	0.474
MOD_GSK3_1	282	289	PF00069	0.302
MOD_GSK3_1	86	93	PF00069	0.566
MOD_N-GLC_2	281	283	PF02516	0.353
MOD_NEK2_1	173	178	PF00069	0.375
MOD_NEK2_1	18	23	PF00069	0.576
MOD_NEK2_2	158	163	PF00069	0.385
MOD_PIKK_1	90	96	PF00454	0.446
MOD_PKA_2	115	121	PF00069	0.442
MOD_PKA_2	216	222	PF00069	0.356
MOD_Plk_1	173	179	PF00069	0.407
MOD_Plk_4	118	124	PF00069	0.442
MOD_Plk_4	158	164	PF00069	0.418
MOD_Plk_4	241	247	PF00069	0.372
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.616
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.556
TRG_ENDOCYTIC_2	169	172	PF00928	0.363
TRG_ENDOCYTIC_2	223	226	PF00928	0.313
TRG_ENDOCYTIC_2	275	278	PF00928	0.354
TRG_ENDOCYTIC_2	40	43	PF00928	0.505
TRG_ER_diArg_1	216	218	PF00400	0.334
TRG_ER_diArg_1	7	9	PF00400	0.522
TRG_NES_CRM1_1	70	85	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB7	Leptomonas seymouri	83%	100%
A0A1X0P4P9	Trypanosomatidae	70%	100%
A0A3S7WYX0	Leishmania donovani	100%	100%
A4HEF5	Leishmania braziliensis	94%	100%
D0A5J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AXE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QA32	Leishmania major	98%	100%
V5BN61	Trypanosoma cruzi	69%	100%