Tyrosine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tyrosine phosphatase family - putative

Species:

Leishmania infantum

UniProt:

A4I198_LEIIN

TriTrypDb:

LINF_250010900

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I198

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I198

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.742
CLV_C14_Caspase3-7	308	312	PF00656	0.546
CLV_NRD_NRD_1	285	287	PF00675	0.336
CLV_NRD_NRD_1	301	303	PF00675	0.222
CLV_NRD_NRD_1	332	334	PF00675	0.517
CLV_PCSK_KEX2_1	301	303	PF00082	0.307
CLV_PCSK_KEX2_1	332	334	PF00082	0.517
DEG_Nend_UBRbox_1	1	4	PF02207	0.526
DEG_SPOP_SBC_1	173	177	PF00917	0.710
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.546
DOC_USP7_MATH_1	123	127	PF00917	0.751
DOC_USP7_MATH_1	182	186	PF00917	0.689
DOC_USP7_MATH_1	233	237	PF00917	0.767
DOC_USP7_MATH_1	62	66	PF00917	0.541
DOC_USP7_MATH_1	97	101	PF00917	0.705
DOC_WW_Pin1_4	202	207	PF00397	0.672
LIG_14-3-3_CanoR_1	163	173	PF00244	0.693
LIG_14-3-3_CanoR_1	198	207	PF00244	0.615
LIG_APCC_ABBA_1	316	321	PF00400	0.546
LIG_BRCT_BRCA1_1	200	204	PF00533	0.623
LIG_BRCT_BRCA1_1	226	230	PF00533	0.730
LIG_Clathr_ClatBox_1	323	327	PF01394	0.546
LIG_FHA_1	34	40	PF00498	0.439
LIG_FHA_2	244	250	PF00498	0.546
LIG_FHA_2	82	88	PF00498	0.717
LIG_GBD_Chelix_1	251	259	PF00786	0.346
LIG_Integrin_isoDGR_2	330	332	PF01839	0.436
LIG_LIR_Gen_1	313	323	PF02991	0.546
LIG_LIR_Nem_3	201	207	PF02991	0.651
LIG_LIR_Nem_3	261	267	PF02991	0.526
LIG_LIR_Nem_3	298	303	PF02991	0.543
LIG_LIR_Nem_3	313	318	PF02991	0.460
LIG_LIR_Nem_3	58	63	PF02991	0.575
LIG_LYPXL_yS_3	265	268	PF13949	0.546
LIG_NRBOX	255	261	PF00104	0.546
LIG_PDZ_Class_2	335	340	PF00595	0.579
LIG_Pex14_2	315	319	PF04695	0.504
LIG_SH2_CRK	26	30	PF00017	0.467
LIG_SH2_CRK	80	84	PF00017	0.780
LIG_SH2_NCK_1	80	84	PF00017	0.702
LIG_SH2_STAT5	10	13	PF00017	0.498
LIG_SH2_STAT5	214	217	PF00017	0.628
LIG_SH2_STAT5	80	83	PF00017	0.779
LIG_SH3_3	204	210	PF00018	0.653
LIG_SUMO_SIM_par_1	265	270	PF11976	0.546
LIG_SUMO_SIM_par_1	292	299	PF11976	0.546
LIG_SUMO_SIM_par_1	320	327	PF11976	0.619
LIG_TRAF2_1	113	116	PF00917	0.628
MOD_CK1_1	176	182	PF00069	0.808
MOD_CK1_1	202	208	PF00069	0.695
MOD_CK1_1	55	61	PF00069	0.576
MOD_CK2_1	141	147	PF00069	0.737
MOD_CK2_1	243	249	PF00069	0.532
MOD_CK2_1	292	298	PF00069	0.546
MOD_CK2_1	6	12	PF00069	0.362
MOD_Cter_Amidation	330	333	PF01082	0.551
MOD_GlcNHglycan	125	128	PF01048	0.702
MOD_GlcNHglycan	226	229	PF01048	0.804
MOD_GlcNHglycan	277	280	PF01048	0.313
MOD_GlcNHglycan	54	57	PF01048	0.495
MOD_GlcNHglycan	99	102	PF01048	0.698
MOD_GSK3_1	119	126	PF00069	0.803
MOD_GSK3_1	164	171	PF00069	0.801
MOD_GSK3_1	172	179	PF00069	0.712
MOD_GSK3_1	198	205	PF00069	0.657
MOD_GSK3_1	322	329	PF00069	0.690
MOD_GSK3_1	62	69	PF00069	0.579
MOD_GSK3_1	87	94	PF00069	0.740
MOD_N-GLC_1	105	110	PF02516	0.714
MOD_N-GLC_1	141	146	PF02516	0.761
MOD_N-GLC_1	199	204	PF02516	0.712
MOD_N-GLC_1	305	310	PF02516	0.346
MOD_N-GLC_1	6	11	PF02516	0.360
MOD_NEK2_1	267	272	PF00069	0.524
MOD_NEK2_1	28	33	PF00069	0.471
MOD_NEK2_1	326	331	PF00069	0.429
MOD_NEK2_1	52	57	PF00069	0.482
MOD_PIKK_1	141	147	PF00454	0.698
MOD_PIKK_1	64	70	PF00454	0.644
MOD_PKA_1	332	338	PF00069	0.514
MOD_PKA_2	332	338	PF00069	0.514
MOD_Plk_1	141	147	PF00069	0.725
MOD_Plk_1	6	12	PF00069	0.362
MOD_Plk_2-3	322	328	PF00069	0.619
MOD_Plk_4	251	257	PF00069	0.546
MOD_Plk_4	292	298	PF00069	0.546
MOD_Plk_4	332	338	PF00069	0.514
MOD_Plk_4	55	61	PF00069	0.528
MOD_Plk_4	78	84	PF00069	0.699
MOD_ProDKin_1	202	208	PF00069	0.667
MOD_SUMO_for_1	113	116	PF00179	0.725
MOD_SUMO_rev_2	236	241	PF00179	0.760
TRG_DiLeu_BaEn_4	321	327	PF01217	0.546
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.546
TRG_ENDOCYTIC_2	26	29	PF00928	0.458
TRG_ENDOCYTIC_2	264	267	PF00928	0.526
TRG_ENDOCYTIC_2	300	303	PF00928	0.546
TRG_ENDOCYTIC_2	80	83	PF00928	0.779
TRG_ER_diArg_1	300	302	PF00400	0.546
TRG_ER_diArg_1	332	334	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW7	Leptomonas seymouri	58%	90%
A0A3S7WYV2	Leishmania donovani	100%	100%
A4HEG1	Leishmania braziliensis	81%	100%
E9AXD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	96%
Q4QA38	Leishmania major	93%	100%