FFD domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scd6-like Sm domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I195_LEIIN

TriTrypDb:

LINF_250010600

Length:

297

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1990124	messenger ribonucleoprotein complex	3	1
GO:1990904	ribonucleoprotein complex	2	1

Phosphorylation

Amastigote: 118, 124, 126, 244, 270, 272, 280

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I195

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I195

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033962	P-body assembly	7	1
GO:0034063	stress granule assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.507
CLV_NRD_NRD_1	184	186	PF00675	0.494
CLV_NRD_NRD_1	265	267	PF00675	0.525
CLV_NRD_NRD_1	285	287	PF00675	0.486
CLV_NRD_NRD_1	45	47	PF00675	0.262
CLV_PCSK_KEX2_1	144	146	PF00082	0.507
CLV_PCSK_KEX2_1	184	186	PF00082	0.494
CLV_PCSK_KEX2_1	285	287	PF00082	0.592
CLV_PCSK_SKI1_1	72	76	PF00082	0.262
DEG_Nend_UBRbox_3	1	3	PF02207	0.442
DOC_USP7_MATH_1	109	113	PF00917	0.509
DOC_USP7_MATH_1	115	119	PF00917	0.455
DOC_USP7_UBL2_3	231	235	PF12436	0.432
DOC_USP7_UBL2_3	239	243	PF12436	0.416
DOC_WW_Pin1_4	79	84	PF00397	0.586
LIG_14-3-3_CanoR_1	122	128	PF00244	0.548
LIG_APCC_ABBA_1	74	79	PF00400	0.420
LIG_BRCT_BRCA1_1	123	127	PF00533	0.524
LIG_BRCT_BRCA1_1	243	247	PF00533	0.427
LIG_FHA_1	30	36	PF00498	0.378
LIG_FHA_1	55	61	PF00498	0.488
LIG_FHA_2	190	196	PF00498	0.465
LIG_LIR_Gen_1	244	253	PF02991	0.420
LIG_LIR_Gen_1	58	66	PF02991	0.378
LIG_LIR_Nem_3	244	250	PF02991	0.414
LIG_LIR_Nem_3	58	64	PF02991	0.407
LIG_MLH1_MIPbox_1	243	247	PF16413	0.427
LIG_PCNA_yPIPBox_3	2	14	PF02747	0.234
LIG_Pex14_2	207	211	PF04695	0.407
LIG_SH2_NCK_1	128	132	PF00017	0.512
LIG_SH2_SRC	128	131	PF00017	0.609
LIG_SH2_STAT3	19	22	PF00017	0.417
LIG_SH3_3	90	96	PF00018	0.610
LIG_SUMO_SIM_par_1	28	36	PF11976	0.385
MOD_CDK_SPxxK_3	79	86	PF00069	0.591
MOD_CK1_1	118	124	PF00069	0.632
MOD_CK1_1	25	31	PF00069	0.437
MOD_CK2_1	10	16	PF00069	0.462
MOD_CK2_1	222	228	PF00069	0.559
MOD_Cter_Amidation	44	47	PF01082	0.262
MOD_GlcNHglycan	111	114	PF01048	0.510
MOD_GlcNHglycan	117	120	PF01048	0.487
MOD_GlcNHglycan	179	182	PF01048	0.573
MOD_GSK3_1	111	118	PF00069	0.667
MOD_GSK3_1	242	249	PF00069	0.515
MOD_GSK3_1	25	32	PF00069	0.412
MOD_GSK3_1	272	279	PF00069	0.459
MOD_N-GLC_1	161	166	PF02516	0.715
MOD_NEK2_1	1	6	PF00069	0.459
MOD_NEK2_1	246	251	PF00069	0.486
MOD_NEK2_1	277	282	PF00069	0.467
MOD_NEK2_1	77	82	PF00069	0.521
MOD_NEK2_2	123	128	PF00069	0.546
MOD_PKA_1	222	228	PF00069	0.440
MOD_PKA_2	121	127	PF00069	0.683
MOD_PKA_2	66	72	PF00069	0.378
MOD_PKA_2	77	83	PF00069	0.522
MOD_Plk_1	241	247	PF00069	0.489
MOD_Plk_1	29	35	PF00069	0.433
MOD_Plk_1	72	78	PF00069	0.395
MOD_Plk_2-3	242	248	PF00069	0.451
MOD_Plk_4	242	248	PF00069	0.499
MOD_Plk_4	72	78	PF00069	0.413
MOD_ProDKin_1	79	85	PF00069	0.588
MOD_SUMO_rev_2	189	199	PF00179	0.525
MOD_SUMO_rev_2	218	225	PF00179	0.441
MOD_SUMO_rev_2	228	236	PF00179	0.466
MOD_SUMO_rev_2	69	74	PF00179	0.462
TRG_ER_diArg_1	183	185	PF00400	0.526
TRG_ER_diArg_1	284	286	PF00400	0.483
TRG_ER_diArg_1	291	294	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC4	Leptomonas seymouri	70%	100%
A0A1X0P4R0	Trypanosomatidae	49%	100%
A0A3Q8IGG5	Leishmania donovani	100%	100%
A0A3R7KUL5	Trypanosoma rangeli	41%	100%
A4HEG4	Leishmania braziliensis	81%	99%
D0A5I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
P45978	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	85%
Q4QA41	Leishmania major	88%	99%
Q9BX40	Homo sapiens	31%	77%