Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein - putative

Species:

Leishmania infantum

UniProt:

A4I193_LEIIN

TriTrypDb:

LINF_250010400

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0032991	protein-containing complex	1	3
GO:1990904	ribonucleoprotein complex	2	3

Expansion

Sequence features

A4I193

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I193

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	113	117	PF00082	0.298
CLV_PCSK_SKI1_1	229	233	PF00082	0.481
DOC_MAPK_MEF2A_6	133	141	PF00069	0.391
DOC_SPAK_OSR1_1	107	111	PF12202	0.476
DOC_USP7_MATH_1	14	18	PF00917	0.589
DOC_USP7_MATH_1	146	150	PF00917	0.389
DOC_USP7_MATH_1	165	169	PF00917	0.518
DOC_USP7_MATH_1	214	218	PF00917	0.689
DOC_USP7_MATH_1	221	225	PF00917	0.608
DOC_WW_Pin1_4	229	234	PF00397	0.553
DOC_WW_Pin1_4	9	14	PF00397	0.594
LIG_14-3-3_CanoR_1	133	141	PF00244	0.364
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_FHA_1	230	236	PF00498	0.472
LIG_FHA_1	97	103	PF00498	0.486
LIG_LIR_Gen_1	127	137	PF02991	0.379
LIG_LIR_Gen_1	149	158	PF02991	0.430
LIG_LIR_Nem_3	127	132	PF02991	0.412
LIG_LIR_Nem_3	149	155	PF02991	0.306
LIG_LIR_Nem_3	181	185	PF02991	0.499
LIG_LIR_Nem_3	62	67	PF02991	0.501
LIG_LIR_Nem_3	84	90	PF02991	0.486
LIG_LYPXL_S_1	208	212	PF13949	0.490
LIG_LYPXL_yS_3	209	212	PF13949	0.487
LIG_PDZ_Class_2	235	240	PF00595	0.503
LIG_SH2_CRK	129	133	PF00017	0.412
LIG_SH2_CRK	152	156	PF00017	0.311
LIG_SH2_CRK	77	81	PF00017	0.479
LIG_SH2_CRK	87	91	PF00017	0.492
LIG_SH2_GRB2like	119	122	PF00017	0.401
LIG_SH2_GRB2like	185	188	PF00017	0.514
LIG_SH2_NCK_1	119	123	PF00017	0.364
LIG_SH2_NCK_1	77	81	PF00017	0.476
LIG_SH2_SRC	119	122	PF00017	0.401
LIG_SH2_SRC	50	53	PF00017	0.441
LIG_SH2_STAT3	151	154	PF00017	0.483
LIG_SH2_STAT5	219	222	PF00017	0.483
LIG_SH2_STAT5	50	53	PF00017	0.490
LIG_TYR_ITIM	75	80	PF00017	0.481
MOD_CK1_1	8	14	PF00069	0.532
MOD_CK2_1	14	20	PF00069	0.731
MOD_Cter_Amidation	111	114	PF01082	0.239
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.436
MOD_GlcNHglycan	1	4	PF01048	0.491
MOD_GlcNHglycan	134	137	PF01048	0.541
MOD_GlcNHglycan	172	175	PF01048	0.549
MOD_GlcNHglycan	199	202	PF01048	0.559
MOD_GlcNHglycan	223	226	PF01048	0.527
MOD_GlcNHglycan	32	35	PF01048	0.567
MOD_GlcNHglycan	7	10	PF01048	0.502
MOD_GlcNHglycan	96	99	PF01048	0.287
MOD_GSK3_1	166	173	PF00069	0.522
MOD_GSK3_1	221	228	PF00069	0.548
MOD_GSK3_1	5	12	PF00069	0.529
MOD_GSK3_1	96	103	PF00069	0.499
MOD_N-GLC_1	5	10	PF02516	0.524
MOD_NEK2_1	132	137	PF00069	0.384
MOD_NEK2_1	94	99	PF00069	0.455
MOD_NEK2_2	146	151	PF00069	0.413
MOD_NEK2_2	214	219	PF00069	0.455
MOD_PK_1	69	75	PF00069	0.476
MOD_PKA_2	132	138	PF00069	0.360
MOD_PKA_2	197	203	PF00069	0.496
MOD_Plk_4	146	152	PF00069	0.416
MOD_Plk_4	214	220	PF00069	0.603
MOD_ProDKin_1	229	235	PF00069	0.551
MOD_ProDKin_1	9	15	PF00069	0.596
TRG_ENDOCYTIC_2	129	132	PF00928	0.375
TRG_ENDOCYTIC_2	152	155	PF00928	0.434
TRG_ENDOCYTIC_2	209	212	PF00928	0.487
TRG_ENDOCYTIC_2	61	64	PF00928	0.503
TRG_ENDOCYTIC_2	77	80	PF00928	0.447
TRG_ENDOCYTIC_2	87	90	PF00928	0.492
TRG_ENDOCYTIC_2	92	95	PF00928	0.486
TRG_ER_diArg_1	195	198	PF00400	0.529
TRG_NES_CRM1_1	130	143	PF08389	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P674	Leptomonas seymouri	58%	100%
A0A3Q8IBN4	Leishmania donovani	100%	100%
A0A3S7WYY4	Leishmania donovani	47%	100%
A4HDZ4	Leishmania braziliensis	69%	100%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AXC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QA43	Leishmania major	93%	100%
Q4QA45	Leishmania major	45%	100%
V5BSY3	Trypanosoma cruzi	56%	100%