Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I192_LEIIN

TriTrypDb:

LINF_250010300

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I192

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I192

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.708
CLV_C14_Caspase3-7	401	405	PF00656	0.716
CLV_NRD_NRD_1	189	191	PF00675	0.778
CLV_NRD_NRD_1	362	364	PF00675	0.660
CLV_NRD_NRD_1	371	373	PF00675	0.487
CLV_NRD_NRD_1	498	500	PF00675	0.748
CLV_NRD_NRD_1	512	514	PF00675	0.498
CLV_NRD_NRD_1	90	92	PF00675	0.709
CLV_PCSK_KEX2_1	189	191	PF00082	0.778
CLV_PCSK_KEX2_1	362	364	PF00082	0.660
CLV_PCSK_KEX2_1	371	373	PF00082	0.487
CLV_PCSK_KEX2_1	498	500	PF00082	0.748
CLV_PCSK_KEX2_1	512	514	PF00082	0.498
CLV_PCSK_KEX2_1	90	92	PF00082	0.688
CLV_PCSK_PC7_1	367	373	PF00082	0.647
CLV_PCSK_SKI1_1	119	123	PF00082	0.567
CLV_PCSK_SKI1_1	134	138	PF00082	0.465
CLV_PCSK_SKI1_1	22	26	PF00082	0.702
CLV_PCSK_SKI1_1	248	252	PF00082	0.545
CLV_PCSK_SKI1_1	322	326	PF00082	0.611
CLV_PCSK_SKI1_1	362	366	PF00082	0.617
CLV_PCSK_SKI1_1	367	371	PF00082	0.482
CLV_PCSK_SKI1_1	541	545	PF00082	0.560
CLV_PCSK_SKI1_1	90	94	PF00082	0.609
CLV_Separin_Metazoa	459	463	PF03568	0.520
DEG_APCC_DBOX_1	118	126	PF00400	0.644
DEG_APCC_DBOX_1	247	255	PF00400	0.570
DEG_APCC_DBOX_1	321	329	PF00400	0.601
DEG_APCC_DBOX_1	366	374	PF00400	0.648
DEG_SPOP_SBC_1	490	494	PF00917	0.651
DOC_CYCLIN_RxL_1	166	175	PF00134	0.571
DOC_CYCLIN_RxL_1	19	29	PF00134	0.700
DOC_CYCLIN_RxL_1	359	366	PF00134	0.614
DOC_MAPK_gen_1	19	27	PF00069	0.566
DOC_MAPK_gen_1	371	378	PF00069	0.531
DOC_MAPK_gen_1	414	423	PF00069	0.464
DOC_MAPK_gen_1	512	519	PF00069	0.572
DOC_MAPK_gen_1	546	554	PF00069	0.538
DOC_MAPK_MEF2A_6	19	27	PF00069	0.566
DOC_MAPK_MEF2A_6	414	423	PF00069	0.566
DOC_PP1_RVXF_1	132	139	PF00149	0.677
DOC_PP2B_LxvP_1	171	174	PF13499	0.683
DOC_PP2B_LxvP_1	242	245	PF13499	0.499
DOC_PP2B_LxvP_1	25	28	PF13499	0.559
DOC_PP2B_LxvP_1	421	424	PF13499	0.675
DOC_PP2B_LxvP_1	517	520	PF13499	0.615
DOC_PP4_FxxP_1	241	244	PF00568	0.657
DOC_PP4_FxxP_1	377	380	PF00568	0.676
DOC_USP7_MATH_1	10	14	PF00917	0.674
DOC_USP7_MATH_1	310	314	PF00917	0.720
DOC_USP7_MATH_1	317	321	PF00917	0.576
DOC_USP7_MATH_1	470	474	PF00917	0.623
DOC_USP7_MATH_1	489	493	PF00917	0.596
DOC_USP7_MATH_1	529	533	PF00917	0.644
DOC_WW_Pin1_4	180	185	PF00397	0.763
DOC_WW_Pin1_4	221	226	PF00397	0.717
DOC_WW_Pin1_4	227	232	PF00397	0.741
DOC_WW_Pin1_4	308	313	PF00397	0.686
DOC_WW_Pin1_4	315	320	PF00397	0.634
DOC_WW_Pin1_4	472	477	PF00397	0.759
DOC_WW_Pin1_4	49	54	PF00397	0.524
DOC_WW_Pin1_4	71	76	PF00397	0.688
LIG_14-3-3_CanoR_1	134	139	PF00244	0.604
LIG_14-3-3_CanoR_1	14	21	PF00244	0.700
LIG_14-3-3_CanoR_1	140	145	PF00244	0.573
LIG_14-3-3_CanoR_1	195	199	PF00244	0.665
LIG_14-3-3_CanoR_1	248	254	PF00244	0.535
LIG_14-3-3_CanoR_1	387	397	PF00244	0.638
LIG_14-3-3_CanoR_1	448	453	PF00244	0.680
LIG_14-3-3_CanoR_1	553	557	PF00244	0.541
LIG_BIR_III_2	356	360	PF00653	0.675
LIG_BRCT_BRCA1_1	434	438	PF00533	0.803
LIG_eIF4E_1	116	122	PF01652	0.652
LIG_FHA_1	168	174	PF00498	0.631
LIG_FHA_1	257	263	PF00498	0.518
LIG_FHA_1	316	322	PF00498	0.645
LIG_FHA_1	364	370	PF00498	0.549
LIG_FHA_1	392	398	PF00498	0.769
LIG_FHA_1	80	86	PF00498	0.605
LIG_FHA_2	209	215	PF00498	0.565
LIG_FHA_2	424	430	PF00498	0.676
LIG_FHA_2	43	49	PF00498	0.726
LIG_GBD_Chelix_1	117	125	PF00786	0.646
LIG_Integrin_RGD_1	382	384	PF01839	0.647
LIG_LIR_Apic_2	238	244	PF02991	0.681
LIG_LIR_Gen_1	196	206	PF02991	0.669
LIG_LIR_Nem_3	196	201	PF02991	0.686
LIG_LIR_Nem_3	252	258	PF02991	0.642
LIG_LIR_Nem_3	48	54	PF02991	0.744
LIG_NRBOX	274	280	PF00104	0.431
LIG_NRBOX	335	341	PF00104	0.541
LIG_NRBOX	456	462	PF00104	0.515
LIG_Pex14_1	194	198	PF04695	0.498
LIG_SH2_CRK	198	202	PF00017	0.662
LIG_SH2_CRK	326	330	PF00017	0.537
LIG_SH2_SRC	207	210	PF00017	0.661
LIG_SH2_STAP1	198	202	PF00017	0.662
LIG_SH2_STAP1	393	397	PF00017	0.556
LIG_SH2_STAT5	116	119	PF00017	0.665
LIG_SH2_STAT5	256	259	PF00017	0.537
LIG_SH2_STAT5	326	329	PF00017	0.483
LIG_SH2_STAT5	393	396	PF00017	0.564
LIG_SH2_STAT5	516	519	PF00017	0.615
LIG_SH3_1	179	185	PF00018	0.553
LIG_SH3_3	179	185	PF00018	0.767
LIG_SH3_3	219	225	PF00018	0.756
LIG_SH3_3	286	292	PF00018	0.718
LIG_SH3_3	515	521	PF00018	0.630
LIG_SH3_4	303	310	PF00018	0.580
LIG_SUMO_SIM_anti_2	261	268	PF11976	0.627
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.615
LIG_SUMO_SIM_par_1	23	29	PF11976	0.560
LIG_SUMO_SIM_par_1	256	261	PF11976	0.528
LIG_TRAF2_1	108	111	PF00917	0.746
LIG_TRAF2_1	443	446	PF00917	0.686
LIG_TRFH_1	554	558	PF08558	0.503
LIG_TYR_ITIM	253	258	PF00017	0.635
LIG_TYR_ITIM	324	329	PF00017	0.628
LIG_TYR_ITIM	514	519	PF00017	0.647
LIG_WRC_WIRS_1	209	214	PF05994	0.555
MOD_CDK_SPxxK_3	315	322	PF00069	0.662
MOD_CK1_1	100	106	PF00069	0.775
MOD_CK1_1	193	199	PF00069	0.691
MOD_CK1_1	299	305	PF00069	0.718
MOD_CK1_1	311	317	PF00069	0.632
MOD_CK1_1	392	398	PF00069	0.632
MOD_CK1_1	400	406	PF00069	0.615
MOD_CK1_1	422	428	PF00069	0.708
MOD_CK1_1	43	49	PF00069	0.741
MOD_CK1_1	52	58	PF00069	0.537
MOD_CK1_1	8	14	PF00069	0.646
MOD_CK2_1	105	111	PF00069	0.677
MOD_CK2_1	208	214	PF00069	0.657
MOD_CK2_1	277	283	PF00069	0.733
MOD_CK2_1	423	429	PF00069	0.672
MOD_CK2_1	78	84	PF00069	0.679
MOD_GlcNHglycan	102	105	PF01048	0.677
MOD_GlcNHglycan	111	115	PF01048	0.655
MOD_GlcNHglycan	202	205	PF01048	0.598
MOD_GlcNHglycan	279	282	PF01048	0.557
MOD_GlcNHglycan	298	301	PF01048	0.584
MOD_GlcNHglycan	40	43	PF01048	0.763
MOD_GlcNHglycan	438	441	PF01048	0.674
MOD_GlcNHglycan	45	48	PF01048	0.692
MOD_GlcNHglycan	471	475	PF01048	0.683
MOD_GlcNHglycan	476	479	PF01048	0.721
MOD_GlcNHglycan	487	490	PF01048	0.631
MOD_GlcNHglycan	493	496	PF01048	0.589
MOD_GlcNHglycan	500	503	PF01048	0.769
MOD_GlcNHglycan	531	534	PF01048	0.668
MOD_GlcNHglycan	7	10	PF01048	0.669
MOD_GSK3_1	134	141	PF00069	0.615
MOD_GSK3_1	163	170	PF00069	0.598
MOD_GSK3_1	180	187	PF00069	0.658
MOD_GSK3_1	190	197	PF00069	0.727
MOD_GSK3_1	227	234	PF00069	0.798
MOD_GSK3_1	306	313	PF00069	0.775
MOD_GSK3_1	38	45	PF00069	0.685
MOD_GSK3_1	388	395	PF00069	0.755
MOD_GSK3_1	419	426	PF00069	0.662
MOD_GSK3_1	428	435	PF00069	0.680
MOD_GSK3_1	470	477	PF00069	0.669
MOD_GSK3_1	485	492	PF00069	0.626
MOD_GSK3_1	529	536	PF00069	0.707
MOD_GSK3_1	552	559	PF00069	0.609
MOD_GSK3_1	95	102	PF00069	0.671
MOD_LATS_1	132	138	PF00433	0.597
MOD_LATS_1	361	367	PF00433	0.621
MOD_N-GLC_1	49	54	PF02516	0.629
MOD_NEK2_1	167	172	PF00069	0.672
MOD_NEK2_1	298	303	PF00069	0.589
MOD_NEK2_1	552	557	PF00069	0.530
MOD_NEK2_1	85	90	PF00069	0.646
MOD_NEK2_1	95	100	PF00069	0.620
MOD_OFUCOSY	94	101	PF10250	0.632
MOD_PKA_1	498	504	PF00069	0.603
MOD_PKA_2	13	19	PF00069	0.698
MOD_PKA_2	194	200	PF00069	0.674
MOD_PKA_2	497	503	PF00069	0.684
MOD_PKA_2	552	558	PF00069	0.564
MOD_Plk_1	265	271	PF00069	0.644
MOD_Plk_4	134	140	PF00069	0.611
MOD_Plk_4	163	169	PF00069	0.598
MOD_Plk_4	208	214	PF00069	0.558
MOD_Plk_4	249	255	PF00069	0.649
MOD_Plk_4	324	330	PF00069	0.585
MOD_Plk_4	406	412	PF00069	0.644
MOD_Plk_4	52	58	PF00069	0.712
MOD_ProDKin_1	180	186	PF00069	0.766
MOD_ProDKin_1	221	227	PF00069	0.718
MOD_ProDKin_1	229	235	PF00069	0.752
MOD_ProDKin_1	308	314	PF00069	0.682
MOD_ProDKin_1	315	321	PF00069	0.625
MOD_ProDKin_1	472	478	PF00069	0.768
MOD_ProDKin_1	49	55	PF00069	0.516
MOD_ProDKin_1	71	77	PF00069	0.684
TRG_DiLeu_BaEn_1	332	337	PF01217	0.638
TRG_DiLeu_BaEn_1	459	464	PF01217	0.618
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.715
TRG_DiLeu_LyEn_5	459	464	PF01217	0.618
TRG_ENDOCYTIC_2	198	201	PF00928	0.669
TRG_ENDOCYTIC_2	255	258	PF00928	0.640
TRG_ENDOCYTIC_2	326	329	PF00928	0.620
TRG_ENDOCYTIC_2	516	519	PF00928	0.615
TRG_ER_diArg_1	139	142	PF00400	0.708
TRG_ER_diArg_1	362	364	PF00400	0.654
TRG_ER_diArg_1	370	372	PF00400	0.494
TRG_ER_diArg_1	512	514	PF00400	0.592
TRG_ER_diArg_1	89	91	PF00400	0.707
TRG_NES_CRM1_1	413	427	PF08389	0.531
TRG_NES_CRM1_1	455	469	PF08389	0.627
TRG_NES_CRM1_1	84	97	PF08389	0.599
TRG_Pf-PMV_PEXEL_1	462	467	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J4	Leptomonas seymouri	29%	100%
A0A3Q8ID76	Leishmania donovani	100%	100%
A4HDZ3	Leishmania braziliensis	66%	100%
E9AXC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA44	Leishmania major	86%	100%