Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I189_LEIIN

TriTrypDb:

LINF_250009800

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I189

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I189

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.511
CLV_PCSK_KEX2_1	109	111	PF00082	0.678
CLV_PCSK_KEX2_1	6	8	PF00082	0.511
CLV_PCSK_KEX2_1	70	72	PF00082	0.478
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.678
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.511
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.478
CLV_PCSK_SKI1_1	79	83	PF00082	0.411
DEG_APCC_DBOX_1	78	86	PF00400	0.546
DOC_CKS1_1	30	35	PF01111	0.703
DOC_MAPK_gen_1	6	14	PF00069	0.709
DOC_MAPK_HePTP_8	4	16	PF00069	0.708
DOC_MAPK_MEF2A_6	7	16	PF00069	0.709
DOC_MAPK_MEF2A_6	79	87	PF00069	0.375
DOC_WW_Pin1_4	17	22	PF00397	0.718
DOC_WW_Pin1_4	25	30	PF00397	0.697
DOC_WW_Pin1_4	53	58	PF00397	0.746
LIG_APCC_ABBA_1	22	27	PF00400	0.720
LIG_eIF4E_1	80	86	PF01652	0.338
LIG_FHA_1	86	92	PF00498	0.513
LIG_FHA_2	26	32	PF00498	0.714
LIG_FHA_2	37	43	PF00498	0.689
LIG_FHA_2	99	105	PF00498	0.435
LIG_LIR_Gen_1	78	87	PF02991	0.546
LIG_NRBOX	86	92	PF00104	0.455
LIG_PDZ_Class_3	128	133	PF00595	0.482
LIG_SH2_CRK	72	76	PF00017	0.647
LIG_SH2_STAT5	80	83	PF00017	0.411
LIG_SH3_3	114	120	PF00018	0.451
LIG_SH3_3	27	33	PF00018	0.811
LIG_SH3_3	51	57	PF00018	0.741
LIG_SUMO_SIM_par_1	82	88	PF11976	0.364
LIG_TRAF2_1	38	41	PF00917	0.701
MOD_CK1_1	52	58	PF00069	0.810
MOD_CK2_1	29	35	PF00069	0.726
MOD_CK2_1	36	42	PF00069	0.724
MOD_CK2_1	44	50	PF00069	0.646
MOD_CK2_1	98	104	PF00069	0.445
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.745
MOD_GSK3_1	118	125	PF00069	0.524
MOD_GSK3_1	25	32	PF00069	0.733
MOD_GSK3_1	49	56	PF00069	0.736
MOD_NEK2_1	49	54	PF00069	0.766
MOD_NEK2_1	85	90	PF00069	0.369
MOD_NEK2_1	92	97	PF00069	0.349
MOD_PK_1	8	14	PF00069	0.726
MOD_PKA_2	52	58	PF00069	0.810
MOD_Plk_1	8	14	PF00069	0.693
MOD_Plk_2-3	100	106	PF00069	0.462
MOD_Plk_4	85	91	PF00069	0.424
MOD_ProDKin_1	17	23	PF00069	0.720
MOD_ProDKin_1	25	31	PF00069	0.699
MOD_ProDKin_1	53	59	PF00069	0.747
MOD_SUMO_rev_2	104	111	PF00179	0.435
MOD_SUMO_rev_2	95	103	PF00179	0.595
TRG_DiLeu_BaEn_1	78	83	PF01217	0.619
TRG_ENDOCYTIC_2	72	75	PF00928	0.649
TRG_ENDOCYTIC_2	80	83	PF00928	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C5	Leptomonas seymouri	50%	100%
A0A3S7WYV4	Leishmania donovani	100%	100%
A4HDY8	Leishmania braziliensis	70%	100%
E9AXC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QA49	Leishmania major	88%	100%