G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ferrous iron transport protein B/50S ribosome-binding GTPase/Protein of unknown function - DUF258 - putative

Species:

Leishmania infantum

UniProt:

A4I188_LEIIN

TriTrypDb:

LINF_250009700

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I188

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I188

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	1
GO:0002097	tRNA wobble base modification	7	1
GO:0002098	tRNA wobble uridine modification	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0030488	tRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.552
CLV_NRD_NRD_1	125	127	PF00675	0.503
CLV_NRD_NRD_1	157	159	PF00675	0.501
CLV_NRD_NRD_1	265	267	PF00675	0.234
CLV_NRD_NRD_1	28	30	PF00675	0.555
CLV_NRD_NRD_1	309	311	PF00675	0.363
CLV_NRD_NRD_1	385	387	PF00675	0.562
CLV_NRD_NRD_1	425	427	PF00675	0.505
CLV_PCSK_FUR_1	263	267	PF00082	0.335
CLV_PCSK_KEX2_1	124	126	PF00082	0.496
CLV_PCSK_KEX2_1	148	150	PF00082	0.532
CLV_PCSK_KEX2_1	157	159	PF00082	0.456
CLV_PCSK_KEX2_1	265	267	PF00082	0.257
CLV_PCSK_KEX2_1	28	30	PF00082	0.555
CLV_PCSK_KEX2_1	309	311	PF00082	0.423
CLV_PCSK_KEX2_1	385	387	PF00082	0.562
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.610
CLV_PCSK_SKI1_1	109	113	PF00082	0.508
CLV_PCSK_SKI1_1	200	204	PF00082	0.266
CLV_PCSK_SKI1_1	28	32	PF00082	0.430
CLV_PCSK_SKI1_1	386	390	PF00082	0.500
CLV_PCSK_SKI1_1	474	478	PF00082	0.333
CLV_Separin_Metazoa	306	310	PF03568	0.492
CLV_Separin_Metazoa	399	403	PF03568	0.340
DEG_APCC_DBOX_1	340	348	PF00400	0.452
DEG_SPOP_SBC_1	41	45	PF00917	0.470
DOC_CKS1_1	251	256	PF01111	0.431
DOC_CKS1_1	328	333	PF01111	0.392
DOC_CKS1_1	58	63	PF01111	0.504
DOC_CYCLIN_RxL_1	109	120	PF00134	0.502
DOC_CYCLIN_RxL_1	331	342	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.326
DOC_MAPK_gen_1	17	26	PF00069	0.463
DOC_MAPK_gen_1	28	34	PF00069	0.425
DOC_MAPK_MEF2A_6	314	322	PF00069	0.330
DOC_MAPK_MEF2A_6	47	54	PF00069	0.497
DOC_PP1_RVXF_1	198	204	PF00149	0.265
DOC_PP1_RVXF_1	332	339	PF00149	0.378
DOC_PP1_RVXF_1	418	425	PF00149	0.352
DOC_PP2B_LxvP_1	24	27	PF13499	0.448
DOC_PP2B_LxvP_1	287	290	PF13499	0.297
DOC_PP2B_LxvP_1	347	350	PF13499	0.439
DOC_PP2B_LxvP_1	391	394	PF13499	0.513
DOC_PP4_FxxP_1	203	206	PF00568	0.498
DOC_PP4_FxxP_1	440	443	PF00568	0.348
DOC_PP4_FxxP_1	480	483	PF00568	0.376
DOC_USP7_MATH_1	183	187	PF00917	0.632
DOC_USP7_MATH_1	42	46	PF00917	0.472
DOC_USP7_UBL2_3	234	238	PF12436	0.456
DOC_WW_Pin1_4	157	162	PF00397	0.458
DOC_WW_Pin1_4	17	22	PF00397	0.447
DOC_WW_Pin1_4	250	255	PF00397	0.431
DOC_WW_Pin1_4	327	332	PF00397	0.408
DOC_WW_Pin1_4	46	51	PF00397	0.503
DOC_WW_Pin1_4	57	62	PF00397	0.481
LIG_14-3-3_CanoR_1	118	122	PF00244	0.536
LIG_14-3-3_CanoR_1	130	135	PF00244	0.531
LIG_14-3-3_CanoR_1	402	406	PF00244	0.464
LIG_APCC_ABBA_1	436	441	PF00400	0.444
LIG_Clathr_ClatBox_1	248	252	PF01394	0.442
LIG_FHA_1	110	116	PF00498	0.602
LIG_FHA_1	210	216	PF00498	0.456
LIG_FHA_1	235	241	PF00498	0.454
LIG_FHA_1	244	250	PF00498	0.441
LIG_FHA_1	251	257	PF00498	0.479
LIG_FHA_1	259	265	PF00498	0.491
LIG_FHA_1	303	309	PF00498	0.549
LIG_FHA_1	352	358	PF00498	0.489
LIG_FHA_1	429	435	PF00498	0.397
LIG_FHA_1	46	52	PF00498	0.647
LIG_FHA_1	84	90	PF00498	0.470
LIG_FHA_2	158	164	PF00498	0.434
LIG_FHA_2	240	246	PF00498	0.535
LIG_FHA_2	321	327	PF00498	0.338
LIG_FHA_2	340	346	PF00498	0.353
LIG_FHA_2	402	408	PF00498	0.431
LIG_FHA_2	423	429	PF00498	0.378
LIG_FHA_2	462	468	PF00498	0.503
LIG_LIR_Apic_2	437	443	PF02991	0.341
LIG_LIR_Gen_1	404	413	PF02991	0.487
LIG_LIR_LC3C_4	282	286	PF02991	0.497
LIG_LIR_Nem_3	107	111	PF02991	0.491
LIG_LIR_Nem_3	156	162	PF02991	0.444
LIG_LIR_Nem_3	163	169	PF02991	0.451
LIG_LIR_Nem_3	404	408	PF02991	0.474
LIG_LIR_Nem_3	448	453	PF02991	0.349
LIG_Pex14_2	473	477	PF04695	0.405
LIG_REV1ctd_RIR_1	437	442	PF16727	0.335
LIG_SH2_CRK	108	112	PF00017	0.361
LIG_SH2_CRK	276	280	PF00017	0.535
LIG_SH2_CRK	375	379	PF00017	0.358
LIG_SH2_NCK_1	159	163	PF00017	0.431
LIG_SH2_NCK_1	375	379	PF00017	0.358
LIG_SH2_STAP1	276	280	PF00017	0.535
LIG_SH2_STAP1	83	87	PF00017	0.454
LIG_SH2_STAT5	159	162	PF00017	0.423
LIG_SH2_STAT5	337	340	PF00017	0.353
LIG_SH2_STAT5	83	86	PF00017	0.541
LIG_SH3_3	187	193	PF00018	0.480
LIG_SH3_3	325	331	PF00018	0.379
LIG_SH3_3	55	61	PF00018	0.498
LIG_SH3_3	94	100	PF00018	0.501
LIG_Sin3_3	30	37	PF02671	0.436
LIG_SUMO_SIM_anti_2	245	253	PF11976	0.458
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.442
LIG_SUMO_SIM_anti_2	48	56	PF11976	0.498
LIG_SUMO_SIM_par_1	130	137	PF11976	0.625
LIG_SUMO_SIM_par_1	245	253	PF11976	0.445
LIG_SUMO_SIM_par_1	363	370	PF11976	0.334
LIG_SUMO_SIM_par_1	48	56	PF11976	0.501
LIG_TRAF2_1	161	164	PF00917	0.432
LIG_WRC_WIRS_1	446	451	PF05994	0.347
MOD_CDK_SPK_2	327	332	PF00069	0.365
MOD_CDK_SPxxK_3	327	334	PF00069	0.395
MOD_CK1_1	120	126	PF00069	0.483
MOD_CK1_1	133	139	PF00069	0.500
MOD_CK1_1	186	192	PF00069	0.547
MOD_CK1_1	429	435	PF00069	0.369
MOD_CK1_1	43	49	PF00069	0.500
MOD_CK2_1	157	163	PF00069	0.431
MOD_CK2_1	339	345	PF00069	0.357
MOD_CK2_1	401	407	PF00069	0.470
MOD_CK2_1	422	428	PF00069	0.466
MOD_CK2_1	461	467	PF00069	0.540
MOD_GlcNHglycan	180	183	PF01048	0.634
MOD_GlcNHglycan	269	272	PF01048	0.271
MOD_GlcNHglycan	362	365	PF01048	0.442
MOD_GlcNHglycan	428	431	PF01048	0.395
MOD_GSK3_1	116	123	PF00069	0.539
MOD_GSK3_1	210	217	PF00069	0.456
MOD_GSK3_1	230	237	PF00069	0.345
MOD_GSK3_1	239	246	PF00069	0.409
MOD_GSK3_1	339	346	PF00069	0.362
MOD_GSK3_1	351	358	PF00069	0.412
MOD_GSK3_1	41	48	PF00069	0.497
MOD_GSK3_1	422	429	PF00069	0.397
MOD_GSK3_1	53	60	PF00069	0.496
MOD_GSK3_1	65	72	PF00069	0.508
MOD_GSK3_1	73	80	PF00069	0.459
MOD_GSK3_1	83	90	PF00069	0.440
MOD_N-GLC_1	17	22	PF02516	0.447
MOD_NEK2_1	104	109	PF00069	0.446
MOD_NEK2_1	111	116	PF00069	0.440
MOD_NEK2_1	178	183	PF00069	0.657
MOD_NEK2_1	214	219	PF00069	0.452
MOD_NEK2_1	32	37	PF00069	0.450
MOD_NEK2_1	401	406	PF00069	0.420
MOD_NEK2_1	422	427	PF00069	0.498
MOD_NEK2_2	239	244	PF00069	0.431
MOD_NEK2_2	445	450	PF00069	0.332
MOD_PIKK_1	243	249	PF00454	0.431
MOD_PIKK_1	258	264	PF00454	0.431
MOD_PK_1	130	136	PF00069	0.493
MOD_PKA_1	426	432	PF00069	0.389
MOD_PKA_2	117	123	PF00069	0.572
MOD_PKA_2	258	264	PF00069	0.500
MOD_PKA_2	401	407	PF00069	0.372
MOD_Plk_1	355	361	PF00069	0.406
MOD_Plk_4	130	136	PF00069	0.493
MOD_Plk_4	210	216	PF00069	0.448
MOD_Plk_4	320	326	PF00069	0.473
MOD_Plk_4	401	407	PF00069	0.470
MOD_ProDKin_1	157	163	PF00069	0.460
MOD_ProDKin_1	17	23	PF00069	0.447
MOD_ProDKin_1	250	256	PF00069	0.431
MOD_ProDKin_1	327	333	PF00069	0.408
MOD_ProDKin_1	46	52	PF00069	0.505
MOD_ProDKin_1	57	63	PF00069	0.483
MOD_SUMO_rev_2	297	303	PF00179	0.354
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.496
TRG_ENDOCYTIC_2	108	111	PF00928	0.366
TRG_ENDOCYTIC_2	159	162	PF00928	0.423
TRG_ENDOCYTIC_2	276	279	PF00928	0.535
TRG_ENDOCYTIC_2	337	340	PF00928	0.353
TRG_ENDOCYTIC_2	450	453	PF00928	0.350
TRG_ER_diArg_1	124	126	PF00400	0.500
TRG_ER_diArg_1	14	17	PF00400	0.470
TRG_ER_diArg_1	157	159	PF00400	0.492
TRG_ER_diArg_1	263	266	PF00400	0.436
TRG_ER_diArg_1	27	29	PF00400	0.421
TRG_ER_diArg_1	308	310	PF00400	0.502
TRG_ER_diArg_1	331	334	PF00400	0.420
TRG_ER_diArg_1	384	386	PF00400	0.563
TRG_ER_diArg_1	417	420	PF00400	0.353
TRG_NES_CRM1_1	315	326	PF08389	0.476
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER9	Leptomonas seymouri	83%	100%
A0A0S4IU66	Bodo saltans	50%	100%
A0A1X0P4I4	Trypanosomatidae	64%	100%
A0A3R7NZ49	Trypanosoma rangeli	66%	100%
A0A3S5H7E2	Leishmania donovani	100%	100%
A4HDY7	Leishmania braziliensis	91%	100%
D0A5H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AXC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QA50	Leishmania major	94%	98%
V5B7N0	Trypanosoma cruzi	65%	100%