Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat/Utp13 specific WD40 associated domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I186_LEIIN

TriTrypDb:

LINF_250009500

Length:

1017

Annotations

Annotations by Jardim et al.

RNA Processing, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005840	ribosome	5	12
GO:0030684	preribosome	3	12
GO:0030686	90S preribosome	4	1
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12

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Phosphorylation

Promastigote: 99

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I186

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I186

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0030515	snoRNA binding	5	1
GO:0034511	U3 snoRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.592
CLV_MEL_PAP_1	641	647	PF00089	0.348
CLV_NRD_NRD_1	1004	1006	PF00675	0.635
CLV_NRD_NRD_1	367	369	PF00675	0.310
CLV_NRD_NRD_1	379	381	PF00675	0.478
CLV_NRD_NRD_1	432	434	PF00675	0.386
CLV_NRD_NRD_1	466	468	PF00675	0.650
CLV_NRD_NRD_1	712	714	PF00675	0.203
CLV_NRD_NRD_1	856	858	PF00675	0.271
CLV_NRD_NRD_1	962	964	PF00675	0.354

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W8	Leptomonas seymouri	71%	100%
A0A0S4IPM0	Bodo saltans	41%	100%
A0A1X0P4G2	Trypanosomatidae	53%	100%
A0A3Q8IN66	Leishmania donovani	100%	100%
A0A3S5IS62	Trypanosoma rangeli	50%	100%
A4HDY5	Leishmania braziliensis	84%	100%
D0A5H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AXC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q05946	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q12788	Homo sapiens	28%	100%

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