LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Translation initiation factor SUI1 - putative
Species:
Leishmania infantum
UniProt:
A4I184_LEIIN
TriTrypDb:
LINF_250009300
Length:
295

Annotations

Annotations by Jardim et al.

Translation, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I184
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I184

Function

Biological processes
Term Name Level Count
GO:0001731 formation of translation preinitiation complex 7 1
GO:0002183 cytoplasmic translational initiation 4 1
GO:0002188 translation reinitiation 5 1
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003743 translation initiation factor activity 4 11
GO:0005488 binding 1 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003723 RNA binding 4 1
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 165 169 PF00656 0.555
CLV_NRD_NRD_1 173 175 PF00675 0.475
CLV_NRD_NRD_1 176 178 PF00675 0.510
CLV_NRD_NRD_1 212 214 PF00675 0.286
CLV_NRD_NRD_1 235 237 PF00675 0.348
CLV_NRD_NRD_1 94 96 PF00675 0.754
CLV_PCSK_FUR_1 174 178 PF00082 0.497
CLV_PCSK_FUR_1 3 7 PF00082 0.670
CLV_PCSK_KEX2_1 175 177 PF00082 0.507
CLV_PCSK_KEX2_1 208 210 PF00082 0.357
CLV_PCSK_KEX2_1 212 214 PF00082 0.338
CLV_PCSK_KEX2_1 237 239 PF00082 0.348
CLV_PCSK_KEX2_1 5 7 PF00082 0.701
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.486
CLV_PCSK_PC1ET2_1 208 210 PF00082 0.357
CLV_PCSK_PC1ET2_1 237 239 PF00082 0.348
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.701
CLV_PCSK_PC7_1 172 178 PF00082 0.491
CLV_PCSK_PC7_1 233 239 PF00082 0.336
CLV_PCSK_SKI1_1 176 180 PF00082 0.515
CLV_PCSK_SKI1_1 192 196 PF00082 0.568
CLV_PCSK_SKI1_1 213 217 PF00082 0.314
DOC_CKS1_1 54 59 PF01111 0.713
DOC_MAPK_gen_1 195 203 PF00069 0.475
DOC_MAPK_gen_1 276 284 PF00069 0.564
DOC_MAPK_gen_1 84 93 PF00069 0.621
DOC_USP7_MATH_1 278 282 PF00917 0.521
DOC_USP7_UBL2_3 77 81 PF12436 0.669
DOC_USP7_UBL2_3 97 101 PF12436 0.605
DOC_WW_Pin1_4 53 58 PF00397 0.722
LIG_14-3-3_CanoR_1 176 185 PF00244 0.501
LIG_14-3-3_CanoR_1 212 221 PF00244 0.473
LIG_14-3-3_CanoR_1 236 245 PF00244 0.556
LIG_14-3-3_CanoR_1 6 15 PF00244 0.578
LIG_Actin_RPEL_3 185 204 PF02755 0.516
LIG_Actin_WH2_2 214 231 PF00022 0.543
LIG_deltaCOP1_diTrp_1 234 239 PF00928 0.458
LIG_FHA_2 178 184 PF00498 0.500
LIG_GBD_Chelix_1 263 271 PF00786 0.258
LIG_LIR_Apic_2 273 278 PF02991 0.472
LIG_LIR_Nem_3 132 138 PF02991 0.428
LIG_LIR_Nem_3 147 151 PF02991 0.387
LIG_Pex14_1 158 162 PF04695 0.347
LIG_Pex14_1 235 239 PF04695 0.458
LIG_SH2_CRK 135 139 PF00017 0.409
LIG_SH2_CRK 275 279 PF00017 0.458
LIG_SH2_STAP1 162 166 PF00017 0.371
LIG_SH2_STAT5 135 138 PF00017 0.398
LIG_SH2_STAT5 283 286 PF00017 0.448
LIG_SH3_3 288 294 PF00018 0.554
LIG_SUMO_SIM_anti_2 199 205 PF11976 0.302
LIG_SUMO_SIM_par_1 119 126 PF11976 0.651
LIG_SUMO_SIM_par_1 199 205 PF11976 0.321
LIG_TRAF2_1 118 121 PF00917 0.688
LIG_TRAF2_1 247 250 PF00917 0.458
LIG_TYR_ITIM 133 138 PF00017 0.422
MOD_CK1_1 4 10 PF00069 0.711
MOD_CK2_1 14 20 PF00069 0.681
MOD_Cter_Amidation 172 175 PF01082 0.480
MOD_Cter_Amidation 210 213 PF01082 0.272
MOD_Cter_Amidation 286 289 PF01082 0.580
MOD_GlcNHglycan 147 151 PF01048 0.439
MOD_GlcNHglycan 26 29 PF01048 0.768
MOD_GlcNHglycan 46 49 PF01048 0.712
MOD_GlcNHglycan 60 63 PF01048 0.691
MOD_GSK3_1 24 31 PF00069 0.709
MOD_GSK3_1 58 65 PF00069 0.714
MOD_NEK2_1 1 6 PF00069 0.648
MOD_NEK2_1 123 128 PF00069 0.587
MOD_NEK2_1 214 219 PF00069 0.486
MOD_NEK2_1 270 275 PF00069 0.548
MOD_NEK2_2 278 283 PF00069 0.518
MOD_PKA_1 237 243 PF00069 0.548
MOD_PKA_1 96 102 PF00069 0.513
MOD_PKA_2 237 243 PF00069 0.556
MOD_PKA_2 62 68 PF00069 0.715
MOD_Plk_4 214 220 PF00069 0.548
MOD_Plk_4 278 284 PF00069 0.513
MOD_Plk_4 28 34 PF00069 0.555
MOD_ProDKin_1 53 59 PF00069 0.722
MOD_SUMO_rev_2 100 109 PF00179 0.697
TRG_DiLeu_BaEn_1 280 285 PF01217 0.550
TRG_DiLeu_BaLyEn_6 119 124 PF01217 0.555
TRG_ENDOCYTIC_2 135 138 PF00928 0.426
TRG_ER_diArg_1 174 177 PF00400 0.497
TRG_ER_diArg_1 212 214 PF00400 0.543
TRG_ER_diArg_1 235 238 PF00400 0.548
TRG_NLS_Bipartite_1 79 99 PF00514 0.691
TRG_NLS_MonoCore_2 173 178 PF00514 0.469
TRG_NLS_MonoExtC_3 287 292 PF00514 0.525
TRG_NLS_MonoExtC_3 94 100 PF00514 0.616
TRG_NLS_MonoExtN_4 172 179 PF00514 0.472
TRG_NLS_MonoExtN_4 233 240 PF00514 0.548
TRG_NLS_MonoExtN_4 3 9 PF00514 0.599
TRG_Pf-PMV_PEXEL_1 177 181 PF00026 0.566

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAD2 Leptomonas seymouri 59% 100%
A0A1X0P4H3 Trypanosomatidae 60% 100%
A0A3Q8ICD2 Leishmania donovani 99% 100%
A0A3R7KWX6 Trypanosoma rangeli 55% 100%
A4HDY3 Leishmania braziliensis 79% 100%
D0A5G8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AXB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QA54 Leishmania major 91% 100%
V5BN78 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS