Fcf2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I180_LEIIN

TriTrypDb:

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I180

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I180

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.528
CLV_NRD_NRD_1	115	117	PF00675	0.269
CLV_NRD_NRD_1	171	173	PF00675	0.636
CLV_NRD_NRD_1	36	38	PF00675	0.498
CLV_NRD_NRD_1	45	47	PF00675	0.481
CLV_PCSK_FUR_1	111	115	PF00082	0.269
CLV_PCSK_FUR_1	138	142	PF00082	0.448
CLV_PCSK_FUR_1	42	46	PF00082	0.612
CLV_PCSK_KEX2_1	113	115	PF00082	0.314
CLV_PCSK_KEX2_1	140	142	PF00082	0.428
CLV_PCSK_KEX2_1	167	169	PF00082	0.491
CLV_PCSK_KEX2_1	171	173	PF00082	0.495
CLV_PCSK_KEX2_1	44	46	PF00082	0.506
CLV_PCSK_KEX2_1	60	62	PF00082	0.295
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.314
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.441
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.491
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.495
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.578
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.345
CLV_PCSK_PC7_1	111	117	PF00082	0.269
CLV_PCSK_SKI1_1	16	20	PF00082	0.459
DEG_SPOP_SBC_1	17	21	PF00917	0.459
DOC_PP4_FxxP_1	79	82	PF00568	0.303
DOC_USP7_MATH_1	17	21	PF00917	0.462
DOC_USP7_MATH_1	3	7	PF00917	0.540
DOC_USP7_UBL2_3	140	144	PF12436	0.532
DOC_USP7_UBL2_3	163	167	PF12436	0.493
DOC_USP7_UBL2_3	171	175	PF12436	0.517
LIG_14-3-3_CanoR_1	115	121	PF00244	0.274
LIG_BRCT_BRCA1_1	20	24	PF00533	0.456
LIG_deltaCOP1_diTrp_1	122	131	PF00928	0.414
LIG_LIR_Gen_1	97	107	PF02991	0.297
LIG_LIR_Nem_3	97	103	PF02991	0.297
LIG_PDZ_Class_3	174	179	PF00595	0.665
LIG_Pex14_2	120	124	PF04695	0.269
LIG_PTB_Apo_2	125	132	PF02174	0.414
LIG_SH2_STAT5	105	108	PF00017	0.354
LIG_SUMO_SIM_anti_2	70	75	PF11976	0.269
LIG_WRC_WIRS_1	117	122	PF05994	0.247
MOD_CK1_1	4	10	PF00069	0.668
MOD_GlcNHglycan	20	23	PF01048	0.568
MOD_GlcNHglycan	3	6	PF01048	0.638
MOD_GSK3_1	167	174	PF00069	0.594
MOD_PIKK_1	50	56	PF00454	0.269
MOD_PKA_1	140	146	PF00069	0.566
MOD_PKA_1	167	173	PF00069	0.507
MOD_PKA_2	140	146	PF00069	0.472
MOD_PKA_2	167	173	PF00069	0.636
MOD_PKB_1	114	122	PF00069	0.269
MOD_SUMO_rev_2	43	51	PF00179	0.501
TRG_ENDOCYTIC_2	117	120	PF00928	0.359
TRG_ENDOCYTIC_2	76	79	PF00928	0.328
TRG_ER_diArg_1	114	116	PF00400	0.269
TRG_NLS_Bipartite_1	155	176	PF00514	0.504
TRG_NLS_Bipartite_1	44	63	PF00514	0.367
TRG_NLS_MonoCore_2	112	117	PF00514	0.269
TRG_NLS_MonoExtC_3	170	175	PF00514	0.528
TRG_NLS_MonoExtN_4	111	117	PF00514	0.269
TRG_NLS_MonoExtN_4	168	175	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK2	Leptomonas seymouri	81%	100%
A0A0S4JBE6	Bodo saltans	52%	97%
A0A1X0P5L4	Trypanosomatidae	54%	100%
A0A3R7RI11	Trypanosoma rangeli	57%	96%
A0A3S7WYT4	Leishmania donovani	99%	100%
A4H4A5	Leishmania braziliensis	82%	100%
D0A5G5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AXB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QA58	Leishmania major	97%	100%
V5B7R5	Trypanosoma cruzi	56%	100%