Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I176_LEIIN

TriTrypDb:

LINF_250008500

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I176

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I176

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	2
GO:0005198	structural molecule activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.729
CLV_C14_Caspase3-7	502	506	PF00656	0.497
CLV_NRD_NRD_1	342	344	PF00675	0.764
CLV_NRD_NRD_1	364	366	PF00675	0.640
CLV_NRD_NRD_1	423	425	PF00675	0.722
CLV_NRD_NRD_1	457	459	PF00675	0.705
CLV_NRD_NRD_1	562	564	PF00675	0.729
CLV_NRD_NRD_1	573	575	PF00675	0.664
CLV_PCSK_FUR_1	560	564	PF00082	0.823
CLV_PCSK_FUR_1	571	575	PF00082	0.483
CLV_PCSK_KEX2_1	248	250	PF00082	0.850
CLV_PCSK_KEX2_1	342	344	PF00082	0.772
CLV_PCSK_KEX2_1	423	425	PF00082	0.722
CLV_PCSK_KEX2_1	457	459	PF00082	0.705
CLV_PCSK_KEX2_1	562	564	PF00082	0.729
CLV_PCSK_KEX2_1	573	575	PF00082	0.664
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.850
CLV_PCSK_PC7_1	338	344	PF00082	0.729
CLV_PCSK_PC7_1	419	425	PF00082	0.705
CLV_PCSK_SKI1_1	119	123	PF00082	0.656
CLV_PCSK_SKI1_1	129	133	PF00082	0.542
CLV_PCSK_SKI1_1	372	376	PF00082	0.578
CLV_PCSK_SKI1_1	585	589	PF00082	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.723
DEG_SCF_FBW7_2	300	306	PF00400	0.758
DEG_SPOP_SBC_1	152	156	PF00917	0.704
DEG_SPOP_SBC_1	609	613	PF00917	0.679
DOC_CKS1_1	265	270	PF01111	0.719
DOC_CKS1_1	300	305	PF01111	0.759
DOC_CKS1_1	427	432	PF01111	0.685
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.717
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.485
DOC_MAPK_DCC_7	661	671	PF00069	0.483
DOC_MAPK_gen_1	127	134	PF00069	0.690
DOC_MAPK_gen_1	571	580	PF00069	0.569
DOC_MAPK_MEF2A_6	571	580	PF00069	0.569
DOC_PP1_RVXF_1	476	483	PF00149	0.546
DOC_PP2B_LxvP_1	400	403	PF13499	0.513
DOC_PP2B_LxvP_1	525	528	PF13499	0.513
DOC_USP7_MATH_1	103	107	PF00917	0.672
DOC_USP7_MATH_1	110	114	PF00917	0.700
DOC_USP7_MATH_1	152	156	PF00917	0.676
DOC_USP7_MATH_1	22	26	PF00917	0.761
DOC_USP7_MATH_1	244	248	PF00917	0.698
DOC_USP7_MATH_1	255	259	PF00917	0.783
DOC_USP7_MATH_1	276	280	PF00917	0.814
DOC_USP7_MATH_1	285	289	PF00917	0.756
DOC_USP7_MATH_1	293	297	PF00917	0.645
DOC_USP7_MATH_1	307	311	PF00917	0.786
DOC_USP7_MATH_1	325	329	PF00917	0.633
DOC_USP7_MATH_1	411	415	PF00917	0.660
DOC_USP7_MATH_1	439	443	PF00917	0.641
DOC_USP7_MATH_1	77	81	PF00917	0.742
DOC_USP7_MATH_1	86	90	PF00917	0.688
DOC_WW_Pin1_4	148	153	PF00397	0.661
DOC_WW_Pin1_4	166	171	PF00397	0.493
DOC_WW_Pin1_4	18	23	PF00397	0.742
DOC_WW_Pin1_4	186	191	PF00397	0.666
DOC_WW_Pin1_4	213	218	PF00397	0.737
DOC_WW_Pin1_4	259	264	PF00397	0.810
DOC_WW_Pin1_4	279	284	PF00397	0.605
DOC_WW_Pin1_4	287	292	PF00397	0.706
DOC_WW_Pin1_4	29	34	PF00397	0.660
DOC_WW_Pin1_4	294	299	PF00397	0.685
DOC_WW_Pin1_4	326	331	PF00397	0.762
DOC_WW_Pin1_4	348	353	PF00397	0.725
DOC_WW_Pin1_4	360	365	PF00397	0.762
DOC_WW_Pin1_4	426	431	PF00397	0.677
DOC_WW_Pin1_4	433	438	PF00397	0.704
DOC_WW_Pin1_4	441	446	PF00397	0.711
DOC_WW_Pin1_4	47	52	PF00397	0.692
DOC_WW_Pin1_4	547	552	PF00397	0.519
LIG_14-3-3_CanoR_1	159	165	PF00244	0.748
LIG_14-3-3_CanoR_1	204	209	PF00244	0.846
LIG_14-3-3_CanoR_1	324	330	PF00244	0.732
LIG_14-3-3_CanoR_1	342	350	PF00244	0.644
LIG_14-3-3_CanoR_1	365	374	PF00244	0.788
LIG_14-3-3_CanoR_1	424	430	PF00244	0.720
LIG_14-3-3_CanoR_1	539	545	PF00244	0.552
LIG_BIR_III_4	238	242	PF00653	0.650
LIG_BRCT_BRCA1_1	540	544	PF00533	0.387
LIG_EVH1_2	260	264	PF00568	0.625
LIG_FHA_1	404	410	PF00498	0.678
LIG_FHA_1	427	433	PF00498	0.629
LIG_FHA_1	448	454	PF00498	0.700
LIG_FHA_1	48	54	PF00498	0.657
LIG_FHA_1	502	508	PF00498	0.505
LIG_FHA_1	600	606	PF00498	0.464
LIG_FHA_2	447	453	PF00498	0.567
LIG_IBAR_NPY_1	90	92	PF08397	0.804
LIG_KLC1_Yacidic_2	643	647	PF13176	0.560
LIG_LIR_Apic_2	462	468	PF02991	0.621
LIG_LIR_Apic_2	618	624	PF02991	0.650
LIG_LIR_Apic_2	96	100	PF02991	0.791
LIG_LIR_Nem_3	584	590	PF02991	0.489
LIG_NRBOX	677	683	PF00104	0.342
LIG_PDZ_Class_2	680	685	PF00595	0.472
LIG_Pex14_2	544	548	PF04695	0.467
LIG_PTAP_UEV_1	256	261	PF05743	0.628
LIG_SH2_CRK	54	58	PF00017	0.730
LIG_SH2_CRK	621	625	PF00017	0.623
LIG_SH2_SRC	465	468	PF00017	0.699
LIG_SH2_SRC	625	628	PF00017	0.613
LIG_SH2_SRC	645	648	PF00017	0.252
LIG_SH2_STAP1	45	49	PF00017	0.753
LIG_SH2_STAT5	229	232	PF00017	0.742
LIG_SH2_STAT5	45	48	PF00017	0.753
LIG_SH2_STAT5	497	500	PF00017	0.395
LIG_SH2_STAT5	599	602	PF00017	0.463
LIG_SH2_STAT5	645	648	PF00017	0.582
LIG_SH2_STAT5	67	70	PF00017	0.753
LIG_SH2_STAT5	72	75	PF00017	0.726
LIG_SH2_STAT5	92	95	PF00017	0.730
LIG_SH3_1	347	353	PF00018	0.783
LIG_SH3_1	361	367	PF00018	0.556
LIG_SH3_1	465	471	PF00018	0.578
LIG_SH3_1	621	627	PF00018	0.621
LIG_SH3_2	100	105	PF14604	0.678
LIG_SH3_2	300	305	PF14604	0.759
LIG_SH3_3	159	165	PF00018	0.689
LIG_SH3_3	208	214	PF00018	0.749
LIG_SH3_3	251	257	PF00018	0.759
LIG_SH3_3	297	303	PF00018	0.705
LIG_SH3_3	347	353	PF00018	0.783
LIG_SH3_3	361	367	PF00018	0.556
LIG_SH3_3	435	441	PF00018	0.785
LIG_SH3_3	465	471	PF00018	0.678
LIG_SH3_3	621	627	PF00018	0.621
LIG_SH3_3	662	668	PF00018	0.492
LIG_SH3_3	80	86	PF00018	0.789
LIG_SH3_3	97	103	PF00018	0.586
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.624
LIG_SUMO_SIM_par_1	667	673	PF11976	0.443
LIG_SxIP_EBH_1	19	33	PF03271	0.806
MOD_CDC14_SPxK_1	292	295	PF00782	0.746
MOD_CDC14_SPxK_1	331	334	PF00782	0.837
MOD_CDC14_SPxK_1	34	37	PF00782	0.691
MOD_CDC14_SPxK_1	363	366	PF00782	0.783
MOD_CDK_SPK_2	360	365	PF00069	0.773
MOD_CDK_SPxK_1	289	295	PF00069	0.754
MOD_CDK_SPxK_1	299	305	PF00069	0.718
MOD_CDK_SPxK_1	31	37	PF00069	0.691
MOD_CDK_SPxK_1	328	334	PF00069	0.831
MOD_CDK_SPxK_1	360	366	PF00069	0.791
MOD_CDK_SPxxK_3	441	448	PF00069	0.696
MOD_CK1_1	151	157	PF00069	0.772
MOD_CK1_1	184	190	PF00069	0.754
MOD_CK1_1	215	221	PF00069	0.746
MOD_CK1_1	279	285	PF00069	0.660
MOD_CK1_1	310	316	PF00069	0.737
MOD_CK1_1	328	334	PF00069	0.715
MOD_CK1_1	360	366	PF00069	0.826
MOD_CK1_1	461	467	PF00069	0.694
MOD_CK1_1	55	61	PF00069	0.679
MOD_CK1_1	550	556	PF00069	0.585
MOD_CK1_1	610	616	PF00069	0.664
MOD_CK1_1	75	81	PF00069	0.461
MOD_CK1_1	9	15	PF00069	0.639
MOD_CK2_1	120	126	PF00069	0.632
MOD_CK2_1	309	315	PF00069	0.755
MOD_CK2_1	41	47	PF00069	0.800
MOD_CK2_1	446	452	PF00069	0.567
MOD_GlcNHglycan	105	108	PF01048	0.800
MOD_GlcNHglycan	112	115	PF01048	0.646
MOD_GlcNHglycan	155	158	PF01048	0.781
MOD_GlcNHglycan	220	223	PF01048	0.737
MOD_GlcNHglycan	24	27	PF01048	0.756
MOD_GlcNHglycan	256	260	PF01048	0.640
MOD_GlcNHglycan	278	281	PF01048	0.730
MOD_GlcNHglycan	29	32	PF01048	0.681
MOD_GlcNHglycan	318	321	PF01048	0.818
MOD_GlcNHglycan	368	371	PF01048	0.770
MOD_GlcNHglycan	38	42	PF01048	0.576
MOD_GlcNHglycan	403	406	PF01048	0.629
MOD_GlcNHglycan	486	489	PF01048	0.430
MOD_GlcNHglycan	54	57	PF01048	0.463
MOD_GlcNHglycan	557	560	PF01048	0.729
MOD_GlcNHglycan	59	62	PF01048	0.686
MOD_GlcNHglycan	613	616	PF01048	0.691
MOD_GlcNHglycan	64	67	PF01048	0.610
MOD_GlcNHglycan	672	675	PF01048	0.502
MOD_GlcNHglycan	74	77	PF01048	0.454
MOD_GlcNHglycan	8	11	PF01048	0.598
MOD_GSK3_1	148	155	PF00069	0.655
MOD_GSK3_1	18	25	PF00069	0.769
MOD_GSK3_1	181	188	PF00069	0.734
MOD_GSK3_1	255	262	PF00069	0.811
MOD_GSK3_1	27	34	PF00069	0.716
MOD_GSK3_1	285	292	PF00069	0.746
MOD_GSK3_1	307	314	PF00069	0.739
MOD_GSK3_1	316	323	PF00069	0.706
MOD_GSK3_1	348	355	PF00069	0.754
MOD_GSK3_1	37	44	PF00069	0.558
MOD_GSK3_1	55	62	PF00069	0.657
MOD_GSK3_1	581	588	PF00069	0.552
MOD_GSK3_1	607	614	PF00069	0.579
MOD_GSK3_1	71	78	PF00069	0.592
MOD_GSK3_1	86	93	PF00069	0.522
MOD_NEK2_1	153	158	PF00069	0.669
MOD_NEK2_1	160	165	PF00069	0.729
MOD_NEK2_1	409	414	PF00069	0.627
MOD_NEK2_1	432	437	PF00069	0.801
MOD_NEK2_1	535	540	PF00069	0.494
MOD_NEK2_1	57	62	PF00069	0.747
MOD_NEK2_1	598	603	PF00069	0.457
MOD_PIKK_1	342	348	PF00454	0.636
MOD_PKA_1	342	348	PF00069	0.636
MOD_PKA_2	158	164	PF00069	0.745
MOD_PKA_2	341	347	PF00069	0.749
MOD_PKA_2	425	431	PF00069	0.740
MOD_PKA_2	447	453	PF00069	0.742
MOD_PKA_2	538	544	PF00069	0.401
MOD_PKA_2	555	561	PF00069	0.631
MOD_Plk_1	176	182	PF00069	0.748
MOD_Plk_1	37	43	PF00069	0.728
MOD_ProDKin_1	148	154	PF00069	0.667
MOD_ProDKin_1	166	172	PF00069	0.491
MOD_ProDKin_1	18	24	PF00069	0.742
MOD_ProDKin_1	186	192	PF00069	0.664
MOD_ProDKin_1	213	219	PF00069	0.735
MOD_ProDKin_1	259	265	PF00069	0.811
MOD_ProDKin_1	279	285	PF00069	0.604
MOD_ProDKin_1	287	293	PF00069	0.706
MOD_ProDKin_1	29	35	PF00069	0.658
MOD_ProDKin_1	294	300	PF00069	0.685
MOD_ProDKin_1	326	332	PF00069	0.761
MOD_ProDKin_1	348	354	PF00069	0.724
MOD_ProDKin_1	360	366	PF00069	0.758
MOD_ProDKin_1	426	432	PF00069	0.683
MOD_ProDKin_1	433	439	PF00069	0.705
MOD_ProDKin_1	441	447	PF00069	0.712
MOD_ProDKin_1	47	53	PF00069	0.691
MOD_ProDKin_1	547	553	PF00069	0.531
TRG_DiLeu_BaEn_2	592	598	PF01217	0.486
TRG_ENDOCYTIC_2	54	57	PF00928	0.731
TRG_ER_diArg_1	143	146	PF00400	0.584
TRG_ER_diArg_1	423	425	PF00400	0.653
TRG_ER_diArg_1	456	458	PF00400	0.711
TRG_ER_diArg_1	560	563	PF00400	0.731
TRG_ER_diArg_1	571	574	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X1	Leptomonas seymouri	41%	95%
A0A3S7WYR3	Leishmania donovani	100%	100%
A4HDY0	Leishmania braziliensis	71%	100%
E9AXB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QA62	Leishmania major	89%	100%