Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I173_LEIIN

TriTrypDb:

LINF_250008200

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I173

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I173

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.620
CLV_NRD_NRD_1	87	89	PF00675	0.496
CLV_PCSK_FUR_1	85	89	PF00082	0.491
CLV_PCSK_KEX2_1	46	48	PF00082	0.686
CLV_PCSK_KEX2_1	87	89	PF00082	0.496
DEG_APCC_DBOX_1	45	53	PF00400	0.516
DOC_MAPK_gen_1	46	53	PF00069	0.486
DOC_MAPK_MEF2A_6	34	41	PF00069	0.550
DOC_MAPK_MEF2A_6	46	55	PF00069	0.417
DOC_MAPK_NFAT4_5	34	42	PF00069	0.454
DOC_USP7_UBL2_3	25	29	PF12436	0.561
DOC_WW_Pin1_4	24	29	PF00397	0.599
DOC_WW_Pin1_4	39	44	PF00397	0.521
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	62	66	PF00533	0.332
LIG_FHA_2	40	46	PF00498	0.535
LIG_GBD_Chelix_1	53	61	PF00786	0.555
LIG_SH2_CRK	80	84	PF00017	0.662
LIG_Sin3_3	54	61	PF02671	0.356
LIG_TYR_ITIM	78	83	PF00017	0.568
MOD_CDK_SPK_2	24	29	PF00069	0.560
MOD_CDK_SPxxK_3	39	46	PF00069	0.542
MOD_CK1_1	23	29	PF00069	0.590
MOD_CK2_1	24	30	PF00069	0.541
MOD_CK2_1	39	45	PF00069	0.545
MOD_GlcNHglycan	1	4	PF01048	0.836
MOD_GlcNHglycan	22	25	PF01048	0.794
MOD_GlcNHglycan	30	34	PF01048	0.739
MOD_GlcNHglycan	74	77	PF01048	0.436
MOD_GSK3_1	16	23	PF00069	0.585
MOD_GSK3_1	35	42	PF00069	0.404
MOD_NEK2_1	37	42	PF00069	0.442
MOD_ProDKin_1	24	30	PF00069	0.598
MOD_ProDKin_1	39	45	PF00069	0.516
TRG_DiLeu_BaEn_1	45	50	PF01217	0.515
TRG_ENDOCYTIC_2	80	83	PF00928	0.724
TRG_ER_diArg_1	85	88	PF00400	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID69	Leishmania donovani	99%	100%
E9AIR4	Leishmania braziliensis	61%	100%
E9AXA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QA65	Leishmania major	87%	100%