Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I167_LEIIN

TriTrypDb:

LINF_250007600

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I167

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I167

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.482
CLV_C14_Caspase3-7	697	701	PF00656	0.570
CLV_C14_Caspase3-7	773	777	PF00656	0.486
CLV_NRD_NRD_1	49	51	PF00675	0.395
CLV_NRD_NRD_1	502	504	PF00675	0.553
CLV_NRD_NRD_1	650	652	PF00675	0.458
CLV_NRD_NRD_1	718	720	PF00675	0.499
CLV_NRD_NRD_1	842	844	PF00675	0.585
CLV_NRD_NRD_1	870	872	PF00675	0.637
CLV_NRD_NRD_1	97	99	PF00675	0.570
CLV_PCSK_KEX2_1	502	504	PF00082	0.499
CLV_PCSK_KEX2_1	650	652	PF00082	0.458
CLV_PCSK_KEX2_1	717	719	PF00082	0.459
CLV_PCSK_KEX2_1	842	844	PF00082	0.585
CLV_PCSK_KEX2_1	869	871	PF00082	0.634
CLV_PCSK_KEX2_1	97	99	PF00082	0.570
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.527
CLV_PCSK_PC7_1	498	504	PF00082	0.470
CLV_PCSK_SKI1_1	19	23	PF00082	0.560
CLV_PCSK_SKI1_1	229	233	PF00082	0.576
CLV_PCSK_SKI1_1	533	537	PF00082	0.481
CLV_PCSK_SKI1_1	696	700	PF00082	0.487
CLV_PCSK_SKI1_1	748	752	PF00082	0.572
CLV_PCSK_SKI1_1	763	767	PF00082	0.555
CLV_Separin_Metazoa	734	738	PF03568	0.444
CLV_Separin_Metazoa	760	764	PF03568	0.529
DEG_APCC_DBOX_1	586	594	PF00400	0.483
DEG_APCC_DBOX_1	695	703	PF00400	0.509
DEG_APCC_DBOX_1	708	716	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.343
DEG_SPOP_SBC_1	57	61	PF00917	0.340
DEG_SPOP_SBC_1	670	674	PF00917	0.559
DOC_CDC14_PxL_1	862	870	PF14671	0.564
DOC_CKS1_1	399	404	PF01111	0.658
DOC_CKS1_1	77	82	PF01111	0.476
DOC_CKS1_1	781	786	PF01111	0.787
DOC_CKS1_1	872	877	PF01111	0.632
DOC_CYCLIN_RxL_1	255	266	PF00134	0.400
DOC_CYCLIN_RxL_1	619	631	PF00134	0.461
DOC_MAPK_gen_1	584	592	PF00069	0.519
DOC_MAPK_gen_1	620	628	PF00069	0.465
DOC_USP7_MATH_1	237	241	PF00917	0.424
DOC_USP7_MATH_1	359	363	PF00917	0.676
DOC_USP7_MATH_1	388	392	PF00917	0.588
DOC_USP7_MATH_1	422	426	PF00917	0.632
DOC_USP7_MATH_1	450	454	PF00917	0.747
DOC_USP7_MATH_1	517	521	PF00917	0.520
DOC_USP7_MATH_1	524	528	PF00917	0.510
DOC_USP7_MATH_1	542	546	PF00917	0.504
DOC_USP7_MATH_1	550	554	PF00917	0.470
DOC_USP7_MATH_1	555	559	PF00917	0.438
DOC_USP7_MATH_1	560	564	PF00917	0.560
DOC_USP7_MATH_1	670	674	PF00917	0.571
DOC_USP7_MATH_1	701	705	PF00917	0.411
DOC_USP7_MATH_1	727	731	PF00917	0.493
DOC_USP7_MATH_1	810	814	PF00917	0.671
DOC_USP7_UBL2_3	643	647	PF12436	0.538
DOC_WW_Pin1_4	246	251	PF00397	0.398
DOC_WW_Pin1_4	277	282	PF00397	0.422
DOC_WW_Pin1_4	398	403	PF00397	0.620
DOC_WW_Pin1_4	417	422	PF00397	0.492
DOC_WW_Pin1_4	76	81	PF00397	0.424
DOC_WW_Pin1_4	780	785	PF00397	0.656
DOC_WW_Pin1_4	799	804	PF00397	0.618
DOC_WW_Pin1_4	834	839	PF00397	0.599
DOC_WW_Pin1_4	871	876	PF00397	0.622
LIG_14-3-3_CanoR_1	16	22	PF00244	0.519
LIG_14-3-3_CanoR_1	187	195	PF00244	0.486
LIG_14-3-3_CanoR_1	229	238	PF00244	0.473
LIG_14-3-3_CanoR_1	28	33	PF00244	0.459
LIG_14-3-3_CanoR_1	305	314	PF00244	0.380
LIG_14-3-3_CanoR_1	408	416	PF00244	0.580
LIG_14-3-3_CanoR_1	48	54	PF00244	0.264
LIG_14-3-3_CanoR_1	519	523	PF00244	0.445
LIG_14-3-3_CanoR_1	584	593	PF00244	0.591
LIG_14-3-3_CanoR_1	668	676	PF00244	0.502
LIG_14-3-3_CanoR_1	687	695	PF00244	0.445
LIG_14-3-3_CanoR_1	82	90	PF00244	0.431
LIG_14-3-3_CanoR_1	842	850	PF00244	0.649
LIG_14-3-3_CanoR_1	97	102	PF00244	0.459
LIG_Actin_WH2_2	480	497	PF00022	0.545
LIG_BIR_III_2	445	449	PF00653	0.544
LIG_BIR_III_2	833	837	PF00653	0.621
LIG_BRCT_BRCA1_1	200	204	PF00533	0.402
LIG_BRCT_BRCA1_1	390	394	PF00533	0.651
LIG_BRCT_BRCA1_1	813	817	PF00533	0.633
LIG_FHA_1	255	261	PF00498	0.423
LIG_FHA_1	469	475	PF00498	0.504
LIG_FHA_1	599	605	PF00498	0.644
LIG_FHA_1	705	711	PF00498	0.520
LIG_FHA_2	129	135	PF00498	0.491
LIG_FHA_2	153	159	PF00498	0.439
LIG_FHA_2	163	169	PF00498	0.439
LIG_FHA_2	221	227	PF00498	0.449
LIG_FHA_2	290	296	PF00498	0.391
LIG_FHA_2	38	44	PF00498	0.423
LIG_FHA_2	495	501	PF00498	0.464
LIG_FHA_2	687	693	PF00498	0.425
LIG_FHA_2	781	787	PF00498	0.593
LIG_FHA_2	98	104	PF00498	0.441
LIG_GBD_Chelix_1	582	590	PF00786	0.433
LIG_HCF-1_HBM_1	618	621	PF13415	0.490
LIG_LIR_Gen_1	162	172	PF02991	0.396
LIG_LIR_Gen_1	189	200	PF02991	0.388
LIG_LIR_Gen_1	216	227	PF02991	0.376
LIG_LIR_Gen_1	63	74	PF02991	0.422
LIG_LIR_Gen_1	849	858	PF02991	0.658
LIG_LIR_Nem_3	162	167	PF02991	0.394
LIG_LIR_Nem_3	169	175	PF02991	0.387
LIG_LIR_Nem_3	178	184	PF02991	0.395
LIG_LIR_Nem_3	189	195	PF02991	0.286
LIG_LIR_Nem_3	216	222	PF02991	0.383
LIG_LIR_Nem_3	23	29	PF02991	0.436
LIG_LIR_Nem_3	278	282	PF02991	0.375
LIG_LIR_Nem_3	470	475	PF02991	0.482
LIG_LIR_Nem_3	52	58	PF02991	0.407
LIG_LIR_Nem_3	63	69	PF02991	0.334
LIG_LIR_Nem_3	849	853	PF02991	0.564
LIG_NRBOX	258	264	PF00104	0.401
LIG_Pex14_1	275	279	PF04695	0.332
LIG_Pex14_2	202	206	PF04695	0.397
LIG_Pex14_2	293	297	PF04695	0.389
LIG_RPA_C_Fungi	230	242	PF08784	0.460
LIG_RPA_C_Fungi	645	657	PF08784	0.528
LIG_SH2_CRK	472	476	PF00017	0.476
LIG_SH2_CRK	66	70	PF00017	0.414
LIG_SH2_PTP2	172	175	PF00017	0.347
LIG_SH2_STAP1	307	311	PF00017	0.367
LIG_SH2_STAP1	522	526	PF00017	0.529
LIG_SH2_STAP1	66	70	PF00017	0.468
LIG_SH2_STAP1	743	747	PF00017	0.471
LIG_SH2_STAT3	743	746	PF00017	0.528
LIG_SH2_STAT5	172	175	PF00017	0.410
LIG_SH2_STAT5	261	264	PF00017	0.441
LIG_SH2_STAT5	30	33	PF00017	0.353
LIG_SH2_STAT5	780	783	PF00017	0.551
LIG_SH2_STAT5	99	102	PF00017	0.413
LIG_SH3_1	869	875	PF00018	0.661
LIG_SH3_3	114	120	PF00018	0.486
LIG_SH3_3	396	402	PF00018	0.670
LIG_SH3_3	415	421	PF00018	0.681
LIG_SH3_3	66	72	PF00018	0.396
LIG_SH3_3	74	80	PF00018	0.373
LIG_SH3_3	778	784	PF00018	0.727
LIG_SH3_3	869	875	PF00018	0.661
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.454
LIG_SUMO_SIM_anti_2	308	317	PF11976	0.470
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.429
LIG_SUMO_SIM_anti_2	588	594	PF11976	0.486
LIG_SUMO_SIM_par_1	280	286	PF11976	0.454
LIG_SUMO_SIM_par_1	40	47	PF11976	0.475
LIG_SUMO_SIM_par_1	624	629	PF11976	0.515
LIG_SUMO_SIM_par_1	86	91	PF11976	0.360
LIG_TRAF2_1	292	295	PF00917	0.460
LIG_TRAF2_1	458	461	PF00917	0.611
LIG_TRFH_1	261	265	PF08558	0.340
LIG_UBA3_1	259	264	PF00899	0.427
LIG_WRC_WIRS_1	199	204	PF05994	0.324
LIG_WRC_WIRS_1	219	224	PF05994	0.222
LIG_WRC_WIRS_1	276	281	PF05994	0.419
LIG_WW_3	802	806	PF00397	0.650
MOD_CDC14_SPxK_1	802	805	PF00782	0.555
MOD_CDK_SPxK_1	76	82	PF00069	0.474
MOD_CDK_SPxK_1	799	805	PF00069	0.654
MOD_CDK_SPxxK_3	780	787	PF00069	0.654
MOD_CK1_1	11	17	PF00069	0.602
MOD_CK1_1	128	134	PF00069	0.437
MOD_CK1_1	177	183	PF00069	0.467
MOD_CK1_1	20	26	PF00069	0.508
MOD_CK1_1	280	286	PF00069	0.401
MOD_CK1_1	368	374	PF00069	0.693
MOD_CK1_1	376	382	PF00069	0.670
MOD_CK1_1	426	432	PF00069	0.725
MOD_CK1_1	543	549	PF00069	0.495
MOD_CK1_1	553	559	PF00069	0.518
MOD_CK1_1	60	66	PF00069	0.495
MOD_CK1_1	704	710	PF00069	0.471
MOD_CK1_1	752	758	PF00069	0.508
MOD_CK1_1	825	831	PF00069	0.650
MOD_CK1_1	846	852	PF00069	0.620
MOD_CK2_1	152	158	PF00069	0.450
MOD_CK2_1	162	168	PF00069	0.444
MOD_CK2_1	220	226	PF00069	0.425
MOD_CK2_1	280	286	PF00069	0.451
MOD_CK2_1	289	295	PF00069	0.418
MOD_CK2_1	510	516	PF00069	0.623
MOD_CK2_1	671	677	PF00069	0.630
MOD_CK2_1	686	692	PF00069	0.392
MOD_DYRK1A_RPxSP_1	871	875	PF00069	0.619
MOD_GlcNHglycan	12	16	PF01048	0.487
MOD_GlcNHglycan	127	130	PF01048	0.429
MOD_GlcNHglycan	239	242	PF01048	0.425
MOD_GlcNHglycan	321	324	PF01048	0.577
MOD_GlcNHglycan	378	382	PF01048	0.647
MOD_GlcNHglycan	390	393	PF01048	0.692
MOD_GlcNHglycan	411	414	PF01048	0.674
MOD_GlcNHglycan	460	465	PF01048	0.508
MOD_GlcNHglycan	552	555	PF01048	0.528
MOD_GlcNHglycan	557	560	PF01048	0.530
MOD_GlcNHglycan	673	676	PF01048	0.520
MOD_GlcNHglycan	753	757	PF01048	0.423
MOD_GlcNHglycan	824	827	PF01048	0.733
MOD_GlcNHglycan	845	848	PF01048	0.738
MOD_GlcNHglycan	93	96	PF01048	0.496
MOD_GSK3_1	121	128	PF00069	0.450
MOD_GSK3_1	246	253	PF00069	0.409
MOD_GSK3_1	28	35	PF00069	0.567
MOD_GSK3_1	373	380	PF00069	0.664
MOD_GSK3_1	407	414	PF00069	0.631
MOD_GSK3_1	422	429	PF00069	0.567
MOD_GSK3_1	456	463	PF00069	0.587
MOD_GSK3_1	56	63	PF00069	0.401
MOD_GSK3_1	735	742	PF00069	0.584
MOD_GSK3_1	766	773	PF00069	0.495
MOD_GSK3_1	776	783	PF00069	0.677
MOD_GSK3_1	811	818	PF00069	0.591
MOD_LATS_1	17	23	PF00433	0.479
MOD_N-GLC_1	134	139	PF02516	0.483
MOD_N-GLC_1	213	218	PF02516	0.368
MOD_N-GLC_1	314	319	PF02516	0.523
MOD_NEK2_1	109	114	PF00069	0.442
MOD_NEK2_1	206	211	PF00069	0.425
MOD_NEK2_1	231	236	PF00069	0.445
MOD_NEK2_1	252	257	PF00069	0.393
MOD_NEK2_1	306	311	PF00069	0.419
MOD_NEK2_1	314	319	PF00069	0.555
MOD_NEK2_1	409	414	PF00069	0.576
MOD_NEK2_1	58	63	PF00069	0.529
MOD_NEK2_1	73	78	PF00069	0.321
MOD_NEK2_1	735	740	PF00069	0.522
MOD_NEK2_1	765	770	PF00069	0.461
MOD_NEK2_1	798	803	PF00069	0.747
MOD_PIKK_1	20	26	PF00454	0.423
MOD_PIKK_1	365	371	PF00454	0.765
MOD_PIKK_1	60	66	PF00454	0.413
MOD_PIKK_1	704	710	PF00454	0.492
MOD_PIKK_1	81	87	PF00454	0.453
MOD_PKA_1	97	103	PF00069	0.446
MOD_PKA_2	186	192	PF00069	0.493
MOD_PKA_2	376	382	PF00069	0.693
MOD_PKA_2	407	413	PF00069	0.636
MOD_PKA_2	429	435	PF00069	0.556
MOD_PKA_2	49	55	PF00069	0.445
MOD_PKA_2	494	500	PF00069	0.506
MOD_PKA_2	518	524	PF00069	0.499
MOD_PKA_2	686	692	PF00069	0.483
MOD_PKA_2	81	87	PF00069	0.453
MOD_PKA_2	97	103	PF00069	0.475
MOD_Plk_1	134	140	PF00069	0.462
MOD_Plk_1	177	183	PF00069	0.469
MOD_Plk_1	213	219	PF00069	0.364
MOD_Plk_1	314	320	PF00069	0.450
MOD_Plk_1	35	41	PF00069	0.450
MOD_Plk_1	543	549	PF00069	0.485
MOD_Plk_1	775	781	PF00069	0.631
MOD_Plk_2-3	134	140	PF00069	0.513
MOD_Plk_2-3	152	158	PF00069	0.563
MOD_Plk_2-3	289	295	PF00069	0.467
MOD_Plk_2-3	510	516	PF00069	0.546
MOD_Plk_2-3	686	692	PF00069	0.498
MOD_Plk_4	152	158	PF00069	0.505
MOD_Plk_4	263	269	PF00069	0.397
MOD_Plk_4	28	34	PF00069	0.391
MOD_Plk_4	280	286	PF00069	0.497
MOD_Plk_4	314	320	PF00069	0.474
MOD_Plk_4	37	43	PF00069	0.373
MOD_Plk_4	543	549	PF00069	0.427
MOD_Plk_4	73	79	PF00069	0.438
MOD_Plk_4	776	782	PF00069	0.541
MOD_Plk_4	97	103	PF00069	0.430
MOD_ProDKin_1	246	252	PF00069	0.394
MOD_ProDKin_1	277	283	PF00069	0.426
MOD_ProDKin_1	398	404	PF00069	0.620
MOD_ProDKin_1	417	423	PF00069	0.492
MOD_ProDKin_1	76	82	PF00069	0.423
MOD_ProDKin_1	780	786	PF00069	0.655
MOD_ProDKin_1	799	805	PF00069	0.620
MOD_ProDKin_1	834	840	PF00069	0.597
MOD_ProDKin_1	871	877	PF00069	0.629
MOD_SUMO_for_1	750	753	PF00179	0.489
MOD_SUMO_rev_2	744	752	PF00179	0.487
TRG_DiLeu_BaEn_1	599	604	PF01217	0.503
TRG_DiLeu_BaEn_2	678	684	PF01217	0.498
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.428
TRG_DiLeu_BaLyEn_6	863	868	PF01217	0.488
TRG_ENDOCYTIC_2	172	175	PF00928	0.374
TRG_ENDOCYTIC_2	29	32	PF00928	0.359
TRG_ENDOCYTIC_2	472	475	PF00928	0.475
TRG_ENDOCYTIC_2	55	58	PF00928	0.451
TRG_ENDOCYTIC_2	66	69	PF00928	0.334
TRG_ENDOCYTIC_2	99	102	PF00928	0.413
TRG_ER_diArg_1	360	363	PF00400	0.653
TRG_ER_diArg_1	501	503	PF00400	0.430
TRG_ER_diArg_1	621	624	PF00400	0.453
TRG_ER_diArg_1	693	696	PF00400	0.487
TRG_ER_diArg_1	709	712	PF00400	0.434
TRG_ER_diArg_1	842	845	PF00400	0.682
TRG_ER_diArg_1	868	871	PF00400	0.625
TRG_ER_diArg_1	97	99	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	584	589	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	748	753	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP5	Leptomonas seymouri	48%	97%
A0A3Q8IN51	Leishmania donovani	100%	100%
A0A3R7KB27	Trypanosoma rangeli	30%	96%
A4HDX2	Leishmania braziliensis	73%	100%
E9AXA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QA71	Leishmania major	89%	100%