Pre-mRNA-splicing factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pre-mRNA-splicing factor of RES complex - putative

Species:

Leishmania infantum

UniProt:

A4I166_LEIIN

TriTrypDb:

LINF_250007500

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I166

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I166

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.594
CLV_NRD_NRD_1	159	161	PF00675	0.300
CLV_NRD_NRD_1	9	11	PF00675	0.558
CLV_PCSK_KEX2_1	7	9	PF00082	0.567
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.567
CLV_PCSK_SKI1_1	115	119	PF00082	0.414
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.396
DOC_PP2B_LxvP_1	126	129	PF13499	0.392
DOC_USP7_MATH_1	84	88	PF00917	0.685
DOC_WW_Pin1_4	150	155	PF00397	0.541
DOC_WW_Pin1_4	24	29	PF00397	0.511
LIG_14-3-3_CanoR_1	137	144	PF00244	0.537
LIG_14-3-3_CanoR_1	24	28	PF00244	0.532
LIG_APCC_ABBAyCdc20_2	99	105	PF00400	0.559
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BRCT_BRCA1_1	34	38	PF00533	0.585
LIG_BRCT_BRCA1_1	99	103	PF00533	0.493
LIG_FHA_1	138	144	PF00498	0.488
LIG_FHA_1	38	44	PF00498	0.561
LIG_FHA_2	43	49	PF00498	0.682
LIG_FHA_2	67	73	PF00498	0.692
LIG_LIR_Gen_1	17	28	PF02991	0.554
LIG_LIR_Nem_3	113	117	PF02991	0.653
LIG_LIR_Nem_3	17	23	PF02991	0.569
LIG_MYND_3	43	47	PF01753	0.578
LIG_PTB_Apo_2	121	128	PF02174	0.425
LIG_SH2_CRK	114	118	PF00017	0.419
LIG_SH2_CRK	163	167	PF00017	0.430
LIG_SH2_GRB2like	163	166	PF00017	0.484
LIG_SH2_PTP2	20	23	PF00017	0.570
LIG_SH2_SRC	70	73	PF00017	0.589
LIG_SH2_STAT5	132	135	PF00017	0.444
LIG_SH2_STAT5	20	23	PF00017	0.647
LIG_SH2_STAT5	70	73	PF00017	0.589
LIG_UBA3_1	126	135	PF00899	0.473
MOD_CK2_1	153	159	PF00069	0.575
MOD_CK2_1	66	72	PF00069	0.681
MOD_GlcNHglycan	1	4	PF01048	0.766
MOD_GlcNHglycan	118	121	PF01048	0.500
MOD_GlcNHglycan	155	158	PF01048	0.578
MOD_GlcNHglycan	34	37	PF01048	0.482
MOD_GlcNHglycan	60	63	PF01048	0.598
MOD_GlcNHglycan	81	84	PF01048	0.572
MOD_GlcNHglycan	85	89	PF01048	0.598
MOD_GlcNHglycan	92	95	PF01048	0.565
MOD_NEK2_1	23	28	PF00069	0.463
MOD_OFUCOSY	134	139	PF10250	0.474
MOD_PIKK_1	142	148	PF00454	0.627
MOD_PIKK_1	55	61	PF00454	0.617
MOD_PKA_2	23	29	PF00069	0.538
MOD_PKB_1	8	16	PF00069	0.556
MOD_Plk_2-3	42	48	PF00069	0.702
MOD_Plk_2-3	66	72	PF00069	0.602
MOD_Plk_4	66	72	PF00069	0.693
MOD_ProDKin_1	150	156	PF00069	0.545
MOD_ProDKin_1	24	30	PF00069	0.508
MOD_SUMO_rev_2	107	117	PF00179	0.414
MOD_SUMO_rev_2	156	162	PF00179	0.268
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.500
TRG_ENDOCYTIC_2	114	117	PF00928	0.450
TRG_ENDOCYTIC_2	163	166	PF00928	0.430
TRG_ENDOCYTIC_2	20	23	PF00928	0.570
TRG_ER_diArg_1	179	182	PF00400	0.469
TRG_ER_diArg_1	8	10	PF00400	0.563
TRG_NES_CRM1_1	121	131	PF08389	0.422
TRG_NLS_MonoCore_2	6	11	PF00514	0.563
TRG_NLS_MonoExtC_3	6	12	PF00514	0.561
TRG_NLS_MonoExtN_4	5	11	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X4	Leptomonas seymouri	50%	96%
A0A3Q8ICC4	Leishmania donovani	98%	100%
A4HDX1	Leishmania braziliensis	63%	100%
E9AXA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QA72	Leishmania major	86%	100%