RUN domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I164_LEIIN

TriTrypDb:

LINF_250007300

Length:

713

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I164

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I164

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.508
CLV_C14_Caspase3-7	38	42	PF00656	0.498
CLV_C14_Caspase3-7	507	511	PF00656	0.414
CLV_NRD_NRD_1	142	144	PF00675	0.569
CLV_NRD_NRD_1	237	239	PF00675	0.462
CLV_NRD_NRD_1	253	255	PF00675	0.474
CLV_NRD_NRD_1	475	477	PF00675	0.388
CLV_PCSK_FUR_1	237	241	PF00082	0.467
CLV_PCSK_KEX2_1	237	239	PF00082	0.463
CLV_PCSK_KEX2_1	262	264	PF00082	0.521
CLV_PCSK_KEX2_1	313	315	PF00082	0.431
CLV_PCSK_KEX2_1	447	449	PF00082	0.487
CLV_PCSK_KEX2_1	475	477	PF00082	0.398
CLV_PCSK_KEX2_1	629	631	PF00082	0.527
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.469
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.550
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.431
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.487
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.527
CLV_PCSK_SKI1_1	360	364	PF00082	0.362
CLV_PCSK_SKI1_1	447	451	PF00082	0.499
CLV_PCSK_SKI1_1	55	59	PF00082	0.331
CLV_PCSK_SKI1_1	64	68	PF00082	0.349
CLV_PCSK_SKI1_1	77	81	PF00082	0.373
DEG_APCC_DBOX_1	237	245	PF00400	0.475
DEG_APCC_DBOX_1	54	62	PF00400	0.456
DEG_APCC_DBOX_1	76	84	PF00400	0.340
DEG_SPOP_SBC_1	277	281	PF00917	0.655
DOC_CYCLIN_RxL_1	444	454	PF00134	0.419
DOC_MAPK_gen_1	143	153	PF00069	0.627
DOC_MAPK_gen_1	313	321	PF00069	0.383
DOC_MAPK_gen_1	634	643	PF00069	0.576
DOC_MAPK_MEF2A_6	104	111	PF00069	0.376
DOC_MAPK_MEF2A_6	314	323	PF00069	0.370
DOC_MAPK_MEF2A_6	564	572	PF00069	0.494
DOC_PP4_FxxP_1	559	562	PF00568	0.481
DOC_PP4_FxxP_1	609	612	PF00568	0.524
DOC_PP4_FxxP_1	707	710	PF00568	0.600
DOC_USP7_MATH_1	127	131	PF00917	0.641
DOC_USP7_MATH_1	133	137	PF00917	0.784
DOC_USP7_MATH_1	277	281	PF00917	0.658
DOC_USP7_MATH_1	289	293	PF00917	0.520
DOC_USP7_MATH_1	400	404	PF00917	0.359
DOC_USP7_UBL2_3	134	138	PF12436	0.615
DOC_WW_Pin1_4	364	369	PF00397	0.500
LIG_14-3-3_CanoR_1	146	153	PF00244	0.659
LIG_14-3-3_CanoR_1	343	348	PF00244	0.390
LIG_14-3-3_CanoR_1	418	427	PF00244	0.340
LIG_14-3-3_CanoR_1	448	453	PF00244	0.460
LIG_14-3-3_CanoR_1	550	558	PF00244	0.475
LIG_14-3-3_CanoR_1	569	573	PF00244	0.505
LIG_14-3-3_CanoR_1	634	639	PF00244	0.572
LIG_14-3-3_CanoR_1	91	99	PF00244	0.494
LIG_Actin_RPEL_3	526	545	PF02755	0.450
LIG_AP_GAE_1	596	602	PF02883	0.562
LIG_APCC_ABBA_1	524	529	PF00400	0.454
LIG_BIR_II_1	1	5	PF00653	0.412
LIG_BIR_III_4	432	436	PF00653	0.521
LIG_BRCT_BRCA1_1	107	111	PF00533	0.504
LIG_BRCT_BRCA1_1	366	370	PF00533	0.488
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.383
LIG_FHA_1	164	170	PF00498	0.575
LIG_FHA_1	367	373	PF00498	0.372
LIG_FHA_1	420	426	PF00498	0.334
LIG_FHA_1	550	556	PF00498	0.477
LIG_FHA_1	626	632	PF00498	0.505
LIG_FHA_2	652	658	PF00498	0.540
LIG_FHA_2	90	96	PF00498	0.515
LIG_LIR_Apic_2	608	612	PF02991	0.552
LIG_LIR_Gen_1	295	303	PF02991	0.441
LIG_LIR_Gen_1	361	370	PF02991	0.378
LIG_LIR_Gen_1	656	666	PF02991	0.668
LIG_LIR_Gen_1	93	103	PF02991	0.369
LIG_LIR_Nem_3	290	296	PF02991	0.521
LIG_LIR_Nem_3	355	359	PF02991	0.417
LIG_LIR_Nem_3	361	365	PF02991	0.391
LIG_LIR_Nem_3	367	373	PF02991	0.398
LIG_LIR_Nem_3	391	397	PF02991	0.463
LIG_LIR_Nem_3	482	488	PF02991	0.409
LIG_LIR_Nem_3	575	579	PF02991	0.375
LIG_LIR_Nem_3	656	662	PF02991	0.632
LIG_LIR_Nem_3	93	99	PF02991	0.379
LIG_Pex14_2	620	624	PF04695	0.546
LIG_SH2_SRC	198	201	PF00017	0.545
LIG_SH2_SRC	233	236	PF00017	0.573
LIG_SH3_3	197	203	PF00018	0.549
LIG_SH3_3	552	558	PF00018	0.427
LIG_SH3_3	559	565	PF00018	0.476
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.359
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.353
LIG_SUMO_SIM_par_1	448	454	PF11976	0.433
LIG_SUMO_SIM_par_1	611	618	PF11976	0.511
LIG_TRAF2_1	248	251	PF00917	0.502
LIG_UBA3_1	119	128	PF00899	0.528
LIG_WW_3	561	565	PF00397	0.497
MOD_CDK_SPxxK_3	364	371	PF00069	0.418
MOD_CK1_1	105	111	PF00069	0.505
MOD_CK1_1	14	20	PF00069	0.593
MOD_CK1_1	193	199	PF00069	0.699
MOD_CK1_1	270	276	PF00069	0.709
MOD_CK1_1	342	348	PF00069	0.524
MOD_CK1_1	618	624	PF00069	0.650
MOD_CK2_1	245	251	PF00069	0.613
MOD_CK2_1	281	287	PF00069	0.796
MOD_CK2_1	448	454	PF00069	0.433
MOD_CK2_1	590	596	PF00069	0.549
MOD_CK2_1	597	603	PF00069	0.551
MOD_CK2_1	651	657	PF00069	0.561
MOD_CK2_1	89	95	PF00069	0.537
MOD_GlcNHglycan	129	132	PF01048	0.700
MOD_GlcNHglycan	172	176	PF01048	0.553
MOD_GlcNHglycan	269	272	PF01048	0.719
MOD_GlcNHglycan	284	287	PF01048	0.729
MOD_GlcNHglycan	3	6	PF01048	0.565
MOD_GlcNHglycan	49	52	PF01048	0.546
MOD_GlcNHglycan	669	672	PF01048	0.693
MOD_GSK3_1	107	114	PF00069	0.406
MOD_GSK3_1	11	18	PF00069	0.506
MOD_GSK3_1	145	152	PF00069	0.649
MOD_GSK3_1	190	197	PF00069	0.747
MOD_GSK3_1	272	279	PF00069	0.733
MOD_GSK3_1	339	346	PF00069	0.371
MOD_GSK3_1	43	50	PF00069	0.468
MOD_GSK3_1	649	656	PF00069	0.612
MOD_GSK3_1	98	105	PF00069	0.436
MOD_N-GLC_1	681	686	PF02516	0.631
MOD_NEK2_1	1	6	PF00069	0.392
MOD_NEK2_1	102	107	PF00069	0.353
MOD_NEK2_1	111	116	PF00069	0.356
MOD_NEK2_1	145	150	PF00069	0.661
MOD_NEK2_1	190	195	PF00069	0.582
MOD_NEK2_1	43	48	PF00069	0.397
MOD_NEK2_1	479	484	PF00069	0.432
MOD_NEK2_1	662	667	PF00069	0.697
MOD_PIKK_1	185	191	PF00454	0.563
MOD_PIKK_1	649	655	PF00454	0.555
MOD_PIKK_1	665	671	PF00454	0.584
MOD_PKA_2	145	151	PF00069	0.633
MOD_PKA_2	342	348	PF00069	0.365
MOD_PKA_2	381	387	PF00069	0.538
MOD_PKA_2	549	555	PF00069	0.414
MOD_PKA_2	568	574	PF00069	0.484
MOD_PKA_2	625	631	PF00069	0.505
MOD_PKA_2	90	96	PF00069	0.514
MOD_PKB_1	263	271	PF00069	0.650
MOD_PKB_1	476	484	PF00069	0.545
MOD_Plk_1	390	396	PF00069	0.558
MOD_Plk_1	43	49	PF00069	0.502
MOD_Plk_1	516	522	PF00069	0.432
MOD_Plk_2-3	590	596	PF00069	0.554
MOD_Plk_2-3	597	603	PF00069	0.543
MOD_Plk_4	111	117	PF00069	0.329
MOD_Plk_4	615	621	PF00069	0.565
MOD_Plk_4	67	73	PF00069	0.425
MOD_Plk_4	98	104	PF00069	0.394
MOD_ProDKin_1	364	370	PF00069	0.494
MOD_SUMO_rev_2	125	130	PF00179	0.624
MOD_SUMO_rev_2	172	180	PF00179	0.685
MOD_SUMO_rev_2	506	516	PF00179	0.551
MOD_SUMO_rev_2	625	631	PF00179	0.505
TRG_DiLeu_BaEn_1	336	341	PF01217	0.357
TRG_DiLeu_BaEn_2	574	580	PF01217	0.389
TRG_ENDOCYTIC_2	293	296	PF00928	0.533
TRG_ENDOCYTIC_2	576	579	PF00928	0.380
TRG_ENDOCYTIC_2	659	662	PF00928	0.634
TRG_ER_diArg_1	237	240	PF00400	0.464
TRG_ER_diArg_1	406	409	PF00400	0.410
TRG_ER_diArg_1	474	476	PF00400	0.374
TRG_ER_diArg_1	708	711	PF00400	0.748
TRG_NES_CRM1_1	113	126	PF08389	0.585
TRG_NLS_MonoExtC_3	237	242	PF00514	0.469
TRG_NLS_MonoExtC_3	261	267	PF00514	0.557
TRG_NLS_MonoExtN_4	237	242	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I765	Leptomonas seymouri	82%	100%
A0A0S4JHQ3	Bodo saltans	42%	82%
A0A1X0P4I5	Trypanosomatidae	60%	100%
A0A3S7WYX6	Leishmania donovani	100%	100%
A0A422NF47	Trypanosoma rangeli	60%	100%
A4HDW9	Leishmania braziliensis	88%	100%
D0A5F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AX98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QA74	Leishmania major	95%	100%
V5DPB1	Trypanosoma cruzi	60%	100%