LeishMANIAdb
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Ubiquitin carboxyl-terminal hydrolase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin carboxyl-terminal hydrolase
Gene product:
ubiquitin carboxyl-terminal hydrolase - putative
Species:
Leishmania infantum
UniProt:
A4I161_LEIIN
TriTrypDb:
LINF_250007000
Length:
233

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin carboxyl-terminal hydrolase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I161
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I161

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 11
GO:0006511 ubiquitin-dependent protein catabolic process 7 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009056 catabolic process 2 11
GO:0009057 macromolecule catabolic process 4 11
GO:0009987 cellular process 1 11
GO:0019538 protein metabolic process 3 11
GO:0019941 modification-dependent protein catabolic process 6 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043632 modification-dependent macromolecule catabolic process 5 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044248 cellular catabolic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044265 obsolete cellular macromolecule catabolic process 4 11
GO:0051603 proteolysis involved in protein catabolic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901575 organic substance catabolic process 3 11
GO:0016579 protein deubiquitination 6 1
GO:0036211 protein modification process 4 1
GO:0043412 macromolecule modification 4 1
GO:0070646 protein modification by small protein removal 5 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004843 cysteine-type deubiquitinase activity 5 11
GO:0008233 peptidase activity 3 11
GO:0008234 cysteine-type peptidase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0019783 ubiquitin-like protein peptidase activity 4 11
GO:0101005 deubiquitinase activity 5 11
GO:0140096 catalytic activity, acting on a protein 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 117 121 PF00656 0.390
CLV_C14_Caspase3-7 197 201 PF00656 0.419
CLV_NRD_NRD_1 187 189 PF00675 0.314
CLV_NRD_NRD_1 61 63 PF00675 0.307
CLV_NRD_NRD_1 77 79 PF00675 0.223
CLV_PCSK_KEX2_1 61 63 PF00082 0.387
CLV_PCSK_SKI1_1 202 206 PF00082 0.300
DEG_APCC_DBOX_1 106 114 PF00400 0.283
DEG_APCC_KENBOX_2 188 192 PF00400 0.259
DEG_Nend_Nbox_1 1 3 PF02207 0.387
DOC_PP1_RVXF_1 23 29 PF00149 0.274
DOC_USP7_MATH_1 114 118 PF00917 0.283
DOC_USP7_MATH_1 127 131 PF00917 0.181
DOC_USP7_MATH_1 4 8 PF00917 0.290
DOC_WW_Pin1_4 41 46 PF00397 0.381
LIG_14-3-3_CanoR_1 14 20 PF00244 0.331
LIG_14-3-3_CanoR_1 202 212 PF00244 0.241
LIG_14-3-3_CanoR_1 78 82 PF00244 0.237
LIG_BRCT_BRCA1_1 221 225 PF00533 0.351
LIG_BRCT_BRCA1_1 79 83 PF00533 0.199
LIG_CSL_BTD_1 1 4 PF09270 0.334
LIG_EH1_1 224 232 PF00400 0.383
LIG_FHA_1 16 22 PF00498 0.352
LIG_FHA_1 226 232 PF00498 0.426
LIG_FHA_1 69 75 PF00498 0.412
LIG_FHA_1 84 90 PF00498 0.219
LIG_FHA_1 94 100 PF00498 0.219
LIG_FHA_2 127 133 PF00498 0.259
LIG_FHA_2 195 201 PF00498 0.199
LIG_LIR_Gen_1 169 178 PF02991 0.216
LIG_LIR_Nem_3 169 175 PF02991 0.216
LIG_SH2_STAT5 15 18 PF00017 0.256
LIG_SH3_3 39 45 PF00018 0.257
LIG_Sin3_3 48 55 PF02671 0.223
LIG_TRAF2_1 153 156 PF00917 0.334
LIG_TRAF2_1 211 214 PF00917 0.379
MOD_CK1_1 145 151 PF00069 0.381
MOD_CK1_1 203 209 PF00069 0.457
MOD_CK2_1 218 224 PF00069 0.358
MOD_Cter_Amidation 186 189 PF01082 0.311
MOD_GlcNHglycan 147 150 PF01048 0.301
MOD_GSK3_1 141 148 PF00069 0.388
MOD_GSK3_1 15 22 PF00069 0.398
MOD_GSK3_1 196 203 PF00069 0.344
MOD_N-GLC_1 200 205 PF02516 0.331
MOD_N-GLC_2 92 94 PF02516 0.256
MOD_NEK2_1 194 199 PF00069 0.369
MOD_NEK2_1 225 230 PF00069 0.428
MOD_NEK2_1 77 82 PF00069 0.263
MOD_NEK2_1 83 88 PF00069 0.248
MOD_PKA_2 77 83 PF00069 0.355
MOD_Plk_1 141 147 PF00069 0.283
MOD_Plk_1 200 206 PF00069 0.333
MOD_Plk_4 114 120 PF00069 0.343
MOD_ProDKin_1 41 47 PF00069 0.381
MOD_SUMO_rev_2 17 26 PF00179 0.434
TRG_ER_diArg_1 61 63 PF00400 0.445
TRG_NES_CRM1_1 10 23 PF08389 0.311
TRG_Pf-PMV_PEXEL_1 61 65 PF00026 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0E1 Leptomonas seymouri 63% 99%
A0A0N1I1H5 Leptomonas seymouri 28% 76%
A0A0S4J7R4 Bodo saltans 23% 75%
A0A0S4JHD6 Bodo saltans 45% 99%
A0A1X0NIK0 Trypanosomatidae 27% 73%
A0A1X0P4J5 Trypanosomatidae 45% 99%
A0A3Q8IGE5 Leishmania donovani 100% 100%
A0A3R7LDV5 Trypanosoma rangeli 27% 75%
A0A3S7WY30 Leishmania donovani 26% 76%
A4HD98 Leishmania braziliensis 28% 100%
A4HDW6 Leishmania braziliensis 78% 100%
D0A5E6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 99%
D0A712 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 75%
E9AH53 Leishmania infantum 26% 100%
E9AWN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AX95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O01391 Aplysia californica 35% 100%
O04482 Arabidopsis thaliana 27% 71%
P09936 Homo sapiens 33% 100%
P15374 Homo sapiens 36% 100%
P23356 Bos taurus 30% 92%
P35122 Drosophila melanogaster 35% 100%
P35127 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 99%
P50103 Monodelphis domestica 34% 100%
P58321 Mus musculus 34% 100%
Q00981 Rattus norvegicus 32% 100%
Q06AB3 Sus scrofa 36% 100%
Q06AT3 Sus scrofa 25% 71%
Q09444 Caenorhabditis elegans 23% 73%
Q10171 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
Q2TBG8 Bos taurus 37% 100%
Q4QA77 Leishmania major 93% 100%
Q4QAT9 Leishmania major 28% 100%
Q54N38 Dictyostelium discoideum 24% 68%
Q54T48 Dictyostelium discoideum 32% 91%
Q60HC8 Macaca fascicularis 33% 100%
Q6SEG5 Sus scrofa 32% 100%
Q8GWE1 Arabidopsis thaliana 38% 100%
Q8IKM8 Plasmodium falciparum (isolate 3D7) 34% 100%
Q91Y78 Rattus norvegicus 36% 100%
Q9FFF2 Arabidopsis thaliana 27% 70%
Q9GM50 Equus caballus 32% 100%
Q9JKB1 Mus musculus 37% 100%
Q9R0P9 Mus musculus 32% 100%
Q9UUB6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 78%
Q9WUP7 Mus musculus 26% 71%
Q9XSJ0 Bos taurus 26% 71%
Q9Y5K5 Homo sapiens 25% 71%
V5BN93 Trypanosoma cruzi 44% 99%
V5DSM1 Trypanosoma cruzi 24% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS