Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I158_LEIIN

TriTrypDb:

LINF_250006700

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I158

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I158

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.601
CLV_NRD_NRD_1	154	156	PF00675	0.628
CLV_NRD_NRD_1	179	181	PF00675	0.546
CLV_NRD_NRD_1	187	189	PF00675	0.566
CLV_NRD_NRD_1	39	41	PF00675	0.582
CLV_PCSK_FUR_1	37	41	PF00082	0.595
CLV_PCSK_KEX2_1	154	156	PF00082	0.628
CLV_PCSK_KEX2_1	186	188	PF00082	0.566
CLV_PCSK_KEX2_1	39	41	PF00082	0.582
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.584
CLV_PCSK_SKI1_1	133	137	PF00082	0.486
CLV_PCSK_SKI1_1	154	158	PF00082	0.629
CLV_PCSK_SKI1_1	82	86	PF00082	0.506
CLV_Separin_Metazoa	34	38	PF03568	0.583
DOC_MAPK_gen_1	133	141	PF00069	0.491
DOC_MAPK_MEF2A_6	142	150	PF00069	0.375
DOC_USP7_MATH_1	41	45	PF00917	0.630
DOC_USP7_MATH_1	54	58	PF00917	0.539
DOC_USP7_MATH_2	60	66	PF00917	0.649
DOC_WW_Pin1_4	204	209	PF00397	0.680
LIG_14-3-3_CanoR_1	40	46	PF00244	0.575
LIG_Actin_WH2_2	24	41	PF00022	0.553
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BIR_III_3	1	5	PF00653	0.608
LIG_BIR_III_4	3	7	PF00653	0.387
LIG_Clathr_ClatBox_1	9	13	PF01394	0.473
LIG_FHA_1	124	130	PF00498	0.548
LIG_FHA_1	5	11	PF00498	0.486
LIG_FHA_2	174	180	PF00498	0.419
LIG_FHA_2	65	71	PF00498	0.578
LIG_LIR_Gen_1	179	189	PF02991	0.561
LIG_LIR_Gen_1	83	93	PF02991	0.483
LIG_LIR_LC3C_4	137	141	PF02991	0.516
LIG_LIR_Nem_3	83	88	PF02991	0.483
LIG_NRBOX	87	93	PF00104	0.418
LIG_RPA_C_Fungi	35	47	PF08784	0.531
LIG_SH2_SRC	189	192	PF00017	0.523
LIG_SH2_STAP1	189	193	PF00017	0.518
LIG_SH3_3	205	211	PF00018	0.676
LIG_SUMO_SIM_par_1	6	11	PF11976	0.529
MOD_CDK_SPK_2	209	214	PF00069	0.524
MOD_CK2_1	173	179	PF00069	0.558
MOD_CK2_1	64	70	PF00069	0.643
MOD_GlcNHglycan	64	67	PF01048	0.771
MOD_GlcNHglycan	73	78	PF01048	0.637
MOD_GSK3_1	4	11	PF00069	0.521
MOD_N-GLC_1	41	46	PF02516	0.542
MOD_NEK2_1	173	178	PF00069	0.418
MOD_PIKK_1	206	212	PF00454	0.602
MOD_PIKK_1	22	28	PF00454	0.605
MOD_PK_1	142	148	PF00069	0.376
MOD_Plk_1	117	123	PF00069	0.557
MOD_Plk_1	41	47	PF00069	0.635
MOD_Plk_4	173	179	PF00069	0.419
MOD_Plk_4	4	10	PF00069	0.577
MOD_Plk_4	41	47	PF00069	0.624
MOD_ProDKin_1	204	210	PF00069	0.685
TRG_DiLeu_BaEn_4	130	136	PF01217	0.585
TRG_ENDOCYTIC_2	182	185	PF00928	0.582
TRG_ER_diArg_1	110	113	PF00400	0.538
TRG_ER_diArg_1	153	155	PF00400	0.633
TRG_ER_diArg_1	187	189	PF00400	0.625
TRG_ER_diArg_1	36	39	PF00400	0.555
TRG_ER_diArg_1	98	101	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM96	Leptomonas seymouri	45%	96%
A0A1X0P602	Trypanosomatidae	31%	69%
A0A3Q8ID59	Leishmania donovani	100%	100%
A0A422NF37	Trypanosoma rangeli	34%	69%
A4HDW3	Leishmania braziliensis	74%	100%
D0A5E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	68%
E9AX92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QA80	Leishmania major	88%	100%
V5BXK9	Trypanosoma cruzi	32%	69%