Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I157_LEIIN

TriTrypDb:

LINF_250006600

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I157

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I157

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.498
CLV_C14_Caspase3-7	283	287	PF00656	0.439
CLV_C14_Caspase3-7	372	376	PF00656	0.456
CLV_NRD_NRD_1	100	102	PF00675	0.557
CLV_NRD_NRD_1	185	187	PF00675	0.513
CLV_NRD_NRD_1	209	211	PF00675	0.561
CLV_NRD_NRD_1	493	495	PF00675	0.370
CLV_NRD_NRD_1	518	520	PF00675	0.389
CLV_NRD_NRD_1	97	99	PF00675	0.545
CLV_PCSK_FUR_1	98	102	PF00082	0.566
CLV_PCSK_KEX2_1	185	187	PF00082	0.513
CLV_PCSK_KEX2_1	209	211	PF00082	0.565
CLV_PCSK_KEX2_1	493	495	PF00082	0.367
CLV_PCSK_KEX2_1	518	520	PF00082	0.389
CLV_PCSK_KEX2_1	99	101	PF00082	0.540
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.602
CLV_PCSK_SKI1_1	100	104	PF00082	0.601
CLV_PCSK_SKI1_1	140	144	PF00082	0.526
CLV_PCSK_SKI1_1	186	190	PF00082	0.582
CLV_PCSK_SKI1_1	451	455	PF00082	0.346
CLV_PCSK_SKI1_1	503	507	PF00082	0.419
CLV_PCSK_SKI1_1	555	559	PF00082	0.385
CLV_PCSK_SKI1_1	566	570	PF00082	0.616
CLV_Separin_Metazoa	200	204	PF03568	0.322
DEG_APCC_DBOX_1	139	147	PF00400	0.244
DEG_APCC_DBOX_1	185	193	PF00400	0.373
DEG_APCC_DBOX_1	197	205	PF00400	0.242
DEG_APCC_DBOX_1	554	562	PF00400	0.510
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DOC_CKS1_1	267	272	PF01111	0.571
DOC_CKS1_1	633	638	PF01111	0.270
DOC_CYCLIN_RxL_1	448	458	PF00134	0.541
DOC_CYCLIN_RxL_1	500	509	PF00134	0.516
DOC_CYCLIN_RxL_1	97	106	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.267
DOC_MAPK_DCC_7	140	148	PF00069	0.247
DOC_MAPK_gen_1	196	204	PF00069	0.422
DOC_MAPK_gen_1	441	450	PF00069	0.432
DOC_MAPK_gen_1	518	528	PF00069	0.573
DOC_MAPK_MEF2A_6	132	139	PF00069	0.303
DOC_MAPK_MEF2A_6	140	148	PF00069	0.307
DOC_MAPK_MEF2A_6	198	206	PF00069	0.412
DOC_MAPK_MEF2A_6	519	528	PF00069	0.571
DOC_MAPK_MEF2A_6	685	693	PF00069	0.489
DOC_MAPK_MEF2A_6	86	93	PF00069	0.310
DOC_MAPK_RevD_3	87	100	PF00069	0.344
DOC_PP1_RVXF_1	449	456	PF00149	0.486
DOC_PP4_FxxP_1	390	393	PF00568	0.321
DOC_PP4_FxxP_1	609	612	PF00568	0.272
DOC_USP7_MATH_1	166	170	PF00917	0.444
DOC_USP7_MATH_1	549	553	PF00917	0.276
DOC_USP7_MATH_1	567	571	PF00917	0.346
DOC_USP7_MATH_1	582	586	PF00917	0.419
DOC_USP7_MATH_1	637	641	PF00917	0.389
DOC_USP7_MATH_1	676	680	PF00917	0.371
DOC_USP7_MATH_1	683	687	PF00917	0.400
DOC_USP7_MATH_1	75	79	PF00917	0.282
DOC_USP7_MATH_2	386	392	PF00917	0.381
DOC_WW_Pin1_4	162	167	PF00397	0.565
DOC_WW_Pin1_4	263	268	PF00397	0.547
DOC_WW_Pin1_4	382	387	PF00397	0.462
DOC_WW_Pin1_4	578	583	PF00397	0.402
DOC_WW_Pin1_4	632	637	PF00397	0.325
DOC_WW_Pin1_4	691	696	PF00397	0.381
DOC_WW_Pin1_4	70	75	PF00397	0.403
LIG_14-3-3_CanoR_1	101	111	PF00244	0.497
LIG_14-3-3_CanoR_1	122	128	PF00244	0.350
LIG_14-3-3_CanoR_1	247	257	PF00244	0.434
LIG_14-3-3_CanoR_1	277	285	PF00244	0.419
LIG_14-3-3_CanoR_1	408	417	PF00244	0.422
LIG_14-3-3_CanoR_1	441	450	PF00244	0.518
LIG_14-3-3_CanoR_1	519	525	PF00244	0.567
LIG_14-3-3_CanoR_1	566	575	PF00244	0.429
LIG_14-3-3_CanoR_1	667	672	PF00244	0.425
LIG_Actin_WH2_2	135	151	PF00022	0.335
LIG_Actin_WH2_2	194	211	PF00022	0.251
LIG_Actin_WH2_2	425	443	PF00022	0.342
LIG_APCC_ABBA_1	89	94	PF00400	0.316
LIG_BIR_III_2	150	154	PF00653	0.345
LIG_BRCT_BRCA1_1	314	318	PF00533	0.409
LIG_Clathr_ClatBox_1	368	372	PF01394	0.457
LIG_deltaCOP1_diTrp_1	31	40	PF00928	0.299
LIG_EVH1_1	241	245	PF00568	0.438
LIG_FHA_1	129	135	PF00498	0.401
LIG_FHA_1	249	255	PF00498	0.493
LIG_FHA_1	292	298	PF00498	0.337
LIG_FHA_1	521	527	PF00498	0.520
LIG_FHA_2	209	215	PF00498	0.419
LIG_FHA_2	281	287	PF00498	0.530
LIG_FHA_2	410	416	PF00498	0.345
LIG_FHA_2	675	681	PF00498	0.468
LIG_FHA_2	692	698	PF00498	0.439
LIG_GBD_Chelix_1	403	411	PF00786	0.471
LIG_GBD_Chelix_1	524	532	PF00786	0.365
LIG_LIR_Apic_2	387	393	PF02991	0.337
LIG_LIR_Apic_2	606	612	PF02991	0.285
LIG_LIR_Gen_1	109	119	PF02991	0.368
LIG_LIR_Gen_1	31	40	PF02991	0.346
LIG_LIR_Gen_1	492	502	PF02991	0.510
LIG_LIR_Gen_1	78	88	PF02991	0.308
LIG_LIR_LC3C_4	611	615	PF02991	0.354
LIG_LIR_Nem_3	109	114	PF02991	0.391
LIG_LIR_Nem_3	31	35	PF02991	0.336
LIG_LIR_Nem_3	387	392	PF02991	0.310
LIG_LIR_Nem_3	492	498	PF02991	0.515
LIG_LIR_Nem_3	78	83	PF02991	0.279
LIG_LIR_Nem_3	85	91	PF02991	0.276
LIG_LYPXL_yS_3	550	553	PF13949	0.393
LIG_MYND_3	22	26	PF01753	0.389
LIG_NRBOX	449	455	PF00104	0.563
LIG_NRBOX	557	563	PF00104	0.375
LIG_PDZ_Class_2	708	713	PF00595	0.293
LIG_RPA_C_Fungi	439	451	PF08784	0.315
LIG_SH2_CRK	227	231	PF00017	0.422
LIG_SH2_PTP2	80	83	PF00017	0.349
LIG_SH2_PTP2	88	91	PF00017	0.376
LIG_SH2_STAP1	421	425	PF00017	0.541
LIG_SH2_STAP1	495	499	PF00017	0.449
LIG_SH2_STAT5	389	392	PF00017	0.380
LIG_SH2_STAT5	436	439	PF00017	0.308
LIG_SH2_STAT5	466	469	PF00017	0.443
LIG_SH2_STAT5	80	83	PF00017	0.299
LIG_SH2_STAT5	88	91	PF00017	0.304
LIG_SH3_2	242	247	PF14604	0.560
LIG_SH3_3	236	242	PF00018	0.578
LIG_SH3_3	264	270	PF00018	0.606
LIG_SH3_3	64	70	PF00018	0.555
LIG_SH3_4	180	187	PF00018	0.482
LIG_Sin3_3	219	226	PF02671	0.339
LIG_SUMO_SIM_par_1	135	141	PF11976	0.278
LIG_SUMO_SIM_par_1	367	372	PF11976	0.566
LIG_SUMO_SIM_par_1	399	405	PF11976	0.355
LIG_SUMO_SIM_par_1	504	509	PF11976	0.333
LIG_SUMO_SIM_par_1	522	527	PF11976	0.365
LIG_SUMO_SIM_par_1	587	593	PF11976	0.447
LIG_SUMO_SIM_par_1	62	68	PF11976	0.482
LIG_SUMO_SIM_par_1	694	700	PF11976	0.501
LIG_TRAF2_1	385	388	PF00917	0.491
LIG_TRAF2_1	470	473	PF00917	0.469
LIG_WRC_WIRS_1	108	113	PF05994	0.423
LIG_WRC_WIRS_1	495	500	PF05994	0.424
MOD_CDK_SPK_2	266	271	PF00069	0.497
MOD_CK1_1	179	185	PF00069	0.477
MOD_CK1_1	266	272	PF00069	0.687
MOD_CK1_1	312	318	PF00069	0.409
MOD_CK1_1	326	332	PF00069	0.544
MOD_CK1_1	382	388	PF00069	0.490
MOD_CK1_1	424	430	PF00069	0.285
MOD_CK1_1	489	495	PF00069	0.588
MOD_CK1_1	603	609	PF00069	0.475
MOD_CK1_1	63	69	PF00069	0.476
MOD_CK1_1	632	638	PF00069	0.418
MOD_CK2_1	209	215	PF00069	0.630
MOD_CK2_1	278	284	PF00069	0.609
MOD_CK2_1	382	388	PF00069	0.557
MOD_CK2_1	409	415	PF00069	0.409
MOD_CK2_1	467	473	PF00069	0.361
MOD_CK2_1	674	680	PF00069	0.475
MOD_GlcNHglycan	166	169	PF01048	0.579
MOD_GlcNHglycan	214	220	PF01048	0.590
MOD_GlcNHglycan	311	314	PF01048	0.440
MOD_GlcNHglycan	325	328	PF01048	0.385
MOD_GlcNHglycan	35	38	PF01048	0.462
MOD_GlcNHglycan	377	380	PF01048	0.631
MOD_GlcNHglycan	381	384	PF01048	0.599
MOD_GlcNHglycan	423	426	PF01048	0.355
MOD_GlcNHglycan	444	447	PF01048	0.412
MOD_GlcNHglycan	46	49	PF01048	0.560
MOD_GlcNHglycan	460	463	PF01048	0.317
MOD_GlcNHglycan	469	472	PF01048	0.464
MOD_GlcNHglycan	508	511	PF01048	0.392
MOD_GlcNHglycan	606	609	PF01048	0.474
MOD_GlcNHglycan	639	642	PF01048	0.470
MOD_GSK3_1	1	8	PF00069	0.664
MOD_GSK3_1	152	159	PF00069	0.606
MOD_GSK3_1	162	169	PF00069	0.578
MOD_GSK3_1	170	177	PF00069	0.498
MOD_GSK3_1	226	233	PF00069	0.359
MOD_GSK3_1	246	253	PF00069	0.657
MOD_GSK3_1	347	354	PF00069	0.602
MOD_GSK3_1	375	382	PF00069	0.546
MOD_GSK3_1	415	422	PF00069	0.567
MOD_GSK3_1	42	49	PF00069	0.538
MOD_GSK3_1	578	585	PF00069	0.538
MOD_GSK3_1	59	66	PF00069	0.404
MOD_GSK3_1	600	607	PF00069	0.404
MOD_NEK2_1	138	143	PF00069	0.412
MOD_NEK2_1	208	213	PF00069	0.474
MOD_NEK2_1	246	251	PF00069	0.665
MOD_NEK2_1	289	294	PF00069	0.472
MOD_NEK2_1	323	328	PF00069	0.450
MOD_NEK2_1	419	424	PF00069	0.474
MOD_NEK2_1	44	49	PF00069	0.592
MOD_NEK2_1	506	511	PF00069	0.362
MOD_NEK2_1	520	525	PF00069	0.402
MOD_NEK2_1	540	545	PF00069	0.207
MOD_NEK2_1	60	65	PF00069	0.440
MOD_NEK2_1	604	609	PF00069	0.364
MOD_NEK2_1	699	704	PF00069	0.386
MOD_NEK2_2	75	80	PF00069	0.330
MOD_PIKK_1	597	603	PF00454	0.394
MOD_PK_1	645	651	PF00069	0.407
MOD_PKA_1	209	215	PF00069	0.475
MOD_PKA_2	156	162	PF00069	0.691
MOD_PKA_2	208	214	PF00069	0.397
MOD_PKA_2	246	252	PF00069	0.603
MOD_PKA_2	342	348	PF00069	0.734
MOD_PKA_2	52	58	PF00069	0.520
MOD_Plk_1	533	539	PF00069	0.371
MOD_Plk_1	645	651	PF00069	0.440
MOD_Plk_1	689	695	PF00069	0.471
MOD_Plk_4	364	370	PF00069	0.608
MOD_Plk_4	424	430	PF00069	0.285
MOD_Plk_4	494	500	PF00069	0.412
MOD_Plk_4	540	546	PF00069	0.295
MOD_Plk_4	582	588	PF00069	0.385
MOD_Plk_4	60	66	PF00069	0.392
MOD_Plk_4	667	673	PF00069	0.521
MOD_Plk_4	75	81	PF00069	0.256
MOD_ProDKin_1	162	168	PF00069	0.730
MOD_ProDKin_1	263	269	PF00069	0.710
MOD_ProDKin_1	382	388	PF00069	0.578
MOD_ProDKin_1	578	584	PF00069	0.489
MOD_ProDKin_1	632	638	PF00069	0.393
MOD_ProDKin_1	691	697	PF00069	0.463
MOD_ProDKin_1	70	76	PF00069	0.495
MOD_SUMO_for_1	568	571	PF00179	0.397
MOD_SUMO_rev_2	173	182	PF00179	0.671
TRG_DiLeu_BaEn_1	200	205	PF01217	0.428
TRG_DiLeu_BaEn_1	364	369	PF01217	0.555
TRG_DiLeu_BaEn_4	387	393	PF01217	0.378
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.594
TRG_ENDOCYTIC_2	227	230	PF00928	0.421
TRG_ENDOCYTIC_2	32	35	PF00928	0.366
TRG_ENDOCYTIC_2	389	392	PF00928	0.370
TRG_ENDOCYTIC_2	495	498	PF00928	0.454
TRG_ENDOCYTIC_2	550	553	PF00928	0.331
TRG_ENDOCYTIC_2	80	83	PF00928	0.318
TRG_ENDOCYTIC_2	88	91	PF00928	0.361
TRG_ER_diArg_1	195	198	PF00400	0.357
TRG_ER_diArg_1	208	210	PF00400	0.309
TRG_ER_diArg_1	257	260	PF00400	0.580
TRG_ER_diArg_1	493	495	PF00400	0.521
TRG_ER_diArg_1	518	520	PF00400	0.564
TRG_ER_diArg_1	535	538	PF00400	0.271
TRG_ER_diArg_1	98	101	PF00400	0.417
TRG_NES_CRM1_1	611	623	PF08389	0.443
TRG_NLS_MonoExtN_4	98	103	PF00514	0.506
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAE2	Leptomonas seymouri	39%	85%
A0A1X0P4U7	Trypanosomatidae	24%	98%
A0A3Q8ID38	Leishmania donovani	100%	100%
A0A422NF62	Trypanosoma rangeli	22%	99%
A4HDW2	Leishmania braziliensis	69%	100%
D0A5E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
E9AX91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QA81	Leishmania major	90%	100%