Beta galactofuranosyl transferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta galactofuranosyl transferase

Species:

Leishmania infantum

UniProt:

A4I143_LEIIN

TriTrypDb:

LINF_250005000

Length:

434

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Annotations by Jardim et al.

Glycolipid biosynthesis, Beta galactofuranosyl transferase LPG1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4I143

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I143

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	38
GO:0016740	transferase activity	2	38
GO:0016757	glycosyltransferase activity	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	15	21	PF00089	0.177
CLV_NRD_NRD_1	11	13	PF00675	0.456
CLV_NRD_NRD_1	204	206	PF00675	0.643
CLV_NRD_NRD_1	365	367	PF00675	0.489
CLV_NRD_NRD_1	403	405	PF00675	0.534
CLV_PCSK_FUR_1	202	206	PF00082	0.462
CLV_PCSK_KEX2_1	10	12	PF00082	0.466
CLV_PCSK_KEX2_1	204	206	PF00082	0.628
CLV_PCSK_KEX2_1	365	367	PF00082	0.512
CLV_PCSK_KEX2_1	402	404	PF00082	0.527
CLV_PCSK_PC7_1	361	367	PF00082	0.558
CLV_PCSK_SKI1_1	120	124	PF00082	0.562
CLV_PCSK_SKI1_1	158	162	PF00082	0.444
CLV_PCSK_SKI1_1	224	228	PF00082	0.584
CLV_PCSK_SKI1_1	337	341	PF00082	0.714
CLV_PCSK_SKI1_1	365	369	PF00082	0.534
CLV_PCSK_SKI1_1	95	99	PF00082	0.522
DEG_APCC_DBOX_1	119	127	PF00400	0.355
DEG_APCC_DBOX_1	17	25	PF00400	0.493
DOC_CYCLIN_RxL_1	117	124	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.251
DOC_MAPK_DCC_7	79	89	PF00069	0.346
DOC_MAPK_gen_1	10	19	PF00069	0.636
DOC_MAPK_gen_1	417	426	PF00069	0.443
DOC_MAPK_MEF2A_6	10	19	PF00069	0.606
DOC_MAPK_MEF2A_6	79	87	PF00069	0.344
DOC_PP1_RVXF_1	317	324	PF00149	0.319
DOC_PP1_RVXF_1	423	430	PF00149	0.260
DOC_PP4_FxxP_1	314	317	PF00568	0.364
DOC_PP4_MxPP_1	1	4	PF00568	0.530
DOC_USP7_MATH_1	118	122	PF00917	0.410
DOC_USP7_MATH_1	226	230	PF00917	0.393
DOC_WW_Pin1_4	46	51	PF00397	0.286
LIG_14-3-3_CanoR_1	117	123	PF00244	0.410
LIG_14-3-3_CanoR_1	228	235	PF00244	0.270
LIG_14-3-3_CanoR_1	243	248	PF00244	0.381
LIG_14-3-3_CanoR_1	69	73	PF00244	0.402
LIG_Actin_WH2_2	203	220	PF00022	0.274
LIG_APCC_ABBA_1	374	379	PF00400	0.268
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_BIR_III_1	1	5	PF00653	0.527
LIG_BIR_III_3	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	348	352	PF00533	0.389
LIG_eIF4E_1	133	139	PF01652	0.356
LIG_eIF4E_1	22	28	PF01652	0.226
LIG_FHA_1	257	263	PF00498	0.345
LIG_FHA_1	271	277	PF00498	0.352
LIG_FHA_1	388	394	PF00498	0.378
LIG_FHA_2	172	178	PF00498	0.227
LIG_FHA_2	43	49	PF00498	0.419
LIG_FXI_DFP_1	426	430	PF00024	0.432
LIG_HCF-1_HBM_1	298	301	PF13415	0.381
LIG_LIR_Gen_1	106	115	PF02991	0.223
LIG_LIR_Gen_1	60	70	PF02991	0.363
LIG_LIR_Gen_1	88	98	PF02991	0.315
LIG_LIR_Nem_3	106	110	PF02991	0.313
LIG_LIR_Nem_3	258	263	PF02991	0.261
LIG_LIR_Nem_3	289	295	PF02991	0.290
LIG_LIR_Nem_3	418	422	PF02991	0.407
LIG_LIR_Nem_3	60	66	PF02991	0.356
LIG_LIR_Nem_3	88	94	PF02991	0.341
LIG_NRBOX	20	26	PF00104	0.373
LIG_Pex14_2	270	274	PF04695	0.232
LIG_PTB_Apo_2	110	117	PF02174	0.353
LIG_PTB_Apo_2	219	226	PF02174	0.240
LIG_PTB_Apo_2	339	346	PF02174	0.282
LIG_PTB_Phospho_1	339	345	PF10480	0.280
LIG_SH2_CRK	22	26	PF00017	0.438
LIG_SH2_PTP2	30	33	PF00017	0.223
LIG_SH2_PTP2	82	85	PF00017	0.217
LIG_SH2_SRC	91	94	PF00017	0.405
LIG_SH2_STAP1	149	153	PF00017	0.238
LIG_SH2_STAP1	22	26	PF00017	0.213
LIG_SH2_STAP1	422	426	PF00017	0.256
LIG_SH2_STAT3	133	136	PF00017	0.203
LIG_SH2_STAT3	345	348	PF00017	0.397
LIG_SH2_STAT3	72	75	PF00017	0.284
LIG_SH2_STAT5	107	110	PF00017	0.352
LIG_SH2_STAT5	133	136	PF00017	0.332
LIG_SH2_STAT5	22	25	PF00017	0.376
LIG_SH2_STAT5	264	267	PF00017	0.268
LIG_SH2_STAT5	291	294	PF00017	0.273
LIG_SH2_STAT5	30	33	PF00017	0.344
LIG_SH2_STAT5	301	304	PF00017	0.300
LIG_SH2_STAT5	313	316	PF00017	0.297
LIG_SH2_STAT5	345	348	PF00017	0.406
LIG_SH2_STAT5	82	85	PF00017	0.235
LIG_SH3_3	217	223	PF00018	0.371
LIG_SH3_3	427	433	PF00018	0.419
LIG_SH3_3	80	86	PF00018	0.381
LIG_TRAF2_1	248	251	PF00917	0.421
LIG_TRFH_1	82	86	PF08558	0.453
LIG_TYR_ITIM	80	85	PF00017	0.247
LIG_ULM_U2AF65_1	365	370	PF00076	0.372
LIG_WRC_WIRS_1	271	276	PF05994	0.385
LIG_WRPW_2	419	422	PF00400	0.278
LIG_WW_3	2	6	PF00397	0.382
MOD_CDK_SPK_2	46	51	PF00069	0.321
MOD_CK2_1	402	408	PF00069	0.227
MOD_CK2_1	68	74	PF00069	0.303
MOD_GlcNHglycan	150	153	PF01048	0.356
MOD_GlcNHglycan	332	335	PF01048	0.407
MOD_GlcNHglycan	51	54	PF01048	0.564
MOD_GSK3_1	270	277	PF00069	0.443
MOD_GSK3_1	38	45	PF00069	0.560
MOD_GSK3_1	99	106	PF00069	0.428
MOD_N-GLC_1	161	166	PF02516	0.203
MOD_N-GLC_1	38	43	PF02516	0.379
MOD_N-GLC_1	387	392	PF02516	0.500
MOD_N-GLC_1	99	104	PF02516	0.313
MOD_NEK2_1	161	166	PF00069	0.266
MOD_NEK2_1	227	232	PF00069	0.481
MOD_NEK2_1	256	261	PF00069	0.494
MOD_NEK2_1	270	275	PF00069	0.369
MOD_NEK2_1	340	345	PF00069	0.548
MOD_NEK2_1	346	351	PF00069	0.426
MOD_NEK2_1	387	392	PF00069	0.500
MOD_PIKK_1	187	193	PF00454	0.456
MOD_PIKK_1	227	233	PF00454	0.470
MOD_PK_1	402	408	PF00069	0.489
MOD_PKA_1	402	408	PF00069	0.448
MOD_PKA_2	227	233	PF00069	0.386
MOD_PKA_2	402	408	PF00069	0.498
MOD_PKA_2	68	74	PF00069	0.502
MOD_PKB_1	40	48	PF00069	0.343
MOD_Plk_1	161	167	PF00069	0.443
MOD_Plk_1	99	105	PF00069	0.320
MOD_Plk_2-3	68	74	PF00069	0.319
MOD_Plk_4	103	109	PF00069	0.480
MOD_Plk_4	20	26	PF00069	0.431
MOD_Plk_4	372	378	PF00069	0.356
MOD_ProDKin_1	46	52	PF00069	0.350
MOD_SUMO_rev_2	90	97	PF00179	0.412
TRG_DiLeu_BaEn_2	315	321	PF01217	0.258
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.438
TRG_ENDOCYTIC_2	107	110	PF00928	0.456
TRG_ENDOCYTIC_2	22	25	PF00928	0.332
TRG_ENDOCYTIC_2	260	263	PF00928	0.307
TRG_ENDOCYTIC_2	357	360	PF00928	0.376
TRG_ENDOCYTIC_2	82	85	PF00928	0.468
TRG_ENDOCYTIC_2	91	94	PF00928	0.424
TRG_ER_diArg_1	10	12	PF00400	0.566
TRG_ER_diArg_1	202	205	PF00400	0.544
TRG_ER_diArg_1	242	245	PF00400	0.402
TRG_ER_diArg_1	364	366	PF00400	0.372
TRG_ER_diArg_1	402	404	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P269	Leptomonas seymouri	52%	100%
A0A0N1IJD9	Leptomonas seymouri	26%	76%
A0A0N1PC27	Leptomonas seymouri	30%	96%
A0A0N1PES8	Leptomonas seymouri	58%	98%
A0A1X0NWK3	Trypanosomatidae	33%	100%
A0A1X0NWM3	Trypanosomatidae	34%	100%
A0A3R7N1J7	Trypanosoma rangeli	32%	100%
A0A3S5H7D9	Leishmania donovani	100%	100%
A0A3S7WZK8	Leishmania donovani	29%	81%
A0A3S7X6F1	Leishmania donovani	31%	94%
A4HDU8	Leishmania braziliensis	73%	100%
A4HL36	Leishmania braziliensis	29%	75%
A4I1Y7	Leishmania infantum	29%	81%
A4I8P7	Leishmania infantum	31%	94%
E9AHM5	Leishmania infantum	29%	73%
E9AXX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AY34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B3H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B3L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q05889	Leishmania donovani	99%	100%
Q4Q9D9	Leishmania major	28%	100%
Q4QD44	Leishmania major	27%	72%
Q6XFB5	Leishmania major	32%	100%
Q9NC61	Leishmania major	85%	100%
V5AJV9	Trypanosoma cruzi	32%	100%
V5AJW5	Trypanosoma cruzi	33%	100%
V5AM55	Trypanosoma cruzi	32%	100%
V5AR28	Trypanosoma cruzi	33%	100%
V5ASN8	Trypanosoma cruzi	33%	100%
V5AUJ2	Trypanosoma cruzi	32%	100%
V5B2H2	Trypanosoma cruzi	34%	100%
V5B4V1	Trypanosoma cruzi	32%	100%
V5B8H6	Trypanosoma cruzi	32%	100%
V5BB47	Trypanosoma cruzi	32%	100%
V5BRK8	Trypanosoma cruzi	33%	100%
V5BXG8	Trypanosoma cruzi	33%	100%
V5DD11	Trypanosoma cruzi	32%	100%