Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I138_LEIIN

TriTrypDb:

LINF_240029200

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I138

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I138

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.566
CLV_PCSK_KEX2_1	21	23	PF00082	0.566
CLV_PCSK_PC7_1	17	23	PF00082	0.565
CLV_PCSK_SKI1_1	138	142	PF00082	0.678
CLV_PCSK_SKI1_1	169	173	PF00082	0.615
DEG_APCC_DBOX_1	137	145	PF00400	0.672
DEG_APCC_DBOX_1	168	176	PF00400	0.671
DEG_Nend_UBRbox_2	1	3	PF02207	0.780
DOC_MIT_MIM_1	97	105	PF04212	0.561
DOC_USP7_MATH_1	20	24	PF00917	0.751
DOC_USP7_MATH_1	25	29	PF00917	0.679
DOC_USP7_MATH_1	49	53	PF00917	0.686
DOC_USP7_MATH_1	66	70	PF00917	0.460
DOC_USP7_UBL2_3	107	111	PF12436	0.642
LIG_14-3-3_CanoR_1	101	106	PF00244	0.552
LIG_14-3-3_CanoR_1	138	148	PF00244	0.536
LIG_14-3-3_CanoR_1	211	219	PF00244	0.648
LIG_Actin_WH2_2	141	157	PF00022	0.647
LIG_Actin_WH2_2	56	74	PF00022	0.665
LIG_Clathr_ClatBox_1	123	127	PF01394	0.607
LIG_DLG_GKlike_1	101	109	PF00625	0.553
LIG_FHA_1	149	155	PF00498	0.506
LIG_FHA_1	35	41	PF00498	0.403
LIG_FHA_2	117	123	PF00498	0.616
LIG_LIR_Gen_1	146	154	PF02991	0.544
LIG_LIR_Gen_1	2	11	PF02991	0.714
LIG_LIR_Gen_1	58	68	PF02991	0.569
LIG_LIR_Gen_1	78	86	PF02991	0.471
LIG_LIR_Nem_3	146	150	PF02991	0.546
LIG_LIR_Nem_3	2	7	PF02991	0.693
LIG_LIR_Nem_3	58	63	PF02991	0.573
LIG_LIR_Nem_3	78	83	PF02991	0.465
LIG_NRBOX	108	114	PF00104	0.512
LIG_SH2_GRB2like	33	36	PF00017	0.706
LIG_SH2_NCK_1	227	231	PF00017	0.427
LIG_SH2_NCK_1	33	37	PF00017	0.625
LIG_SH2_NCK_1	4	8	PF00017	0.695
LIG_SH2_SRC	227	230	PF00017	0.429
LIG_SH2_SRC	33	36	PF00017	0.706
LIG_SH2_STAP1	4	8	PF00017	0.773
LIG_SH2_STAT5	39	42	PF00017	0.635
LIG_SUMO_SIM_par_1	121	127	PF11976	0.619
LIG_SUMO_SIM_par_1	52	61	PF11976	0.575
LIG_TRAF2_1	119	122	PF00917	0.612
LIG_TYR_ITIM	225	230	PF00017	0.433
LIG_WRC_WIRS_1	144	149	PF05994	0.562
MOD_CK1_1	131	137	PF00069	0.559
MOD_CK1_1	139	145	PF00069	0.486
MOD_CK1_1	153	159	PF00069	0.527
MOD_CK1_1	213	219	PF00069	0.627
MOD_CK1_1	23	29	PF00069	0.685
MOD_CK1_1	92	98	PF00069	0.651
MOD_CK2_1	116	122	PF00069	0.650
MOD_CK2_1	197	203	PF00069	0.541
MOD_GlcNHglycan	133	136	PF01048	0.679
MOD_GlcNHglycan	212	215	PF01048	0.566
MOD_GlcNHglycan	27	30	PF01048	0.691
MOD_GSK3_1	127	134	PF00069	0.542
MOD_GSK3_1	139	146	PF00069	0.474
MOD_GSK3_1	156	163	PF00069	0.508
MOD_GSK3_1	20	27	PF00069	0.758
MOD_GSK3_1	209	216	PF00069	0.565
MOD_GSK3_1	47	54	PF00069	0.598
MOD_GSK3_1	88	95	PF00069	0.673
MOD_GSK3_1	97	104	PF00069	0.529
MOD_N-GLC_1	128	133	PF02516	0.716
MOD_N-GLC_1	179	184	PF02516	0.496
MOD_N-GLC_1	34	39	PF02516	0.408
MOD_NEK2_1	13	18	PF00069	0.691
MOD_NEK2_1	148	153	PF00069	0.619
MOD_NEK2_1	209	214	PF00069	0.669
MOD_PK_1	3	9	PF00069	0.693
MOD_PKA_2	20	26	PF00069	0.678
MOD_PKA_2	210	216	PF00069	0.661
MOD_Plk_1	105	111	PF00069	0.632
MOD_Plk_1	128	134	PF00069	0.623
MOD_Plk_1	66	72	PF00069	0.613
MOD_Plk_2-3	122	128	PF00069	0.615
MOD_Plk_4	143	149	PF00069	0.569
MOD_Plk_4	66	72	PF00069	0.684
MOD_SUMO_rev_2	193	200	PF00179	0.635
TRG_DiLeu_BaEn_4	121	127	PF01217	0.612
TRG_ENDOCYTIC_2	227	230	PF00928	0.452
TRG_ENDOCYTIC_2	4	7	PF00928	0.758
TRG_ER_diArg_1	15	18	PF00400	0.574
TRG_ER_diArg_1	20	22	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C0	Leptomonas seymouri	26%	100%
A0A3S7WYM3	Leishmania donovani	99%	100%
A4HDU1	Leishmania braziliensis	60%	100%
E9AX76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAA0	Leishmania major	86%	100%