Putative fatty-acid desaturase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty-acid desaturase - putative

Species:

Leishmania infantum

UniProt:

A4I134_LEIIN

TriTrypDb:

LINF_240028700

Length:

431

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, fatty-acid desaturase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

A4I134

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I134

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	16
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	16
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	16
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	16
GO:0005488	binding	1	6
GO:0005506	iron ion binding	6	2
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.480
CLV_NRD_NRD_1	17	19	PF00675	0.458
CLV_NRD_NRD_1	314	316	PF00675	0.362
CLV_NRD_NRD_1	348	350	PF00675	0.341
CLV_PCSK_KEX2_1	17	19	PF00082	0.458
CLV_PCSK_SKI1_1	172	176	PF00082	0.217
CLV_PCSK_SKI1_1	208	212	PF00082	0.304
CLV_PCSK_SKI1_1	308	312	PF00082	0.299
CLV_PCSK_SKI1_1	349	353	PF00082	0.309
CLV_PCSK_SKI1_1	397	401	PF00082	0.270
CLV_PCSK_SKI1_1	422	426	PF00082	0.248
CLV_PCSK_SKI1_1	427	431	PF00082	0.371
CLV_PCSK_SKI1_1	9	13	PF00082	0.434
DOC_CKS1_1	295	300	PF01111	0.493
DOC_CYCLIN_RxL_1	305	314	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.571
DOC_MAPK_MEF2A_6	324	332	PF00069	0.590
DOC_PP1_RVXF_1	206	212	PF00149	0.245
DOC_PP1_RVXF_1	281	288	PF00149	0.450
DOC_PP1_RVXF_1	374	381	PF00149	0.550
DOC_PP2B_LxvP_1	328	331	PF13499	0.561
DOC_PP2B_LxvP_1	37	40	PF13499	0.259
DOC_USP7_UBL2_3	172	176	PF12436	0.482
DOC_USP7_UBL2_3	308	312	PF12436	0.519
DOC_WW_Pin1_4	294	299	PF00397	0.460
LIG_14-3-3_CanoR_1	237	245	PF00244	0.431
LIG_14-3-3_CanoR_1	283	288	PF00244	0.580
LIG_14-3-3_CanoR_1	349	354	PF00244	0.442
LIG_14-3-3_CanoR_1	80	87	PF00244	0.460
LIG_Actin_WH2_2	414	429	PF00022	0.500
LIG_BRCT_BRCA1_1	89	93	PF00533	0.498
LIG_deltaCOP1_diTrp_1	196	202	PF00928	0.256
LIG_deltaCOP1_diTrp_1	335	338	PF00928	0.522
LIG_FHA_1	214	220	PF00498	0.229
LIG_FHA_1	276	282	PF00498	0.417
LIG_FHA_1	402	408	PF00498	0.469
LIG_FHA_1	59	65	PF00498	0.285
LIG_FHA_2	123	129	PF00498	0.459
LIG_FHA_2	19	25	PF00498	0.542
LIG_FHA_2	248	254	PF00498	0.438
LIG_FHA_2	295	301	PF00498	0.502
LIG_FHA_2	321	327	PF00498	0.570
LIG_LIR_Gen_1	149	158	PF02991	0.464
LIG_LIR_Gen_1	160	169	PF02991	0.419
LIG_LIR_Gen_1	225	234	PF02991	0.406
LIG_LIR_Gen_1	253	263	PF02991	0.438
LIG_LIR_Gen_1	28	39	PF02991	0.418
LIG_LIR_Gen_1	303	311	PF02991	0.547
LIG_LIR_Gen_1	335	346	PF02991	0.520
LIG_LIR_Gen_1	75	82	PF02991	0.244
LIG_LIR_Gen_1	90	100	PF02991	0.442
LIG_LIR_Nem_3	149	153	PF02991	0.445
LIG_LIR_Nem_3	160	166	PF02991	0.419
LIG_LIR_Nem_3	225	231	PF02991	0.439
LIG_LIR_Nem_3	253	258	PF02991	0.438
LIG_LIR_Nem_3	28	34	PF02991	0.418
LIG_LIR_Nem_3	335	341	PF02991	0.510
LIG_LIR_Nem_3	75	81	PF02991	0.261
LIG_LIR_Nem_3	90	96	PF02991	0.456
LIG_PCNA_yPIPBox_3	349	362	PF02747	0.538
LIG_Pex14_1	197	201	PF04695	0.242
LIG_Pex14_1	95	99	PF04695	0.456
LIG_Pex14_2	258	262	PF04695	0.415
LIG_REV1ctd_RIR_1	172	180	PF16727	0.415
LIG_SH2_CRK	150	154	PF00017	0.448
LIG_SH2_CRK	163	167	PF00017	0.448
LIG_SH2_CRK	203	207	PF00017	0.229
LIG_SH2_CRK	78	82	PF00017	0.456
LIG_SH2_GRB2like	255	258	PF00017	0.442
LIG_SH2_GRB2like	381	384	PF00017	0.477
LIG_SH2_PTP2	31	34	PF00017	0.361
LIG_SH2_SRC	22	25	PF00017	0.624
LIG_SH2_SRC	408	411	PF00017	0.406
LIG_SH2_STAP1	203	207	PF00017	0.245
LIG_SH2_STAP1	27	31	PF00017	0.468
LIG_SH2_STAT3	130	133	PF00017	0.426
LIG_SH2_STAT3	165	168	PF00017	0.426
LIG_SH2_STAT5	122	125	PF00017	0.455
LIG_SH2_STAT5	165	168	PF00017	0.549
LIG_SH2_STAT5	201	204	PF00017	0.229
LIG_SH2_STAT5	31	34	PF00017	0.362
LIG_SH2_STAT5	371	374	PF00017	0.542
LIG_SH2_STAT5	417	420	PF00017	0.527
LIG_SH2_STAT5	87	90	PF00017	0.464
LIG_SH3_3	180	186	PF00018	0.302
LIG_SH3_3	292	298	PF00018	0.487
LIG_SUMO_SIM_anti_2	357	364	PF11976	0.546
LIG_TRAF2_1	21	24	PF00917	0.544
LIG_TYR_ITIM	29	34	PF00017	0.499
LIG_TYR_ITIM	76	81	PF00017	0.267
LIG_UBA3_1	390	397	PF00899	0.456
LIG_WRC_WIRS_1	248	253	PF05994	0.415
MOD_CDK_SPK_2	294	299	PF00069	0.426
MOD_CK1_1	240	246	PF00069	0.415
MOD_CK1_1	364	370	PF00069	0.518
MOD_CK1_1	83	89	PF00069	0.456
MOD_CK2_1	18	24	PF00069	0.585
MOD_CK2_1	247	253	PF00069	0.404
MOD_CMANNOS	194	197	PF00535	0.427
MOD_Cter_Amidation	347	350	PF01082	0.346
MOD_GlcNHglycan	106	110	PF01048	0.205
MOD_GlcNHglycan	180	183	PF01048	0.229
MOD_GlcNHglycan	332	335	PF01048	0.334
MOD_GSK3_1	101	108	PF00069	0.390
MOD_GSK3_1	218	225	PF00069	0.305
MOD_GSK3_1	232	239	PF00069	0.436
MOD_GSK3_1	330	337	PF00069	0.501
MOD_GSK3_1	397	404	PF00069	0.464
MOD_GSK3_1	83	90	PF00069	0.474
MOD_GSK3_1	9	16	PF00069	0.600
MOD_N-GLC_1	232	237	PF02516	0.215
MOD_N-GLC_2	69	71	PF02516	0.361
MOD_NEK2_1	105	110	PF00069	0.444
MOD_NEK2_1	136	141	PF00069	0.442
MOD_NEK2_1	218	223	PF00069	0.312
MOD_NEK2_1	311	316	PF00069	0.586
MOD_NEK2_1	361	366	PF00069	0.560
MOD_NEK2_1	72	77	PF00069	0.336
MOD_PKA_1	349	355	PF00069	0.447
MOD_PKA_2	236	242	PF00069	0.431
MOD_Plk_1	148	154	PF00069	0.498
MOD_Plk_1	334	340	PF00069	0.510
MOD_Plk_4	148	154	PF00069	0.512
MOD_Plk_4	184	190	PF00069	0.229
MOD_Plk_4	213	219	PF00069	0.245
MOD_Plk_4	240	246	PF00069	0.455
MOD_Plk_4	283	289	PF00069	0.564
MOD_Plk_4	349	355	PF00069	0.472
MOD_Plk_4	413	419	PF00069	0.466
MOD_Plk_4	55	61	PF00069	0.204
MOD_ProDKin_1	294	300	PF00069	0.462
TRG_ENDOCYTIC_2	150	153	PF00928	0.460
TRG_ENDOCYTIC_2	163	166	PF00928	0.424
TRG_ENDOCYTIC_2	203	206	PF00928	0.229
TRG_ENDOCYTIC_2	255	258	PF00928	0.415
TRG_ENDOCYTIC_2	31	34	PF00928	0.408
TRG_ENDOCYTIC_2	78	81	PF00928	0.442
TRG_NLS_MonoExtC_3	311	316	PF00514	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI5	Leptomonas seymouri	84%	100%
A0A0S4KNP4	Bodo saltans	59%	97%
A0A1X0NW01	Trypanosomatidae	65%	100%
A0A3Q8I9W7	Leishmania donovani	46%	92%
A0A3Q8IBJ0	Leishmania donovani	100%	100%
A0A3R7MEL0	Trypanosoma rangeli	66%	100%
A4H6I1	Leishmania braziliensis	46%	100%
A4HDT6	Leishmania braziliensis	93%	100%
A4HVZ3	Leishmania infantum	46%	100%
B7SB91	Acheta domesticus	30%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9APP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
G5ED44	Caenorhabditis elegans	32%	100%
G5EGH6	Caenorhabditis elegans	32%	100%
O00767	Homo sapiens	30%	100%
O02858	Sus scrofa	29%	100%
O44390	Trichoplusia ni	31%	100%
O62849	Ovis aries	29%	100%
O65797	Arabidopsis thaliana	26%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	90%
P13011	Mus musculus	28%	100%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	85%
Q12618	Ajellomyces capsulatus	39%	91%
Q4QAA5	Leishmania major	97%	100%
Q4QFT4	Leishmania major	46%	100%
Q64420	Mesocricetus auratus	27%	100%
Q6P7B9	Rattus norvegicus	29%	100%
Q6US81	Spodoptera littoralis	32%	100%
Q95MI7	Capra hircus	29%	100%
Q99PL7	Mus musculus	30%	100%
Q9FPD5	Arabidopsis thaliana	26%	100%
Q9LMI3	Arabidopsis thaliana	25%	100%
Q9LVZ3	Arabidopsis thaliana	27%	100%
Q9SID2	Arabidopsis thaliana	29%	100%
Q9TT94	Bos taurus	28%	100%