LeishMANIAdb
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Cob_adeno_trans domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cob_adeno_trans domain-containing protein
Gene product:
Cobalamin adenosyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I133_LEIIN
TriTrypDb:
LINF_240028600
Length:
376

Annotations

Annotations by Jardim et al.

Mitochondrial protein, ATP:cob(I)alamin adenosyltransferase, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4I133
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I133

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0008817 corrinoid adenosyltransferase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 148 152 PF00656 0.711
CLV_C14_Caspase3-7 291 295 PF00656 0.468
CLV_NRD_NRD_1 196 198 PF00675 0.277
CLV_NRD_NRD_1 31 33 PF00675 0.463
CLV_NRD_NRD_1 324 326 PF00675 0.275
CLV_NRD_NRD_1 328 330 PF00675 0.275
CLV_NRD_NRD_1 372 374 PF00675 0.443
CLV_NRD_NRD_1 67 69 PF00675 0.426
CLV_PCSK_KEX2_1 127 129 PF00082 0.441
CLV_PCSK_KEX2_1 195 197 PF00082 0.275
CLV_PCSK_KEX2_1 31 33 PF00082 0.464
CLV_PCSK_KEX2_1 324 326 PF00082 0.275
CLV_PCSK_KEX2_1 328 330 PF00082 0.275
CLV_PCSK_KEX2_1 67 69 PF00082 0.426
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.441
CLV_PCSK_PC7_1 320 326 PF00082 0.275
CLV_PCSK_SKI1_1 105 109 PF00082 0.329
CLV_PCSK_SKI1_1 128 132 PF00082 0.483
CLV_PCSK_SKI1_1 220 224 PF00082 0.329
CLV_PCSK_SKI1_1 268 272 PF00082 0.295
CLV_PCSK_SKI1_1 329 333 PF00082 0.329
CLV_PCSK_SKI1_1 346 350 PF00082 0.205
DEG_Nend_Nbox_1 1 3 PF02207 0.501
DOC_CKS1_1 254 259 PF01111 0.475
DOC_MAPK_gen_1 324 333 PF00069 0.475
DOC_MAPK_MEF2A_6 296 304 PF00069 0.529
DOC_PP4_FxxP_1 303 306 PF00568 0.475
DOC_USP7_MATH_1 146 150 PF00917 0.732
DOC_USP7_MATH_1 173 177 PF00917 0.623
DOC_USP7_MATH_1 235 239 PF00917 0.512
DOC_USP7_MATH_1 362 366 PF00917 0.529
DOC_WW_Pin1_4 253 258 PF00397 0.475
DOC_WW_Pin1_4 47 52 PF00397 0.696
DOC_WW_Pin1_4 6 11 PF00397 0.474
LIG_14-3-3_CanoR_1 11 17 PF00244 0.361
LIG_14-3-3_CanoR_1 128 138 PF00244 0.689
LIG_14-3-3_CanoR_1 328 334 PF00244 0.498
LIG_14-3-3_CanoR_1 346 351 PF00244 0.441
LIG_14-3-3_CanoR_1 354 361 PF00244 0.448
LIG_14-3-3_CanoR_1 92 98 PF00244 0.495
LIG_Actin_WH2_2 209 226 PF00022 0.529
LIG_Actin_WH2_2 332 348 PF00022 0.400
LIG_BRCT_BRCA1_1 187 191 PF00533 0.475
LIG_BRCT_BRCA1_1 355 359 PF00533 0.475
LIG_FHA_1 269 275 PF00498 0.522
LIG_FHA_1 281 287 PF00498 0.443
LIG_FHA_1 340 346 PF00498 0.529
LIG_FHA_1 7 13 PF00498 0.453
LIG_FHA_1 76 82 PF00498 0.438
LIG_FHA_2 146 152 PF00498 0.704
LIG_FHA_2 330 336 PF00498 0.500
LIG_FHA_2 85 91 PF00498 0.473
LIG_KLC1_Yacidic_2 85 90 PF13176 0.529
LIG_LIR_Apic_2 275 280 PF02991 0.478
LIG_LIR_Gen_1 200 209 PF02991 0.475
LIG_LIR_Gen_1 85 95 PF02991 0.518
LIG_LIR_Gen_1 96 104 PF02991 0.443
LIG_LIR_Nem_3 200 206 PF02991 0.475
LIG_LIR_Nem_3 356 361 PF02991 0.475
LIG_LIR_Nem_3 85 91 PF02991 0.518
LIG_LIR_Nem_3 93 98 PF02991 0.464
LIG_MLH1_MIPbox_1 355 359 PF16413 0.475
LIG_PCNA_PIPBox_1 330 339 PF02747 0.529
LIG_PCNA_PIPBox_1 352 361 PF02747 0.495
LIG_SH2_GRB2like 341 344 PF00017 0.482
LIG_SH2_GRB2like 351 354 PF00017 0.503
LIG_SH2_PTP2 88 91 PF00017 0.529
LIG_SH2_STAP1 341 345 PF00017 0.529
LIG_SH2_STAT5 179 182 PF00017 0.475
LIG_SH2_STAT5 27 30 PF00017 0.327
LIG_SH2_STAT5 341 344 PF00017 0.475
LIG_SH2_STAT5 88 91 PF00017 0.475
LIG_SH3_3 251 257 PF00018 0.524
LIG_SUMO_SIM_anti_2 15 21 PF11976 0.340
LIG_SUMO_SIM_par_1 329 335 PF11976 0.460
LIG_UBA3_1 103 108 PF00899 0.529
MOD_CDK_SPK_2 6 11 PF00069 0.474
MOD_CDK_SPxxK_3 253 260 PF00069 0.529
MOD_CK1_1 142 148 PF00069 0.744
MOD_CK2_1 222 228 PF00069 0.577
MOD_CK2_1 362 368 PF00069 0.486
MOD_GlcNHglycan 141 144 PF01048 0.541
MOD_GlcNHglycan 153 156 PF01048 0.463
MOD_GlcNHglycan 187 190 PF01048 0.315
MOD_GlcNHglycan 22 25 PF01048 0.364
MOD_GlcNHglycan 224 227 PF01048 0.329
MOD_GlcNHglycan 312 315 PF01048 0.275
MOD_GSK3_1 138 145 PF00069 0.690
MOD_GSK3_1 146 153 PF00069 0.697
MOD_GSK3_1 173 180 PF00069 0.627
MOD_GSK3_1 185 192 PF00069 0.475
MOD_GSK3_1 249 256 PF00069 0.488
MOD_GSK3_1 47 54 PF00069 0.776
MOD_LATS_1 344 350 PF00433 0.529
MOD_N-GLC_1 184 189 PF02516 0.269
MOD_N-GLC_2 112 114 PF02516 0.329
MOD_NEK2_1 138 143 PF00069 0.689
MOD_NEK2_1 177 182 PF00069 0.522
MOD_NEK2_1 20 25 PF00069 0.466
MOD_NEK2_1 222 227 PF00069 0.529
MOD_NEK2_2 319 324 PF00069 0.475
MOD_PIKK_1 75 81 PF00454 0.417
MOD_PKA_2 319 325 PF00069 0.475
MOD_PKA_2 353 359 PF00069 0.475
MOD_Plk_1 61 67 PF00069 0.621
MOD_Plk_1 84 90 PF00069 0.475
MOD_Plk_2-3 61 67 PF00069 0.543
MOD_Plk_4 12 18 PF00069 0.340
MOD_Plk_4 173 179 PF00069 0.668
MOD_Plk_4 235 241 PF00069 0.517
MOD_Plk_4 249 255 PF00069 0.439
MOD_Plk_4 346 352 PF00069 0.518
MOD_Plk_4 84 90 PF00069 0.512
MOD_ProDKin_1 253 259 PF00069 0.475
MOD_ProDKin_1 47 53 PF00069 0.695
MOD_ProDKin_1 6 12 PF00069 0.468
MOD_SUMO_rev_2 161 167 PF00179 0.721
MOD_SUMO_rev_2 66 76 PF00179 0.701
TRG_ENDOCYTIC_2 88 91 PF00928 0.495
TRG_ER_diArg_1 195 197 PF00400 0.495
TRG_ER_diArg_1 328 330 PF00400 0.529
TRG_ER_diArg_1 67 69 PF00400 0.626
TRG_Pf-PMV_PEXEL_1 67 72 PF00026 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4KL87 Bodo saltans 44% 100%
A0A3Q8ID37 Leishmania donovani 99% 100%
A4HDT5 Leishmania braziliensis 83% 100%
E9AX70 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QAA6 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS