LeishMANIAdb
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Hypothetical predicted multi-pass transmembrane protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted multi-pass transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I132_LEIIN
TriTrypDb:
LINF_240028500
Length:
175

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Hypothetical predicted multi-pass transmembrane

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
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Phosphorylation

Promastigote: 162, 164

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I132
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I132

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 5 7 PF00675 0.387
CLV_NRD_NRD_1 8 10 PF00675 0.384
CLV_PCSK_FUR_1 6 10 PF00082 0.400
CLV_PCSK_KEX2_1 7 9 PF00082 0.402
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.402
CLV_PCSK_SKI1_1 101 105 PF00082 0.531
CLV_PCSK_SKI1_1 55 59 PF00082 0.385
DEG_Nend_UBRbox_3 1 3 PF02207 0.639
DOC_CKS1_1 59 64 PF01111 0.473
DOC_MAPK_gen_1 6 15 PF00069 0.526
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P3C1 Leptomonas seymouri 64% 100%
A0A0S4IMU6 Bodo saltans 32% 78%
A0A1X0NWM1 Trypanosomatidae 35% 100%
A0A3R7LPV2 Trypanosoma rangeli 32% 100%
A0A3S7WYQ2 Leishmania donovani 99% 100%
A4HDT4 Leishmania braziliensis 69% 100%
C9ZW76 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AX69 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QAA7 Leishmania major 92% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS