Hypothetical predicted multi-pass transmembrane protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I132_LEIIN

TriTrypDb:

LINF_240028500

Length:

175

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Hypothetical predicted multi-pass transmembrane

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Phosphorylation

Promastigote: 162, 164

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I132

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I132

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.387
CLV_NRD_NRD_1	8	10	PF00675	0.384
CLV_PCSK_FUR_1	6	10	PF00082	0.400
CLV_PCSK_KEX2_1	7	9	PF00082	0.402
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.402
CLV_PCSK_SKI1_1	101	105	PF00082	0.531
CLV_PCSK_SKI1_1	55	59	PF00082	0.385
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DOC_CKS1_1	59	64	PF01111	0.473
DOC_MAPK_gen_1	6	15	PF00069	0.526
DOC_MAPK_MEF2A_6	126	135	PF00069	0.344
DOC_MAPK_MEF2A_6	8	17	PF00069	0.494
DOC_USP7_MATH_1	161	165	PF00917	0.615
DOC_WW_Pin1_4	58	63	PF00397	0.392
LIG_14-3-3_CanoR_1	106	115	PF00244	0.264
LIG_14-3-3_CanoR_1	6	12	PF00244	0.559
LIG_Actin_WH2_2	41	57	PF00022	0.401
LIG_EH1_1	44	52	PF00400	0.389
LIG_eIF4E_1	25	31	PF01652	0.344
LIG_EVH1_2	71	75	PF00568	0.574
LIG_FHA_1	130	136	PF00498	0.374
LIG_FHA_1	8	14	PF00498	0.560
LIG_FHA_1	80	86	PF00498	0.402
LIG_FHA_2	140	146	PF00498	0.594
LIG_GBD_Chelix_1	15	23	PF00786	0.357
LIG_GBD_Chelix_1	46	54	PF00786	0.389
LIG_LIR_Gen_1	74	83	PF02991	0.557
LIG_LIR_Nem_3	61	67	PF02991	0.574
LIG_LIR_Nem_3	74	78	PF02991	0.573
LIG_Pex14_1	14	18	PF04695	0.435
LIG_SH2_STAT5	114	117	PF00017	0.310
LIG_SH2_STAT5	129	132	PF00017	0.269
LIG_SH2_STAT5	18	21	PF00017	0.311
LIG_SH2_STAT5	25	28	PF00017	0.308
LIG_SH3_3	128	134	PF00018	0.381
LIG_TRAF2_1	142	145	PF00917	0.551
LIG_WRC_WIRS_1	80	85	PF05994	0.402
MOD_CDK_SPxxK_3	58	65	PF00069	0.449
MOD_CK2_1	139	145	PF00069	0.573
MOD_GlcNHglycan	155	158	PF01048	0.466
MOD_GlcNHglycan	161	164	PF01048	0.495
MOD_GlcNHglycan	26	29	PF01048	0.425
MOD_GSK3_1	125	132	PF00069	0.367
MOD_NEK2_1	153	158	PF00069	0.643
MOD_NEK2_2	79	84	PF00069	0.402
MOD_PKA_1	7	13	PF00069	0.547
MOD_PKA_2	105	111	PF00069	0.349
MOD_PKA_2	7	13	PF00069	0.555
MOD_Plk_1	139	145	PF00069	0.591
MOD_Plk_4	79	85	PF00069	0.347
MOD_ProDKin_1	58	64	PF00069	0.390
TRG_DiLeu_BaEn_1	144	149	PF01217	0.592
TRG_ENDOCYTIC_2	18	21	PF00928	0.310
TRG_ENDOCYTIC_2	67	70	PF00928	0.525
TRG_ENDOCYTIC_2	80	83	PF00928	0.363
TRG_ER_diArg_1	6	9	PF00400	0.522
TRG_NLS_MonoExtN_4	6	11	PF00514	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C1	Leptomonas seymouri	64%	100%
A0A0S4IMU6	Bodo saltans	32%	78%
A0A1X0NWM1	Trypanosomatidae	35%	100%
A0A3R7LPV2	Trypanosoma rangeli	32%	100%
A0A3S7WYQ2	Leishmania donovani	99%	100%
A4HDT4	Leishmania braziliensis	69%	100%
C9ZW76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AX69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAA7	Leishmania major	92%	100%