ATPase_AAA_core domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I131_LEIIN

TriTrypDb:

LINF_240028400

Length:

397

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 8
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I131

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I131

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0016887	ATP hydrolysis activity	7	16
GO:0017076	purine nucleotide binding	4	16
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	369	371	PF00675	0.250
CLV_NRD_NRD_1	47	49	PF00675	0.628
CLV_PCSK_FUR_1	80	84	PF00082	0.510
CLV_PCSK_KEX2_1	369	371	PF00082	0.250
CLV_PCSK_KEX2_1	82	84	PF00082	0.494
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.535
CLV_PCSK_SKI1_1	242	246	PF00082	0.406
CLV_PCSK_SKI1_1	316	320	PF00082	0.346
CLV_PCSK_SKI1_1	51	55	PF00082	0.485
DEG_APCC_DBOX_1	102	110	PF00400	0.243
DOC_CYCLIN_RxL_1	238	246	PF00134	0.497
DOC_CYCLIN_RxL_1	313	322	PF00134	0.460
DOC_MAPK_DCC_7	168	176	PF00069	0.246
DOC_MAPK_gen_1	125	134	PF00069	0.345
DOC_MAPK_gen_1	369	375	PF00069	0.440
DOC_MAPK_MEF2A_6	127	136	PF00069	0.349
DOC_MAPK_MEF2A_6	168	176	PF00069	0.368
DOC_MAPK_MEF2A_6	268	277	PF00069	0.478
DOC_MAPK_MEF2A_6	6	14	PF00069	0.440
DOC_PP1_RVXF_1	323	330	PF00149	0.553
DOC_PP2B_LxvP_1	18	21	PF13499	0.396
DOC_PP4_FxxP_1	23	26	PF00568	0.310
DOC_USP7_MATH_1	143	147	PF00917	0.379
DOC_USP7_MATH_1	218	222	PF00917	0.349
DOC_WW_Pin1_4	202	207	PF00397	0.328
DOC_WW_Pin1_4	67	72	PF00397	0.264
LIG_14-3-3_CanoR_1	210	215	PF00244	0.321
LIG_14-3-3_CanoR_1	240	245	PF00244	0.554
LIG_14-3-3_CanoR_1	248	258	PF00244	0.518
LIG_14-3-3_CanoR_1	369	374	PF00244	0.451
LIG_14-3-3_CanoR_1	90	95	PF00244	0.376
LIG_Actin_WH2_2	54	69	PF00022	0.274
LIG_APCC_ABBA_1	187	192	PF00400	0.352
LIG_APCC_ABBAyCdc20_2	370	376	PF00400	0.432
LIG_CtBP_PxDLS_1	274	278	PF00389	0.458
LIG_FHA_1	142	148	PF00498	0.346
LIG_FHA_1	149	155	PF00498	0.273
LIG_FHA_1	3	9	PF00498	0.318
LIG_FHA_1	313	319	PF00498	0.584
LIG_FHA_1	353	359	PF00498	0.657
LIG_FHA_1	370	376	PF00498	0.565
LIG_FHA_2	155	161	PF00498	0.315
LIG_FHA_2	192	198	PF00498	0.387
LIG_FHA_2	277	283	PF00498	0.473
LIG_Integrin_isoDGR_2	323	325	PF01839	0.266
LIG_IRF3_LxIS_1	270	276	PF10401	0.556
LIG_IRF3_LxIS_1	298	304	PF10401	0.427
LIG_KLC1_Yacidic_2	356	361	PF13176	0.508
LIG_LIR_Apic_2	25	31	PF02991	0.440
LIG_LIR_Gen_1	252	263	PF02991	0.528
LIG_LIR_Gen_1	356	367	PF02991	0.639
LIG_LIR_Nem_3	252	258	PF02991	0.484
LIG_LIR_Nem_3	269	275	PF02991	0.441
LIG_LIR_Nem_3	356	362	PF02991	0.651
LIG_LIR_Nem_3	70	76	PF02991	0.338
LIG_NRBOX	14	20	PF00104	0.318
LIG_NRBOX	334	340	PF00104	0.484
LIG_SH2_PTP2	28	31	PF00017	0.321
LIG_SH2_SRC	28	31	PF00017	0.311
LIG_SH2_SRC	359	362	PF00017	0.679
LIG_SH2_SRC	84	87	PF00017	0.238
LIG_SH2_STAP1	259	263	PF00017	0.589
LIG_SH2_STAT5	28	31	PF00017	0.321
LIG_SH2_STAT5	359	362	PF00017	0.562
LIG_SH2_STAT5	76	79	PF00017	0.293
LIG_SH2_STAT5	84	87	PF00017	0.295
LIG_SH3_1	268	274	PF00018	0.518
LIG_SH3_1	62	68	PF00018	0.261
LIG_SH3_3	200	206	PF00018	0.286
LIG_SH3_3	212	218	PF00018	0.304
LIG_SH3_3	268	274	PF00018	0.492
LIG_SH3_3	62	68	PF00018	0.379
LIG_SUMO_SIM_par_1	149	155	PF11976	0.277
LIG_SUMO_SIM_par_1	224	232	PF11976	0.216
LIG_SUMO_SIM_par_1	273	279	PF11976	0.566
LIG_UBA3_1	131	139	PF00899	0.224
MOD_CDK_SPxxK_3	67	74	PF00069	0.257
MOD_CK1_1	155	161	PF00069	0.292
MOD_CK1_1	276	282	PF00069	0.490
MOD_CK2_1	160	166	PF00069	0.312
MOD_CK2_1	191	197	PF00069	0.363
MOD_CK2_1	210	216	PF00069	0.218
MOD_CK2_1	240	246	PF00069	0.523
MOD_CK2_1	94	100	PF00069	0.404
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.254
MOD_GlcNHglycan	154	157	PF01048	0.455
MOD_GlcNHglycan	293	296	PF01048	0.334
MOD_GlcNHglycan	305	308	PF01048	0.412
MOD_GlcNHglycan	349	352	PF01048	0.543
MOD_GlcNHglycan	62	65	PF01048	0.646
MOD_GSK3_1	143	150	PF00069	0.314
MOD_GSK3_1	192	199	PF00069	0.347
MOD_GSK3_1	236	243	PF00069	0.521
MOD_GSK3_1	262	269	PF00069	0.487
MOD_GSK3_1	377	384	PF00069	0.552
MOD_GSK3_1	385	392	PF00069	0.638
MOD_GSK3_1	90	97	PF00069	0.415
MOD_N-GLC_1	344	349	PF02516	0.460
MOD_NEK2_1	152	157	PF00069	0.255
MOD_NEK2_1	381	386	PF00069	0.592
MOD_NEK2_1	57	62	PF00069	0.323
MOD_OFUCOSY	140	145	PF10250	0.582
MOD_PK_1	90	96	PF00069	0.400
MOD_PKA_1	369	375	PF00069	0.440
MOD_PKA_2	209	215	PF00069	0.327
MOD_PKA_2	369	375	PF00069	0.459
MOD_PKB_1	238	246	PF00069	0.530
MOD_Plk_1	148	154	PF00069	0.282
MOD_Plk_1	191	197	PF00069	0.319
MOD_Plk_1	49	55	PF00069	0.392
MOD_Plk_2-3	160	166	PF00069	0.332
MOD_Plk_2-3	192	198	PF00069	0.374
MOD_Plk_4	148	154	PF00069	0.272
MOD_Plk_4	240	246	PF00069	0.578
MOD_Plk_4	369	375	PF00069	0.541
MOD_Plk_4	94	100	PF00069	0.382
MOD_ProDKin_1	202	208	PF00069	0.327
MOD_ProDKin_1	67	73	PF00069	0.253
TRG_DiLeu_BaEn_2	245	251	PF01217	0.582
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.267
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.229
TRG_ENDOCYTIC_2	159	162	PF00928	0.341
TRG_ENDOCYTIC_2	359	362	PF00928	0.588
TRG_ER_diArg_1	101	104	PF00400	0.309
TRG_ER_diArg_1	368	370	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R1	Leptomonas seymouri	59%	100%
A0A0N1PFB4	Leptomonas seymouri	36%	80%
A0A0S4KNW8	Bodo saltans	39%	100%
A0A1X0NMJ2	Trypanosomatidae	34%	90%
A0A1X0NW12	Trypanosomatidae	43%	100%
A0A3Q8ID18	Leishmania donovani	100%	100%
A0A3R7RCD3	Trypanosoma rangeli	34%	89%
A0A422N6P1	Trypanosoma rangeli	46%	100%
A4H5R3	Leishmania braziliensis	30%	71%
C9ZW77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A9G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
E9AX68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAA8	Leishmania major	94%	100%
V5B864	Trypanosoma cruzi	34%	89%