PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentatricopeptide repeat domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I129_LEIIN

TriTrypDb:

LINF_240028200

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I129

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I129

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.471
CLV_PCSK_KEX2_1	209	211	PF00082	0.415
CLV_PCSK_KEX2_1	239	241	PF00082	0.509
CLV_PCSK_KEX2_1	86	88	PF00082	0.331
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.469
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.415
CLV_PCSK_SKI1_1	122	126	PF00082	0.468
CLV_PCSK_SKI1_1	219	223	PF00082	0.571
CLV_PCSK_SKI1_1	239	243	PF00082	0.494
CLV_PCSK_SKI1_1	83	87	PF00082	0.407
DOC_AGCK_PIF_1	161	166	PF00069	0.431
DOC_CYCLIN_RxL_1	213	226	PF00134	0.568
DOC_CYCLIN_RxL_1	236	245	PF00134	0.489
DOC_PP1_SILK_1	63	68	PF00149	0.262
DOC_PP2B_LxvP_1	241	244	PF13499	0.703
DOC_PP4_FxxP_1	217	220	PF00568	0.379
DOC_PP4_MxPP_1	1	4	PF00568	0.515
DOC_USP7_MATH_1	231	235	PF00917	0.667
LIG_ActinCP_TwfCPI_2	217	227	PF01115	0.375
LIG_eIF4E_1	164	170	PF01652	0.365
LIG_FHA_1	121	127	PF00498	0.447
LIG_FHA_1	165	171	PF00498	0.271
LIG_FHA_1	61	67	PF00498	0.299
LIG_LIR_Gen_1	114	125	PF02991	0.408
LIG_LIR_Gen_1	165	172	PF02991	0.310
LIG_LIR_Gen_1	60	70	PF02991	0.330
LIG_LIR_Nem_3	114	120	PF02991	0.367
LIG_LIR_Nem_3	165	169	PF02991	0.310
LIG_LIR_Nem_3	60	65	PF02991	0.327
LIG_Pex14_1	18	22	PF04695	0.491
LIG_Pex14_2	242	246	PF04695	0.455
LIG_SH2_NCK_1	110	114	PF00017	0.310
LIG_SH2_SRC	110	113	PF00017	0.307
LIG_SH2_STAP1	166	170	PF00017	0.311
LIG_SH2_STAP1	181	185	PF00017	0.415
LIG_SH2_STAT3	26	29	PF00017	0.397
LIG_SH2_STAT5	164	167	PF00017	0.299
LIG_SH3_3	157	163	PF00018	0.430
LIG_SUMO_SIM_par_1	200	206	PF11976	0.494
LIG_TRAF2_1	137	140	PF00917	0.479
LIG_TRAF2_1	50	53	PF00917	0.415
LIG_WRC_WIRS_1	117	122	PF05994	0.467
MOD_CK1_1	60	66	PF00069	0.400
MOD_Cter_Amidation	207	210	PF01082	0.358
MOD_GlcNHglycan	140	143	PF01048	0.548
MOD_GlcNHglycan	222	225	PF01048	0.517
MOD_GlcNHglycan	229	232	PF01048	0.526
MOD_GlcNHglycan	34	38	PF01048	0.508
MOD_GlcNHglycan	5	8	PF01048	0.614
MOD_GSK3_1	116	123	PF00069	0.442
MOD_GSK3_1	227	234	PF00069	0.554
MOD_GSK3_1	57	64	PF00069	0.424
MOD_N-GLC_1	57	62	PF02516	0.365
MOD_NEK2_1	120	125	PF00069	0.437
MOD_NEK2_1	235	240	PF00069	0.740
MOD_NEK2_1	46	51	PF00069	0.294
MOD_NEK2_1	57	62	PF00069	0.272
MOD_PIKK_1	194	200	PF00454	0.415
MOD_PKB_1	136	144	PF00069	0.361
MOD_Plk_1	57	63	PF00069	0.335
MOD_Plk_4	120	126	PF00069	0.475
MOD_Plk_4	61	67	PF00069	0.315
MOD_SUMO_for_1	85	88	PF00179	0.415
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.404
TRG_ENDOCYTIC_2	110	113	PF00928	0.470
TRG_ENDOCYTIC_2	166	169	PF00928	0.331
TRG_ER_diArg_1	135	138	PF00400	0.450
TRG_NES_CRM1_1	114	127	PF08389	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ2	Leptomonas seymouri	75%	99%
A0A0N1I1J7	Leptomonas seymouri	25%	88%
A0A0S4IYI9	Bodo saltans	24%	91%
A0A0S4KKY6	Bodo saltans	55%	100%
A0A1X0NXK5	Trypanosomatidae	61%	100%
A0A1X0P0D8	Trypanosomatidae	24%	78%
A0A3Q8IF22	Leishmania donovani	100%	100%
A0A3Q8IJ22	Leishmania donovani	25%	88%
A0A3R7KPI7	Trypanosoma rangeli	26%	88%
A4HDT1	Leishmania braziliensis	88%	100%
A4IDQ9	Leishmania infantum	25%	88%
C9ZW80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AX66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAB0	Leishmania major	96%	100%
V5DLI8	Trypanosoma cruzi	25%	81%