LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I128_LEIIN
TriTrypDb:
LINF_240028100
Length:
247

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0005635 nuclear envelope 4 1
GO:0016020 membrane 2 6
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0110165 cellular anatomical entity 1 6
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Expansion

Sequence features

A4I128
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I128

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 123 125 PF00675 0.664
CLV_NRD_NRD_1 177 179 PF00675 0.618
CLV_NRD_NRD_1 65 67 PF00675 0.493
CLV_PCSK_KEX2_1 123 125 PF00082 0.630
CLV_PCSK_KEX2_1 177 179 PF00082 0.595
CLV_PCSK_KEX2_1 192 194 PF00082 0.624
CLV_PCSK_KEX2_1 50 52 PF00082 0.514
CLV_PCSK_KEX2_1 65 67 PF00082 0.352
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.619
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.513
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Homologs

ProteinTaxonomySequence identityCoverage
A0A1X0NXC1 Trypanosomatidae 32% 100%
A0A3Q8IC37 Leishmania donovani 99% 100%
A0A422MRD3 Trypanosoma rangeli 36% 100%
A4HDT0 Leishmania braziliensis 74% 100%
C9ZW81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 98%
E9AX65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QAB1 Leishmania major 85% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS