LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function N-terminal domain (DUF2450)/Protein of unknown function C-terminus (DUF2451) - putative
Species:
Leishmania infantum
UniProt:
A4I126_LEIIN
TriTrypDb:
LINF_240027900
Length:
1016

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 11
GO:0032991 protein-containing complex 1 11
GO:0110165 cellular anatomical entity 1 11
GO:1990745 EARP complex 2 11

Expansion

Sequence features

A4I126
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I126

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0009987 cellular process 1 11
GO:0016192 vesicle-mediated transport 4 11
GO:0016197 endosomal transport 4 11
GO:0016482 cytosolic transport 4 11
GO:0032456 endocytic recycling 5 11
GO:0042147 retrograde transport, endosome to Golgi 5 11
GO:0046907 intracellular transport 3 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0051668 localization within membrane 3 11
GO:0098876 vesicle-mediated transport to the plasma membrane 4 11
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 115 119 PF00656 0.354
CLV_C14_Caspase3-7 174 178 PF00656 0.416
CLV_C14_Caspase3-7 595 599 PF00656 0.591
CLV_C14_Caspase3-7 684 688 PF00656 0.343
CLV_NRD_NRD_1 156 158 PF00675 0.351
CLV_NRD_NRD_1 193 195 PF00675 0.319
CLV_NRD_NRD_1 23 25 PF00675 0.524
CLV_NRD_NRD_1 419 421 PF00675 0.537
CLV_NRD_NRD_1 54 56 PF00675 0.547
CLV_NRD_NRD_1 737 739 PF00675 0.442
CLV_NRD_NRD_1 877 879 PF00675 0.493
CLV_PCSK_KEX2_1 155 157 PF00082 0.290
CLV_PCSK_KEX2_1 232 234 PF00082 0.379
CLV_PCSK_KEX2_1 253 255 PF00082 0.552
CLV_PCSK_KEX2_1 54 56 PF00082 0.525
CLV_PCSK_KEX2_1 737 739 PF00082 0.442
CLV_PCSK_KEX2_1 877 879 PF00082 0.377
CLV_PCSK_KEX2_1 912 914 PF00082 0.558
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.279
CLV_PCSK_PC1ET2_1 232 234 PF00082 0.379
CLV_PCSK_PC1ET2_1 253 255 PF00082 0.552
CLV_PCSK_PC1ET2_1 912 914 PF00082 0.558
CLV_PCSK_SKI1_1 100 104 PF00082 0.345
CLV_PCSK_SKI1_1 156 160 PF00082 0.277
CLV_PCSK_SKI1_1 27 31 PF00082 0.535
CLV_PCSK_SKI1_1 285 289 PF00082 0.480
CLV_PCSK_SKI1_1 309 313 PF00082 0.399
CLV_PCSK_SKI1_1 342 346 PF00082 0.484
CLV_PCSK_SKI1_1 479 483 PF00082 0.403
CLV_PCSK_SKI1_1 533 537 PF00082 0.382
CLV_PCSK_SKI1_1 54 58 PF00082 0.525
CLV_PCSK_SKI1_1 893 897 PF00082 0.339
CLV_PCSK_SKI1_1 950 954 PF00082 0.408
DEG_APCC_DBOX_1 232 240 PF00400 0.320
DEG_APCC_KENBOX_2 212 216 PF00400 0.427
DEG_COP1_1 940 947 PF00400 0.404
DEG_Nend_UBRbox_2 1 3 PF02207 0.539
DEG_SCF_FBW7_2 880 887 PF00400 0.426
DEG_SPOP_SBC_1 569 573 PF00917 0.585
DEG_SPOP_SBC_1 640 644 PF00917 0.482
DOC_ANK_TNKS_1 132 139 PF00023 0.416
DOC_CKS1_1 490 495 PF01111 0.478
DOC_CKS1_1 729 734 PF01111 0.539
DOC_CKS1_1 881 886 PF01111 0.420
DOC_MAPK_FxFP_2 753 756 PF00069 0.426
DOC_MAPK_gen_1 232 239 PF00069 0.320
DOC_MAPK_gen_1 285 293 PF00069 0.504
DOC_MAPK_gen_1 852 860 PF00069 0.507
DOC_MAPK_gen_1 911 919 PF00069 0.452
DOC_MAPK_JIP1_4 989 995 PF00069 0.494
DOC_MAPK_MEF2A_6 286 295 PF00069 0.476
DOC_MAPK_MEF2A_6 446 454 PF00069 0.461
DOC_PP1_RVXF_1 891 897 PF00149 0.399
DOC_PP4_FxxP_1 303 306 PF00568 0.502
DOC_PP4_FxxP_1 490 493 PF00568 0.407
DOC_PP4_FxxP_1 753 756 PF00568 0.542
DOC_USP7_MATH_1 199 203 PF00917 0.488
DOC_USP7_MATH_1 569 573 PF00917 0.585
DOC_USP7_MATH_1 782 786 PF00917 0.325
DOC_USP7_MATH_1 840 844 PF00917 0.494
DOC_USP7_MATH_1 885 889 PF00917 0.451
DOC_USP7_UBL2_3 13 17 PF12436 0.583
DOC_USP7_UBL2_3 27 31 PF12436 0.492
DOC_USP7_UBL2_3 529 533 PF12436 0.533
DOC_USP7_UBL2_3 846 850 PF12436 0.426
DOC_USP7_UBL2_3 908 912 PF12436 0.459
DOC_USP7_UBL2_3 97 101 PF12436 0.330
DOC_WW_Pin1_4 399 404 PF00397 0.565
DOC_WW_Pin1_4 489 494 PF00397 0.487
DOC_WW_Pin1_4 507 512 PF00397 0.459
DOC_WW_Pin1_4 521 526 PF00397 0.451
DOC_WW_Pin1_4 728 733 PF00397 0.525
DOC_WW_Pin1_4 798 803 PF00397 0.490
DOC_WW_Pin1_4 880 885 PF00397 0.438
LIG_14-3-3_CanoR_1 24 30 PF00244 0.581
LIG_14-3-3_CanoR_1 438 444 PF00244 0.427
LIG_14-3-3_CanoR_1 540 548 PF00244 0.547
LIG_14-3-3_CanoR_1 913 920 PF00244 0.491
LIG_Actin_WH2_2 26 41 PF00022 0.602
LIG_Actin_WH2_2 525 542 PF00022 0.343
LIG_Actin_WH2_2 837 854 PF00022 0.497
LIG_APCC_ABBA_1 391 396 PF00400 0.489
LIG_BRCT_BRCA1_1 763 767 PF00533 0.541
LIG_BRCT_BRCA1_1 787 791 PF00533 0.365
LIG_BRCT_BRCA1_1 914 918 PF00533 0.398
LIG_EH_1 557 561 PF12763 0.406
LIG_EH1_1 450 458 PF00400 0.324
LIG_eIF4E_1 975 981 PF01652 0.418
LIG_FHA_1 167 173 PF00498 0.400
LIG_FHA_1 217 223 PF00498 0.288
LIG_FHA_1 24 30 PF00498 0.493
LIG_FHA_1 286 292 PF00498 0.445
LIG_FHA_1 294 300 PF00498 0.359
LIG_FHA_1 3 9 PF00498 0.633
LIG_FHA_1 322 328 PF00498 0.436
LIG_FHA_1 42 48 PF00498 0.407
LIG_FHA_1 429 435 PF00498 0.398
LIG_FHA_1 569 575 PF00498 0.441
LIG_FHA_1 577 583 PF00498 0.399
LIG_FHA_1 613 619 PF00498 0.700
LIG_FHA_1 625 631 PF00498 0.547
LIG_FHA_1 881 887 PF00498 0.445
LIG_FHA_2 121 127 PF00498 0.344
LIG_FHA_2 180 186 PF00498 0.320
LIG_FHA_2 438 444 PF00498 0.320
LIG_FHA_2 593 599 PF00498 0.722
LIG_FHA_2 603 609 PF00498 0.608
LIG_FHA_2 682 688 PF00498 0.339
LIG_FHA_2 729 735 PF00498 0.592
LIG_GBD_Chelix_1 426 434 PF00786 0.396
LIG_LIR_Apic_2 300 306 PF02991 0.515
LIG_LIR_Apic_2 751 756 PF02991 0.565
LIG_LIR_Gen_1 367 376 PF02991 0.478
LIG_LIR_Gen_1 382 391 PF02991 0.207
LIG_LIR_Gen_1 687 697 PF02991 0.389
LIG_LIR_Gen_1 905 914 PF02991 0.402
LIG_LIR_Nem_3 276 280 PF02991 0.407
LIG_LIR_Nem_3 367 371 PF02991 0.499
LIG_LIR_Nem_3 382 386 PF02991 0.214
LIG_LIR_Nem_3 402 407 PF02991 0.531
LIG_LIR_Nem_3 458 464 PF02991 0.457
LIG_LIR_Nem_3 526 531 PF02991 0.426
LIG_LIR_Nem_3 577 583 PF02991 0.471
LIG_LIR_Nem_3 687 692 PF02991 0.360
LIG_LIR_Nem_3 752 758 PF02991 0.579
LIG_LIR_Nem_3 905 909 PF02991 0.386
LIG_NRBOX 994 1000 PF00104 0.401
LIG_PCNA_yPIPBox_3 930 939 PF02747 0.410
LIG_PDZ_Class_2 1011 1016 PF00595 0.533
LIG_Pex14_2 580 584 PF04695 0.493
LIG_REV1ctd_RIR_1 100 108 PF16727 0.345
LIG_REV1ctd_RIR_1 54 64 PF16727 0.646
LIG_SH2_CRK 387 391 PF00017 0.459
LIG_SH2_CRK 404 408 PF00017 0.292
LIG_SH2_CRK 906 910 PF00017 0.390
LIG_SH2_NCK_1 683 687 PF00017 0.339
LIG_SH2_SRC 107 110 PF00017 0.368
LIG_SH2_SRC 368 371 PF00017 0.260
LIG_SH2_SRC 385 388 PF00017 0.459
LIG_SH2_STAP1 387 391 PF00017 0.451
LIG_SH2_STAP1 793 797 PF00017 0.443
LIG_SH2_STAP1 976 980 PF00017 0.464
LIG_SH2_STAT3 538 541 PF00017 0.547
LIG_SH2_STAT3 863 866 PF00017 0.432
LIG_SH2_STAT5 122 125 PF00017 0.427
LIG_SH2_STAT5 268 271 PF00017 0.533
LIG_SH2_STAT5 368 371 PF00017 0.502
LIG_SH2_STAT5 385 388 PF00017 0.441
LIG_SH2_STAT5 538 541 PF00017 0.421
LIG_SH2_STAT5 681 684 PF00017 0.328
LIG_SH2_STAT5 730 733 PF00017 0.463
LIG_SH2_STAT5 863 866 PF00017 0.374
LIG_SH2_STAT5 947 950 PF00017 0.373
LIG_SH3_3 505 511 PF00018 0.457
LIG_SH3_3 519 525 PF00018 0.399
LIG_SH3_3 615 621 PF00018 0.750
LIG_SH3_3 631 637 PF00018 0.512
LIG_SH3_3 658 664 PF00018 0.475
LIG_SH3_3 799 805 PF00018 0.416
LIG_SH3_3 876 882 PF00018 0.495
LIG_SH3_3 939 945 PF00018 0.444
LIG_SUMO_SIM_anti_2 202 208 PF11976 0.442
LIG_SUMO_SIM_anti_2 288 297 PF11976 0.497
LIG_SUMO_SIM_anti_2 428 436 PF11976 0.382
LIG_SUMO_SIM_anti_2 785 791 PF11976 0.334
LIG_SUMO_SIM_anti_2 977 982 PF11976 0.462
LIG_SUMO_SIM_par_1 430 436 PF11976 0.434
LIG_TRAF2_1 84 87 PF00917 0.603
LIG_UBA3_1 222 227 PF00899 0.350
LIG_UBA3_1 236 244 PF00899 0.276
LIG_WRC_WIRS_1 528 533 PF05994 0.518
LIG_WRC_WIRS_1 686 691 PF05994 0.448
MOD_CDK_SPK_2 489 494 PF00069 0.483
MOD_CDK_SPK_2 728 733 PF00069 0.520
MOD_CK1_1 164 170 PF00069 0.409
MOD_CK1_1 455 461 PF00069 0.450
MOD_CK1_1 510 516 PF00069 0.539
MOD_CK1_1 639 645 PF00069 0.390
MOD_CK1_1 688 694 PF00069 0.473
MOD_CK1_1 785 791 PF00069 0.334
MOD_CK1_1 907 913 PF00069 0.497
MOD_CK2_1 120 126 PF00069 0.351
MOD_CK2_1 164 170 PF00069 0.353
MOD_CK2_1 340 346 PF00069 0.375
MOD_CK2_1 539 545 PF00069 0.540
MOD_CK2_1 608 614 PF00069 0.650
MOD_CK2_1 80 86 PF00069 0.629
MOD_CK2_1 867 873 PF00069 0.381
MOD_Cter_Amidation 230 233 PF01082 0.416
MOD_Cter_Amidation 418 421 PF01082 0.430
MOD_GlcNHglycan 166 169 PF01048 0.427
MOD_GlcNHglycan 241 244 PF01048 0.410
MOD_GlcNHglycan 435 438 PF01048 0.436
MOD_GlcNHglycan 598 601 PF01048 0.737
MOD_GlcNHglycan 618 621 PF01048 0.619
MOD_GlcNHglycan 643 646 PF01048 0.399
MOD_GlcNHglycan 703 707 PF01048 0.431
MOD_GlcNHglycan 740 743 PF01048 0.528
MOD_GlcNHglycan 768 771 PF01048 0.540
MOD_GSK3_1 175 182 PF00069 0.385
MOD_GSK3_1 293 300 PF00069 0.392
MOD_GSK3_1 319 326 PF00069 0.404
MOD_GSK3_1 345 352 PF00069 0.472
MOD_GSK3_1 395 402 PF00069 0.353
MOD_GSK3_1 428 435 PF00069 0.448
MOD_GSK3_1 523 530 PF00069 0.428
MOD_GSK3_1 540 547 PF00069 0.472
MOD_GSK3_1 570 577 PF00069 0.485
MOD_GSK3_1 592 599 PF00069 0.593
MOD_GSK3_1 608 615 PF00069 0.663
MOD_GSK3_1 626 633 PF00069 0.580
MOD_GSK3_1 636 643 PF00069 0.491
MOD_GSK3_1 681 688 PF00069 0.398
MOD_GSK3_1 76 83 PF00069 0.620
MOD_GSK3_1 761 768 PF00069 0.462
MOD_GSK3_1 804 811 PF00069 0.398
MOD_GSK3_1 840 847 PF00069 0.359
MOD_N-GLC_1 175 180 PF02516 0.424
MOD_N-GLC_1 601 606 PF02516 0.528
MOD_N-GLC_1 748 753 PF02516 0.614
MOD_N-GLC_1 777 782 PF02516 0.451
MOD_NEK2_1 179 184 PF00069 0.301
MOD_NEK2_1 239 244 PF00069 0.379
MOD_NEK2_1 260 265 PF00069 0.516
MOD_NEK2_1 327 332 PF00069 0.409
MOD_NEK2_1 340 345 PF00069 0.315
MOD_NEK2_1 386 391 PF00069 0.340
MOD_NEK2_1 574 579 PF00069 0.454
MOD_NEK2_1 641 646 PF00069 0.382
MOD_NEK2_1 859 864 PF00069 0.490
MOD_NEK2_1 867 872 PF00069 0.491
MOD_NEK2_1 937 942 PF00069 0.481
MOD_NEK2_2 12 17 PF00069 0.414
MOD_NEK2_2 885 890 PF00069 0.468
MOD_OFUCOSY 320 325 PF10250 0.470
MOD_PIKK_1 199 205 PF00454 0.448
MOD_PIKK_1 231 237 PF00454 0.379
MOD_PIKK_1 312 318 PF00454 0.496
MOD_PIKK_1 406 412 PF00454 0.436
MOD_PIKK_1 473 479 PF00454 0.393
MOD_PIKK_1 574 580 PF00454 0.526
MOD_PK_1 25 31 PF00069 0.647
MOD_PK_1 39 45 PF00069 0.518
MOD_PK_1 438 444 PF00069 0.503
MOD_PKA_1 285 291 PF00069 0.529
MOD_PKA_1 912 918 PF00069 0.421
MOD_PKA_2 193 199 PF00069 0.383
MOD_PKA_2 23 29 PF00069 0.579
MOD_PKA_2 437 443 PF00069 0.426
MOD_PKA_2 539 545 PF00069 0.489
MOD_PKA_2 761 767 PF00069 0.514
MOD_PKA_2 912 918 PF00069 0.510
MOD_Plk_1 103 109 PF00069 0.328
MOD_Plk_1 175 181 PF00069 0.435
MOD_Plk_1 216 222 PF00069 0.314
MOD_Plk_1 260 266 PF00069 0.486
MOD_Plk_1 345 351 PF00069 0.394
MOD_Plk_1 569 575 PF00069 0.488
MOD_Plk_1 601 607 PF00069 0.770
MOD_Plk_1 748 754 PF00069 0.503
MOD_Plk_1 777 783 PF00069 0.514
MOD_Plk_1 793 799 PF00069 0.322
MOD_Plk_4 161 167 PF00069 0.360
MOD_Plk_4 175 181 PF00069 0.469
MOD_Plk_4 25 31 PF00069 0.604
MOD_Plk_4 323 329 PF00069 0.399
MOD_Plk_4 345 351 PF00069 0.496
MOD_Plk_4 386 392 PF00069 0.468
MOD_Plk_4 428 434 PF00069 0.481
MOD_Plk_4 452 458 PF00069 0.324
MOD_Plk_4 527 533 PF00069 0.511
MOD_Plk_4 534 540 PF00069 0.477
MOD_Plk_4 570 576 PF00069 0.564
MOD_Plk_4 636 642 PF00069 0.414
MOD_Plk_4 681 687 PF00069 0.352
MOD_Plk_4 782 788 PF00069 0.346
MOD_Plk_4 808 814 PF00069 0.425
MOD_Plk_4 859 865 PF00069 0.408
MOD_Plk_4 885 891 PF00069 0.421
MOD_Plk_4 932 938 PF00069 0.478
MOD_ProDKin_1 399 405 PF00069 0.558
MOD_ProDKin_1 489 495 PF00069 0.483
MOD_ProDKin_1 507 513 PF00069 0.462
MOD_ProDKin_1 521 527 PF00069 0.450
MOD_ProDKin_1 728 734 PF00069 0.537
MOD_ProDKin_1 798 804 PF00069 0.490
MOD_ProDKin_1 880 886 PF00069 0.428
MOD_SUMO_for_1 252 255 PF00179 0.545
MOD_SUMO_for_1 350 353 PF00179 0.420
MOD_SUMO_rev_2 134 140 PF00179 0.387
MOD_SUMO_rev_2 183 189 PF00179 0.427
MOD_SUMO_rev_2 530 537 PF00179 0.440
MOD_SUMO_rev_2 96 103 PF00179 0.310
TRG_DiLeu_BaEn_2 246 252 PF01217 0.501
TRG_DiLeu_BaEn_2 496 502 PF01217 0.486
TRG_DiLeu_BaLyEn_6 799 804 PF01217 0.384
TRG_DiLeu_BaLyEn_6 890 895 PF01217 0.435
TRG_ENDOCYTIC_2 368 371 PF00928 0.514
TRG_ENDOCYTIC_2 387 390 PF00928 0.468
TRG_ENDOCYTIC_2 404 407 PF00928 0.300
TRG_ENDOCYTIC_2 683 686 PF00928 0.438
TRG_ENDOCYTIC_2 906 909 PF00928 0.388
TRG_ENDOCYTIC_2 975 978 PF00928 0.479
TRG_ER_diArg_1 156 158 PF00400 0.355
TRG_ER_diArg_1 53 55 PF00400 0.556
TRG_ER_diArg_1 736 738 PF00400 0.421
TRG_ER_diArg_1 814 817 PF00400 0.466
TRG_ER_diArg_1 877 879 PF00400 0.493
TRG_NES_CRM1_1 170 185 PF08389 0.416
TRG_NES_CRM1_1 916 930 PF08389 0.407
TRG_NLS_MonoExtC_3 910 916 PF00514 0.458
TRG_NLS_MonoExtN_4 908 915 PF00514 0.447
TRG_Pf-PMV_PEXEL_1 1001 1006 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 141 145 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 173 177 PF00026 0.364
TRG_Pf-PMV_PEXEL_1 342 346 PF00026 0.358
TRG_Pf-PMV_PEXEL_1 710 714 PF00026 0.484
TRG_Pf-PMV_PEXEL_1 817 821 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 872 876 PF00026 0.546

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIU4 Leptomonas seymouri 76% 100%
A0A0S4KHU7 Bodo saltans 32% 100%
A0A1X0NVY5 Trypanosomatidae 45% 100%
A0A3S7WYM4 Leishmania donovani 99% 100%
A0A422NWJ9 Trypanosoma rangeli 44% 100%
A4HDS8 Leishmania braziliensis 84% 100%
E9AX63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QAB3 Leishmania major 95% 100%
V5D5L5 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS