Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin-conjugating enzyme - putative

Species:

Leishmania infantum

UniProt:

A4I123_LEIIN

TriTrypDb:

LINF_240027600

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I123

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I123

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.436
CLV_C14_Caspase3-7	86	90	PF00656	0.502
CLV_NRD_NRD_1	258	260	PF00675	0.428
CLV_NRD_NRD_1	26	28	PF00675	0.388
CLV_NRD_NRD_1	263	265	PF00675	0.410
CLV_PCSK_KEX2_1	197	199	PF00082	0.531
CLV_PCSK_KEX2_1	258	260	PF00082	0.428
CLV_PCSK_KEX2_1	26	28	PF00082	0.388
CLV_PCSK_KEX2_1	263	265	PF00082	0.410
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.509
CLV_PCSK_PC7_1	254	260	PF00082	0.547
CLV_PCSK_SKI1_1	197	201	PF00082	0.503
CLV_PCSK_SKI1_1	226	230	PF00082	0.314
CLV_PCSK_SKI1_1	264	268	PF00082	0.445
CLV_PCSK_SKI1_1	27	31	PF00082	0.432
CLV_PCSK_SKI1_1	317	321	PF00082	0.577
CLV_PCSK_SKI1_1	67	71	PF00082	0.461
DEG_APCC_DBOX_1	316	324	PF00400	0.489
DEG_ODPH_VHL_1	99	111	PF01847	0.221
DEG_SCF_FBW7_2	41	46	PF00400	0.518
DEG_SPOP_SBC_1	59	63	PF00917	0.503
DOC_CYCLIN_RxL_1	16	28	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.354
DOC_MAPK_DCC_7	132	142	PF00069	0.393
DOC_MAPK_gen_1	197	203	PF00069	0.426
DOC_MAPK_gen_1	26	32	PF00069	0.487
DOC_MAPK_MEF2A_6	214	222	PF00069	0.453
DOC_PP1_RVXF_1	224	230	PF00149	0.329
DOC_PP2B_LxvP_1	70	73	PF13499	0.368
DOC_PP4_FxxP_1	135	138	PF00568	0.310
DOC_USP7_MATH_1	145	149	PF00917	0.300
DOC_USP7_MATH_1	190	194	PF00917	0.668
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_USP7_MATH_2	231	237	PF00917	0.403
DOC_WW_Pin1_4	110	115	PF00397	0.312
DOC_WW_Pin1_4	179	184	PF00397	0.667
DOC_WW_Pin1_4	188	193	PF00397	0.658
DOC_WW_Pin1_4	237	242	PF00397	0.415
DOC_WW_Pin1_4	39	44	PF00397	0.555
DOC_WW_Pin1_4	4	9	PF00397	0.564
DOC_WW_Pin1_4	61	66	PF00397	0.488
DOC_WW_Pin1_4	81	86	PF00397	0.697
LIG_14-3-3_CanoR_1	214	218	PF00244	0.351
LIG_14-3-3_CanoR_1	263	273	PF00244	0.460
LIG_Actin_WH2_2	52	69	PF00022	0.517
LIG_APCC_ABBA_1	200	205	PF00400	0.347
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_deltaCOP1_diTrp_1	233	238	PF00928	0.454
LIG_FHA_1	141	147	PF00498	0.470
LIG_FHA_1	265	271	PF00498	0.466
LIG_FHA_1	302	308	PF00498	0.603
LIG_FHA_1	314	320	PF00498	0.427
LIG_FHA_1	32	38	PF00498	0.455
LIG_FHA_1	61	67	PF00498	0.449
LIG_FHA_2	189	195	PF00498	0.550
LIG_FHA_2	243	249	PF00498	0.471
LIG_FHA_2	297	303	PF00498	0.528
LIG_FHA_2	40	46	PF00498	0.600
LIG_LIR_Apic_2	236	241	PF02991	0.404
LIG_LIR_Gen_1	204	215	PF02991	0.431
LIG_LIR_Nem_3	102	108	PF02991	0.338
LIG_LIR_Nem_3	17	23	PF02991	0.433
LIG_LIR_Nem_3	204	210	PF02991	0.362
LIG_MYND_1	97	101	PF01753	0.455
LIG_Pex14_2	125	129	PF04695	0.363
LIG_Pex14_2	288	292	PF04695	0.580
LIG_SH2_NCK_1	207	211	PF00017	0.478
LIG_SH2_STAP1	315	319	PF00017	0.586
LIG_SH2_STAT5	126	129	PF00017	0.340
LIG_SH2_STAT5	18	21	PF00017	0.408
LIG_SH2_STAT5	24	27	PF00017	0.351
LIG_SH2_STAT5	279	282	PF00017	0.466
LIG_SH2_STAT5	315	318	PF00017	0.541
LIG_SH2_STAT5	76	79	PF00017	0.481
LIG_SH3_3	108	114	PF00018	0.391
LIG_SH3_3	124	130	PF00018	0.264
LIG_SH3_3	131	137	PF00018	0.352
LIG_SH3_3	196	202	PF00018	0.449
LIG_SH3_4	274	281	PF00018	0.524
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.545
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.406
LIG_SUMO_SIM_par_1	138	143	PF11976	0.312
LIG_SUMO_SIM_par_1	28	34	PF11976	0.490
LIG_TRAF2_1	202	205	PF00917	0.469
LIG_TRAF2_1	43	46	PF00917	0.577
LIG_WW_1	73	76	PF00397	0.501
MOD_CDC14_SPxK_1	182	185	PF00782	0.594
MOD_CDC14_SPxK_1	64	67	PF00782	0.355
MOD_CDK_SPxK_1	179	185	PF00069	0.595
MOD_CDK_SPxK_1	61	67	PF00069	0.395
MOD_CDK_SPxxK_3	113	120	PF00069	0.300
MOD_CK1_1	113	119	PF00069	0.341
MOD_CK1_1	12	18	PF00069	0.518
MOD_CK1_1	171	177	PF00069	0.754
MOD_CK1_1	188	194	PF00069	0.640
MOD_CK1_1	237	243	PF00069	0.572
MOD_CK1_1	39	45	PF00069	0.655
MOD_CK1_1	4	10	PF00069	0.686
MOD_CK1_1	58	64	PF00069	0.424
MOD_CK2_1	188	194	PF00069	0.559
MOD_CK2_1	39	45	PF00069	0.672
MOD_GlcNHglycan	163	166	PF01048	0.672
MOD_GlcNHglycan	248	251	PF01048	0.635
MOD_GlcNHglycan	38	41	PF01048	0.538
MOD_GlcNHglycan	85	88	PF01048	0.613
MOD_GSK3_1	168	175	PF00069	0.715
MOD_GSK3_1	184	191	PF00069	0.676
MOD_GSK3_1	233	240	PF00069	0.467
MOD_GSK3_1	242	249	PF00069	0.606
MOD_GSK3_1	292	299	PF00069	0.521
MOD_GSK3_1	301	308	PF00069	0.725
MOD_GSK3_1	51	58	PF00069	0.726
MOD_GSK3_1	79	86	PF00069	0.623
MOD_NEK2_1	1	6	PF00069	0.584
MOD_NEK2_1	19	24	PF00069	0.320
MOD_NEK2_1	213	218	PF00069	0.362
MOD_NEK2_1	30	35	PF00069	0.392
MOD_NEK2_1	303	308	PF00069	0.525
MOD_NEK2_2	192	197	PF00069	0.515
MOD_PIKK_1	264	270	PF00454	0.457
MOD_PK_1	51	57	PF00069	0.597
MOD_PKA_2	213	219	PF00069	0.360
MOD_PKA_2	246	252	PF00069	0.539
MOD_PKA_2	262	268	PF00069	0.442
MOD_Plk_4	213	219	PF00069	0.360
MOD_ProDKin_1	110	116	PF00069	0.312
MOD_ProDKin_1	179	185	PF00069	0.670
MOD_ProDKin_1	188	194	PF00069	0.656
MOD_ProDKin_1	237	243	PF00069	0.415
MOD_ProDKin_1	39	45	PF00069	0.559
MOD_ProDKin_1	4	10	PF00069	0.561
MOD_ProDKin_1	61	67	PF00069	0.484
MOD_ProDKin_1	81	87	PF00069	0.700
TRG_AP2beta_CARGO_1	17	27	PF09066	0.447
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.443
TRG_ENDOCYTIC_2	126	129	PF00928	0.334
TRG_ENDOCYTIC_2	207	210	PF00928	0.359
TRG_ER_diArg_1	25	27	PF00400	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S2	Leptomonas seymouri	51%	100%
A0A1X0NWL0	Trypanosomatidae	34%	100%
A0A3Q8ID23	Leishmania donovani	99%	100%
A0A3S5IS47	Trypanosoma rangeli	34%	100%
A4HDS5	Leishmania braziliensis	72%	98%
E9AX60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAB6	Leishmania major	91%	100%
V5BEA3	Trypanosoma cruzi	34%	100%