CID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I119_LEIIN

TriTrypDb:

LINF_240027200

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I119

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I119

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.557
CLV_NRD_NRD_1	296	298	PF00675	0.640
CLV_NRD_NRD_1	301	303	PF00675	0.623
CLV_NRD_NRD_1	64	66	PF00675	0.435
CLV_PCSK_KEX2_1	294	296	PF00082	0.651
CLV_PCSK_KEX2_1	300	302	PF00082	0.621
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.712
CLV_PCSK_PC7_1	296	302	PF00082	0.626
CLV_PCSK_SKI1_1	202	206	PF00082	0.663
CLV_PCSK_SKI1_1	208	212	PF00082	0.670
CLV_PCSK_SKI1_1	65	69	PF00082	0.453
DOC_CKS1_1	235	240	PF01111	0.666
DOC_MAPK_DCC_7	281	290	PF00069	0.702
DOC_MAPK_gen_1	281	290	PF00069	0.702
DOC_MAPK_MEF2A_6	281	290	PF00069	0.702
DOC_MAPK_MEF2A_6	91	100	PF00069	0.406
DOC_PP2B_LxvP_1	100	103	PF13499	0.437
DOC_PP2B_LxvP_1	288	291	PF13499	0.701
DOC_USP7_MATH_1	151	155	PF00917	0.551
DOC_USP7_MATH_1	167	171	PF00917	0.654
DOC_USP7_MATH_1	200	204	PF00917	0.650
DOC_WW_Pin1_4	12	17	PF00397	0.629
DOC_WW_Pin1_4	172	177	PF00397	0.636
DOC_WW_Pin1_4	223	228	PF00397	0.788
DOC_WW_Pin1_4	234	239	PF00397	0.619
DOC_WW_Pin1_4	270	275	PF00397	0.658
LIG_14-3-3_CanoR_1	121	126	PF00244	0.592
LIG_14-3-3_CanoR_1	208	217	PF00244	0.611
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_Clathr_ClatBox_1	125	129	PF01394	0.546
LIG_eIF4E_1	84	90	PF01652	0.368
LIG_FHA_1	209	215	PF00498	0.731
LIG_FHA_1	23	29	PF00498	0.543
LIG_Integrin_isoDGR_2	242	244	PF01839	0.661
LIG_LIR_Apic_2	232	238	PF02991	0.732
LIG_LIR_Gen_1	134	143	PF02991	0.474
LIG_LIR_Gen_1	187	195	PF02991	0.479
LIG_LIR_Gen_1	59	69	PF02991	0.419
LIG_LIR_Nem_3	134	138	PF02991	0.406
LIG_LIR_Nem_3	187	192	PF02991	0.475
LIG_LIR_Nem_3	59	64	PF02991	0.383
LIG_LIR_Nem_3	81	86	PF02991	0.432
LIG_NRBOX	159	165	PF00104	0.592
LIG_PALB2_WD40_1	123	131	PF16756	0.524
LIG_PTAP_UEV_1	226	231	PF05743	0.594
LIG_SH2_CRK	144	148	PF00017	0.522
LIG_SH2_CRK	235	239	PF00017	0.774
LIG_SH2_CRK	30	34	PF00017	0.524
LIG_SH2_STAP1	24	28	PF00017	0.587
LIG_SH2_STAT3	108	111	PF00017	0.438
LIG_SH2_STAT5	108	111	PF00017	0.419
LIG_SH2_STAT5	24	27	PF00017	0.586
LIG_SH2_STAT5	272	275	PF00017	0.598
LIG_SH2_STAT5	84	87	PF00017	0.351
LIG_SH3_3	13	19	PF00018	0.670
LIG_SH3_3	173	179	PF00018	0.616
LIG_SH3_3	224	230	PF00018	0.790
LIG_SH3_3	93	99	PF00018	0.384
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.608
LIG_SUMO_SIM_par_1	213	220	PF11976	0.538
LIG_TYR_ITIM	28	33	PF00017	0.515
MOD_CDK_SPK_2	12	17	PF00069	0.713
MOD_CK1_1	223	229	PF00069	0.747
MOD_CK1_1	3	9	PF00069	0.450
MOD_CK1_1	57	63	PF00069	0.487
MOD_CK2_1	153	159	PF00069	0.483
MOD_Cter_Amidation	298	301	PF01082	0.766
MOD_GlcNHglycan	144	147	PF01048	0.473
MOD_GlcNHglycan	155	158	PF01048	0.430
MOD_GlcNHglycan	20	23	PF01048	0.384
MOD_GlcNHglycan	227	230	PF01048	0.658
MOD_GlcNHglycan	231	234	PF01048	0.712
MOD_GlcNHglycan	5	8	PF01048	0.628
MOD_GlcNHglycan	56	59	PF01048	0.457
MOD_GSK3_1	18	25	PF00069	0.549
MOD_GSK3_1	221	228	PF00069	0.716
MOD_LATS_1	206	212	PF00433	0.610
MOD_N-GLC_1	78	83	PF02516	0.477
MOD_NEK2_1	106	111	PF00069	0.504
MOD_NEK2_2	200	205	PF00069	0.706
MOD_PIKK_1	255	261	PF00454	0.725
MOD_Plk_1	106	112	PF00069	0.511
MOD_Plk_1	167	173	PF00069	0.630
MOD_Plk_1	78	84	PF00069	0.475
MOD_Plk_4	121	127	PF00069	0.520
MOD_Plk_4	200	206	PF00069	0.680
MOD_ProDKin_1	12	18	PF00069	0.624
MOD_ProDKin_1	172	178	PF00069	0.626
MOD_ProDKin_1	223	229	PF00069	0.789
MOD_ProDKin_1	234	240	PF00069	0.617
MOD_ProDKin_1	270	276	PF00069	0.664
MOD_SUMO_rev_2	218	224	PF00179	0.548
TRG_DiLeu_BaEn_1	159	164	PF01217	0.588
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.479
TRG_ENDOCYTIC_2	144	147	PF00928	0.512
TRG_ENDOCYTIC_2	30	33	PF00928	0.513
TRG_ER_diArg_1	295	297	PF00400	0.635
TRG_ER_diArg_1	300	302	PF00400	0.625
TRG_NES_CRM1_1	123	136	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R9	Leptomonas seymouri	65%	100%
A0A1X0NWE2	Trypanosomatidae	39%	100%
A0A3S7WYL9	Leishmania donovani	99%	100%
A4HDS1	Leishmania braziliensis	85%	100%
C9ZW91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AX56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAC0	Leishmania major	94%	100%
V5AV25	Trypanosoma cruzi	41%	100%